Articles tagged with Cell Therapies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Recent advances in T cell therapy have brought the idea of fighting chronic infections and cancers closer to reality. The use of potent cells with a safety mechanism has been demonstrated, and clinical trials have yielded highly promising results.
A recent study by McGill University researchers has made significant progress in understanding the mechanisms responsible for multiple sclerosis and identifying potential new treatments. By targeting a subset of B cells known as GM-CSF-producing B cells, the therapy shows promise in reducing disease activity.
Researchers at Griffith University have developed a new technique for growing cells in three dimensions, allowing them to freely associate and form natural structures. This method, using floating liquid marbles, has the potential to increase cell growth and function, particularly useful for spinal cord transplantation repair.
Kazan researchers compared direct gene and blood cell-mediated therapy for spinal cord injuries, revealing similar recovery outcomes in rats. The study found that both therapies preserved myelinated fibers, with cell-based therapy extending therapeutic influence over longer distances.
A clinical trial of a personalized cell therapy, CTL019, achieved an overall response rate of 57% and complete remissions in eight out of 14 patients with chronic lymphocytic leukemia (CLL). The therapy, developed by Penn researchers, involves reprogramming patients' own T cells to hunt and kill cancer cells.
Natural killer cells are impaired in the tumor microenvironment, but can be restored in normal conditions. Researchers identified two key factors blocking NK cell function: inflammatory cytokine IL-10 and down-regulated NKG2D ligands.
Researchers have successfully used autologous fat cell transplants to improve symptoms of osteoarthritis in patients. The treatment showed significant improvements in pain management and joint mobility, with most patients experiencing a minimum of 50% score improvement after 12 months.
A clinical trial found that patients who received more CD34+ bone marrow cells experienced significant benefits, with improved ejection fraction and lower rates of major adverse cardiac events. The study, which enrolled 161 patients, showed a dose-dependent trend in the effects of cell therapy on heart function.
Rapid lowering of body temperature after a heart attack can minimize damage to the heart muscle. New research highlights the need for faster and more effective cooling techniques to realize the full potential of therapeutic hypothermia.
A new technology developed by VIB/UGent scientists has simplified the production of biotech medicines by truncating complex sugar structures, retaining therapeutic efficiency. This innovation has the potential to make biotech medicine production cheaper and more efficient.
Researchers discovered that nimotuzumab promotes autophagic cell death, enhancing the antitumor effects of chemotherapy and radiation in ESCC cells with high EGFR expression. This finding suggests a potential strategy for improving therapeutic efficacy in esophageal squamous cell carcinoma.
Researchers discovered how Fragile X mental retardation protein affects brain cell protein production, leading to the development of potential therapies for the genetic disorder. The study identified a critical binding site on the ribosome that could be targeted by drugs.
Scientists have discovered a molecule that can induce cell death (apoptosis) in dendritic cells, a key type of immune cell. This understanding may lead to new therapies that shut down dendritic cell activity and reduce an immune reaction.
Researchers found therapeutic hypothermia to be beneficial for some patients following cardiac arrest, but ineffective or even worsening outcomes in others. The study suggests a need for more rigid guidelines to ensure appropriate application of cooling strategies.
New research reveals that macrophage populations mediate tumor cell removal following monoclonal antibody treatment. Additionally, targeting the p57Kip2 pathway in adults with type 2 diabetes may improve β cell function and expand β cell mass.
A new therapy for preventing production of sphingolipids in lymphoma cells has been developed, selectively killing virus-infected cells. The treatment, ABC294640, shows promise in treating primary effusion lymphoma, an aggressive variant of diffuse large B-cell lymphoma caused by viruses.
The university's premier biomedical instrument is expected to provide breakthroughs in treating animal and human health conditions, including cancer. The instrument uses thermal cell therapy and high-resolution imaging to target specific cells and tumors.
Researchers found that mild hypothermia improved behavioral scores and increased surviving neurons in rats with TBI. The treatment also reduced harmful protein levels linked to brain injury and cognitive dysfunction.
Researchers develop a therapeutic strategy that manipulates cellular heterogeneity to treat advanced melanoma. The approach uses a new drug-like molecule in combination with an existing chemotherapy, targeting only melanoma cells and suppressing tumor growth and metastasis.
Researchers have identified two key compounds produced by mast cells that promote fibrogenesis, leading to pulmonary fibrosis. Introducing mast cells into mice lungs can reverse disease protection and cause pulmonary fibrosis.
Researchers at VIB developed a mouse model to study the molecular mechanisms determining cellular identity, enabling targeted manipulation of iPS cells for safer and more effective therapies. This breakthrough advances cell therapy using iPS cells for regenerative medicine applications.
