Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A focused update of the European Society of Cardiology (ESC) Heart Failure Guidelines incorporates latest evidence-based treatments for improved patient outcomes. New recommendations include SGLT2 inhibitors and intensive treatment strategies to reduce hospitalization and mortality.
The COVID-19 pandemic worsened treatment outcomes for patients admitted with acute myocardial infarction (AMI), but did not significantly amplify existing racial and ethnic disparities in care. Additional efforts are needed to mitigate these inequities, particularly during periods of high hospital COVID-19 burden.
A study of 612 women found that adherence to preconception healthy dietary patterns before infertility treatment may be associated with a lower likelihood of pregnancy loss. The findings suggest a potential benefit of healthy eating habits for fertility outcomes.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
A new study finds that severe behavioral symptoms in older adults are associated with a higher likelihood of divorce, while those with more advanced dementia are less likely to end their marriages. The research analyzed data from 263 married couples and found a positive correlation between neuropsychiatric symptoms and divorce risk.
A new study published in the Journal of the American Heart Association found that people who experience pain after a heart attack are more likely to die within the next 8.5 years. The study analyzed data from over 18,300 adults who had a heart attack and found that moderate or extreme pain was linked to a higher mortality risk.
A new study has identified thousands of shared genetic variants between patients with irritable bowel syndrome (IBS) and psychiatric disorders such as bipolar disorder, schizophrenia, depression, and anxiety. This discovery provides a new understanding of the brain-gut axis and holds promise for developing effective treatments for IBS.
Researchers found that US physicians propagate COVID-19 misinformation about vaccines, treatments, and masks on large social media platforms. A wide reach was observed among the physicians based on their number of followers.
HBP researchers used glucose uptake to locate alpha waves' generation, finding subcortical areas drive cortical activity associated with consciousness. The study reveals an inverted u-shape relation between alpha power and brain function in patients with disorders of consciousness.
A systematic review found that social media use interventions improved mental wellbeing in over a third of studies, with significant improvements in depression. Therapy-based interventions were most effective, with 83% improvement rates compared to limited or no social media use.
Researchers found that delivering at 39 weeks reduced perinatal risk in term singleton pregnancies conceived through infertility treatment. This study suggests a specific gestational age for optimal birth outcomes in these cases.
Researchers tested an automated microscope combined with AI software to diagnose malaria in blood samples. The system achieved 88% accuracy, comparable to expert microscopists, and has potential benefits including reducing workload and increasing patient load.
Researchers demonstrate the potential of optical imaging for safely measuring vocal fold elasticity and pliability. The study found good agreement between Brillouin microspectroscopy results and conventional elasticity measurements.
The first locally acquired malaria cases in the US in 20 years have been reported, highlighting the need for clinicians to be vigilant about the disease's symptoms. Malaria thrives in warmer climates and can cause serious illness and death if not treated, emphasizing the importance of rapid diagnosis and treatment.
A new study published in JAMA Network Open shows that methadone use following surgery in infants can increase hospital stay and delay recovery. Babies who required methadone needed to stay in the hospital an average of 21 days longer after surgery, as well as more days on ventilators and IV nutrition.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
A new study from the University of East Anglia found that most vapers believe a 'Swap-to-Stop' scheme providing free e-cigarettes would have helped them quit smoking. However, some respondents prefer to purchase e-cigarettes commercially due to personal preference for specific products.
A study found that only 22% of people with opioid use disorder received evidence-based medication treatments in 2021. Telehealth services were associated with a significantly increased likelihood of receiving these life-saving medications.
A new drug targeting Netrin-1 blocks Epithelial-Mesenchymal Transition (EMT) in cancer cells, reducing metastasis and sensitizing tumors to chemotherapy. In clinical trials, the therapeutic antibody showed no toxicity and decreased EMT in patients with endometrial cancers.
Consistent disparities among marginalized populations are more likely to experience unexplained queue jumps and hallway placement. Standardizing triage processes can help mitigate conscious and unconscious biases in emergency departments.
