Research on the tests that detect and monitor disease. Covers blood tests, cancer monitoring, emergency diagnostics, and new patent-pending assays.
A new screening tool has been developed to identify pregnant women at risk of eating disorders, allowing for early intervention and treatment. The Prenatal Eating Behaviors Screening (PEBS) tool, created by WVU researchers, uses a 12-question screener to assess symptoms and emotions associated with eating disorders.
Researchers developed a biosensor using nanostructured and nanoporous surfaces to detect biomarkers in clinical samples, overcoming technical challenges of small sample amounts. The new technology can provide quick and accurate diagnoses for diseases like prostate cancer without needing dilution or preprocessing steps.
A wireless pacifier developed by researchers at Washington State University can monitor infants' electrolyte levels without the need for invasive blood draws. This non-invasive method provides real-time monitoring of sodium and potassium ion concentrations in saliva.
A team of scientists led by Professor Barbara Pierscionek has made significant progress in developing an anti-cataract drug. Lab trials showed improvement in refractive index profiles and lens opacity in 61% and 46% of cases, respectively.
A new nanosensor platform uses machine learning to analyze spectral signatures of carbon nanotubes for early detection of ovarian cancer. The approach detects biomarkers and recognizes the cancer itself, offering a promising alternative to traditional methods.
Serial self-testing with untrained individuals revealed a high frequency of procedural steps errors and accurate interpretations were inconsistent. The study suggests that self-performed RADT may not be suitable for mass screening in the workplace.
CHOP researchers developed CancerVar, an artificial intelligence-empowered platform for interpreting somatic cancer mutations. The tool provides standardized procedures for assessing the clinical impacts of over 13 million somatic cancer mutations.
A flexible sensor embedded in a diaper measures multiple components in urine, sharing results over Bluetooth for fast bedside analyses. The technology has potential to provide quick and painless urinalysis for incontinent, elderly or infant patients.
Researchers at the University of Cincinnati are searching for the ideal exosuit design to reduce muscle load and prevent work-related musculoskeletal disorders. The study found that commercially available exosuits have limitations, with the Auxivo LiftSuit being stiff and uncomfortable during prolonged wear.
A new study validates the Canadian Syncope Risk Score as a reliable tool to identify patients at low risk for serious outcomes after 30 days, potentially reducing hospitalization rates. The score showed better performance than another validated score, but its clinical utility remains uncertain and warrants further research.
A new study found that three experimental Alzheimer's blood tests perform differently in Black individuals compared to white individuals, putting Black patients at risk of misdiagnosis and inappropriate medical care. The PrecivityAD test was equally effective across racial groups.
A doctor's visit from the future describes patient care in 2042, where diagnosis and treatment are personalized based on individual biological abnormalities. Researchers believe this approach could lead to more effective treatments for neurodegenerative disorders.
A new type of sampler using felt nibs from pens has been developed for collecting biological samples, offering longer storage life and ease of use. This technology has potential applications in space exploration and medical settings.
Researchers have developed a rapid COVID-19 test that uses molecularly imprinted polymer nanoparticles to detect SARS-CoV-2. The new test is more sensitive and works under extreme conditions than existing antibody-based tests, with preliminary results indicating it can detect a 6,000-times lower amount of the virus.
Researchers at Rutgers University propose a new approach to COVID-19 vaccine testing by combining conventional and challenge trials. This parallel approach, called Combining Conventional and Challenge trials (CCC), aims to facilitate faster and more accurate vaccine assessment and more effective pandemic response.
Researchers found that fighters who rapidly cut weight before bouts are more likely to suffer concussions or be misdiagnosed with head trauma. The study also discovered that the practice may not offer a competitive advantage and can leave fighters at a disadvantage more often than not.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
A new study found that some symptoms commonly used to diagnose concussions, such as fatigue and neck pain, can be caused by intense exercise rather than a brain injury. The research highlights the need to consider these factors when assessing concussion in athletes on the field.
Researchers found that modeling studies have been assuming colonoscopies are more accurate than they really are, detecting fewer small adenomas. However, colonoscopy still appears effective in finding precursors of cancer.
Researchers found that AI-enhanced diagnosis helps doctors accurately detect fetal congenital heart disease, with fellows making the most accurate diagnoses. The new system uses graphical charts to represent the AI's analysis of ultrasound videos, improving accuracy and trust among medical professionals.
