Articles tagged with Translational Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
The grant will support the work of the Irving Institute for Clinical and Translational Research in accelerating the application of scientific discoveries. The funding has enabled the establishment of over 70 services and programs to help Columbia researchers translate medical discoveries into treatments.
A pan-Canadian randomized controlled trial is using digital communication to target common reasons for vaccine hesitancy, including age, language, and education level. Family physicians will receive tailored information to share with patients through email and text message, aiming to improve vaccine uptake.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
A new study showcases the COVIDome Explorer, a public online portal for real-time COVID-19 data analysis, visualization and sharing. The platform enables rapid hypotheses testing, hypothesis generation and discoveries by experts and non-experts.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
Researchers have successfully used nose drops containing genetically modified friendly bacteria to protect against meningitis, showing strong and long-lasting immune responses. The new method, which exploits the natural presence of non-pathogenic Neisseria lactamica in the nose, has potential applications beyond meningitis prevention.
The study reveals that harnessing the microbiome and its associated metabolic pathways could provide a useful approach to treating Alzheimer's disease and Amyotrophic Lateral Sclerosis. Probiotic treatment improved ALS symptoms in mice and humans, suggesting potential therapeutic benefits.
Researchers identified three proteins - FGF20, ANGPT1, and TNFSF12 - that offer protection against progressive kidney decline in diabetes patients. Elevated levels of these proteins were found to reduce the risk of end-stage renal disease.
The study reveals a dominant network of neutrophils and tissue-resident T cells in the bile ducts of patients with primary sclerosing cholangitis (PSC), a severe inflammatory disease. This discovery may pave the way for new treatment strategies against PSC and other biliary disorders.
A new study published in Science Translational Medicine found that intermittent fasting diets are not the most effective way to lose weight. Participants who followed a traditional diet with reduced calorie intake lost more weight and fat mass compared to those who fasted on alternate days.
The LSU Health New Orleans research enterprise will sequence SARS-CoV-2 variants from cases among unvaccinated individuals and vulnerable patients, as well as those treated with immunosuppressants. The project aims to focus on underserved and minority patients in Louisiana.
A new study by the American Society for Nutrition found that people who eat faster or take larger bites tend to consume more food. The researchers suggest that being aware of portion sizes, slowing down while eating, and taking smaller bites can help avoid overconsumption.
C-Path and Tufts Medical Center collaborate to integrate patient-level clinical trial data and real-world data to generate actionable real-world evidence for neonatal drug development. The partnership aims to improve survival and outcome for preterm neonates with limited new drug development.
Boston University School of Medicine director Ridiane Denis has received a Distinguished Service Award for her outstanding contributions to the university. The award recognizes her tireless efforts in supporting research projects and staff, particularly during challenging times like COVID-19.
Researchers discovered subtle changes in potassium, calcium, and sodium levels regulate heartbeats. Increasing sodium and calcium levels together reduces distances between cells, improving cardiac conduction.
Researchers at the University of New Mexico Health Sciences Center have created a powerful computational tool called REDIAL-2020. This online suite of models enables scientists to quickly identify small molecules capable of disarming COVID-19, narrowing the field for future experiments and accelerating the discovery process.
Researchers found that applying fat grafts enriched with adipose-derived stem cells improved fat retention in LoS patients. The study suggested a safe and feasible alternative to conventional treatment methods for correcting facial atrophy.
Researchers have found that Urolithin A can delay the progression of Duchenne Muscle Dystrophy in mice by restoring mitochondrial activity and increasing mitophagy. This natural compound has shown promise in improving muscle health and performance, with significant increases in grip strength and running performance.
Asymptomatic and pre-symptomatic transmission poses a significant challenge in controlling the COVID-19 pandemic. Experts warn that relying solely on vaccination is unlikely to be effective in preventing transmission, highlighting the need for robust surveillance measures.
Researchers created growing heart valves using tissue engineering and regenerative medicine, which showed reduced calcification and improved blood flow function. The valves could prevent repeated surgery in children born with congenital heart defects and be stored for at least six months.
Researchers found that social distancing prevented an acute flaccid myelitis (AFM) outbreak in 2020, likely due to reduced enterovirus D68 (EV-D68) transmission. The study suggests that vaccines targeting EV-D68 could lessen future AFM outbreaks.
