Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
A survey study found that overall trust in scientists as sources of cancer information is high, but ideologically diverse. The results suggest the need for tailored messaging and trusted messengers to reach diverse audiences with evidence-based cancer information.
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
A new study developed an antibody that blocks several ways TNBC cells survive, grow, and evade the immune system. The antibody suppressed primary tumor growth and reenergized cancer-fighting immune cells, including T-cells and macrophages, in preclinical models.
MIT chemists successfully synthesized verticillin A, a fungal compound that has shown potential as an anticancer agent. The researchers then generated derivatives of the compound and tested them against pediatric brain tumors, finding that some were effective against cancer cells with high levels of EZHIP protein.
Researchers at CU Anschutz have discovered a novel therapy combination to offer new hope to ovarian cancer patients who do not respond to existing treatments. The combination of a PARP inhibitor and SM08502 boosts the effectiveness of treatment, even for patients resistant to PARP inhibitors.
Researchers found that sudden cardiac death (SCD) among colorectal cancer patients decreased overall, but disparities remained based on age, sex, and geographic location. The study highlights the need for tailored heart monitoring and care strategies for cancer patients, particularly in underserved groups.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
Scientists at Penn Vet have identified two genes, Ctnna1 and Bcl2l13, that suppress metastasis in preclinical models of colorectal cancer. These findings could lead to better treatments and therapies for patients with metastatic disease.
A recent study by UCLA Health investigators found that mental health conditions significantly raise the likelihood of developing liver cancer among US veterans living with cirrhosis and hepatitis C. The study suggests that these disorders limit access to hepatitis C care, reducing the chance of a cure.
Fred Hutch experts will present CAR-T access expansion, new AML treatment strategies, and the impact of climate on cancer. Experts discuss optimizing maintenance therapy using MRD-directed approaches for high-risk AML patients and evaluating the safety & efficacy of combining PIVEK with FLAG-IDA for adults with untreated AML.
Research highlights the connection between fungi and cancer, revealing that fungal microbiome can promote tumour progression and activate immunosuppressive pathways. Modulating the fungal microbiome may enhance antitumour immunity, with preliminary validation from preclinical and clinical trials.
Robotic exoskeletons enhance cancer patients' mobility, muscle strength, and gait training while providing personalized support and real-time feedback. This innovation integrates traditional therapies, nutritional support, and cognitive behavioral therapy to improve therapeutic outcomes.
This study explores the immune and molecular basis of lung cancer complicated by pulmonary tuberculosis, identifying diagnostic biomarkers through transcriptome analysis. Key findings include increased CD4+ T cells, NK cells, and specific gene expressions, providing a validated four-gene diagnostic signature for external evaluation.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
Researchers from Mass General Brigham Cancer Institute present promising new treatment options for acute myeloid leukemia, autoimmune bleeding disorders, and multiple myeloma. The studies show improved event-free survival, higher overall response rates, and better quality of life for patients treated with novel therapies.
A UTEP research team found that Claudin-4, a protein increasing in ovarian cancer, may help tumors survive and hide from the immune system. Targeting Claudin-4 with a peptide and PARP inhibitor slows tumor growth and enhances the immune system's ability to fight cancer.
A recent study found that more adolescents and young adults (AYAs) with cancer received palliative care between 2018 and 2022 compared to previous studies. However, the researchers also noted challenges in providing quality palliative care, including stigma and high-intensity end-of-life care.
A new study in Molecular Cell reveals that cellular aging is controlled by the ATM kinase response to withered telomeres. Cells grown under low oxygen conditions are more tolerant of short telomeres, while high oxygen accelerates cellular aging due to hyperactive ATM.
The updated 2025 American Society of Hematology guidelines recommend that most older adults with acute myeloid leukemia (AML) receive treatment, including gentler chemotherapy regimens and targeted therapies. The guidelines aim to provide more personalized and effective care for this patient population.
The study analyzed global data from 1990 to 2021, finding that GI cancer risks peak between ages 40-64 and differ by sex, socioeconomic status, and geography. Colorectal cancer has the highest incidence risk, while stomach cancer demonstrates the highest mortality risk.