Researchers have discovered 23 proteins in breast milk that could indicate breast cancer, paving the way for a potential blood test. The study's findings, if confirmed, may enable earlier diagnosis and improve survival rates.
Researchers at UCLA found that premenopausal women with low levels of anti-Mullerian hormone are at a higher risk of experiencing significant bone loss within two to three years. The study suggests that measuring AMH levels could help physicians identify women at risk and provide targeted treatment.
Researchers identified ephrin ligands in saliva samples of patients hospitalized with COVID-19, strongly associated with severe diagnosis. Saliva analysis could provide a simple, non-invasive method to detect infections and guide care.
A study found that omecamtiv mecarbil did not improve exercise capacity or daily physical activity in patients with heart failure with reduced ejection fraction. The drug was well-tolerated, but its effectiveness in improving functional limitations was limited.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
A Johns Hopkins-led study published in New England Journal of Medicine found that convalescent plasma from recovered COVID-19 patients can effectively treat outpatients, with a 54% reduced need for hospitalization. The therapy's effectiveness increases with earlier administration within five days after diagnosis.
The Johns Hopkins-developed sensor combines accuracy levels approaching PCR testing with the speed of rapid antigen tests, offering a strong advantage over existing methods. It can be used for mass testing in disposable chip formats or on rigid or flexible surfaces.
A new device made from silicone and liquid metal, with knotted cords, measures pressure in the digestive tract similar to high-resolution manometry. The invention brings down cost and makes it easier to produce and deploy, offering a cheaper alternative for diagnosing dysmotility disorders.
Researchers at Mayo Clinic have developed a new antibody test to diagnose multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord. The validated test measures kappa immunoglobulin free light chains in cerebrospinal fluid, offering a faster and more cost-effective alternative to existing tests.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
A new study found that clinics with higher FIT completion rates had added staff to support patients, provided educational materials, and offered on-call support. This approach reduced disparities among low-income and racially diverse populations, improving colorectal cancer screening outcomes.
A recent study found that approximately 1 in 3 heart attack survivors experience significant mental decline in the days and months following their heart attack. Cognitive deficits can impact quality of life and treatment adherence, emphasizing the need for cardiologists to monitor patients regularly.
The Texas Tech University Health Sciences Center has received a five-year, $1.87 million NIH grant to investigate the role of vitamin A depletion in Alzheimer's disease. The research aims to test the hypothesis that a lack of antioxidant all-trans retinoic acid (ATRA) promotes reactive oxygen species toxicity.
Genetic testing of saliva samples has been shown to be more quick and sensitive than nasal swab testing for detecting SARS-CoV-2 virus, with implications for improving public acceptance of COVID-19 testing and reducing healthcare worker risks
Researchers developed a novel, in vitro cell culture-based allergy test that simplifies diagnosis and predicts therapy success. The test can generate mature mast cells with IgE receptors, allowing for easy activation and quantification using flow cytometry.
A study assessed SARS-CoV-2 rapid antigen testing accuracy among asymptomatic individuals in workplaces. Repeated testing was found to increase detection of COVID-19 cases, but also led to more false positives and decreased sensitivity.
Scientists have identified a potential new test for diagnosing Lyme disease by detecting autoantibodies to phospholipids. This approach could help clinicians diagnose the disease sooner and determine efficacy of treatments. The researchers' discovery has the potential to identify patients with persistent symptoms after treatment, makin...
During the COVID-19 pandemic, Medicaid patients in Wisconsin with opioid use disorder experienced decreased access to treatment, including buprenorphine and urine drug testing. The study highlights the need for continued support and resources for these individuals.
A study by the University of Washington School of Medicine found that home-based flu tests are comparable in accuracy to rapid diagnostic tests. The tests enable earlier diagnoses and reduce time to care for patients.
Researchers at West Virginia University are using machine learning and geographic information systems to identify areas with low COVID-vaccine uptake. They aim to pinpoint counties with increased risk of outbreaks, predict where testing is most crucial, and develop targeted interventions to increase testing rates. By acknowledging comm...
