Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A survey study found a lower rate of overall fractures among living kidney donors, yet an increased incidence of vertebral fractures after 25 years following donation. Treatment with dietary supplements may help alleviate these issues and patient morbidity.
A new large national study of collegiate student-athletes in the US finds no sex difference in concussion recovery, with similar recovery patterns on cognitive function, symptoms and mental health. Women reported more problems with eye and inner ear function after injury, but there was no significant delay in return to play.
Researchers developed a new photosensitizer, polphylipoprotein (PLP), to improve photodynamic therapy (PDT) efficacy. PLP selectively induces necrosis in cancer cells by exploiting the autophagy mechanism under starvation, leading to high selectivity and potential efficacy.
Researchers found that a team intervention provided by phone leads to persistent improvements in depression, anxiety, and quality of life for people managing chronic illnesses. The program demonstrated early, persistent, and clinically meaningful improvements in adults with COPD, HF, or ILD.
Boston University School of Public Health researchers Sondra Crosby and Leonard Glantz denounce rectal feeding practices at CIA secret prisons, equating them to torture. They call for medical officers who authorized or participated in these nonconsensual practices to be held accountable for violating ethical and legal standards.
A new study found that paying doctors to visit rural areas is a cost-effective way to provide reasonable access and effective care. The study estimates the financial costs of mitigating cardiologist shortages by studying outreach patterns over 30 years in Iowa.
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
Researchers have found a way to control MYC's hyperactivity using a peptide compound with sub-micro-molar affinity. This breakthrough offers hope for more effective treatments for cancer patients.
Researchers from UC San Francisco have found that Paxlovid treatment does not reduce the risk of developing long COVID. They also discovered a higher proportion of individuals with acute symptoms rebounding after treatment, and those who took Paxlovid were just as likely to develop severe Long COVID symptoms as those who did not.
A large-scale German-wide randomized controlled trial found that high-dose therapy with glucocorticoids is not more effective than standard treatment for sudden hearing loss. However, it was associated with a higher risk of side effects. Several hundred thousand people worldwide suffer from sudden hearing loss each year.
A nationwide case-time-control study found an association between benzodiazepine use during pregnancy and an increased risk of miscarriage. The results suggest that healthcare professionals should carefully weigh the benefits and risks of using benzodiazepines to treat psychiatric and sleep disorders in pregnant women.
Researchers found that baseline amyloid burden and brain health are stronger predictors of Alzheimer's progression than age alone. The study also showed that individuals with higher amyloid levels developed dementia two years earlier than those without.
This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
A study of 13,000 patients reveals few completed preoperative life-sustaining treatment documentation, with gaps in rates based on patient characteristics. The disparity affects veterans from different racial, ethnic, and rural backgrounds, as well as those with access to high-volume facilities.
A study of Viking Age teeth from Varnhem in Sweden found that 49% of the population had one or more caries lesions, with children's milk teeth being entirely caries-free. The Vikings also underwent dental treatment, including filing front teeth and relieving pressure through holes drilled into molars.
Patients with lower socioeconomic status in their neighborhoods have a higher risk of nonadherence to guideline-directed medical therapy for heart failure. Neighborhood-level socioeconomic factors play a significant role in shaping healthcare outcomes.
Researchers discovered that Nectandrin B, a bioactive lignan compound from nutmeg, extends the lifespan of Drosophila melanogaster by as much as 42.6%. The study found that Nectandrin B reduces intracellular ROS levels and improves age-related symptoms such as locomotive deterioration and neurodegeneration.
A study published in PLOS ONE reveals that Vikings in Sweden had a high prevalence of tooth decay, with many exhibiting severe caries and other dental pathologies. The findings provide insights into the lives of these ancient Scandinavians and their attempts to treat dental issues.
A new study found that HSP10 treatment improved exploratory preferences, object contacts, and swimming time in aged mice, while also increasing proliferating cells and differentiated neuroblasts. The protein also mitigated age-related gene reductions and increased sirtuin 3 levels.
Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not show a reduction in composite neonatal adverse outcomes. The study suggests that the effect of reducing large-for-gestational-age infant risk after adding metformin to insulin warrants further investigation.
Continued treatment with tirzepatide maintained and augmented initial weight reduction in adults with obesity. Withdrawing tirzepatide led to substantial regain of lost weight in a randomized clinical trial involving 670 participants.
