A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
SourceMichigan Medicine - University of Michigan·JournalCell Reports Medicine·TypeExperimental study·DateMay 6, 2024
Researchers at the University of Missouri have developed a soft, self-charging material that can track vital signs like blood pressure and heart activity wirelessly. This innovation has significant implications for early disease detection and timely interventions in chronic conditions.
SourceUniversity of Missouri-Columbia·JournalNature Nanotechnology·DateApr 30, 2024
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A study by Mount Sinai researchers has identified several pathophysiological mechanisms underlying perianal fistulae in Crohn’s disease. The findings highlight key transcription factor binding events and epigenetic phenomena that contribute to the higher rates of complications in African American patients. The research provides avenues...
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalMed·DateApr 24, 2024
A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
SourceWellcome Trust Sanger Institute·JournalNature Aging·TypeObservational study·DateApr 15, 2024
Researchers have identified three distinct immunological endophenotypes of multiple sclerosis, defined by specific blood immune signatures. These findings could lead to more effective and tailored treatment strategies for patients with the disease.
SourceUniversity of Münster·JournalScience Translational Medicine·DateApr 4, 2024
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
SourceUniversity of Virginia Health System·JournalNature Communications·DateMar 29, 2024
Researchers at Weill Cornell Medicine have developed a novel method to create grafts that accurately replicate the human ear's anatomy and biomechanical properties. The new technique uses 3D printing and tissue engineering to produce cartilage-containing structures that mimic the ear's shape, flexibility, and elasticity.
SourceWeill Cornell Medicine·JournalActa Biomaterialia·DateMar 29, 2024
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers present findings on immunotherapy approaches, a potential biomarker for neuroendocrine carcinomas, and improved treatments for pancreatic cancer and melanoma. A UCLA team identified UCHL1 as a molecular indicator and therapeutic target for aggressive neuroendocrine cancers.
SourceUniversity of California - Los Angeles Health Sciences·DateMar 25, 2024
Young adults in Korea with ideal cardiovascular health had significantly lower risks of developing heart disease, stroke, and kidney disease. The study highlights the importance of achieving and maintaining ideal heart health during young adulthood to prevent these diseases.
A free, weekly home delivery program of fresh fruits and vegetables improved participants' nutrition levels, physical activity levels, and cardiovascular disease risk factors. The 16-week program resulted in significant improvements in food insecurity, diet quality, and indicators of cardiovascular health.
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMar 19, 2024
Researchers found that initial vaccinations against the ancestral SARS-CoV-2 strain shape immune responses to newer variants BA.5 and XBB, with higher B cell repertoire leading to more effective cross-reactive immunity. This 'immunological imprinting' effect could impact future vaccine designs.
SourceUniversity of Pennsylvania School of Medicine·JournalImmunity·DateMar 14, 2024
Researchers have demonstrated novel proteins that can efficiently reach intramembrane targets using a customized computer-based approach. The study yields a general computational process for streamlining protein design aimed at intramembrane targets, opening up possibilities for therapeutic applications and understanding signaling mech...
SourceScripps Research Institute·JournalNature Chemical Biology·DateMar 13, 2024
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
SourceUniversity of California - San Diego·JournalJournal of the American College of Cardiology·TypeExperimental study·DateMar 6, 2024
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new machine learning approach using Alu elements in blood plasma has improved the detection of cancer early by reaching 98.9% specificity. The test can catch 41% more cancer cases than existing biomarkers and is expected to complement other cancer tests.
SourceJohns Hopkins Medicine·JournalScience Translational Medicine·DateMar 4, 2024
A research project led by Lobelia Samavati has developed a tool to rapidly and inexpensively diagnose sarcoidosis using a simple blood test. The tool can accurately identify the disease in patients and may reduce the need for invasive diagnostic tests.
SourceWayne State University - Office of the Vice President for Research·JournalAmerican Journal of Respiratory and Critical Care Medicine·TypeExperimental study·DateFeb 28, 2024
A new American Heart Association scientific statement highlights the value of AI technology in improving cardiovascular disease patient outcomes. Despite its potential, AI applications face gaps and challenges, including robust clinical validation and addressing biases.
SourceAmerican Heart Association·JournalCirculation·DateFeb 28, 2024
The University of Maryland School of Medicine has been awarded $3.5 million in federal funding to develop acute radiation syndrome animal models and advance the development of radiologic and nuclear countermeasures.
