Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
SourcePusan National University·JournalCancer Communications·TypeExperimental study·DateJan 31, 2023
A University of Maryland School of Medicine physician-scientist leads a research program to develop a bio-synthetic whole-blood product for easy use in the field, potentially saving thousands of lives. The product will be designed to stabilize blood pressure and facilitate blood clotting.
SourceUniversity of Maryland School of Medicine·DateJan 31, 2023
Researchers found that MAP4343 reversed excessive alcohol intake in mice modeling alcoholism and normalized blood levels of stress hormone corticosterone. The compound promotes assembly of tubulin proteins into microtubules, suggesting a possible effective treatment strategy for alcohol use disorder.
SourceScripps Research Institute·JournalNeuropsychopharmacology·DateJan 30, 2023
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A personalized brain modeling approach is being tested in a large-scale clinical trial for drug-resistant epilepsy, aiming to improve surgery preparation and patient specificity. The technique uses virtual models of patients' brains to simulate abnormal activity during seizures, helping clinicians identify target areas more effectively.
SourceHuman Brain Project·JournalScience Translational Medicine·DateJan 26, 2023
Researchers at USC Keck School of Medicine found that liver cancer cells hijack circadian clock proteins to replicate and spread. Inhibiting these proteins can prevent cancer cell multiplication and potentially improve outcomes for patients with liver cancer.
SourceKeck School of Medicine of USC·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 5, 2023
Researchers from Okayama University found that Actinidia arguta (Sarunashi) juice and its component isoquercetin inhibit lung cancer development in mice, accelerating DNA repair and suppressing Akt-mediated growth signaling. The study suggests Sarunashi juice as an attractive candidate for chemoprevention.
SourceOkayama University·JournalGenes and Environment·TypeExperimental study·DateDec 28, 2022
Researchers have found that experimental vaccines, including a protein-based vaccine candidate with an adjuvant, provide superior protection against lung disease and higher levels of neutralizing antibodies compared to mRNA vaccines. The results inform the optimization and development of COVID-19 vaccines for young infant populations.
SourceWeill Cornell Medicine·JournalScience Translational Medicine·DateDec 1, 2022
Johns Hopkins researchers have developed a three-dimensional organoid model derived from human tissue to study gastroesophageal junction (GEJ) cancer. The dual knockout of genes in the model has identified key biological targets for treating GEJ cancers with existing drugs.
SourceJohns Hopkins Medicine·JournalScience Translational Medicine·DateDec 1, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A follow-up study found that the 2-dose vaccines still provided protection against lung disease one year after vaccination as infants. The adjuvanted protein vaccine candidate maintained higher levels of neutralizing antibodies and provided superior protection compared to the mRNA vaccine.
SourceUniversity of North Carolina Health Care·JournalScience Translational Medicine·TypeObservational study·DateDec 1, 2022
The Andrew Sabin Family Foundation has donated $10 million to the James P. Allison Institute, a research and innovation hub aiming to unlock cancer cures. The gift will support elite scientists and post-doctoral programs to accelerate breakthroughs in immunobiology.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateNov 16, 2022
Researchers report new findings from a landmark transplant, showing unexpected heart conduction measures that did not contribute to failure. The study suggests genetic modifications made to the pig's heart were not responsible for causing these changes.
SourceUniversity of Maryland School of Medicine·TypeObservational study·DateNov 14, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers used monoclonal antibodies to suppress the immune system in mice, tracking human neural stem cell survival using luciferase. The study reveals that monoclonal antibody-mediated immunosuppression enabled long-term survival of transplanted human neural stem cells in mouse brains for at least six to eight months.
SourceMichigan Medicine - University of Michigan·JournalClinical and Translational Medicine·TypeExperimental study·DateNov 9, 2022
Researchers conducted the largest clinical trial to date of psilocybin, finding a statistically significant rapid reduction in symptoms of depression. The study suggests that COMP360 psilocybin with psychological support could be an effective treatment strategy for people with treatment-resistant depression.
SourceTrinity College Dublin·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateNov 7, 2022
Researchers have discovered a new gene, Schlafen11 (SLFN11), which correlates with chemotherapy response in medulloblastoma. The study's findings suggest SLFN11 can help improve treatment outcomes by increasing sensitivity to cisplatin.
SourceNiigata University·JournalNeuro-Oncology·DateNov 6, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers uncover critical shape-change in cereblon protein that CELMoD drugs must cause to work effectively. The finding enables the development of more effective cancer-fighting treatments.