A randomized clinical trial found that Mindfulness-Oriented Recovery Enhancement (MORE) plus usual care significantly decreased drug use, pain, and depression in individuals with opioid use disorder and chronic pain. Participants who received MORE also showed increased methadone treatment retention and adherence.
Researchers have identified a sequence within therapeutic mRNAs that causes unintended immune responses and found a way to correct these errors. By designing 'slip-resistant' mRNAs, the team aims to produce future mRNA vaccines with improved safety and efficacy.
Researchers at West Virginia University are using artificial intelligence to analyze habanero peppers and develop new methods for predicting genetic traits. The goal is to improve crop yields and prevent genetic diseases, with potential applications in human health.
Research suggests that big data and artificial intelligence can aid in developing bespoke therapies for psychosis. The study proposes refining existing therapies and exploring alternative approaches to improve outcomes for patients.
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
Significant racial and ethnic disparities in atherosclerotic cardiovascular disease treatment were found in a study of 5,218 adults. The disparities persisted despite optimal recommended therapies, underscoring the need for sustained efforts to achieve better outcomes for all patients regardless of their background.
Researchers developed an adhesive gel to seal and heal challenging gastrointestinal tract-to-skin connections, showing promising results in studies. The gel's unique composition ensures it can effectively seal fistulas, preventing further complications and aiding in healing.
Researchers at University College London have discovered that slow waves typically present during sleep can also occur during wakefulness in people with epilepsy, potentially protecting against increased brain excitability. These 'wake' slow waves decrease the impact of epileptic spikes on brain activity and may protect against seizures.
A new study finds that exposure and response prevention (EX/RP) therapy for OCD improves cognitive control by strengthening connections between brain networks. This breakthrough sheds light on the mechanisms underlying EX/RP's effectiveness in treating OCD, paving the way for targeted therapies.
Research published in The American Journal of Psychiatry finds that cannabis use disorder is disproportionately increasing among veterans with psychiatric disorders, particularly those with more severe mental health conditions. The study suggests that factors like increased legalization and potency may contribute to this trend.
Researchers at Nagoya University have discovered a unique healing mechanism in newts that could aid humans in recovering faster from tendon injuries. By understanding how newts regenerate damaged tendons without scar tissue, scientists hope to develop more effective treatments for human athletes.
A UK study found a significant increase in people identifying as transgender in their GP records, rising from 1 in 15,000 to 1 in 2,500 between 2000 and 2018. The study suggests that more individuals are coming forward to seek care, but also highlights the need for improved specialist services due to long waiting times.
A study of 103,000 early-stage breast cancer patients reveals a significant racial disparity in chemosensitivity and survival rates. Black patients are more likely to experience residual disease after neoadjuvant chemotherapy, leading to a higher mortality risk.
Researchers developed a new diagnostic tool to identify and treat Hikikomori, a condition characterized by prolonged physical isolation or social withdrawal. The Hikikomori Diagnostic Evaluation (HiDE) assesses the severity of social withdrawal, providing a practical guide for clinicians.
A study of 278,000 individuals in Sweden found that longer cumulative duration of ADHD medication use was associated with an increased risk of hypertension and arterial disease. Clinicians should regularly monitor cardiovascular signs and symptoms during long-term treatment.
A study of 1.3 million Canadian children found a higher risk of autism spectrum disorder in those born to parents with infertility. The research suggests that certain obstetrical and neonatal factors may contribute to this increased risk, highlighting the need for further exploration of these factors in individuals with infertility.
A randomized clinical trial of 1,175 participants found that treatment with higher-dose fluvoxamine did not improve time to sustained recovery in outpatients with mild to moderate COVID-19. The study compared fluvoxamine 100 mg twice daily for 13 days to placebo.
Community antibiotic consumption in the EU increased by 18.8% between 2021 and 2022, reversing a significant decline seen during the pandemic. The resurgence of infections may have contributed to the rebound, but highlights the need for continued prudent use of antibiotics.
The American Gastroenterological Association released a new guideline recommending the use of biomarkers to help manage Crohn’s disease. Biomarkers such as C-reactive protein and fecal calprotectin can measure levels of inflammation, helping doctors assess disease activity and guide treatment decisions.
Multimodal neuromonitoring (MNM) tracks blood flow, pressure, oxygen and glucose levels in the brain to inform treatment decisions. MNM has improved clinical outcomes for patients with severe traumatic brain injuries at the University of Cincinnati.