SourceUniversity of Maryland School of Medicine·DateFeb 26, 2024
Researchers discovered an antibody that can block deadly toxins in snakes found throughout Africa, Asia, and Australia. The antibody protects against multiple snake species and has the potential to be used as a universal antivenom.
SourceScripps Research Institute·JournalScience Translational Medicine·DateFeb 21, 2024
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study has identified 1,289 genetic markers associated with Type 2 diabetes, including 145 newly discovered markers. The research provides risk scores for diabetes complications and suggests potential genetic targets for new treatments.
SourceUniversity of Massachusetts Amherst·JournalNature·TypeMeta-analysis·DateFeb 19, 2024
Researchers developed a test to predict which heart attack patients are likely to experience dysfunction after receiving mechanical pumps. The test measures pulmonary vascular compliance and its adaptability, helping doctors prevent right ventricle failure.
SourceMassachusetts Institute of Technology·JournalScience Translational Medicine·DateFeb 14, 2024
The new advisory highlights the dramatic advances in understanding and treatment of cardiovascular diseases over the past century. These advancements have saved millions of lives and reduced heart disease death rates by more than half since 1950.
SourceAmerican Heart Association·JournalCirculation·DateFeb 12, 2024
Eleven prominent researchers recognized for groundbreaking work in stroke and brain health, with a focus on improving treatments and addressing disparities. The honorees include experts in magnetic resonance imaging, inherited risk factors, and clinical stroke research.
A Scripps Research team identified the energetic reactions in brain cells that malfunction and lead to neurodegeneration. They successfully restored many neuron-to-neuron connections in nerve cell models derived from human Alzheimer's patient stem cells by addressing a bottleneck in mitochondrial energy production.
SourceScripps Research Institute·JournalAdvanced Science·DateJan 29, 2024
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
UCLA surgeons and scientists present research on ethnic predictors of gastric cancer survival, early liver retransplantation and risk factors for chemical restraint use in adult trauma patients. The studies highlight the importance of understanding these factors to improve patient care.
SourceUniversity of California - Los Angeles Health Sciences·DateJan 25, 2024
Researchers at the Francis Crick Institute and UCL have identified a gene that causes heart defects in Down syndrome, a condition resulting from an extra copy of chromosome 21. Reducing the overactivity of this gene partially reversed these defects in mice, setting the scene for potential future therapies.
SourceThe Francis Crick Institute·JournalScience Translational Medicine·TypeExperimental study·DateJan 24, 2024
Researchers found a shared genetic trait that predicts a higher risk of small lung vessel disease and its severe form, pulmonary arterial hypertension. This discovery could lead to personalized treatments for patients with limited oxygen response.
SourceUniversity of Pittsburgh·JournalScience Translational Medicine·DateJan 10, 2024
Researchers develop injectable hydrogel electrodes for treating ventricular arrhythmia, providing a potential solution to painful defibrillation and improving quality of life. The novel pacing modality addresses the pathophysiology of re-entrant arrhythmia and offers a promising alternative to existing therapies.
SourceTexas Heart Institute·JournalNature Communications·TypeExperimental study·DateJan 9, 2024
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers investigate a molecule in the brain tied to cellular communication, uncovering information about proteins that influence and do not influence alcohol drinking behavior. The study finds that preventing ethanol from interacting with a specific protein does not reduce or increase motivation to consume alcohol.
SourceScripps Research Institute·JournalMolecular Psychiatry·DateJan 8, 2024
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
SourceTechnical University of Munich (TUM)·JournalNature Cancer·TypeObservational study·DateJan 8, 2024
The £30M ADVANCE study aims to accelerate the development of new therapies for people with liver cirrhosis by identifying translational biomarkers. Researchers will enroll 200 patients with cirrhosis and use advanced techniques to analyze gene expression, blood tests, and MRI scans.
The Colorado Center for Personalized Medicine has hit a major milestone of returning clinical genetic results to over 30,000 patients, making it a leader in providing personalized patient care. The center is also studying pharmacogenomics and providing results to guide drug selection and dosing.
SourceUniversity of Colorado Anschutz Medical Campus·JournalThe American Journal of Human Genetics·DateJan 4, 2024
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at MMRI have developed a novel approach to minimize cardiac damage after a heart attack by targeting the spleen with histone deacetylase inhibitors. This targeting strategy results in a significant decrease in cardiac scar size and preservation of heart function, even after just one dose.
