Articles tagged with Radiation Therapy
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Researchers found proton therapy significantly lowers the risk of severe side effects such as hospitalization, while maintaining similar cure rates and effectiveness compared to traditional photon radiation. The study suggests proton therapy offers a way to reduce serious side effects without sacrificing treatment efficacy.
A novel assay developed at the Champalimaud Centre for the Unknown uses zebrafish 'avatars' to test radio-sensitivity in human tumor cells. The assay has shown promising results, with 85% success rate in predicting how tumors will respond to specific drugs.
Researchers found that radiation triggers an immune response that severs connections between nerve cells, leading to damage and cognitive problems. The study suggests two potential approaches to prevent this damage: blocking a receptor responsible for synapse removal or tamping down the brain's immune response.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline for the use of radiation therapy in treating basal and cutaneous squamous cell carcinomas. The guideline provides recommendations on when to use radiation as stand-alone therapy or following surgery, as well as dosing and fractionation schedules.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
A nationwide survey of over 400 US adults with cancer found that nearly all patients felt confident in their treatment decisions but had gaps in knowledge about potential side effects. The study highlights the need for more informed patient counseling and coordination between oncology disciplines to manage treatment-related side effects.
The UK will pioneer the use of FLASH radiotherapy and artificial intelligence in cancer treatment. Cancer Research UK RadNet aims to improve cancer survival by optimising and personalising radiotherapy.
A new study found that only about 6 in 10 lung cancer patients in the US receive recommended treatments, with black patients and those over 80 receiving significantly lower treatment rates. The researchers highlight the importance of communicating benefits of treatment for advanced disease beyond survival.
Researchers at Osaka University have developed a new radiation therapy method that targets pancreatic cancer cells directly, reducing side effects. The treatment uses a radioactive molecule that binds to specific proteins on stroma cells surrounding tumors, delivering high-energy doses of radiation to cancer tissue.
A study shows that hyperbaric oxygen therapy can relieve self-reported symptoms and side-effects of radiotherapy in cancer patients, including bleeding, urinary incontinence, and pain. The treatment, administered for 30-40 sessions, was found to be highly effective for the majority of patients.
A meta-analysis of 11 studies found that RTKI drugs with radiation therapy did not significantly improve survival rates but increased negative side effects. The study suggests holding RTKI drugs during radiation therapy to minimize side effects without affecting survival.
A new study shows that a reduced diversity of gut bacteria is associated with an increased risk of radiotherapy-induced gut damage. Patients at higher risk can be identified before radiotherapy, potentially benefiting from faecal transplants or altered radiation doses.
Researchers at Kyoto University have developed a method to selectively amplify the effect of X-ray radiation on cancer cells. The technique uses specially designed silica nanoparticles loaded with gadolinium, which releases low-energy electrons when hit by precisely tuned X-rays, damaging cancer cell vital components and killing them.
The RADICALS-RT trial found no difference in disease recurrence between men who received radiotherapy shortly after surgery and those who waited for cancer to come back. The study confirms that observation should be the standard approach after surgery, with radiotherapy used only if the cancer recurs.
A new trial found that men with prostate cancer who receive radiotherapy after surgery have no difference in disease recurrence compared to those who do not. The study suggests that observation should be the standard approach and radiotherapy only used if the cancer comes back.
A new analysis finds that long-term hormone therapy increases mortality risk for men with low PSA levels after prostate surgery. The study suggests that patients with high PSAs should continue to receive hormone therapy in addition to radiation, but those with low PSAs may be better off without it.
A randomized clinical trial found that high-dose radiation therapy can generate an immune system response similar to vaccination, sparking a systemic immune reaction against cancer. Patients treated with stereotactic ablative radiotherapy lived significantly longer without disease progression.
A noninvasive radiation therapy called ENCORE has been shown to dramatically reduce episodes of rapid, abnormal heartbeats for more than two years. The treatment, which uses stereotactic body radiation therapy, has also led to a reduction in medication side effects and improved quality of life.
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
A machine-learning model has been developed to predict significant weight loss and need for feeding tube placement in head and neck cancer patients undergoing radiation therapy. The model showed high accuracy in predicting these two endpoints, allowing clinicians to take preventive measures.
Researchers developed a new ultra-hypofractionated stereotactic body radiotherapy (SBRT) technique that safely delivers curative treatment for some prostate cancer patients in just one or two weeks. The study found similar levels of side effects and less overall toxicity compared to the current standard of care.