Research demonstrates that immune system's natural killer cells can kill off virus-infected tumor cells, rendering glioblastoma virotherapy less effective. The study suggests temporarily suppressing the immune system may counteract this response and enhance therapy.
Researchers from Ruhr-University Bochum report that impaired protein degradation causes muscle diseases, including filaminopathies. The study found that protection mechanisms against abnormal protein deposits do not work properly in patients, opening up new avenues for therapies.
The new guidelines recommend that all adults with HIV infection be treated, with no CD4 cell count threshold for initiating therapy. Initial regimens include a combination of nucleoside reverse transcriptase inhibitors and nonnucleoside reverse transcriptase inhibitors.
Researchers found that T-bet and RORα proteins enforce specific classes of memory B cells, which can produce antibodies against various infections. This discovery opens the way for developing vaccines that induce long-term immunity towards desired antibody classes.
A study published in JAMA found that using bone marrow cells to treat chronic ischemic heart failure did not show significant improvements in most measures of heart function. However, exploratory analysis revealed a significant effect on left ventricular ejection fraction (LVEF) among patients under 62 years old.
Researchers found that rituximab, a monoclonal antibody, was safe and effective in reducing liver damage in PBC patients who had an incomplete response to UDCA therapy. The study showed significant reductions in alkaline phosphatase levels and anti-mitochondrial antibodies after treatment.
Researchers studied the role of immune responses in oncolytic adenovirus therapy and found that CD8+ T cells mediate antitumor efficacy. The study proposes a new therapeutic regime combining oncolytic adenovirus with immunotherapy.
Researchers at UCLA have identified dihydromyricetin as a potential treatment for acute alcohol intoxication and withdrawal symptoms. The compound blocks the action of alcohol on the brain's GABAA receptors, reducing voluntary consumption without major side effects.
A study of over 26,000 patients found that therapeutic hypothermia was used in only 0.35% of out-of-hospital cardiac arrest cases in the US. Despite its proven benefits in reducing mortality and improving neurologic outcomes after a heart attack, hypothermic therapy is not being widely adopted in clinical practice.
Researchers at the Weizmann Institute have developed a new form of adoptive cell transfer that overcomes limitations of current therapies. This approach uses a donor pool of immune T cells prepared in advance, which are outfitted with receptors to specifically target and destroy tumors.
Researchers have identified a distinct population of immune cells that contribute to the pathogenesis of type 1 diabetes by helping CD8+ T cells elicit autoimmune responses in the pancreas. This subset of CD4+ T cells produces IL-21 and express CCR9, playing a critical role in autoimmune disease.
University of Cincinnati researchers have successfully produced large RNA nanoparticles using a bipartite approach, overcoming challenges in industry-scale production. The nanoparticles, containing small interfering RNA, show a half-life of between five and 10 hours in animal models, are non-toxic and produce no immune response.
For patients with confirmed high-grade dysplasia, endoscopic eradication therapy is recommended. Surveillance may be considered in some cases, but it is not a substitute for treatment. The American Gastroenterological Association recommends regular screening for cardiovascular risk factors and interventions.
Researchers have developed a cell therapy that selectively dampens vascular inflammation induced by LDL, showing substantial protective effects against atherosclerosis. The treatment has been shown to reduce the disease process by up to 70 percent in mouse studies.
Researchers discovered that activated T cells play a key role in IRIS, producing excessive interferon gamma and triggering an exaggerated immune response. A new animal model also confirmed the involvement of macrophages in sparking IRIS. These findings may lead to targeted prevention or therapy for HIV patients developing IRIS.
Scientists have developed a novel method to deliver therapeutic molecules, proteins, and DNA directly into living cells using laser-activated nanoparticles. The technique, which uses bursts of near-infrared light to create tiny holes in cell membranes, shows promise for gene-based therapies.
Researchers at Medical College of Georgia have identified a rare hybrid cell that can switch the immune system on or off, expressing indoleamine 2,3 dioxygenase to turn off T cells. This unique cell has properties of both dendritic and B cells, with potential implications for cancer and rheumatoid arthritis therapies.
Researchers have identified eIF5A as a crucial player in pancreatic beta cell dysfunction in diabetes. Blocking hypusine modification of eIF5A protected mice in a model of diabetes, suggesting potential therapeutics for preserving beta cell function.
Researchers have found that regulatory T cells slow down the immune response too soon, limiting vaccine effectiveness. By removing these cells, they discovered a two-fold increase in immune response to HIV vaccine.
