Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Terminating metformin treatment was associated with higher risk of developing dementia in a large cohort of adults. The study of 41,000 participants found that early metformin cessation was linked to increased dementia incidence compared to continued use.
Tongxinluo significantly improved 30-day and 1-year clinical outcomes in STEMI patients, according to a randomized clinical trial. Further research is needed to understand its mechanism of action.
Researchers at Children's Hospital Los Angeles have developed a novel app called the CHALF score to predict if a child with acute liver failure needs a transplant. The tool assesses liver failure risk on a scale of 5-60 and has been shown to accurately predict patient outcomes.
A team of University of Waterloo researchers has developed bio-compatible and non-toxic hydrogel composites using sustainable cellulose nanoparticles derived from plants. The tiny robots have the potential to conduct medical procedures, such as biopsy, and cell and tissue transport in a minimally invasive fashion.
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
A randomized clinical trial found that high-frequency electrical stimulation device reduced opioid use and prescribed opioids after cesarean delivery, suggesting a potential adjunct to decrease opioid use without compromising pain control.
A study of 5,435 adolescents and young adults with cancer found that those receiving specialty palliative care experienced a decrease in pain severity. However, the intervention did not affect other symptoms, highlighting the need for new interventions targeting other symptoms during treatment.
Recent studies suggest that probiotics may offer a protective effect against hypertension, but the exact mechanisms are unclear. A new study identifies two probiotic strains, Bifidobacterium lactis and Lactobacillus rhamnosus, as promising treatments for high blood pressure.
A global team of scientists emphasizes the need for collaboration between experts in AI, medicine, ethics, and beyond to develop fair models. They argue that focusing on equity rather than complete equality is a more reasonable approach, considering factors like race, gender, and patient preferences.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
A meta-analysis of 40 studies involving 310,000 youths found low treatment rates for depression and anxiety in children and adolescents. Targeted interventions to improve psychiatric disorder treatment rates are urgently required.
A smart brain-wave cap can diagnose stroke in ambulances, allowing for prompt treatment and potential lifesaving. The cap uses EEG tests to recognize large ischemic strokes, directing patients to specialized hospitals for mechanical removal of blood clots.
A new specimen collection system has been developed to enhance assisted reproductive technologies by providing a simple one-step method for selecting high-quality sperm for ICSI. The system, known as NovaSort, uses a barrier mesh to isolate mobile sperm without damaging their DNA.
A randomized clinical trial found that cefepime increased neurological dysfunction in adults hospitalized with acute infection, while piperacillin-tazobactam did not. The study involved 2,511 participants and suggested that cefepime may be associated with adverse outcomes.
A team of researchers discovered two genetic genes that predispose people to Raynaud's phenomenon: ADRA2A and IRX1. These variations cause small blood vessels to contract in response to stress or cold, leading to vasospasms and limited blood flow. The study could lead to effective treatments for the condition.
A groundbreaking study sheds light on the intricate mechanism behind the immune system's ability to differentiate between self and non-self antigens. Continuous activation of self-reactive T cells is essential for maintaining equilibrium and self-tolerance through regulatory T cells.
A recent study of nearly 13,000 veterans with nonmetastatic castration-resistant prostate cancer found that Black and Hispanic men have improved outcomes when treated in equal-access settings. The research highlights the need for targeted care to address racial disparities in healthcare outcomes.
A large population-level study found that patients with mental health conditions experienced fewer disruptions in care after the transition to virtual psychotherapy, with a shorter time between appointments. Individuals with depressive, anxiety, or bipolar disorders were more likely to maintain consistent visits.
Approximately 1 in 5 adolescents had major depressive disorder, with less than half receiving mental health treatment. Racial and ethnic minority groups, particularly Latinx, experienced the lowest treatment rates.
A new national ALS research consortium, Access for All in ALS, has been launched with a $16.7 million NIH award. The consortium will include 34 clinical sites nationwide and generate a longitudinal biorepository linked to detailed clinical information.