Researchers successfully developed bispecific antibodies that can target and deplete cancer cells without damaging healthy ones, including mutant tumor suppressor genes like p53. These antibodies could be used 'off-the-shelf' and are a promising alternative to engineered immune cell therapies.
A phase I clinical trial reveals adipose-derived stem cells alleviate symptoms of lymphedema, improving upper extremity function and reducing treatment use. Patients experienced sustained benefits for up to four years after treatment.
Researchers at Geisinger Health System developed an AI algorithm using echocardiogram videos to predict mortality within a year. The model outperformed other clinically used predictors and improved cardiologists' prediction accuracy by 13 percent.
AAAS introduces trial basis for cOAlition S-funded authors to publish accepted manuscripts with CC BY or CC BY-ND licenses on Science family journals. This move aims to alleviate financial burden on authors and promote diversity in scientific publishing.
Artificial intelligence can learn new visual concepts faster using a technique that mirrors human visual learning, improving its ability to quickly recognize objects from sparse data. The approach enables computers to leverage prior learning and simplify complex visual concept representations, leading to improved learning efficiency.
A clinical trial evaluated the safety and effectiveness of two cell therapies for treating angiitis-induced critical limb ischemia, yielding satisfactory results. The study found that both therapies provided evidence for precise application under different conditions.
Researchers found that children born by caesarean section have an increased risk of developing asthma if their gut microbiota still carries a caesarean signature at age 1 year. This study proposes restoring the perturbed microbiome to potentially prevent asthma development in high-risk children.
Research from Penn State Clinical and Translational Science Institute finds significant increases in diseases of despair diagnoses, including alcohol-, substance-, and suicide-related disorders. The rates increased by 37%, 94%, and 170% between 2007 and 2018, with the most substantial percentage increase among men ages 35 to 74.
The National COVID Cohort Collaborative (N3C) is a centralized analytics platform storing vast amounts of medical record data from people tested for COVID-19. Regenstrief serves as the national project's Honest Data Broker, creating more complete and informative data sets while ensuring patient privacy.
A new study developed an algorithm that predicts antibiotic resistance and provides personalized treatment recommendations, reducing broad-spectrum antibiotics by 67%. The tool is a step toward reducing antibiotic resistance and improving outpatient care.
Researchers found that sensor data from fitness trackers can identify COVID-19 cases with greater accuracy than symptoms alone. The DETECT study uses mobile app data to analyze changes in heart rate, sleep, and activity levels to detect viral illnesses.
Researchers found that people born without upper limbs who use their feet to reach engage the same brain area as those with hands, revealing a higher-level motor function. This discovery advances basic science and offers potential clinical advances in improving limb prostheses.
A study in STEM CELLS Translational Medicine suggests that amniotic fluid stem cell-derived secretome can restore neuronal plasticity and improve cognition after an ischemic stroke. The findings offer a potential new avenue of treatment for ischemic stroke, which affects 87% of all strokes.
A statewide coalition, led by UCLA, aims to reduce COVID-19 knowledge disparities and increase vaccine uptake among underrepresented populations in California. The initiative combines community-engaged research with local partnerships to build trust and address concerns.
Researchers identified Paenibacillus species as the causative agent of post-infectious hydrocephalus (PIH), which affects millions of children worldwide. The discovery has the potential to reduce morbidity and mortality by shifting treatment from surgery to antibiotics and vaccines.
A new study found that children exhibit higher levels of two immune system molecules, IL-17A and INF-?, which contribute to their better COVID-19 outcomes. This robust innate immune response may protect children from progressing to severe pulmonary disease.
The report highlights a failure in global preparedness during the COVID-19 pandemic, emphasizing governance failures. Experts recommend strategies to re-center governance, including reforming international regulations and increasing funding for the WHO.
Researchers at University of Luxembourg have identified a genetic form of Parkinson's disease caused by a splicing error, offering new potential pharmacological treatments. The discovery was made using patient-based cell cultures reprogrammed into nerve cells in vitro.
An experimental probiotic treatment reduced eczema severity and improved quality of life for children as young as 3 years old. The treatment modified the skin microbiome and increased microbial diversity, reducing Staphylococcus aureus levels and promoting skin repair processes.
Georgetown researchers caution that weather does not significantly impact COVID-19 transmission and that lockdowns and re-openings have a stronger influence. The authors suggest that policy should not be tailored to current understandings of the COVID-climate link.
