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Washington University in St. Louis


Sniffing out error in detection dog data

A new study confirms that three viable explanations exist for detection dogs collecting non-target scat, including natural behaviors of non-target species altering the genetic profile of target scat. This finding has important implications for conservation projects using scat-detection dogs to track animal populations.

SourceWashington University in St. Louis·JournalScientific Reports·DateSep 14, 2018

Focused delivery for brain cancers

A novel technique developed by Hong Chen uses focused ultrasound to target drug delivery to the brainstem, bypassing the blood-brain barrier. This approach has shown promise in treating diffuse intrinsic pontine gliomas (DIPG), a childhood brain cancer with a five-year survival rate of less than three percent.

SourceWashington University in St. Louis·JournalJournal of Controlled Release·DateSep 4, 2018

'Blink' and you won't miss amyloids

Researchers at Washington University in St. Louis create 'blink' method to image amyloids, allowing for non-invasive visualization of these problematic proteins. The technique uses temporary fluorescence, causing amyloids to flash and enabling researchers to better understand their structure and behavior.

SourceWashington University in St. Louis·JournalChemBioChem·DateAug 30, 2018

In sync: How cells make connections could impact circadian rhythm

Scientists at Washington University in St. Louis have created an algorithm to reveal connections between cells over time, potentially impacting circadian rhythms. The approach, called ICON, shows the strength of these connections, which could lead to a better understanding of brain disorders such as epilepsy and Alzheimer's disease.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateAug 27, 2018

Vibrations at an exceptional point

A team of international researchers has developed a lasing system that produces phonons, the energy products of oscillation, or vibration. By tuning the system to create resonance, they can trigger mechanical movement that generates an acoustic wave. This breakthrough could lead to new medical and materials science applications.

SourceWashington University in St. Louis·JournalNature Photonics·DateJul 25, 2018

Leggy lizards don't survive the storm

Researchers found that survivors had larger toe pads on forelimbs and hindlimbs compared to pre-storm populations. Survivors also had proportionately longer fore legs and shorter back legs with smaller bodies. These findings suggest natural selection favors certain characteristics in response to extreme weather events.

Warming alters predator-prey interactions in the Arctic

New research from Washington University in St. Louis found that warming conditions can alter the way wolf spiders interact with their prey, including springtails and fungi, leading to changes in ecosystem processes like decomposition. This shift could potentially alleviate some impacts of global warming on carbon losses from the tundra.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateJul 23, 2018

Gene therapy method developed to target damaged kidney cells

Researchers at Washington University School of Medicine have developed a gene therapy method to target damaged kidney cells, which could lead to improved treatment for chronic kidney disease. The approach uses adeno-associated virus (AAV) to deliver genetic material to targeted cells, showing promise in slowing or reversing cell damage.

SourceWashington University in St. Louis·JournalJournal of the American Society of Nephrology·DateJul 5, 2018

New tools reveal prelude to chaos

Researchers at Washington University in St. Louis developed mathematical tools that determine when randomness emerges in stochastic systems, describing the kinetics before dissolving into randomness. The tools have potential to predict onset of chaos in nanoparticles to checking accounts.

SourceWashington University in St. Louis·JournalPhysical Review E·DateJun 6, 2018

Bugged out by climate change

Research tracked changes in Arctic arthropod populations in response to warming temperatures, finding more plant-eating and parasitic insects, and fewer detritivores. The study suggests that water availability will play a key role in determining which bug species can thrive in a warming Arctic.

SourceWashington University in St. Louis·JournalRoyal Society Open Science·DateApr 17, 2018

Back to the beginning

Researchers at Washington University in St. Louis have developed a new process to generate NP-like cells from human induced pluripotent stem cells (hiPSCs). The team mimicked the embryonic development process to produce nucleus pulposus cells, which could potentially be used to treat degenerative disc disease.

SourceWashington University in St. Louis·JournalStem Cell Research & Therapy·DateApr 17, 2018

New cellular insights in bone development

A team of engineers at Washington University in St. Louis studied the formation of new bone and teeth, discovering that miniscule gaps in collagen's fiber structure facilitate the nucleation of calcium phosphate. The findings provide a new view into the current theory of calcium phosphate nucleation in confined spaces.

SourceWashington University in St. Louis·JournalNature Communications·DateApr 6, 2018

Trap, contain and convert

Scientists at Washington University in St. Louis have developed a new method to convert CO2 into a solid inert mineral in basalt, which holds promise as an effective abatement agent for reducing greenhouse gas emissions. The research revealed that 47 kilograms of CO2 can be converted into mineral inside one cubic meter of basalt.

SourceWashington University in St. Louis·JournalEnvironmental Science & Technology Letters·DateApr 4, 2018

3-D mapping babies' brains

Researchers have developed a new method to precisely map brain folds in premature infants, which could lead to early detection of developmental disorders. The technique uses 3-D imaging and computer algorithms to identify subtle patterns of growth and folding, providing a unique fingerprint for each infant's brain development.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateMar 10, 2018

No progress seen in reducing antibiotics among outpatients

A new study found that antibiotic prescriptions continue to be prescribed at high rates in outpatient settings, contributing to drug-resistant infections and excess healthcare costs. The researchers analyzed data from Express Scripts Holding Co. and found no decline in overall antibiotic prescription rates over a three-year period.

SourceWashington University in St. Louis·JournalInfection Control and Hospital Epidemiology·DateMar 8, 2018

Simplifying samples

Researchers at Washington University developed a novel, low-cost technique to preserve blood and urine samples without refrigeration. The method uses nanoporous materials to protect protein biomarkers, maintaining 95% purity and enabling efficient transportation and analysis.

SourceWashington University in St. Louis·JournalChemistry of Materials·DateMar 2, 2018

Water world

Scientists at Washington University in St. Louis have developed the first experimental map of a cyanobacteria's water world, revealing pathways that could be used to deliver water to the active site. The discovery advances photosynthesis research and has implications for green fuels.

SourceWashington University in St. Louis·JournalScience Advances·DateNov 17, 2017