Researchers at LSU Health Sciences Center have identified a novel mechanism that triggers brain damage during stroke, which they believe can be blocked using a high-potency reagent. This breakthrough may provide a new therapeutic target for stroke therapy, offering hope for patients affected by this devastating disease.
A new technique uses microscopic magnetic particles to target stem cells to sites of cardiovascular injury, resulting in a five-fold increase in cell localization and six-fold increase in cell capture. The method is directly applicable to clinical practice and could lead to the treatment of heart attacks and other vascular injuries usi...
Scientists discover a single transcription factor that can convert alpha cells into functional beta cells, increasing their number eight-fold in mice. The study shows promise for a potential new treatment for type I diabetes, where the body autodestructs beta cells leading to insulin deficiency and complications.
Researchers discovered a protein profile that may accurately predict tamoxifen resistance in breast cancer patients. The study found that the extracellular matrix metalloproteinase inducer (EMMPRIN) was significantly associated with an earlier tumor progression and poor clinical outcome.
A new study found that intermittent IL-7 therapy, combined with conventional antiretroviral therapy (c-ART), boosts the number of CD4+ and CD8+ T cells in HIV-infected patients with low T cell counts. This effect was observed for 48 weeks, suggesting a potential treatment option for these individuals.
A new study reveals that long-term non-progressors' immune cells can effectively contain HIV by stockpiling molecular weapons, enabling them to kill infected cells efficiently. The discovery advances understanding of the unique mechanisms behind this phenomenon and may inform the development of an HIV vaccine.
A phase II trial of Cybor-D, a combination therapy including cyclophosphamide, bortezomib, and dexamethasone, showed an improved response rate compared to traditional lenalidomide-dexamethasone therapy. The treatment resulted in a rapid initial decline and percentage reduction in M protein levels.
Two new studies provide insight into the molecular mechanisms underlying aberrant NF-κB activity in MM tumor cells. The research reveals diverse mutations that lead to pathological activation of NF-κB signaling in MM, highlighting its role as a target for therapy development.
Pazopanib, an oral angiogenesis inhibitor, demonstrated a 27% week 12 response rate and 73% total disease control rate in patients with advanced renal cell carcinoma. The study showed clear clinical activity in treating this type of cancer.
A team of students has invented a protective pouch that could improve cell therapy for diabetes patients. The pouch, made from nylon mesh and metal stents, holds microcapsules containing therapeutic cells, allowing them to thrive and produce insulin in the body.
A team of researchers from biology, chemistry, and engineering have developed a proposal for artificially created cells to treat diseases without injecting drugs. The cells would target and deliver chemicals needed by the body to function properly.
Researchers identified PTEN as a key regulator of Treg responsiveness to IL-2, enabling their proliferation and maintaining suppressive function. This discovery could provide a way to overcome the major challenge of harnessing Tregs for autoimmune disease treatment.
A new technology developed by Pall Corporation enables faster and more efficient cell harvesting for cell therapy, with processing times reduced to under 15 minutes. The system exhibits higher yield of cells and is easy to use, adhering to Good Manufacturing Practice (cGMP) regulations.
Neural transplants have provided long-term clinical benefits to three patients with Huntington's disease, improving motor and cognitive function. The procedure also led to focal improvements in brain metabolic activity, while secondary clinical alterations were observed due to the ongoing disease process.
Researchers at Johns Hopkins University developed tiny self-assembling cube-shaped containers that can deliver medications and cells. The cubes are trackable via MRI and have shown promising results in lab tests, including the release of microbeads and live cells.
Researchers have developed RNA nanoparticles that can carry multiple therapeutic agents into specific cancer cells, where they can halt viral growth or cancer progression. The tiny particles are assembled from three short pieces of ribonucleic acid and possess the right size and structure to gain entry into cells.
Researchers found that intermittent IL-2 administration induces high CD4 and CD8 cell proliferation followed by prolonged CD4 cell survival. This effect helps explain the preferential increase of CD4 cells in patients treated with IL-2 therapy.
Researchers identify optimal T cell selection and preparation strategies for adoptive immunotherapy approaches to treat tumors. Naive and early effector T cells are more effective than differentiated T cells in causing regression of large, established melanomas.
Researchers at UCSD found that statins and cholesterol depletors can reduce intracellular calcium levels and inhibit cell growth in pulmonary artery smooth muscle cells, which contributes to idiopathic pulmonary hypertension. This novel mechanism may provide a new approach for treating IPAH with current and future therapies.
New data from the largest study on CML patients (1106) showed improved rates of progression-free survival and durable responses to imatinib. Patients with early cytogenetic responses achieved higher progression-free survival rates, with 93% at 42 months compared to 74% without