A study using wastewater metrics found accurate assessments of county SARS-CoV-2 incidence and may be the best metric for monitoring virus circulation. Home testing increases and vaccination treatment decrease disease acuity, making wastewater surveillance a reliable option.
The study explores resonance between narrative medicine and traditional Chinese medicine, highlighting similarities in case histories. By integrating ancient wisdom with modern approaches, a more compassionate healthcare system can be developed.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
A new study found that a dedicated older people's emergency department at Norfolk and Norwich University Hospital reduced wait times by 20% compared to the main emergency department. Patients treated under this initiative received earlier frailty assessments within 34 minutes of arrival, leading to fewer hospital admissions.
A University of Ottawa study reveals that a diverse brain's ecosystem is key to maintaining normal function while responding to changes. This concept is inspired by Charles Darwin's idea that biodiversity is crucial for survival, suggesting cell-to-cell diversity helps prevent failures in brain circuits.
Researchers have developed a new study showing that targeted electrical stimulation in patients with traumatic brain injury improved memory recall by 19%. The technology delivers the right stimulation at the right time, informed by the wiring of the individual's brain and that individual's successful memory retrieval.
A large-scale study found that exercise programs for dialysis patients lead to significant improvements in physical fitness, quality of life, and reduced hospital stays. Personalized exercise plans showed low costs per training unit, making them a viable option for standard healthcare coverage.
The Multicultural Psychology Consultation Team (MPCT) fosters a network of clinicians and leaders interested in increasing access for people with rising identities. The team's efforts focus on building cultural humility, multiculturally responsive clinical care, and supporting providers delivering care.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
A new study analyzed data on women born between 1916 and 1975, revealing increases in primary involuntary childlessness and secondary infertility. Meanwhile, the success rate of assisted reproductive technology (ART) increased over time, with significant contributions to population growth.
A new study found that cetuximab plus radiotherapy is an active treatment option for locally advanced cutaneous squamous cell skin cancer, with an objective response rate of 83.2%. The treatment was well-tolerated, with most patients experiencing mild acneiform skin rash or fatigue.
Researchers at Texas A&M University found that substance use impairs cognitive flexibility by inhibiting specific neurons. Chronic cocaine or alcohol use alters the local inhibitory brain circuit, leading to decreased cognitive flexibility and increased risk of academic deficits and lower quality of life.
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
Researchers examine whether robots and AI can replicate the ethical concepts attributed to human nurses, including advocacy, accountability, cooperation, and caring. While AI can inform patients about medical errors and present treatment options, it questions its ability to truly understand and empathize with patients' values.
A study from Aarhus University reveals that PCSK9 regulates a receptor in the kidneys controlling protein excretion, leading to potential new treatment strategies for patients with kidney overloads. The researchers hope to further investigate the use of PCSK9 inhibitors in treating kidney diseases.
A randomized clinical trial found that treatment with these biologics showed no significant difference in time to recovery compared to placebo for patients hospitalized with COVID-19 pneumonia. The study's results suggest that alternative treatments may be needed for this patient population.
Researchers at the University of Pittsburgh School of Medicine found no evidence that prescription stimulant treatment in childhood increases the risk of substance use disorder (SUD) later in life. The study, published in JAMA Psychiatry, suggests that stimulants are an effective treatment for ADHD with few side effects.
A new study published in Human Reproduction found that women with endometriosis are more likely to experience a reduction in live births before receiving a definitive diagnosis. The research, which included over 18,000 women with surgically-confirmed endometriosis, showed that the number of first live births among these women was half ...
A study published in Frontiers in Microbiology found that administering vaginal suppositories with Lactobacillus crispatus can restore a healthy balance of vaginal microbiota and prevent recurrent cystitis. The researchers discovered that postmenopausal women with RC had significantly different bacterial communities compared to those w...
