Researchers designed cpLOV2 using circular permutation to simplify optogenetic device design. The new photoswitch maintained structural integrity and function, providing more choices for optogenetic application developments. It was successfully used to gate ORAI1 Ca2+ channel and control cell activities in a mouse model.
SourceHefei Institutes of Physical Science, Chinese Academy of Sciences·JournalNature Chemical Biology·DateMay 18, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have made a significant breakthrough in immunotherapy design, using specifically designed receptors to completely clear brain cancer tumors in preclinical models. The approach has shown promise and could pave the way for new treatments for people with glioblastoma, an aggressive form of brain cancer.
SourceWalter and Eliza Hall Institute·JournalClinical & Translational Immunology·DateMay 9, 2021
Researchers discovered two subsets of tumor cells that can be targeted using different methods, one inducing ferroptosis and the other inhibiting antioxidant production. The study found that combining these approaches could improve treatment outcomes for small cell lung cancer patients.
SourceUniversity of Cologne·JournalNature Communications·DateApr 6, 2021
Researchers have developed a new CAR T cell engineering technique that allows for the targeting of solid tumors without harming healthy cells. The technique uses ultrasensitive identification of HER2 protein on tumor cells and has shown promise in treating ovarian cancer.
SourceUniversity of Helsinki·JournalScience·DateMar 18, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that tumor cells increase SLC6A14 expression levels in response to methionine deprivation, leading to increased AMPK activation. Targeting both SLC6A14 and AMPK may drive unbalanced metabolism in starved tumor cells, promoting apoptosis.
SourceImpact Journals LLC·JournalOncotarget·DateMar 1, 2021
A significant number of NHL patients achieved complete remission and progression-free survival with Kymriah, a personalized cellular therapy. The study demonstrated the durability of this approach, with most patients remaining in remission five years after treatment.
SourceUniversity of Pennsylvania School of Medicine·JournalNew England Journal of Medicine·DateFeb 17, 2021
The study found that cell turnover and cost of resistance are important factors impacting adaptive therapy success, with higher cell density and smaller pre-existing resistance levels doing better under adaptive conditions. Researchers developed a mathematical model to visualize the dynamics of cell populations and competition between ...
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalCancer Research·DateFeb 15, 2021
Researchers developed a CD45-directed antibody radioconjugate to target and deplete specific immune cells. The treatment safely depleted T cells, B cells, NK cells, and Tregs in mice while sparing red blood cells and platelets.
SourceImpact Journals LLC·JournalOncotarget·DateJan 11, 2021
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Australian researchers have discovered a new mechanism by which prostate cancer cells can adapt and evolve into more aggressive forms, making them resistant to treatment. The study highlights the importance of targeting microRNA-194 to slow down and inhibit the growth of prostate cancer models with neuroendocrine features.
SourceFlinders University·JournalCell Reports·DateJan 5, 2021
Researchers at University of Texas M. D. Anderson Cancer Center discovered NIK protein essential for T cell metabolic shift during activation, regulating anti-tumor immunity. Elevated NIK activity in T cells may improve adoptive therapy efficacy.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Immunology·DateJan 4, 2021
A new consortium, Accelerating Research and Innovation for Advanced Therapies (ARDAT), aims to develop standardized models for predicting ATMP immunogenicity in humans. The €25.5 million project will also build understanding of ATMP drug metabolism within a host.
Researchers developed a novel photodynamic therapy to target insulin-producing lesions, showing promise in slowing tumor growth and inducing cell death. The treatment could provide a minimally invasive option for hyperinsulinemic hypoglycemia, improving patient management.
SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateNov 8, 2020
A new gelatin-based microcarrier offers significantly higher harvest rates of cells grown with over 90% compared to traditional standards. The microcarrier facilitates expansion of mesenchymal stromal cells used to treat various ailments, including heart attacks and immune system rejection.
SourceSingapore-MIT Alliance for Research and Technology (SMART)·JournalBiotechnology Journal·DateOct 29, 2020
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers have developed a computational approach called EpiMogrify that can predict the molecules needed to keep cells healthy in laboratory cultures. The model successfully identified molecules to maintain healthy nerve cells and heart cells, and predicted molecules that trigger stem cells to turn into specific cell types.
SourceDuke-NUS Medical School·JournalCell Systems·DateOct 12, 2020
SMART researchers have discovered a new way to manufacture human red blood cells that cuts the culture time by half compared to existing methods. The new protocol stores cultured cells in liquid nitrogen for 11 days and produces RBCs within 11 days.