SourceMasonic Medical Research Institute·JournalAdvanced Materials·TypeExperimental study·DateDec 20, 2023
Researchers at Scripps Research have found a way to modify picrotoxinin, a plant-derived toxin, with improved properties, making it easier to synthesize and modify. The modified version, 5Me-picrotoxinin, shows better chemical stability and is safer for humans.
SourceScripps Research Institute·JournalNature Communications·DateDec 20, 2023
Researchers found that the severity of muscle wasting depends on the location of the spinal cord injury. They also discovered that hypercortisolism, a hormonal imbalance, worsens muscle loss and can be targeted to rescue muscle tissue.
SourceOhio State University Wexner Medical Center·JournalScience Translational Medicine·TypeExperimental study·DateDec 20, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Flori Corpodean, a postdoctoral researcher at Pennington Biomedical, has been selected as the sole recipient of the 2024 Resident Research Award. She is exploring how the brain and intestinal tract communicate through her research on altered nutrient delivery.
SourcePennington Biomedical Research Center·DateDec 19, 2023
A new study from Scripps Research scientists and collaborators found that local transmission of SARS-CoV-2 was driven by travel between locations, not geographic proximity. The partial closure of the U.S.-Mexico border was ineffective in preventing cross-border transmission.
SourceScripps Research Institute·JournalCell·DateDec 14, 2023
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
SourceWeill Cornell Medicine·JournalNature Communications·DateDec 13, 2023
Researchers have developed an AI-powered algorithm that can detect the risk of atrial fibrillation (AFib) with high accuracy, even in people with infrequent AFib episodes. This new tool has the potential to reduce the incidence of stroke and heart failure by identifying patients at increased risk and guiding targeted interventions.
SourceScripps Research Institute·Journalnpj Digital Medicine·DateDec 12, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
The University of Maryland School of Medicine has received a $29 million NIH grant to conduct a multicenter trial testing interventions to improve health outcomes in people who inject opioid drugs and are hospitalized with infectious complications. The study aims to reduce rehospitalizations and lower complications from infections.
SourceUniversity of Maryland School of Medicine·DateDec 11, 2023
A new study finds that analyzing surgical lymphatic fluid for HPV DNA can predict cancer recurrence and guide treatment decisions. The test was found to be more sensitive than traditional methods, detecting high-risk patients who may be missed by standard tools.
SourceUniversity of Pittsburgh·JournalClinical Cancer Research·TypeObservational study·DateDec 11, 2023
Scientists unveiled a spatial cell atlas of the entire developing human limb, capturing intricate processes governing rapid development. The study uncovers new links between developmental cells and congenital limb syndromes, such as short fingers and extra digits.
SourceWellcome Trust Sanger Institute·JournalNature·TypeObservational study·DateDec 6, 2023
A new experimental model, human precision-cut lung slices (hPCLS), was used to study lung disease mechanisms and understand treatment response. The team leveraged single-cell genomics to analyze cell activity in hPCLS after specific treatments.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalScience Translational Medicine·TypeExperimental study·DateDec 6, 2023
Research reveals that brain inflammation is the primary cause of neuropsychiatric symptoms in Alzheimer's disease, including irritability, agitation, and anxiety. The study found a strong association between microglial activation and neuropsychiatric symptom severity, suggesting new pathways for therapy development.
SourceUniversity of Pittsburgh·JournalJAMA Network Open·DateNov 27, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers developed 'tension-activated repair patches' that release anti-inflammatory molecules, helping discs regain tension and reverse herniation. The patch uses natural biomechanical movement to activate its release, offering a potential early intervention for preventing worsening pain related to disc degeneration.
SourceUniversity of Pennsylvania School of Medicine·JournalScience Translational Medicine·TypeData/statistical analysis·DateNov 15, 2023
A new treatment strategy shows promise in preclinical models of advanced prostate cancer with RB1 gene loss or neuroendocrine features. Decitabine and B7-H3 targeted therapy have been shown to slow tumor growth and improve efficacy when combined.
SourceDana-Farber Cancer Institute·JournalScience Translational Medicine·DateNov 15, 2023
A four-year blood-pressure intervention significantly reduced the risk of developing dementia among adults with high blood pressure, compared to those who received usual care. The study found that lowering systolic blood pressure to less than 130 mm Hg and diastolic blood pressure to less than 80 mm Hg reduced dementia risk.