Researchers found that FOLFIRINOX improved progression-free and overall survival in patients with advanced biliary tract cancer. The treatment may offer a benefit as a second-line option after first-line chemotherapy failure, but toxicity remains a concern.
The study reveals a significant burden of metastatic disease in adolescents and young adults with cancer. The findings expand knowledge on metastatic recurrences, improving care for adolescent and young adult survivors.
The new system can reveal early cancers, lung disease, hidden material defects and changes in porosity without multiple exposures or complex mechanical movement. This method produces low-dose and faster images, lowering patients' radiation dose and making clinical translation feasible.
The SISAQOL-IMI consortium has published key guidelines for patient-reported outcomes in cancer clinical trials, providing a harmonised framework for designing, analysing, and interpreting PRO data. The new online toolkit offers practical resources to support implementation across the research and policy landscape.
Zanidatamab demonstrated significant efficacy in patients with HER2-positive biliary tract cancer, achieving response rates of up to 51.6% and improving symptoms such as pain levels. The trial's results support the emerging role of zanidatamab as a treatment paradigm for this rare and aggressive cancer.
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
A new review connects gut microbiome imbalances to obesity, metabolic syndrome, and colorectal cancer, highlighting the potential for diet and microbiome-based treatments. The study also explores racial and socioeconomic disparities in microbiome-related diseases, emphasizing the need for inclusive prevention strategies.
Researchers have discovered that rhesus macaques shed TIGIT from immune cell surfaces when exposed to plasmin, a natural enzyme involved in blood clot breakdown. This creates a soluble form of TIGIT that can still bind anti-TIGIT monoclonal antibodies, potentially leading to misleading safety and efficacy data for human trials.
Researchers at the University of York have discovered a way to harness radiation from particle accelerator beam dumps to produce medical isotopes used in cancer diagnosis and treatment. Copper-67 is a rare isotope with limited global supplies, but this method could generate it without affecting main physics experiments.
A novel liver cancer vaccine has achieved responses in a rare disease affecting children and young adults, with 75% of patients experiencing disease control. Three patients are now believed to be cancer-free after receiving the therapy, including a 13-year-old patient who achieved a nearly complete response.
A population-based cohort study found that individuals following high-glycemic index diets had a 13% higher chance of developing lung cancer compared to those on low-GI diets. In contrast, those consuming high-glycemic load diets experienced a 28% lower risk of lung cancer.
A global survey led by UC Irvine researchers found that 70% of oncology professionals use or recommend integrative approaches to manage cancer symptoms. However, these services remain underused due to cost, lack of insurance coverage, and limited training opportunities, particularly in low-income countries.
Research reveals that pleural cavity macrophages support lung tumor growth by suppressing anti-tumor immunity. Macrophage depletion leads to increased cytotoxic CD8 T cells, establishing their role as key drivers of tumor progression.
Recent advances reveal circadian rhythms modulate gut microbiota diversity and metabolic functions, affecting the tumor microenvironment and immune cell function. Gut microbial dysbiosis induced by circadian misalignment promotes an immunosuppressive TME and accelerates tumor growth.
A recent study led by Dr. Leah Backhus found that lung cancer patients often receive inadequate posttreatment surveillance, which can lead to a substantial gap in care. The study estimated the true surveillance rates and predictors of guideline-concordant care in patients with early-stage non-small cell lung cancer.
Researchers discovered P. angustum selectively targets colorectal cancer, inducing direct tumor lysis and robust immune activation. The therapy promotes intratumoral infiltration of immune cells and enhances production of inflammatory cytokines, significantly prolonging survival in treated mice.
A study at Technical University of Munich found that AI-simplified CT reports reduced reading time to two minutes and improved patient comprehension. Patients rated the simplified texts as more helpful and informative, with 82% finding them easier to read and understand.
A special issue of Cancer Biology & Medicine highlights scientific progress, policy innovations, and digital health tools to accelerate cervical cancer elimination. The collection provides a comprehensive resource for advancing women's health equity worldwide, tackling vast inequities in health resources and implementation capacity.