SourceSingapore-MIT Alliance for Research and Technology (SMART)·JournalLab on a Chip·DateSep 14, 2020
Researchers propose using nanomaterials to elevate oxygen levels in tumor tissues, reducing resistance to therapies. Additionally, therapeutic gas-generating and radical-generating nanomaterials can control oxygen delivery and induce cell death, offering new avenues for hypoxic tumor treatment.
SourceScience China Press·JournalNational Science Review·DateAug 31, 2020
Scientists create genetically engineered, off-the-shelf therapeutic T cells that can recognize and kill specific cancer cells without requiring personalized training. The 'off-the-shelf' approach solves limitations of original cell immunotherapy methods by avoiding time-consuming processes and resulting in more potent cells.
SourceBaylor College of Medicine·JournalNature Biotechnology·DateAug 20, 2020
A clinical trial led by UNC Lineberger Comprehensive Cancer Center found CAR-T cell therapy to be highly active and safe in patients with relapsed/refractory Hodgkin lymphoma. The treatment resulted in a complete disappearance of tumor in the majority of patients and had an overall survival rate of 94% one year after treatment.
SourceUNC Lineberger Comprehensive Cancer Center·JournalJournal of Clinical Oncology·DateJul 23, 2020
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers found that high levels of pre-treatment interleukin 6 indicate a high risk for neurotoxicity and cytokine release syndrome from CAR T therapy. The study also suggests that targeting the tumor microenvironment prior to therapy may help reduce inflammation and toxicities.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalClinical Cancer Research·DateJul 15, 2020
A new study by the University of Tokyo reveals that cell-laden hydrogel fibers with a diameter of 1.0 mm provide long-term immunoprotection and functionality for pancreatic cells in diabetic mice, outperforming thinner fibers.
SourceInstitute of Industrial Science, The University of Tokyo·JournalBiomaterials·DateJun 15, 2020
A new cell therapy approach has been shown to reduce the need for immunosuppression in kidney transplant recipients, thereby minimizing the risk of side effects. The study found that regulatory cells were just as safe as standard treatment and did not result in higher rejection rates.
SourceCharité - Universitätsmedizin Berlin·JournalThe Lancet·DateJun 10, 2020
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A study published in Oncotarget reports that adoptive cell therapy in combination with checkpoint inhibitors improves T cell fold expansion and increases CD8 T cell tumor reactivity in patients with late-stage metastatic ovarian cancer. The authors suggest that combination immunotherapy may be a way forward for this purpose.
SourceImpact Journals LLC·JournalOncotarget·DateJun 10, 2020
Four critically ill COVID-19 patients improved significantly after receiving the experimental therapeutic CAP-1002, which contains cardiosphere-derived cells. The treatment helped reduce inflammation and showed no adverse effects, with all patients discharged from the hospital.
SourceCedars-Sinai Medical Center·JournalBasic Research in Cardiology·DateMay 12, 2020
Researchers at Lipo-ImmunoTech, a joint venture between Medical University of South Carolina researchers, are developing a novel adoptive cell therapy technology that factors in the role of lipids in suppressing the immune system. The grant aims to enhance the viability and functionality of expanded T cells.
A recent correspondence letter warns against premature use of novel therapies in COVID-19 patients, advocating for traditional critical care principles instead. The authors emphasize the importance of evidence-based practice and caution against abandoning reason during the pandemic.
SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory Cell and Molecular Biology·DateApr 27, 2020
A study published in eLife has identified two strategies used by cancer to survive treatment with immunotherapies, including one that disables energy production in cancer-killing T-cells. Researchers found that some human cancer cells release molecules that inhibit the activity of energy-producing mitochondria in T-cells.
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Calibr's novel cell therapy leverages a patient's own immune cells, directing them to engage cancer targets with a control switch. Clinical trials will test the approach in patients with relapsed/refractory B-cell malignancies.
Scientists at Tokyo Tech and Kyoto University create a PVA-BPA complex that allows boron to remain in cancer cells for longer periods, reducing the need for continuous infusion. This method enhances anti-cancer activities of BNCT and offers a simple solution for drug delivery
SourceTokyo Institute of Technology·JournalScience Advances·DateJan 22, 2020
City of Hope researchers have created a modified CRISPR gene editing tool that improves the accuracy and efficiency of cutting out undesirable genetic information. The new design has shown promise in treating HIV and sickle cell disease by increasing desirable mutations and improving activity at specific target sites.
SourceCity of Hope·JournalScientific Reports·DateNov 7, 2019
Researchers genetically engineered CAR T cells with molecular tags, allowing them to be monitored in animal models using PET imaging. This technology enables clinicians to track the number and location of CAR T cells over time, providing a more accurate measure of therapy durability and potential efficacy.