A new study reveals that esketamine nasal spray is effective in treating treatment-resistant depression, with 27.1% of patients achieving remission after 8 weeks compared to 17.6% on quetiapine XR. Long-term data shows sustained remission rates at 21.7% for esketamine NS and 14.1% for quetiapine XR.
Researchers developed a novel approach to predict therapeutic targets for aging and age-related diseases. They trained a domain-specific BioGPT model on biomedical literature, which improved its performance in identifying prospective targets.
In a randomized clinical trial, weekly tirzepatide showed greater reductions in HbA1c levels and body weight compared to prandial insulin as an additional treatment in people with inadequately controlled type 2 diabetes. The study also found less hypoglycemia with tirzepatide.
A study published in JAMA Network Open found a persistent increase in psychotropic medication dispensation among children and adolescents with type 1 diabetes. The findings highlight the need for integrated pediatric diabetes care and mental health services to detect psychological needs early on.
A University of Melbourne research team is developing an oral therapeutic to restore the activity of common antibiotics used to treat community-acquired bacterial pneumonia. The project aims to combat antibiotic-resistant bacteria and reduce healthcare costs, with potential applications in low- and middle-income countries.
A meta-analysis found that CPAP treatment adherence is associated with a lower risk of recurrent cardiovascular events in patients with obstructive sleep apnea. Adherence to CPAP therapy may be a key factor in secondary cardiovascular prevention.
A study of nearly 10,000 subarachnoid hemorrhage cases in Finland found significant variations in mortality rates among university hospital districts. Patients treated at Helsinki University Hospital and Oulu University Hospital had the lowest mortality rates, with a difference of 52% compared to Turku University Hospital.
The study found that Paxlovid treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals. Severely immunocompromised patients showed the greatest benefit from this treatment.
The journal highlights the complexities of neurological injury and neurodegenerative diseases, emphasizing virtual care as a potential solution. Identifying and treating neuropsychiatric symptoms is crucial for effective rehabilitation.
A 50-state survey study found a strong association between COVID-19 misinformation and the use of non-evidence-based treatments like ivermectin and hydroxychloroquine. The study suggests that misinformation may lead to increased harm from ineffective and potentially toxic treatments.
A study found that a water additive containing pomegranate extract can limit the formation of plaque and tartar in dogs after professional dental cleaning. The additive was shown to reduce plaque buildup by 47% and tartar by 24%, promoting healthy gums.
A recent study by University of Illinois researchers highlights the struggles women face in establishing credibility for their medical problems and receiving proper treatment. These women engage in 'credibility work,' where they meticulously gather evidence, marshal witnesses, and carefully manage their appearance to convey validity. H...
A new study found that living donor liver transplant access optimizes the timing of transplant for older, frail cirrhosis patients. Patients with moderate to severe frailty, short stature, and low MELD scores benefited from LDLT, reducing waitlist mortality and improving post-transplant outcomes.
Researchers have developed an integrated sensor capable of capturing and enhancing bio-signals, paving the way for potential treatments of brain disorders. The innovative technology uses inkjet printing to create a flexible substrate with a custom-made sensor.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
The Mount Sinai Hospital's Cohen Center will expand its research and clinical care to include 'long Lyme Disease/Lyme+', exploring key similarities and differences with long COVID. The center will offer novel therapies, including virtual reality and non-invasive brain stimulation technologies, as well as personalized cognitive rehabili...
A new study found that only one out of four recommended screening tools for sepsis is reliable, with NEWS-2 accurately predicting 72.2% of all sepsis cases. The study also highlights the need for better awareness and more frequent use of effective screening tools to improve early sepsis recognition and survival rates.
The study of 6,499 patients suggests that higher buprenorphine doses can reduce time to discontinuation. This finding challenges current recommended dosages for improving treatment retention.
A study of 194 patients found that those with alcohol-related diagnoses made 44% more visits and had a 138% higher death rate over 20 years compared to controls. Targeted interventions in emergency departments may help reduce this significant health burden.