Researchers found that obstructive sleep apnea (OSA) accelerates the biological aging process and causes epigenetic age acceleration, leading to increased mortality risk. However, one year of CPAP treatment significantly slows down biological age acceleration in OSA patients, suggesting a potential reversal of age-related trends.
A study by Nagoya City University researchers found that patients with persistent postural-perceptual dizziness (PPPD) often exhibit exacerbating factors shortly after onset, worsening symptoms. These factors include upright posture, movement, and visual stimulation.
A new study found that a ketogenic diet significantly improves MS symptoms, including fatigue, depression, and cognitive function. Patients on the keto diet experienced reductions in neurologic disability and enhanced overall quality of life.
Researchers have created a groundbreaking dataset of ultrasonography scans of three major arteries supplying blood to the brain in children. The dataset consists of 821 participants, allowing for the development of machine learning models that can accurately predict a child's age and cognitive abilities based on their ultrasounds.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
A new study led by Kaiser Permanente investigators found that home blood pressure monitoring is a better option for making new diagnoses of hypertension than clinic settings. This method allows for multiple readings to be collected and averaged, providing a more accurate representation of an individual's average blood pressure.
The American Thoracic Society and European Respiratory Society have updated their technical standard for pulmonary function tests to address interpretation uncertainty and health inequity concerns. The new guidelines emphasize the importance of considering an individual's medical history, symptoms, and social circumstances when applyin...
A new report in NeuroRehabilitation found significant variability in prior Functional Movement Disorder studies, particularly in the use of inclusion criteria. The authors propose potential fixes to develop evidence-based diagnostic criteria.
Scientists at Hokkaido University developed a prototype sensor to rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples. The sensor's sensitivity allows for the accurate detection of these molecules, enabling rapid assessment of disease severity.
Researchers have created a portable device that can detect Parkinson's disease by analyzing the unique odor compounds on a person's skin. The 'e-nose' system showed an accuracy of 79.2% in diagnosing PD, with potential for improving diagnosis through machine learning algorithms.
A new blood test developed at Washington University School of Medicine has proven highly accurate in detecting early signs of Alzheimer’s disease, with a 93% accuracy rate. The test assesses amyloid plaques based on the ratio of A´2 and A´0 proteins in the blood, providing a low-cost alternative to expensive brain scans and spinal taps.
A study of 296 children aged 5-14 found that self-collected nasal swabs were effective for COVID-19 surveillance testing. The method was deemed feasible and with minimal errors.
Scientists at Flinders University have developed a new petri-dish that can grow and age live brain cells from patients, enhancing future studies on conditions like dementia, Parkinson's, epilepsy, and autism. The innovation could lead to more effective targeted drug treatments with reduced wait times.
A new poll of people aged 50 and older found that nearly 1 in 3 had a COVID-related delay for healthcare appointments in 2021. Many unvaccinated individuals still haven't rescheduled their appointments, posing concerns about preventive care, chronic condition management, and operations.
A recent study found that early detection of type 1 diabetes in children can effectively monitor and treat the disease. The cost analysis shows that standard screening could reduce costs from 28 euros to 22 euros per child, while also preventing metabolic derailments and their consequences.
Scientists demonstrate a definitive link between mitochondrial oxidative damage and cognitive dysfunction in Alzheimer's disease using a transgenic mouse model. The study found that Aβ1-42 aggregation in the hippocampus caused cognitive impairment, while oxidation led to mitochondrial dysfunction.
Researchers developed a new method using smartphone vibration motor and camera to monitor blood clots, with accuracy similar to commercially available techniques. The device can be used at home, making it easier for patients to test their PT/INR levels, potentially reducing the need for frequent clinical visits.
Researchers in Japan evaluated the cost-effectiveness of adding dipstick hematuria screening to a mass health check-up program. The study found that including routine testing for hematuria would promote early detection and treatment, leading to cost savings and improved patient outcomes. This cost-effective approach has the potential t...
A new method, ONEST, was developed to assess the performance of diagnostic tests with multiple observers. The method helps determine if adding more observers causes agreement to plateau, indicating an unreliable test or a minimum number needed for stable estimation.
Researchers at University of Gothenburg and Umeå University discovered a link between blood levels of neurofilaments and ALS diagnosis. Blood tests can differentiate ALS from other diseases, offering new opportunities for screening and measuring neurofilaments.