Articles tagged with Cancer
Researchers discovered that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, leading to lower levels of tumor-promoting proteins and cancer-suppressing cellular behaviors. Statins downregulate SATB1 while increasing SATB2, making cancer cells less able to grow and spread.
Scientists developed a material that can stick to tumors, pumping out chemotherapy drugs for days, minimizing impact on healthy tissue. Early results show great promise for reducing clinical treatments and improving patient outcomes.
Researchers analyzed US cancer registration systems and found disparities in racial minorities' representation, despite revisions to the established standards. The study revealed significantly lower rates for American Indian or Alaskan Native populations under the 1997 standards compared to the previous 1977 standards.
Patients with common cancers face significant out-of-pocket costs after diagnosis, with the most advanced cases having the highest expenses. Further research is needed to understand the clinical and financial implications of these costs.
Researchers at NTU Singapore and Oxford University have discovered a mechanism by which cells identify and repair highly toxic DNA damage, known as DPCs, that cause cancer, neurodegeneration, and premature ageing. The study reveals how SPRTN, a key repair enzyme, selectively targets DPC lesions, increasing its activity 67-fold.
An international research team has identified three key genes involved in controlling the invasion routes of glioblastoma. The study found that targeting these genes may lead to a potential new treatment strategy for the aggressive brain tumor.
Researchers at Helmholtz Munich discovered that liver metabolism is reprogrammed in cachexia, with a specific gene called REV-ERBα being almost completely shut down. This 'internal clock' regulates liver-derived signaling molecules that drive disease progression and promote physical wasting.
Researchers at Hiroshima University have found that fermenting stevia leaf extract with bacteria kills off pancreatic cancer cells without harming healthy kidney cells. The study identified chlorogenic acid methyl ester as the active anti-cancer compound, which exhibits stronger toxicity to cancer cells than chlorogenic acid alone.
New research from Sylvester Comprehensive Cancer Center shows that partial match transplants can achieve good outcomes with cyclophosphamide treatment. Additionally, lifestyle medicine is playing a pivotal role in improving patient outcomes for cancer survivors.
A recent study identified 37 human-specific genes linked to brain development and cognitive abilities, which are hijacked by cancer to drive tumor growth. The researchers discovered nearly half of these genes become aberrantly activated in cancerous tissues, promoting tumor cell proliferation.
The study reveals diverse microbial profiles within different tumor types, with notable diversity in species composition and spatial localization. Functional effects of intratumoral microbiota on the tumor microenvironment range from immunostimulatory to protumor.
Researchers have discovered an experimental mRNA vaccine that can boost tumor-fighting effects of immunotherapy, sparking a new approach to battling many types of treatment-resistant tumors. The study found that pairing the test vaccine with common anticancer drugs triggered a strong antitumor response.
A recent study published in JAMA Network Open found that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment was associated with reduced all-cause mortality among older patients with cancer and type 2 diabetes. The survival benefit persisted across various subgroups, including age, sex, and cancer type.
Researchers have identified a key gene crucial for vitamin D uptake and metabolism, offering new avenues for precision medicine in cancer therapy and potential benefits for autoimmune diseases. Inhibiting this gene may selectively kill cancer cells while leaving healthy tissues unharmed.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
Researchers Sontheimer and Monje have made groundbreaking discoveries in brain tumor growth, revealing how nerve cells promote the development of aggressive gliomas. Their work has laid the foundation for new treatments and clinical trials, offering hope for innovative therapies.
A new study published in JAMA Oncology found that vaccinated cancer patients are at lower risk for hospitalization and severe illness from COVID-19. The research analyzed data on over 161,000 cancer patients treated during 2022 and 2023, showing a significant reduction in hospitalizations by 29%.
ADLM 2025 will tackle urgent topics like clinical AI integration and fake medical news, as well as leveraging genomics for personalized healthcare. The meeting also explores the health threat of plastics and microbiome medicine to combat diseases.
A retrospective cohort study found that COVID-19 booster vaccinations significantly protected against severe COVID-19, but uptake was low. Interventions are needed to increase COVID-19 vaccine uptake among high-risk populations with cancer.