SourceScripps Research Institute·JournalScience·DateNov 3, 2022
A UCSF-led study sheds light on the mechanisms behind sex differences in ICI-induced myocarditis, a potentially fatal side effect of cancer immunotherapy. The research suggests that immune checkpoint inhibitors may interact with sex hormones to cause cardiac toxicity in female patients.
SourceUniversity of California - San Francisco·JournalScience Translational Medicine·DateNov 2, 2022
Dr. Ralph L. Sacco, a top stroke neurologist, has advanced understanding of cardiovascular and cerebrovascular diseases through his research on race-related stroke risk. He is recognized for his work in creating targeted stroke prevention programs.
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers at La Jolla Institute for Immunology have developed a new therapy for Lassa fever using a trio of rare human antibodies that can block viral infection. The therapy, called Arevirumab-3, was tested in non-human primates and proved 100% effective in treating the disease.
SourceLa Jolla Institute for Immunology·JournalScience Translational Medicine·TypeExperimental study·DateOct 26, 2022
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
SourceUniversity College London·JournalScience Translational Medicine·TypeExperimental study·DateOct 26, 2022
A new study found that frail seniors often use public transportation to get to doctor appointments due to inadequate accessibility. The study highlights the pressing need to improve public transit infrastructure and services in cities to support an aging population.
SourceUniversity of Maryland School of Medicine·JournalJournal of the American Geriatrics Society·TypeMeta-analysis·DateOct 24, 2022
Researchers at FAU's Schmidt College of Medicine are developing a pilot program to tackle health disparities by leveraging electronic health records, artificial intelligence, and machine learning. The project aims to improve AI/ML delivery and research operations in community health centers and federally qualified health centers.
Researchers found that administering nitric oxide to preterm mice after birth can reverse symptoms of congenital hypogonadotropic hypogonadism, including sensory and cognitive disorders. A clinical trial is now underway to test this treatment in human preterm infants.
SourceINSERM (Institut national de la santé et de la recherche médicale)·JournalScience Translational Medicine·TypeExperimental study·DateOct 5, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalGut·DateOct 3, 2022
Cleveland researchers reveal a new strategy to prevent blood clots by targeting overactive neutrophils, reducing clotting risk while minimizing bleeding risk. The findings may be especially impactful for cancer patients who experience blood clot complications.
SourceUniversity Hospitals Cleveland Medical Center·JournalScience Translational Medicine·DateSep 30, 2022
A new drug, NMT5, has shown promising results in blocking SARS-CoV-2 infection in animals. The drug coats the virus with chemicals that temporarily alter the human ACE2 receptor, preventing it from infecting cells. In cell culture experiments, the Omicron variant of SARS-CoV-2 was prevented from attaching to human ACE2 receptors by 95%.
SourceScripps Research Institute·JournalNature Chemical Biology·DateSep 29, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers at Scripps Research have discovered that chronic circadian disruption can increase lung cancer growth in animal models by activating the heat shock factor 1 (HSF1) pathway. This finding suggests a molecular link between disrupted sleep patterns, temperature changes, and tumor formation.
SourceScripps Research Institute·JournalScience Advances·DateSep 28, 2022
Researchers at Newcastle University found that probiotics do not give uniform results in premature babies. The study's findings highlight the need for a personalized medicine approach to provide customized probiotics according to an analysis of their gut flora and other factors.
SourceNewcastle University·JournalNature Microbiology·TypeMeta-analysis·DateSep 27, 2022
Researchers at UCI have made significant progress in precision genome editing for treating inherited retinal diseases, enabling precise gene correction and disease rescue. The study highlights the potential of this technology to revolutionize treatment of genetic disorders of vision, with over 270 causative genes identified.
SourceUniversity of California - Irvine·JournalProceedings of the National Academy of Sciences·DateSep 23, 2022
A new wearable device study, DETECT, found that sensor data significantly improves seven-day average predictions for COVID-19 infection by 32.9% in California and 12.2% nationwide. The study tracked physiological changes before symptom onset, providing a valuable tool for predicting viral threats.
SourceScripps Research Institute·JournalThe Lancet Digital Health·DateSep 22, 2022
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
SourceScripps Research Institute·JournalOpen Biology·DateAug 17, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A national study by UC San Francisco found that basic home blood pressure cuffs and smartphone-connected devices have no significant difference in improving blood pressure control. After six months, patients who used basic cuffs had a lower blood pressure reduction compared to those using Bluetooth-enabled devices.
