Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.
A new study reveals that cardiovascular benefits were only experienced by higher-income populations, while lower-income groups saw stagnant or worsening health risks. The study suggests that improving access to healthcare and social determinants of health is crucial for addressing these inequalities.
The latest issues of APA journals focus on treatment options for youth with irritability, exploring collaborative psychopharmacology approaches. Additionally, the studies examine disparities in the use of restraint among psychiatric patients.
A recent study published in JAMA Network Open reveals that high prices for new diabetes medicines limit access worldwide. The research proposes that increased generic and biosimilar competition could significantly reduce prices, making treatments more affordable.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
A new platform has been developed to identify and optimize peptides targeting the SARS-CoV-2 envelope protein, a potential drug target for treating COVID-19. The study uses synthetic peptides to inhibit the virus's entry into host cells.
A new AI-powered tool developed by the University of Copenhagen and 3Shape predicts how teeth will move, allowing orthodontists to ensure braces are neither too loose nor too tight. The tool uses scanned imagery of teeth and bone structures to simulate how braces should fit, reducing trial and error.
A randomized clinical trial of 345 patients with mild-to-moderate COVID-19 found that viral load and symptom rebound were common after a standard 5-day course of antiviral treatment. Prolonging treatment duration may help reduce COVID-19 rebound
A large observational study of 148,000 individuals with ADHD found that initial dispensation of ADHD medication was associated with lower all-cause and unnatural-cause mortality. The association with natural-cause mortality was not significant in this study.
A study of 15,000 preterm infants reveals racial disparities in care treatment, with Black and Hispanic infants receiving less intensive care. The findings highlight the need to address social determinants of health and improve healthcare access for all infants.
A multicenter randomized trial showed a paclitaxel-coated balloon to be superior to an uncoated balloon in preventing target lesion failure in patients with coronary in-stent restenosis. The study included 600 patients and demonstrated the effectiveness of paclitaxel-coated balloons as a treatment option.
A novel approach estimates metabolic activity and infers blood glucose levels from near-infrared measurements in commercial smartphones and smartwatches. The phase delay between oxyhemoglobin and deoxyhemoglobin signals closely relates to oxygen consumption during cardiac cycles, serving as a gauge for metabolism.
A new study found that more than half of American Indian teens had high levels of cholesterol, with nearly two-thirds of young adults experiencing the same issue. The study suggests a need for early screening and treatment to prevent premature heart disease.
A qualitative study of 25 Black patient interviews reveals significant medical mistrust and anticipation of racism in emergency care. The study suggests system improvements are needed to address these issues and improve health outcomes for Black patients.
A study analyzing nationally representative data found that youth experienced a sustained increase in mental health issues between 2006 and 2019. The findings suggest that treatment and prevention strategies must address preexisting psychiatric needs in addition to the pandemic's direct effects.
Researchers developed a machine learning model to assess the quality of health news stories, outperforming laypeople in evaluating their accuracy. The model used expert criteria to classify articles as 'satisfactory' or 'not satisfactory', highlighting the need for multiple criteria in evaluating news.
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
Researchers found a direct link between loss of smell and decreased olfactory neuron population in nasal mucosa. Early corticosteroid treatment improved recovery of olfactory abilities in animals.
A comprehensive study found pulse oximeters significantly overestimated oxygen saturation readings in individuals with darker skin tones. This could lead to missed treatments and incorrect diagnoses, as devices may not accurately reflect critical oxygen levels.
Researchers at NJIT's Newark College of Engineering and College of Science and Liberal Arts receive $265K in grants from the New Jersey Health Foundation to develop biodegradable materials, enhance bone regeneration, and create air filters for viral removal. The projects focus on addressing environmental impact and promoting healthcare...
Researchers at Pennington Biomedical confirmed the accuracy of remotely gathered physical measurements for children in a weight management study. The findings support the value of remote height and weight measurements for both research and clinical purposes.