The review highlights the progress in gene-editing nucleases and delivery vectors for in vivo gene therapy, enabling targeted correction of genetic errors. Key examples include FDA-approved products targeting monogenic disorders and cancers, showcasing the therapeutic promise of combining genome editors with advanced delivery platforms.
Researchers at Virginia Tech's Fralin Biomedical Research Institute are studying how fluid flow contributes to the spread of glioblastoma tumors. They will use focused ultrasound and advanced MRI techniques to build a map of fluid flow in the whole brain and test the effectiveness of drug delivery.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Linda Bulone, a Queens Cancer Center Oncology nurse, received the 2025 Alliance Clinical Research Professionals Research Integrity Service Excellence (CRP RISE) Award. She has significantly increased clinical trial participation, expanded early screening efforts, and supported reductions in late-stage diagnoses.
New research reveals VEGF(R) inhibitors induce arthritis through increased inflammatory responses and activation of pro-inflammatory pathways. The study provides important mechanistic insights into this treatment-related adverse event, ultimately enhancing oncology care safety.
A team at the University of Pennsylvania has solved the mechanism of action of hydralazine, revealing its potential to halt the growth of brain cancer cells. By blocking an oxygen-sensing enzyme, hydralazine can reduce intracellular calcium levels, causing blood vessels to relax and tumor cells to enter a dormant state.
Researchers at UC San Diego found that cancer cells use non-genetic mechanisms to regrow after targeted therapy, which could help prevent tumor recurrence. By blocking these signaling pathways, future treatments may be able to stop tumors from relapsing during therapy.
A new AI tool, SMMILe, can rapidly analyze complex cancer images and provide detailed information about tumor lesions, including their locations and proportions. This could lead to more accurate diagnoses and personalized treatment options for patients.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
This study evaluates the long-term effects of IMRT on HNC patients' vision, patient well-being, and morbidity. A cohort study of adults with HNC treated with IMRT in Ghana will investigate visual outcomes and quality of life.
Researchers found that bifidobacterium can boost cancer treatment by regulating the immune system, reducing inflammation, and supporting anti-tumor responses. The probiotic also helps detoxify carcinogens and convert food-based substances into cancer-fighting agents, offering a promising natural ally for cancer prevention and treatment.
The new department will drive the next generation of discovery and patient-centered care through advanced imaging and therapy. Key collaborations include UCLA Health, David Geffen School of Medicine, and UCLA Health Jonsson Comprehensive Cancer Center.
The study reveals that mutated and unmutated CLL subtypes originate from distinct stages of B cell development. New molecular biomarkers, including genes LPL, ZNF667, and ZNF667-AS1, have been identified for more precise patient stratification.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
A new study has discovered that cancer cells use different strategies to move through tight tissue gaps, with fibrosarcoma cells being more flexible and deformable. This flexibility allows them to squeeze through narrow gaps more efficiently, but does not affect the direction of their movement.
The 2025 Tata Transformation Prize recognizes Padubidri V. Shivaprasad's epigenetic engineering for climate-resilient rice, Balasubramanian Gopal's sustainable bio-manufacturing platform using E. coli bacteria, and Ambarish Ghosh's cancer-targeting magnetic nanorobots.
A new study finds that reducing arsenic levels in drinking water can decrease death rates from chronic diseases such as heart disease and cancer. Over a 20-year period, efforts to lower arsenic levels resulted in a 70% decrease in chemical levels, halving arsenic levels in urine among study participants.
Researchers have identified a protein complex that drives T cell exhaustion in tumors and show that disrupting it can revive exhausted anti-tumor CTLs. The study's findings offer new hope for improving the efficacy of cancer immunotherapy.
Researchers at The University of Osaka have developed a novel Balloon-Assisted Bronchoscope Delivery (BDBD) technique, enabling safe access to small, early-stage lung cancers hidden in the peripheral lung fields. This innovation promises to revolutionize both early diagnosis and minimally invasive treatment.
Researchers identified a targeted drug that blocks a specific genetic pathway to reverse tumor-driving cellular interactions, potentially restoring DNA function and benefiting patients with synovial sarcoma. The study's findings endorse a promising strategy to improve outcomes for this rare but deadly cancer.