SourceUniversity of California - San Francisco·JournalJAMA Internal Medicine·DateAug 15, 2022
Researchers identify LINE-1 RNA as a key player in premature aging, revealing its role in progeria and potential therapeutic targets. By inhibiting LINE-1 RNA, scientists reverse signs of aging and extend lifespan in mice.
SourceSalk Institute·JournalScience Translational Medicine·DateAug 10, 2022
Researchers have identified key molecular differences between cancer cells that cling to initial tumors and those that spread to distant sites. The study found unique properties in cells that gain migratory ability and survival advantages, leading to the development of new treatment targets.
SourceJohns Hopkins Medicine·JournalScience Translational Medicine·DateAug 8, 2022
The ISM Annual Meeting highlights new topics in oral, vaginal, skin, and gut microbiota, as well as their metabolites and potential implications in diseases like cancer, depression, and stroke. The meeting aims to explore the mechanism behind microbiota efficacy and its potential application in precision medicine.
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
The Heart and Lung Research Institute (HLRI) at the University of Cambridge will bring together over 380 researchers and clinicians to tackle cardiovascular and respiratory diseases. The institute aims to deliver high-impact research to drive breakthroughs in prevention, early diagnosis, and treatment of these diseases, which represent...
A new gene therapy for sickle cell disease was tested in mice but proved ineffective due to the complex genetic make-up of the Berkeley mice. The study suggests that researchers should carefully consider the genetics of the mice used to test human diseases.
SourceThe Company of Biologists·JournalDisease Models & Mechanisms·TypeExperimental study·DateJul 6, 2022
A new analysis published in JAMA Psychiatry shows that brief suicide prevention interventions delivered in healthcare settings drastically underreport the strategies needed for successful implementation. On average, about 85% of these strategies were missing from published reports.
SourceUniversity of Illinois Chicago·JournalJAMA Psychiatry·TypeLiterature review·DateJun 15, 2022
A new review paper has proposed a framework for advancing the application of xenotransplantation, a potential solution to the organ shortage. The study discusses innovations and advances in transplanting animal hearts into human subjects, with a focus on overcoming challenges and barriers.
SourceAmerican College of Cardiology·JournalJACC Basic to Translational Science·TypeCase study·DateJun 15, 2022
A simplified surgical tool called RAIS has been developed to enable laparoscopic surgery in low-to-middle income countries. The device uses a mechanical retractor and does not require CO2 gas or a general anaesthetic, making it more accessible and affordable for rural surgeons.
SourceUniversity of Leeds·TypeRandomized controlled/clinical trial·DateJun 13, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have identified 30 COVID-19 patient antibodies that can neutralize a variety of coronaviruses, including SARS-CoV-1 and bat coronaviruses. These broadly neutralizing antibodies may lead to the development of next-generation coronavirus vaccines offering broader protection.
SourceScripps Research Institute·JournalNature Immunology·DateJun 2, 2022
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
SourceRutgers University·JournalScience Translational Medicine·TypeObservational study·DateMay 30, 2022
Chemists at Scripps Research unveil a new method for synthesizing diverse and complex lactones from cheap dicarboxylic acids. This breakthrough enables the creation of valuable molecules, such as natural antibiotics and fragrances.
SourceScripps Research Institute·JournalScience·DateMay 27, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
The University of Minnesota has received a $66 million grant from the NIAID to establish a center for developing antiviral drugs for pandemic-level viruses, including SARS-CoV-2. The Midwest Antiviral Drug Discovery Center will bring together investigators from the University and sixteen other institutions nationwide.
SourceUniversity of Minnesota Medical School·DateMay 23, 2022
Researchers at MedUni Vienna identified five distinct subtypes of small cell lung cancer, each responding differently to therapies. High ASCL1 expression is linked to poor survival, while high POU2F3 expression correlates with better outcomes and sensitivity to standard chemotherapeutics.
SourceMedical University of Vienna·JournalThe Journal of Pathology·DateMay 17, 2022
A global study found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. The combination of albuterol and budesonide lowers the number of sudden episodes of shortness of breath, wheezing, and coughing in patients.
SourceRutgers University·JournalNew England Journal of Medicine·TypeObservational study·DateMay 16, 2022
Researchers at Scripps Research Institute have synthesized GB18, a psychotropic compound found in the bark of the Galbulimima belgraveana tree. The compound binds to opioid receptors in the brain, potentially offering new hope for treating depression and anxiety. Further studies are needed to adapt it for human use.