A new review focuses on personalised care for diseases like influenza, enabling accurate determination of when the infectious part has passed. The approach involves dialogue about treatment and prevention options, as well as individualised risk assessments to promote transparency and equity in medical care.
A new American Heart Association scientific statement highlights the value of AI technology in improving cardiovascular disease patient outcomes. Despite its potential, AI applications face gaps and challenges, including robust clinical validation and addressing biases.
Researchers at MIT's Picower Institute found that stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer's protein. The study suggests that 40Hz sensory stimulation promotes increased amyloid clearance via the glymphatic system.
After 7 to 12 years of follow-up, bariatric surgery outperformed medical/lifestyle intervention in achieving superior glycemic control with reduced medication use and higher rates of diabetes remission. Individuals who underwent bariatric surgery had better long-term management of their type 2 diabetes.
Researchers have discovered that certain volatile compounds emitted by microbes and food can alter epigenetic states in neurons and other eukaryotic cells. Exposure to these compounds can slow down neurodegeneration and cancer, while also affecting plant growth and responses to stress.
A survey study reveals primary care pediatricians lack preparedness in managing adolescent OUD, with a notable gap compared to other substance use disorders. The results underscore the importance of workforce training programs to address this critical healthcare issue.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
Researchers at City of Hope have developed a new approach to target and destroy hard-to-kill leukemia stem cells. The therapy method uses Type II interferon to disrupt the cancer cells' ability to divide, and a T cell engager antibody to create a bridge between the immune system and the leukemia stem cells.
A recent study published in JAMA Network Open found that vaccinated adults with hematologic cancers were at high risk of severe COVID-19, even after receiving treatment. The study included 6,122 patients and showed no significant decline in severe cases through mid-2022.
A new set of clinical guidelines aim to improve treatment for autistic adolescents living with chronic pain. The recommendations are based on the experiences of 10 autistic teenagers and their mothers, who reported challenges such as sensory issues, lack of autism awareness among staff, and difficulty communicating their pain.
The study of 5,951 women aged 63 to 99 found that higher levels of physical activity and lower amounts of sedentary time were associated with reduced heart failure risk. Promoting regular physical activity and limiting sedentary time may be a prudent strategy for primary prevention of heart failure in older women.
A randomized clinical trial found acupuncture to be clinically efficacious and favorably affect PTSD symptoms in combat veterans. The study suggests that further research is needed to explore the efficacy and mechanisms of acupuncture for PTSD treatment.
Researchers have developed a new class of antibiotics that can overcome drug-resistant bacteria by targeting the physical and functional integrity of the bacterial cell wall. This could be a game-changer in treating infections, particularly those caused by resistant strains.
In a phase 2 clinical trial, zilebesiran significantly reduced 24-hour mean ambulatory systolic blood pressure in adults with mild to moderate hypertension. The treatment was administered subcutaneously at varying doses and intervals, demonstrating its potential as an RNA interference therapeutic for managing hypertension.
Researchers at the University of São Paulo analyzed data from 115 children with syndromic growth disorders and found a high incidence of overlapping genetic alterations. The study highlights the importance of genetic sequencing in accurate diagnosis and treatment.
Weight loss treatments such as nutrition counseling and bariatric surgery increased the patient-level probability of achieving significant weight loss. Current treatment utilization rates are insufficient to impact the population level, highlighting a need for improved access.
A narrative review article in NeuroRehabilitation addresses the medicolegal challenges of litigating cases involving patients with disorders of consciousness. Clinicians and neurolitigators must be aware of the nuances, including terminology, assessment, prognosis, treatment, and patient rights.
Scientists have developed a cage-like molecule to trap sulfate in water, which could help control its concentration in health, industry, and environmental management. The molecular trap can be prepared inexpensively from off-the-shelf chemicals and has potential applications in medicine, such as treating cystic fibrosis.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Earlier anticoagulation reversal is associated with improved outcomes after intracerebral hemorrhage, supporting efforts to accelerate evaluation and treatment. This study supports intensive care strategies to improve survival rates among patients with this devastating form of stroke.
