Articles tagged with Translational Medicine
A new study found that frail seniors often use public transportation to get to doctor appointments due to inadequate accessibility. The study highlights the pressing need to improve public transit infrastructure and services in cities to support an aging population.
Researchers at FAU's Schmidt College of Medicine are developing a pilot program to tackle health disparities by leveraging electronic health records, artificial intelligence, and machine learning. The project aims to improve AI/ML delivery and research operations in community health centers and federally qualified health centers.
Researchers found that administering nitric oxide to preterm mice after birth can reverse symptoms of congenital hypogonadotropic hypogonadism, including sensory and cognitive disorders. A clinical trial is now underway to test this treatment in human preterm infants.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
Cleveland researchers reveal a new strategy to prevent blood clots by targeting overactive neutrophils, reducing clotting risk while minimizing bleeding risk. The findings may be especially impactful for cancer patients who experience blood clot complications.
A new drug, NMT5, has shown promising results in blocking SARS-CoV-2 infection in animals. The drug coats the virus with chemicals that temporarily alter the human ACE2 receptor, preventing it from infecting cells. In cell culture experiments, the Omicron variant of SARS-CoV-2 was prevented from attaching to human ACE2 receptors by 95%.
Researchers at Scripps Research have discovered that chronic circadian disruption can increase lung cancer growth in animal models by activating the heat shock factor 1 (HSF1) pathway. This finding suggests a molecular link between disrupted sleep patterns, temperature changes, and tumor formation.
Researchers at Newcastle University found that probiotics do not give uniform results in premature babies. The study's findings highlight the need for a personalized medicine approach to provide customized probiotics according to an analysis of their gut flora and other factors.
Researchers at UCI have made significant progress in precision genome editing for treating inherited retinal diseases, enabling precise gene correction and disease rescue. The study highlights the potential of this technology to revolutionize treatment of genetic disorders of vision, with over 270 causative genes identified.
A new wearable device study, DETECT, found that sensor data significantly improves seven-day average predictions for COVID-19 infection by 32.9% in California and 12.2% nationwide. The study tracked physiological changes before symptom onset, providing a valuable tool for predicting viral threats.
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
A national study by UC San Francisco found that basic home blood pressure cuffs and smartphone-connected devices have no significant difference in improving blood pressure control. After six months, patients who used basic cuffs had a lower blood pressure reduction compared to those using Bluetooth-enabled devices.
Researchers identify LINE-1 RNA as a key player in premature aging, revealing its role in progeria and potential therapeutic targets. By inhibiting LINE-1 RNA, scientists reverse signs of aging and extend lifespan in mice.
Researchers have identified key molecular differences between cancer cells that cling to initial tumors and those that spread to distant sites. The study found unique properties in cells that gain migratory ability and survival advantages, leading to the development of new treatment targets.
The ISM Annual Meeting highlights new topics in oral, vaginal, skin, and gut microbiota, as well as their metabolites and potential implications in diseases like cancer, depression, and stroke. The meeting aims to explore the mechanism behind microbiota efficacy and its potential application in precision medicine.
The Heart and Lung Research Institute (HLRI) at the University of Cambridge will bring together over 380 researchers and clinicians to tackle cardiovascular and respiratory diseases. The institute aims to deliver high-impact research to drive breakthroughs in prevention, early diagnosis, and treatment of these diseases, which represent...
A new gene therapy for sickle cell disease was tested in mice but proved ineffective due to the complex genetic make-up of the Berkeley mice. The study suggests that researchers should carefully consider the genetics of the mice used to test human diseases.
A new analysis published in JAMA Psychiatry shows that brief suicide prevention interventions delivered in healthcare settings drastically underreport the strategies needed for successful implementation. On average, about 85% of these strategies were missing from published reports.
A new review paper has proposed a framework for advancing the application of xenotransplantation, a potential solution to the organ shortage. The study discusses innovations and advances in transplanting animal hearts into human subjects, with a focus on overcoming challenges and barriers.
A simplified surgical tool called RAIS has been developed to enable laparoscopic surgery in low-to-middle income countries. The device uses a mechanical retractor and does not require CO2 gas or a general anaesthetic, making it more accessible and affordable for rural surgeons.