A new study from Aarhus University has found that applying AI predictions of protein structures enhances the CRISPR technology, making the cuts in a patient's DNA more precise. This discovery may lead to better treatments for patients with genetic disorders and potentially develop cures for various genetic diseases.
A study published in Neurosurgery found that surgical stabilization of odontoid fractures is associated with better outcomes, including lower rates of nonunion, myelopathy, and mortality. The study used propensity score analysis to compare surgical stabilization with nonoperative treatment and found significant benefits in both surviva...
A systematic review of group-based performing arts therapies found promise in reducing symptoms of anxiety and depression. The studies included 669 participants from nine countries, covering five forms of performance art, with dance being the most studied.
A recent meta-analysis of 29 studies found that intranasal insulin treatment can boost cognition in individuals with mild cognitive impairment or Alzheimer's Disease. The analysis suggests potential benefits for this treatment approach, which may be worth further investigation.
A study published in PLOS ONE found that equine-facilitated psychotherapy significantly improves the lives of patients struggling with substance use disorders. The therapy, which involves horses, has been shown to boost mood and overall well-being.
A Nottingham University Business School expert is working with Brazilian nurses to reduce post-caesarean wound infections, a common issue worldwide. The project aims to prevent infections through improved care management, which could improve quality of life and reduce healthcare costs.
An analysis of court cases suggests that mediation might not have resolved conflicts about children's medical treatment, with only around half of cases potentially avoidable. The study highlights the limitations of mediation in resolving complex disputes, particularly when personal values are deeply involved.
A nationwide study of nearly two million women found that those with PCOS who have undergone menopause are more than twice as likely to be diagnosed with ovarian cancer. The risk was also significantly higher for a type of ovarian tumor known as serous borderline, which can lead to cancer later on.
The inaugural issue of CHEST Critical Care focuses on clinically relevant research and patient management guidance for critical care medicine. The journal accepts submissions of original research, case series, and research letters, covering topics such as intensive care medicine and diverse populations.
A small study suggests that vaginal progesterone treatment can increase the chances of conception in couples with unexplained infertility. The treatment, which is safe and low-cost, showed more than double the birth rate among treated women, but further research is needed to confirm these results.
Once-weekly Icodec demonstrated superior HbA1c reduction compared to once-daily Degludec after 26 weeks, but no difference was found in weight change. However, Icodec showed a higher rate of combined level two or three hypoglycemic events
A new study published in JAMA found that bempedoic acid can reduce major adverse cardiovascular events in high-risk primary prevention patients who cannot tolerate recommended doses of statins. The treatment has the potential to improve outcomes for these patients, providing a new option for primary prevention.
A recent study found that elderly patients treated in local intermediate care units have lower mortality rates and fewer hospital readmissions. The research suggests that Norway's healthcare system has improved with the introduction of these units, providing better integrated services adapted to individual users.
Children with parental cancer history face higher rates of unmet economic needs, including food security, housing affordability and transportation access. The study highlights the need for strategies to identify and support these vulnerable children.
Researchers at the University of Queensland have uncovered the atomic structure of the Langya virus, a highly infectious virus with pandemic potential. The study aims to develop broad-spectrum human vaccines and treatments for Henipaviruses, which cause severe disease and have the potential to get out of control.
Leading researchers discuss challenges associated with return to school for children and adolescents with TBI, highlighting the need for improved educator training and communication. Strategies for improving quality of life and outcomes are recommended by experts in this themed issue.
A survey study of 18,000 respondents across seven countries found that civil violence exposure was associated with an elevated risk of mental disorders for many years after initial exposure. The findings suggest that policymakers should consider these associations when projecting future mental disorder treatment needs.
The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for anxiety disorders in older adults. Anxiety disorders are commonly occurring mental health conditions often unrecognized in primary care settings, leading to substantial delays in treatment initiation.
A new study led by UCL researchers found that at least one in five women conceived naturally after having a baby conceived with IVF. This figure remained unchanged even when considering different types and outcomes of fertility treatment. The study analyzed data from 11 studies involving over 5,000 women worldwide.