SourceScripps Research Institute·JournalNature·DateMay 12, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers discovered a link between traumatic brain injuries and changes in the gut microbiome, suggesting a potential diagnostic tool for concussions. The study found two bacterial species that dropped significantly after concussions, indicating a correlation with traumatic brain injury-linked proteins in the blood.
SourceHouston Methodist·JournalBrain Behavior & Immunity - Health·TypeExperimental study·DateMay 10, 2022
Researchers at UC San Diego describe the underlying signaling pathway that causes PAH and a novel monoclonal antibody therapy that blocks abnormal blood vessel formation. The study reveals two opposing roles of NOTCH ligands and opens a door to a potentially new treatment for PAH.
SourceUniversity of California - San Diego·JournalScience Translational Medicine·DateMay 6, 2022
Researchers found that normal-appearing lupus skin contains the same inflammatory signals as skin with rashes, suggesting a primed state for inflammation. The study's findings provide new insights into how UV light triggers rashes in lupus patients and highlight the potential for precision medicine in treating the disease.
SourceMichigan Medicine - University of Michigan·JournalScience Translational Medicine·TypeExperimental study·DateMay 3, 2022
Researchers found that genetic mutations in the MAPK pathway, key to normal cell growth, can also make head and neck cancer vulnerable. Individualized genomic analysis can identify specific mutations and target drugs, offering a promising approach to precision medicine.
SourceMedical College of Georgia at Augusta University·Journalnpj Genomic Medicine·DateApr 28, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers found that vital signs and lab results at hospital admission are key predictors of disease severity. Age groups between 18-50 and 50+ showed different risk factors for severe cases and death. The study's findings suggest a need for updated models reflecting current standard care, where physiological parameters can be more h...
SourceInstitute for Systems Biology·JournalScientific Reports·TypeData/statistical analysis·DateApr 28, 2022
Scientists at Gladstone Institutes have discovered that reducing protein tau levels soon after birth can prevent autism and epilepsy in an experimental model. The study pinpointed the crucial brain cells where tau levels must be reduced to avoid these problems, and showed that lowering tau is still effective when initiated after birth.
SourceGladstone Institutes·JournalScience Translational Medicine·DateApr 27, 2022
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
SourceIstituto Neurologico Mediterraneo Neuromed I.R.C.C.S.·JournalNature·TypeExperimental study·DateApr 27, 2022
A recent study published in Neuro-Oncology found that genomic profiling led to more aggressive patient management resulting in improved clinical outcomes compared to traditional biologically matched historical cohorts.
SourceUniversity of California - San Francisco·JournalNeuro-Oncology·DateApr 21, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new evidence-based matching program aims to improve treatment outcomes by pairing patients with therapists based on their previously established effectiveness strengths. The program, funded by PCORI, has shown promising results in reducing symptoms and improving patient care.
Researchers load CAR-T cells with an oncolytic virus to target and kill solid cancer tumors, providing a potent immune response. The combination approach overcomes challenges in treating solid tumors with CAR-T cell therapy alone.
SourceMayo Clinic·JournalScience Translational Medicine·DateApr 13, 2022
A five-year, $13 million grant will investigate the molecular and cellular mechanisms of prion transmission in CWD. The researchers aim to understand the inter-species transmission potential of the disease and its ability to spread from animals to humans.
SourceUniversity of Texas Health Science Center at Houston·DateApr 13, 2022
A new UCI-led study indicates base editing has tremendous potential to treat inherited retinal degeneration, particularly in Leber congenital amaurosis (LCA) patients. The treatment rescued cone photoreceptors on a long-term basis, suggesting a one-time, durable treatment for LCA patients.
SourceUniversity of California - Irvine·JournalNature Communications·DateApr 5, 2022
Researchers at University of Illinois Chicago are studying long COVID-19 in adults, focusing on vulnerable communities in urban and rural areas. They aim to understand factors that make individuals vulnerable and protective against long-term effects.
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new treatment approach has been proposed for children with congenital muscle disorders, using inhibitors to improve muscle function and movement in mice with mutations in the RYR1 gene. The therapy targets genetic material overload caused by excessive enzyme production, leading to reduced access of genes to cellular machinery.
SourceUniversity of Basel·JournaleLife·TypeExperimental study·DateMar 29, 2022