Researchers have developed a synthetic gut lining that can target the small intestine, delivering drugs and influencing nutrient absorption. The system has shown potential in treating lactose intolerance, diabetes, obesity, and tropical diseases like schistosomiasis.
A Georgetown University Medical Center study reveals that veterans with Gulf War illness (GWI) and patients with Chronic Fatigue Syndrome (CFS) exhibit distinct brain activity patterns after moderate exercise. The finding could lead to improved treatment for veterans with GWI by diagnosing CFS as a separate disorder.
A new approach to deep brain stimulation using light-sensitive proteins and harmless viruses could provide a minimally invasive treatment option for brain disorders. The technique has shown promise in reducing symptoms of Parkinson's disease by targeting non-neuronal brain cells.
Researchers developed a non-invasive tracking strategy using CRISPR/Cas9 editing to insert the sodium/iodide symporter gene into iPSCs. This allows long-term monitoring of cardiomyocytes after implantation, paving the way for preclinical and clinical development of cardiac cell therapies.
Researchers have identified key biological insights that may help solve the mystery of what drives PAH and why a new therapy in clinical trials may work. The fusion protein is more effective than vasodilators at treating PAH and preventing blood vessel remodeling, restoring a normal balance between cell proliferation and death.
Scientists have discovered previously unreported genetic and cellular changes in the lungs of people with pulmonary fibrosis, a devastating lung-scarring disease. The findings provide remarkable insights into the fundamental mechanisms driving disease pathology in PF and may aid the search for new ways to treat or prevent the condition.
Researchers identified important molecules to study and manipulate specific glial cells integral to synapses. This discovery provides a highly specific glial 'bar code', identifying vital cell subtype and enabling targeted therapy development for neuromuscular diseases such as ALS and SMA.
New research highlights potential cardiovascular risk of novel anti-osteoporotic medicine romosozumab. The study found a link between genetic markers and increased cardiovascular risk, supporting previous trial findings.
A study published in the journal Aging, Neuropsychology, and Cognition found that children who attend school for longer periods have better memory abilities in old age, particularly for women. More years of early-life education counteract age-related memory losses, suggesting a protective effect against Alzheimer's disease.
Global health scholars warn of impending crisis in Africa due to slow access to COVID-19 supplies, echoing the experience during the early stages of the HIV/AIDS pandemic. Several African countries have prepared disease response capacities, but geopolitical power struggles hinder supply acquisition.
Warren J. Leonard is recognized for pioneering work in X-linked severe combined immunodeficiency and cloning the IL-2 receptor alpha chain. His findings led to a deeper understanding of cytokine signaling and immune dysregulation.
Scientists at Temple University Health System are exploring the molecular mechanisms of heart injury and repair. They aim to identify new paths to developing innovative heart therapies. The study focuses on understanding the role of molecules known as G protein-coupled receptor kinases (GRKs) in heart function and disease.
Matthew Disney's work has led to a new understanding of druggable targets and reinvigorated research on incurable diseases like Alzheimer's, Parkinson's, and ALS. His RNA-modifying tools show great applicability to cancers and rare genetic disorders.
A new study shows a common eye condition, glaucoma, can be successfully treated with gene therapy using a single injection, providing additional treatment options and benefits. Glaucoma affects over 64 million people worldwide and is a leading cause of irreversible blindness.
Researchers have developed a way to protect thin, flexible neural interfaces from the biological processes of the human body. The new technology uses thermally grown silicon dioxide to create a biocompatible barrier that lasts for more than six years.
The article provides a COVID-19 surge preparedness checklist for emergency departments, created using a translational science approach. The checklist aims to reconfigure Emergency Departments to meet the surge of patients and improve resilience of healthcare systems.
A new two-step technique repairs herniated discs by re-inflating the disc with hyaluronic acid gel and sealing the hole with collagen gel. This method maintains mechanical function and prevents collapse or deterioration, offering a promising alternative to existing treatments.
Researchers have discovered a molecular pathway that, when silenced, restores immune cells' normal function in people with fatty liver disease. Silencing a microRNA molecule called miR144 increases the endogenous antioxidant response, suggesting a promising therapeutic strategy for treating non-alcoholic steatohepatitis.