SourceUniversity of Pennsylvania School of Medicine·JournalMolecular Therapy·DateNov 5, 2019
A new cell therapy approach has been developed by Dr Christopher E Rudd, boosting the immune response of T lymphocytes to malignant tumours.
SourceUniversity of Montreal·JournalNature Communications·DateOct 24, 2019
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A Yale-developed drug stimulates immune cells to shrink or kill tumors in mice, with lasting effects and broad immune response. The therapy is effective alone or in combination with existing cancer immunotherapies, and has shown synergistic effects when combined.
SourceYale University·JournalJournal of Experimental Medicine·DateOct 14, 2019
Researchers at City of Hope have developed a new CAR T cell therapy targeting the B cell-activating factor receptor (BAFF-R), which showed remarkable tumor regression and prolonged survival in animal models. The therapy may potentially be used as a first-line treatment for patients who relapsed after CD19 immunotherapy treatments.
SourceCity of Hope·JournalScience Translational Medicine·DateSep 25, 2019
Amyotrophic Lateral Sclerosis (ALS) researchers found that aggregation of TDP-43 is not harmful but actually protects cells. This discovery challenges the assumption that alleviating protein aggregates is necessary to treat neurodegenerative diseases like ALS. The study opens doors to radically new therapeutic approaches if aggregation...
SourceCenter for Genomic Regulation·JournalNature Communications·DateSep 23, 2019
After a tragic death in 1999, gene therapy faced a setback, but James Wilson's rediscovery of adeno-associated viruses (AAVs) paved the way for its resurgence. Today, AAVs are used in nearly 100 drug development programs and have been approved by the FDA for treating a fatal neurological disease.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateSep 18, 2019
The LIBRETTO-001 trial showed that selpercatinib achieved high response rates of up to 68% in patients with RET fusion-positive non-small cell lung cancer. The median duration of response was also notable at 20.3 months, with an intracranial objective response rate of 91%.
SourceInternational Association for the Study of Lung Cancer·DateSep 9, 2019
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers have created a super-stable form of MHC tetramer reagent, enabling faster detection and manipulation of T cells in patients. This breakthrough opens new possibilities for personalized cancer treatment strategies.
SourceTechnical University of Denmark·JournalScience Immunology·DateAug 9, 2019
Researchers used ultra-sensitive technology to characterize and identify neoantigens driving antitumor responses in a patient with metastatic melanoma. The study reveals new ways to guide the design of personalized adoptive T cell therapies, increasing the number of patients who will benefit from immunotherapy.
SourceUniversity of California - Los Angeles Health Sciences·DateJul 22, 2019
The August edition of SLAS Technology features a review on technologies for the directed evolution of cell therapies, which are moving beyond small molecules and proteins to using whole cells. Researchers can utilize emerging tools like image-activated cell sorters to accelerate high-throughput automation technologies.
SourceSLAS (Society for Laboratory Automation and Screening)·JournalSLAS TECHNOLOGY·DateJul 22, 2019
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Research conducted at the Irvine Lab at MIT's Koch Institute showed that activation of CAR-T cells in lymph nodes leads to massive CAR-T cell expansion and significant functional improvements. The AMP-CAR-T Platform combines CAR-T therapy with Amphiphile immunotherapies to amplify immune responses and combat solid tumors.
Scientists at the University of Edinburgh have developed a system to study endothelial cells, which line blood vessel walls. This breakthrough could lead to therapies that promote new blood vessel growth and help treat conditions like heart disease.
SourceUniversity of Edinburgh·JournalEuropean Heart Journal·DateJun 26, 2019
A new study found that elderly patients with metastatic renal cell carcinoma who received targeted therapies experienced improved overall survival rates compared to those treated with older, more toxic treatments. The study analyzed data from over 1,100 Medicare patients and showed a three-month survival advantage with targeted therapies.
SourceUniversity of Pennsylvania School of Medicine·JournalJAMA Network Open·DateJun 20, 2019
A human enzyme named FANCM is essential for the survival of cancer cells using an alternative telomere lengthening pathway. ALT tumor cells require FANCM activity to prevent telomere instability and cell death.
SourceInstituto de Medicina Molecular·JournalNature Communications·DateMay 28, 2019
Researchers at Seattle Children's have successfully engineered human B cells to produce therapeutic proteins, opening the door for a novel cell therapy. The B cells can survive indefinitely in models, offering a potential advantage over other treatments.