A new study from the University of Pennsylvania found that radiation therapy given 30 days or less before CAR T infusion reduces the risk of serious cytokine release syndrome and neurotoxicity. The therapy may also have potential benefits for NHL patients, according to researchers.
A phase one/two study found that a single high dose of radiation significantly reduces ventricular tachycardia episodes, with a 72% overall survival rate at one year and 52% at two years. The noninvasive procedure is a last line of defense for patients who have exhausted other treatments.
A Phase III trial comparing SBRT and conventional RT found no significant difference in pain response or adverse events between the treatments. The study suggests that a single fraction of 8 Gy EBRT may remain the standard of care for patients with localized spine metastases.
Researchers are developing optical imaging technologies to monitor treatment response during head and neck cancer therapy, allowing for changes to the treatment plan to more effectively treat patients. The goal is to identify how well the treatment is working during the process, enabling doctors and patients to make informed decisions.
Researchers developed a new mathematical model to optimize radiation therapy for brain tumors by targeting the densest areas. This approach has shown promise in increasing the number of tumor cells killed during treatment.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline recommending the use of radiation therapy in pre-surgical, post-surgical, definitive and palliative settings. The guideline emphasizes a patient-centered approach integrating patients' values and preferences into treatment decisions.
Researchers investigated how radiation damages DNA in cancer cells treated with 5-fluorouracil, identifying new fragment ions and their formation thresholds. The study could lead to new ways of protecting normal tissues from radiation damage caused by radiotherapy.
Researchers developed a nonwoven fabric bioabsorbable spacer that creates a space between healthy and cancerous tissues during particle therapy, preserving distance between tumors and normal organs. The spacer safely absorbs by the body without causing serious complications.
Researchers propose focusing high-energy particle beams on small spots deep inside the body to target cancerous tumors precisely, reducing dose to surrounding tissue. The study aims to improve radiotherapy effectiveness and reduce costs using ultra-compact laser-wakefield accelerators.
A new AI framework developed by Cleveland Clinic researchers can now use medical scans and health records to personalize the dose of radiation therapy used to treat cancer patients. The framework has been shown to reduce treatment failure probability to less than 5 percent.
A study published in JAMA Oncology found that introducing a default physician order into electronic health records reduced daily imaging for cancer patients with advanced cancer by half. This change also saved an average of two minutes per session, resulting in faster treatment courses.
Research by Georgia State University found that women undergoing radiation therapy for pediatric brain tumors are more likely to experience long-term cognitive issues. Female survivors were more negatively affected in activities of daily living and higher-order skills compared to male counterparts.
Research found statin therapy significantly reduced stroke risk and overall cardiovascular events in cancer patients who underwent radiation therapy for chest, head, or neck cancer. The study also showed a strong trend toward reduction in cardiovascular deaths.
A retrospective study of 748 NSCLC patients found that the average radiation dose delivered to the heart was associated with an increased risk of major adverse cardiovascular events and death. The team's findings highlight the need for more stringent avoidance of high cardiac radiotherapy doses and collaboration with cardiologists to m...
Researchers at Penn aim to better understand the connection between novel radiation therapies and immune systems to enhance cancer treatments. Five projects will investigate signaling pathways and genetics behind interferon and pattern recognition receptor signaling.
Researchers from CNIO have found that high levels of URI protein protect mice from radiation-induced intestinal damage, while low or no detectable levels lead to gastrointestinal syndrome and death. The study opens up new avenues for treating and preventing gastrointestinal syndrome by inhibiting c-MYC.
A study models the demand, benefit, and cost of implementing a 20-year strategy for radiotherapy to treat cervical cancer in low- and middle-income countries. The research estimates that 9.4 million women will require radiotherapy, generating $151.5 billion in economic benefits.
Researchers found that proton therapy significantly lowers the risk of severe side effects in cancer patients undergoing radiation and chemotherapy, with a relative risk reduction of two-thirds. Cure rates were almost identical between groups.
Researchers at Karolinska Institutet have found that IL-1 inhibitors can reduce chronic inflammation in blood vessels exposed to radiation, which is linked to increased risk of cardiovascular disease. The study used an animal model and gene expression analysis to support the potential treatment.
Kanazawa University researchers have synthesized a radiotheranostic system using astatine and iodine as alpha-particle and gamma-radiation sources, respectively. The system utilizes a peptide carrier molecule to target tumors, achieving high accumulation in cancer cells.