The University of Colorado Anschutz Medical Campus has received a $54 million grant from the National Institutes of Health to advance clinical and translational science. The grant will enable the Colorado Clinical and Translational Sciences Institute (CCTSI) to translate discoveries into better health and patient care across the state.
A study found that school-based health centers (SBHCs) can improve access to care for low-income students. SBHCs were also associated with a reduction in income-based health disparities, supporting their expansion as a solution.
Researchers found that early treatment of child obesity is effective in improving weight status and metabolic health. Children whose parents received parental support had the best results, with more showing a clinically relevant improvement.
Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.
A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.
A recent study found elevated TonEBP expression in patients with lupus nephritis, correlating with inflammatory cytokines and kidney damage. Suppressing TonEBP was shown to halt lupus progression and mitigate kidney damage in animal models.
A dose-response meta-analysis of nine randomized trials found gefapixant to improve cough frequency, severity, and quality of life. However, it also led to increased taste-related adverse events compared to placebo.
A study by Lena Havstam Johansson found that nearly 5% of 70-year-olds had undiagnosed glaucoma, which damages the optic nerve and affects vision. Those with glaucoma reported poorer quality of life due to impaired vision, leading them to avoid social activities and feel frustrated.
Medical cannabis use in Australian patients with chronic health issues is linked to significant improvements in overall health-related quality of life and fatigue levels. Patients also report clinically meaningful reductions in pain and moderate-severe anxiety and depression.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A new study from the University of Michigan found significant language-based disparities in patients' access to cancer care. English-speaking callers were able to get information on next steps 94% of the time, while Spanish-speakers and Mandarin-speakers were only connected at 38% and 28% respectively.
The latest issues of American Psychiatric Association journals focus on postpartum depression, structural racism, and suicidal behaviors. The September issue highlights new solutions to address these topics, including Power Redistribution and Upending White Supremacy in Community Mental Health.
A new study by Indiana University School of Medicine found that increasing pediatric readiness in emergency departments can reduce racial disparities in children and adolescents with acute medical emergencies. The higher the level of readiness, the lower the disparity between racial and ethnic groups.
A new blood-based test called p-tau217 has shown great promise in identifying Alzheimer's disease by stratifying patients into low, intermediate, and high-risk groups. The two-step workflow reduces the need for confirmatory testing in uncertain cases.
A recent study of 31 million pregnant individuals found that infertility treatment is associated with an increased risk of stroke-related hospitalization within 12 months of delivery. The risk was evident as early as 30 days postpartum, highlighting the importance of timely follow-up and long-term monitoring to mitigate stroke risk.
Researchers analyzed data from 220,935 injured mountain bikers and 17,757 injured hikers to find the injury types and affected body areas. Most reported injuries were of low severity, primarily affecting upper limbs in mountain bikers and legs and ankles in hikers.
A global analysis of 2.3 million people reveals women are diagnosed and treated late for cardiac issues, with alarming rise in heart attacks among younger women. Non-traditional symptoms like vomiting, jaw pain, and abdominal pain are more common in women.
A tailored exercise program starting three to six weeks after shoulder surgery is the best approach for preventing a secondary shoulder dislocation. Patients who embark on such a program are twice as likely to avoid a recurrent injury than those using exercise alone.
Two studies published by Aarhus University found that common side effects like malaise, fever, and fatigue occur frequently after COVID-19 vaccination. Menstruating women reported a 30% increase in menstrual cycle changes, with stress, age, and smoking contributing to the correlation.
Muvalaplin, an oral small molecule inhibitor, significantly lowered lipoprotein(a) (Lp[a]) levels in a first-in-human phase 1 study. The treatment showed promise in reducing Lp[a] levels by up to 65% without tolerability concerns.
Researchers found that optimized statin therapy can significantly reduce mortality and cardiovascular events in US military veterans with coronary artery disease. Widespread use of ezetimibe alongside statins may lead to additional reductions in cardiovascular risk.