Researchers found that bariatric surgery led to improved cognition and overall well-being two years after the procedure. The study revealed changes in blood vessel efficiency and cortical thickness of the temporal cortex, offering new treatment options for patients with obesity and dementia.
A new study found that healthcare provider perceptions of patient preferences are the biggest barrier to prescribing oral rehydration salts (ORS), which costs only a few cents. Patients expressing a preference for ORS increased prescribing by 27 percentage points, making it an effective intervention.
A study of 352 patients found that endovascular thrombectomy benefits both directly presenting and transferred patients with large ischemic strokes, with better functional outcomes observed in those presenting directly to EVT-capable centers. Prolonged transfers worsened outcomes due to evolving ischemic change.
A randomized clinical trial of 1,680 patients with acute ischemic stroke due to large-vessel occlusion found no significant improvement in disability with adjunctive methylprednisolone. The study suggests that methylprednisolone may not be effective as an adjunct therapy after endovascular thrombectomy for this patient population.
A research team has discovered a novel mechanism by which stress affects the brain, revealing a potential new pathway for treating depression. Stress increases the production of MMP-8, an enzyme that alters neuron function and leads to behavioral changes.
Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.
A study of over 580 children found that childhood trauma disrupts neural networks involved in self-focus and problem-solving. The research suggests that trauma therapies should address not only thoughts but also the impact on the body, sense of self, emotional processing, and relationships.
Researchers found a correlation between body temperature and depression symptom severity in a large international study. Participants with higher depression scores had higher body temperatures, suggesting that cooling the body may be a novel treatment approach for depression.
A recent study of 1,404 mental health facilities found that mental telehealth services are not equally accessible across the US, with disparities observed at local levels. The findings suggest widespread inequalities in who has access to these services, highlighting the need for targeted solutions.
Researchers found that Black women who develop high blood pressure before age 45 are twice as likely to suffer a stroke. The study, presented at the American Stroke Association’s International Stroke Conference 2024, highlights the disparity in stroke rates among Black and white women.
The review discusses the mechanism of CRISPR/Cas9 and its challenges in delivering genome editing to cancer cells. Nanotechnology-based delivery systems, such as nanoparticles and exosomes, have shown promise in improving the efficiency and specificity of CRISPR/Cas9 gene editing.
A multidisciplinary team created a new algorithm to provide optimal personalized treatment options for individuals with esophageal cancer. The framework uses various heterogeneous factors that facilitate the progression of the disease and demonstrated high accuracy in controlling esophageal cancer.
A new study emphasizes the importance of strict legal rules governing fertility treatment in the UK, warning that recent court cases could create a common law exception to informed consent. The research highlights the need for rigorous consent regimes to protect vulnerable patients from exploitation and misuse of genetic material.
A global collaboration of researchers recommends the use of potassium-enriched salt substitutes in hypertension treatment guidelines due to their health benefits and long-term patient compliance. The shift could help address spiraling rates of uncontrolled high blood pressure and reduce preventable deaths.
A University of Houston optometry researcher has warned against using low-level red light therapy for myopia in children due to potential retinal damage. The therapy, which involves prolonged exposure to a red light-emitting instrument, can put the retina at risk of photochemical and thermal damage.
Researchers developed a new chip that can detect cancer cells in blood samples, enabling clinicians to adapt treatments and improve outcomes for patients with lung cancer. The device traps and concentrates tiny numbers of cancer cells, allowing for regular monitoring of treatment effectiveness.
In a randomized clinical trial of 1,068 smokers, electronic cigarettes were shown to be as effective as varenicline in aiding smoking cessation, while being more effective than nicotine chewing gum. The study suggests that e-cigarettes may offer a viable alternative for quitting smoking with minimal behavioral support.
A study of Medicare patients in 2022 revealed disparities in COVID-19 therapy access based on patient age, race and ethnicity, Medicaid eligibility, and nursing home residence. Higher-risk individuals received COVID-19 therapy less often than those with lower risk factors.