Researchers have identified 30 COVID-19 patient antibodies that can neutralize a variety of coronaviruses, including SARS-CoV-1 and bat coronaviruses. These broadly neutralizing antibodies may lead to the development of next-generation coronavirus vaccines offering broader protection.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
Chemists at Scripps Research unveil a new method for synthesizing diverse and complex lactones from cheap dicarboxylic acids. This breakthrough enables the creation of valuable molecules, such as natural antibiotics and fragrances.
The University of Minnesota has received a $66 million grant from the NIAID to establish a center for developing antiviral drugs for pandemic-level viruses, including SARS-CoV-2. The Midwest Antiviral Drug Discovery Center will bring together investigators from the University and sixteen other institutions nationwide.
Researchers at MedUni Vienna identified five distinct subtypes of small cell lung cancer, each responding differently to therapies. High ASCL1 expression is linked to poor survival, while high POU2F3 expression correlates with better outcomes and sensitivity to standard chemotherapeutics.
A global study found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. The combination of albuterol and budesonide lowers the number of sudden episodes of shortness of breath, wheezing, and coughing in patients.
Researchers at Scripps Research Institute have synthesized GB18, a psychotropic compound found in the bark of the Galbulimima belgraveana tree. The compound binds to opioid receptors in the brain, potentially offering new hope for treating depression and anxiety. Further studies are needed to adapt it for human use.
Researchers discovered a link between traumatic brain injuries and changes in the gut microbiome, suggesting a potential diagnostic tool for concussions. The study found two bacterial species that dropped significantly after concussions, indicating a correlation with traumatic brain injury-linked proteins in the blood.
Researchers at UC San Diego describe the underlying signaling pathway that causes PAH and a novel monoclonal antibody therapy that blocks abnormal blood vessel formation. The study reveals two opposing roles of NOTCH ligands and opens a door to a potentially new treatment for PAH.
Researchers found that normal-appearing lupus skin contains the same inflammatory signals as skin with rashes, suggesting a primed state for inflammation. The study's findings provide new insights into how UV light triggers rashes in lupus patients and highlight the potential for precision medicine in treating the disease.
Researchers found that genetic mutations in the MAPK pathway, key to normal cell growth, can also make head and neck cancer vulnerable. Individualized genomic analysis can identify specific mutations and target drugs, offering a promising approach to precision medicine.
Researchers found that vital signs and lab results at hospital admission are key predictors of disease severity. Age groups between 18-50 and 50+ showed different risk factors for severe cases and death. The study's findings suggest a need for updated models reflecting current standard care, where physiological parameters can be more h...
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
Scientists at Gladstone Institutes have discovered that reducing protein tau levels soon after birth can prevent autism and epilepsy in an experimental model. The study pinpointed the crucial brain cells where tau levels must be reduced to avoid these problems, and showed that lowering tau is still effective when initiated after birth.
A recent study published in Neuro-Oncology found that genomic profiling led to more aggressive patient management resulting in improved clinical outcomes compared to traditional biologically matched historical cohorts.
A new evidence-based matching program aims to improve treatment outcomes by pairing patients with therapists based on their previously established effectiveness strengths. The program, funded by PCORI, has shown promising results in reducing symptoms and improving patient care.
Researchers load CAR-T cells with an oncolytic virus to target and kill solid cancer tumors, providing a potent immune response. The combination approach overcomes challenges in treating solid tumors with CAR-T cell therapy alone.
A five-year, $13 million grant will investigate the molecular and cellular mechanisms of prion transmission in CWD. The researchers aim to understand the inter-species transmission potential of the disease and its ability to spread from animals to humans.
A new UCI-led study indicates base editing has tremendous potential to treat inherited retinal degeneration, particularly in Leber congenital amaurosis (LCA) patients. The treatment rescued cone photoreceptors on a long-term basis, suggesting a one-time, durable treatment for LCA patients.
Researchers at University of Illinois Chicago are studying long COVID-19 in adults, focusing on vulnerable communities in urban and rural areas. They aim to understand factors that make individuals vulnerable and protective against long-term effects.
A new treatment approach has been proposed for children with congenital muscle disorders, using inhibitors to improve muscle function and movement in mice with mutations in the RYR1 gene. The therapy targets genetic material overload caused by excessive enzyme production, leading to reduced access of genes to cellular machinery.
Dr. Steven A. Rosenberg's pioneering work on IL-2 and its use in treating metastatic melanoma and other cancers led to the FDA approval of first U.S.-born cancer immunotherapy. His subsequent research on CAR T-cell therapy has resulted in promising clinical results for various types of cancer.