Researchers at UTHealth Houston are studying the impact of circadian rhythm on heart attacks and cardiac surgery, with a focus on identifying novel therapies to protect the heart. They will investigate the role of key genes and signaling pathways in modulating daytime variations in cardiac injury.
SourceUniversity of Texas Health Science Center at Houston·DateNov 9, 2023
A recent analysis of the Golden Retriever Lifetime Study data notes a potential correlation between canine sterilization and hemangiosarcoma development. Intact females consistently have lower diagnosis rates, while spayed females show an increasing risk beyond 8 years old.
SourceMorris Animal Foundation·JournalVeterinary and Comparative Oncology·TypeMeta-analysis·DateNov 2, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers found that SARS-CoV-2 alters mitochondria on a genetic level, leading to widespread 'energy outages' throughout the body and its major organs. This affects the heart, brain, and lungs, contributing to long COVID symptoms.
SourceUniversity of North Carolina Health Care·JournalScience Translational Medicine·DateOct 31, 2023
Researchers developed the SOMMA Vigor to Frailty Score to rank older adults from 0 (vigorous) to 12 (frail), predicting their resilience to stress. Patients on the high end of the continuum are up to 31 times more likely to have functional limitations.
SourceUniversity of Pittsburgh·JournalJournal of Gerontology·DateOct 25, 2023
The partnership aims to reduce disparities in cancer research and drug development through collaborations, resources, and training programs. Key projects will focus on breast and pancreatic cancers, particularly luminal B breast cancers disproportionately affecting women of African descent.
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers at Penn Medicine have received a $10 million grant to develop a new strategy for preventing breast cancer recurrence by targeting dormant tumor cells. In a phase II clinical trial, the team successfully cleared dormant cells from over 80% of patients, offering a promising proof-of-concept for this approach.
SourceUniversity of Pennsylvania School of Medicine·DateOct 23, 2023
A new hormone replacement therapy, Pulsatility, has shown promising results in improving symptoms and quality of life for patients with adrenal insufficiency conditions. The treatment, which delivers hydrocortisone in a pulsatile pattern, decreased fatigue by 10% and improved mood and energy levels by 30%.
SourceUniversity of Bristol·JournalJournal of Internal Medicine·TypeRandomized controlled/clinical trial·DateOct 19, 2023
Researchers identified enhanced B-cell and T-cell responses in fully vaccinated individuals who became infected with SARS-CoV-2, generating immunological memory to prevent severe infection. Vaccine-primed memory T cells play a critical role in preventing severe COVID-19.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Immunology·TypeRandomized controlled/clinical trial·DateOct 19, 2023
Researchers at H. Lee Moffitt Cancer Center & Research Institute have identified a new drug, NFX-179, that can prevent the development of cutaneous squamous cell carcinoma with minimal side effects. The topical application of NFX-179 gel was shown to reduce tumor formation by up to 92% in pre-clinical models.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalScience Translational Medicine·TypeExperimental study·DateOct 11, 2023
A new clinical trial has shown that infusing immune cells from living donors into recipients before transplantation may reduce the need for lifelong immunosuppressant medication. The treatment involves infusing donor-derived regulatory dendritic cells, which help the recipient's immune system distinguish between foreign and self-cells.
SourceUniversity of Pittsburgh·JournalScience Translational Medicine·TypeRandomized controlled/clinical trial·DateOct 11, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at Linköping University developed an AI-based method applicable to various medical and biological issues, accurately estimating people's chronological age and determining smoking status. The models identify previously known epigenetic markers used in other models, but also new markers associated with conditions.
SourceLinköping University·JournalBriefings in Bioinformatics·TypeComputational simulation/modeling·DateOct 11, 2023
A new blood test called OvaPrint TM detects specific nucleic acids in the blood, distinguishing between cancerous and benign pelvic masses with high accuracy. The test has the potential to improve treatment outcomes by identifying the best surgical approach for patients with a pelvic mass.
SourceKeck School of Medicine of USC·JournalClinical Cancer Research·DateOct 10, 2023
The STARTUP Central project empowers public university researchers to commercialize their biomedical innovations. A smart online educational curriculum, InspireU2 iTi, will train academics on product development, business structuring, and more. The program aims to bridge the gap between groundbreaking discoveries and real-world solutions.