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A team of scientists at the Gladstone Institutes has developed a reliable method to identify potential off-target effects in therapeutically relevant cell types. The DISCOVER-Seq technique uses DNA repair factors to pinpoint exact sites where CRISPR cuts occur, enabling more accurate genome editing.
The RESTORE Health initiative aims to develop advanced therapies for curative treatments, backed by an international and interdisciplinary community. The consortium plans to invest up to €1 billion in new research projects over the long term.
Charité is leading three new EU-funded projects: ReSHAPE, VirtualBrainCloud, and ENDOSCAPE. The ReSHAPE project aims to develop a treatment for transplant rejection using regulatory T cells, while VirtualBrainCloud creates personalized brain simulations for neurodegenerative diseases. ENDOSCOPE develops non-viral gene delivery technolo...
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers have discovered a new population of immune cells that respond to immunotherapy treatment, as well as a critical molecular factor required for the therapy's success. The study highlights the importance of early-stage T cells and the need for further understanding of how checkpoint blockade therapies work.
SourceBrigham and Women's Hospital·JournalImmunity·DateJan 8, 2019
The Wyss Institute aims to develop 'Time-Tolerant Biostasis Therapeutics' that slow down critical processes in the human body, giving time to repair life-threatening injuries. The goal is to stabilize molecules, cells, organs, and metabolic state using temperature-independent mechanisms.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·DateDec 17, 2018
Researchers developed a strategy to block GM-CSF protein, reducing toxicities and improving CAR-T cell efficacy. A second strategy involves combining CAR-T cell therapy with a drug targeting AXL protein, potentially enhancing potency and lowering toxicity.
The phase-2 JULIET trial found that CAR-T cell therapy achieved a 52% favorable response rate in patients with relapsed or refractory diffuse large B-cell lymphoma, with 40% experiencing complete responses. Sixty-five percent of patients remained relapse-free after one year.
SourceUniversity of Chicago Medical Center·JournalNew England Journal of Medicine·DateDec 1, 2018
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers discovered small populations of T cells expressing functional SAP at normal levels in patients with XLP1, potentially modifying disease severity. This finding suggests gene therapy or adoptive cellular therapy could be effective treatments for the disease.
SourceTokyo Medical and Dental University·JournalJournal of Allergy and Clinical Immunology·DateNov 9, 2018
The SQZ Biotechnologies platform has been shown to preserve key biological functions essential for cell therapies, unlike electroporation technology. This study highlights the superiority of SQZ in delivering target-specific immune responses and enabling scalable cell therapy development.
SourceLifeSci Public Relations·JournalProceedings of the National Academy of Sciences·DateNov 1, 2018
Researchers developed a microfluidic technique to monitor specific biomolecules, indicating the health of living cell cultures. The technique uses electrospray ionization mass spectrometry and can detect low concentrations of biomolecules, guiding process control and improving quality control in cell manufacturing.
SourceGeorgia Institute of Technology·JournalBiotechnology and Bioengineering·DateOct 12, 2018
A new screening process, called Fast Indication of Nanoparticle Discovery (FIND), allows researchers to identify nanoparticles suitable for delivering therapeutic RNA into living cells. The technique inserts unique DNA snippets and a red-glowing Cre protein to verify nanoparticle entry into specific organs and cells.
SourceGeorgia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateOct 1, 2018
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new HIV immunotherapy study has demonstrated the safety and tolerability of a cell therapy approach involving ex vivo expansion of T cells. The study found that the treatment was well-tolerated with few adverse events, although no significant enhancement of the magnitude of the HIV-specific immune response was observed.
A team of researchers has identified a new type of pulmonary ionocyte, which is the site of cystic fibrosis-causing CFTR gene activity. This discovery could lead to new therapeutic approaches by increasing CFTR activity in affected cells.
SourceNovartis Institutes for BioMedical Research·JournalNature·DateAug 1, 2018
Senescent cells, also known as 'zombie cells,' interfere with tissue function and contribute to aging diseases. Researchers have designed a nano-carrier that selectively targets these cells, releasing drugs to kill them and improving therapeutic outcomes in pulmonary fibrosis and cancer models.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalEMBO Molecular Medicine·DateJul 26, 2018
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The NSU research team aims to improve therapeutic cell efficiency through manipulation of autophagy, a self-digestion pathway affecting exosome content. Understanding this process can lead to faster wound healing and improved organ regeneration.
Researchers have developed a new way to introduce molecules and therapeutic genes into human cells using ultrafast compression, which can improve cell transfection efficiency. The technique involves compressing cells in microfluidic devices, causing them to take up surrounding fluid and macromolecules.
SourceGeorgia Institute of Technology·JournalMaterials Today·DateApr 30, 2018