The updated guideline recommends adjuvant radiotherapy for patients with adverse pathologic findings, such as seminal vesicle invasion and positive surgical margins. Hormonal therapy is also recommended for patients who receive salvage radiotherapy, based on evidence from randomized controlled trials.
In a mouse model of unresectable pancreatic cancer, administration of the EGLN inhibitor FG-4592 prior to ablative radiotherapy provided protection against fatal gastrointestinal bleeding and improved survival. The study found that FG-4592 effectively mimicked hypoxia in normal tissues, protecting them from radiation damage.
A combination of biological markers and genetic changes can predict radiation sensitivity, helping doctors assess patients at risk of side effects. The study found that the time of day when radiotherapy is given can also affect side effects, particularly in breast cancer patients.
A new study presents evidence that pencil beam scanning proton therapy offers the best hope of preserving cognitive functions in children with brain tumors. The treatment delivers low doses of radiation to critical areas of the brain, including the temporal lobes and hippocampus.
Research presented at ESTRO 38 conference finds that high dose radiation therapy significantly improves two-year survival rates for mesothelioma patients. The study, led by Dr. Marco Trovo, suggests radical hemi-thoracic radiotherapy as a new standard of care for this rare and aggressive cancer.
Researchers found that radiotherapy after chemotherapy improved survival in patients with large tumours, with a 7-10% survival benefit at three and five years. This trial suggests that radiotherapy should be considered for these patients to balance cure rates with toxic side effects.
The new software automates image capture and analysis, providing more accurate radiation beam targeting and refined patient positioning. This technology enhances the quality assurance strategy in radiation therapy, potentially reducing toxicity and improving treatment outcomes.
Women with early, low-risk hormone-driven breast cancer who receive radiotherapy after surgery have a significantly lower risk of recurrence and improved disease-free survival compared to those without radiotherapy. The study found that whole breast irradiation is effective in reducing in-breast recurrences and improving overall survival.
Radiation oncologists provide guidance on preparing for and responding to natural disasters, including creating emergency operations plans, providing patients with access to treatment plans via flash drives, and identifying alternative sources of power. The tips aim to minimize treatment delays during a disaster.
A clinical study demonstrated the safety and efficacy of high-dose stereotactic body radiotherapy (SBRT) for patients with centrally located non-small cell lung cancer. The treatment resulted in high tumor control rates, comparable to those seen in patients with peripheral tumors.
A genetic study has identified a risk factor for stroke among childhood cancer survivors who received cranial radiation therapy. Variants in the chromosomal region 5p15.33 increase the risk of stroke approximately five-fold among those treated with intermediate dose radiation.
Researchers have developed 3D organ-on-a-chip models to test the effects of different levels and types of radiation on human tissues. This technology could lead to more effective therapies with fewer side effects for cancer patients.
Two new studies highlight advances in lung cancer treatment. A multidisciplinary thoracic cancers symposium presents findings on local consolidative therapy linked to improved overall survival for patients with oligometastatic non-small cell lung cancer (NSCLC). Another study demonstrates the effectiveness of structured exposure to NSC...
A new study uses Raman spectroscopy to analyze changes in biochemical composition of tumors, enabling prediction of radiation response. The findings have the potential to reduce medical overtreatment and improve treatment plans for cancer patients.
A study published in Annals of Oncology found that one course of chemotherapy or radiotherapy after surgery does not have a long-term effect on sperm count and concentration in men with early stage testicular cancer. Sperm number and concentration recovered in all groups up to five years after treatment.
A researcher at the University of Cincinnati is using a $1.4 million VA grant to study radiation resistance in head and neck cancer. The goal is to target molecular pathways to make radiation therapy more effective, reducing side effects and improving treatment outcomes for patients.
A phase III trial found hypofractionated radiotherapy (H-RT) to have similar QOL outcomes as conventional radiotherapy (C-RT) in men with low risk prostate cancer. H-RT delivers a total dose over a shorter period, reducing treatment duration and potential side effects.
A new UCLA-led study shows that men with low- or intermediate-risk prostate cancer can safely undergo higher doses of radiation over a significantly shorter period and still have the same successful outcomes as from a much longer course of treatment. The study analyzed data from 2,142 men treated with stereotactic body radiotherapy for...
The University of Nebraska is leading a $11 million study to develop drug therapies protecting military service members from radiation exposure. The project, in collaboration with the Department of Defense, aims to identify and develop therapeutic candidates that can prevent and counteract radiation effects.