A recent study by Harvard researchers provides an engineering approach to understanding the failure of macrophages in cancer therapies. The team found that different phenotypes exhibit different penetration into tumors, with M0 macrophages showing improved transport efficiency.
Researchers developed 'tension-activated repair patches' that release anti-inflammatory molecules, helping discs regain tension and reverse herniation. The patch uses natural biomechanical movement to activate its release, offering a potential early intervention for preventing worsening pain related to disc degeneration.
Researchers at UMass Lowell found that anti-inflammatory bacteria were less abundant in people with Parkinson's disease, suggesting a potential biomarker for early diagnosis. A new study on Latinos may also uncover novel biomarkers for Alzheimer's disease.
Researchers aim to optimize digital weight-loss programs for rural populations by adding human components, such as weekly group video sessions and individual coaching calls. The goal is to help residents manage their weight and fight the obesity epidemic in areas with limited access to in-person programs.
Researchers at Uppsala University have developed an instrument to measure 21 biomarkers for cardiovascular disease, improving prediction and treatment. The CVD-21 panel reflects functional disturbances influencing cardiovascular development and treatment outcomes.
A study found that 20% of patients treated with nirmatrelvir-ritavir (N-R) experienced virologic rebound, a phenomenon where viral load increases after initial decline. In contrast, only 1 untreated patient was affected. The researchers suggest considering the risks and benefits of N-R treatment in patients at low risk for severe disease.
Lepodisiran, a short interfering RNA, targets hepatic synthesis of apolipoprotein(a), reducing serum lipoprotein(a) concentrations. Phase 1 study results support further investigation of lepodisiran's efficacy in treating elevated lipoprotein(a) levels.
Patients with heart failure treated with dapagliflozin experienced frequent initial estimated glomerular filtration rate declines, but without increased cardiovascular or kidney event risks. The study suggests that sodium-glucose cotransporter-2 inhibitors can be safely continued in patients experiencing eGFR decline.
A randomized clinical trial found that avoiding aspirin as part of an antithrombotic regimen reduces bleeding events without increasing thromboembolism risk in patients with advanced heart failure treated with left ventricular assist devices. The study suggests that aspirin avoidance may be a viable option for these patients.
Researchers at CNIC reveal the essential role of neuregulin-1 in transforming the delicate primordial heart structure into a powerful pumping organ. The study sheds light on the pathways of human heart formation and suggests new strategies for heart health and regenerative medicine.
Researchers at the University of São Paulo have tested a synthetic molecule called AD-9308, which has shown potential in treating heart failure by activating the enzyme aldehyde dehydrogenase 2. The study found that the molecule improved mitochondrial filtration, eliminating cellular pollutants and boosting heart function by up to 40%.
A study published at ACR Convergence 2023 found that patients with acute calcium pyrophosphate deposition disease have a doubled risk of fractures. The researchers analyzed data from over 1,100 patients and compared them to matched comparators without the disease.
Maintenance immunosuppressive drugs linked to increased COVID-19 hospitalization risk in solid organ transplant patients. Clinicians treating transplant recipients should consider these findings for epidemic-related decisions.
Researchers found that changing treatment can lead to significant improvement in mobility and quality of life for patients with advanced Parkinson's disease. A nationwide registry is planned to develop scientifically sound guidelines for combination therapies.
The study demonstrates that concurrent DNA and RNA sequencing improves the detection of novel variants in individuals undergoing hereditary cancer testing, expanding identification of those with hereditary cancer predisposition. This advancement enables personalized therapeutics and surveillance for these individuals.
A new study by UC San Francisco found that poor sleep is significantly associated with a 15% greater risk of experiencing atrial fibrillation the next day. The researchers suggest strategies like going to bed at a reasonable time, avoiding alcohol and caffeine before bedtime, and exercising regularly to improve general sleep quality.
The study analyzed global data from the past three decades, revealing an overall increase in hypertensive heart disease (HHD) prevalence but a decrease in mortality and disability-adjusted life years (DALYs). The burden of HHD is particularly concerning for healthcare systems due to higher prevalence with lower mortality rates.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
A randomized clinical trial involving 126 patients found that landiolol did not prevent organ failure in those with established septic shock. The study concluded that this beta-blocker is not a suitable treatment option for managing tachycardia in these patients.