A team of Canadian scientists developed a scalable serology assay to track COVID-19 antibodies, informing public health decisions and vaccine timing. The assay has been used in over 30 studies across Canada, capturing natural infection and vaccination responses with high accuracy.
The new center aims to develop quantitative imaging markers to reduce subjectivity in medical image diagnosis and improve consistency. Researchers will explore cutting-edge imaging modalities and extract effective image features from existing clinical imaging modalities to aid in cancer detection and treatment.
The Tufts Clinical and Translational Science Institute has published a comprehensive resource on broadly engaged team science, which aims to include stakeholders in the research process. The book features perspectives and best practices from over 60 experts to inspire researchers and stakeholders to build diverse, inclusive teams.
Researchers have discovered a streamlined method for synthesizing novel neuroactive compounds found in the bark of Galbulimima trees, which may lead to new psychiatric and neurological drugs. The new approach enables easy synthesis at scale, paving the way for further study of these compounds' biological effects.
Researchers at Lewis Katz School of Medicine at Temple University discover a molecular pathway driving maladaptive processes in heart failure, revealing the importance of GRK5's catalytic activity and nuclear presence. The study opens doors to new therapeutic strategies for treating this devastating condition.
The Southeastern Consortium for Lung Cancer Health Equity aims to address disparities in lung cancer screening among racially and ethnically diverse populations. Researchers will develop more precise methods for identifying those at highest risk of lung cancer diagnoses.
A new smartphone app developed by Scripps Research calculates genetic risk for coronary artery disease and finds that users at high risk are more likely to start using statins or other cholesterol-lowering therapies. The app, called MyGeneRank, uses genetic data from 23andMe and outputs a CAD risk score.
Researchers discovered that an inorganic polyphosphate released by nerve cells contributes to the death of motor neurons in people with ALS and frontotemporal dementia. The study found that lowering levels of this toxin may be an innovative therapeutic strategy for diverse types of ALS/FTD.
The green Mediterranean diet induces specific microbial changes in the gut microbiome, enriching with bacteria that positively affect glucose metabolism and insulin sensitivity. This novel diet also promotes genetic pathways involved in reducing branched-chain amino acids linked to insulin resistance.
Researchers at West Virginia University are using machine learning and geographic information systems to identify areas with low COVID-vaccine uptake. They aim to pinpoint counties with increased risk of outbreaks, predict where testing is most crucial, and develop targeted interventions to increase testing rates. By acknowledging comm...
Researchers created a dental tool that measures plaque acidity using an LED light and FDA-approved chemical dye, providing dentists with early warning signs of cavity development. The device can help limit the need for specific harmful bacteria tests and educate patients about sugar's impact on oral health.
Scientists at Scripps Research identified a common target on the spike protein of multiple coronaviruses, including SARS-CoV-2, that can be targeted by a broad-spectrum vaccine. The discovery could inform the design of effective vaccines and antibody therapies against future coronavirus pandemics.
Researchers have identified an antibody drug that significantly improves survival rates in pet dogs with advanced prostate cancer. By targeting regulatory T cells, the treatment may offer a new hope for patients with this devastating disease.
Researchers at GIST demonstrate that ultrasound pulses can reduce β-amyloid plaque concentration and tau protein levels in AD-model mice, suggesting a promising non-invasive therapeutic strategy. The treatment also improves brain connectivity without causing harm to brain tissue.
Scientists at the University of Missouri discovered that bisphenol A (BPA) exposure during pregnancy can negatively impact fetal brain development. MicroRNAs in the placenta play a key role in regulating cellular functions, including neural development. Researchers believe that microRNA packages could reach the brain through the placen...
Regrowing healthy cartilage in damaged joints is a promising approach to treating arthritis. UConn bioengineers successfully regrowed cartilage in a rabbit's knee using piezoelectricity, a phenomenon that also exists in the human body.
Researchers at Penn Medicine have discovered a new method to prevent the body's proteins from attacking treatment-carrying nanoparticles, allowing for more effective delivery of therapies. By coating nanoparticles with natural suppressors of complement activation, such as Factor I, the team has shown improved protection against immune ...
Researchers find that toxic aggregates form inside brain cells, causing axon damage and neuronal death. Silencing specific proteins can block the aggregation process, potentially preventing or treating prion diseases and other neurodegenerative disorders.