A study found that children who lived near Coldwater Creek, a Missouri River tributary polluted by nuclear waste, had a higher risk of developing cancer. The researchers estimated that those living less than one kilometer away from the creek had a 44% higher risk of cancer compared to those living more than 20 kilometers away.
Researchers developed a new method to generate CAR-T cells in laboratory mice with mRNA-based vaccines, which proved effective and safe. The approach eradicated tumors in 75% of mice with B cell lymphoma after several doses.
Researchers identified key factors behind a successful immunotherapy response in a young patient with rhabdoid tumour. The study highlights the potential of sequencing technologies to track immune cell profiles and develops personalized cell therapies.
Researchers at MD Anderson identified specific co-mutations in KRAS-mutant non-small cell lung cancer (NSCLC) that improve treatment response to ATR inhibitors. Additionally, chemotherapy was found to drive changes to the genome and clonal architecture of blood stem cells, increasing the risk of secondary malignancies.
A team led by University of Houston engineer Tianfu Wu aims to find better biomarkers for ovarian cancer using autoantibodies and machine learning. By detecting ovarian cancer earlier, mortality rates could be reduced by 10-30%.
Researchers explore the design of microrobots for targeted cancer therapy, including tumor cell eradication, improved penetration, and immune system modulation. The review also discusses advanced delivery strategies and imaging technologies to enhance treatment efficiency and precision.
Chemotherapy-induced pyroptosis in bladder cancer can actually make the disease more resistant to treatment by fueling cancer stem cells. Blocking this inflammatory process with belnacasan may overcome chemoresistance in preclinical models.
A new study found that exercise can improve the quality of life and symptom management for CLL patients, but personalized guidance is needed. Patients prefer virtual classes, expert advice from cancer care specialists, and tailored programs addressing their unique challenges.
The review critically examines anti-TGFβ therapies for cancer treatment, highlighting the importance of targeting specific epitopes to mitigate off-target toxicity. It suggests implementing intermittent dosing schedules or optimally timed interventions to alleviate toxicity without compromising efficacy.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
Researchers from Korea University have discovered that the protein WEE1 can paradoxically drive immune resistance in cancer cells when located in the cytoplasm. This study suggests that targeting WEE1 with an inhibitor, such as adavosertib, may sensitize tumors to immunotherapy and reinvigorate antitumor immunity.
The study reveals how nutrients and lipids shape bone marrow blood stem cells from health to aging and leukemia, identifying choline as a key player. Healthy stem cells had high choline levels, which decreased with specialization and aging, suggesting nutritional interventions could maintain stem cell function.
This special issue focuses on cutting-edge advancements in polypharmacology for cancer therapy, addressing mechanisms of drug resistance and rational design of drug combinations. It also covers computational and AI-driven methodologies for discovering novel polypharmacological agents.
Researchers used AI model ChatGPT-4 to extract clinical variables from MRI and CT scans of nearly 1,000 adults with pancreatic cysts. The accuracy rate ranged from 97% for solid components to 99% for calcific lesions, comparable to human performance.
Researchers developed a novel immunotherapy that disrupts the IL-33/IL1RL1 signaling loop to boost immune function and improve survival in leukemia patients. The treatment targeted leukemia stem cells, reducing relapse rates and improving survival without major side effects.
A new study from Uppsala University found that most men with prostate cancer who receive recommended treatment have a good prognosis, with a lower risk of dying from prostate cancer than other causes. The study's findings highlight the importance of assessing a patient's life expectancy in choosing an appropriate treatment strategy.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
A new study by The Endocrine Society finds a strong link between acromegaly and an increased risk of various cancers, often at younger ages than expected. Patients with the rare growth hormone disorder had higher rates of certain types of cancer, including colon, gastric, breast, lung, ovarian, prostate, and blood cancers.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.
Researchers discovered a cancer signaling pathway's role in regulating the blood-retina barrier, potentially damaging protective mechanisms. The study also identified a new gene linked to inherited eye condition FEVR, highlighting the need for further investigation into vascular disorders.
A study using AI language models analyzed sentiments and emotions expressed by almost 400 pediatric patients on social media, finding that 94% of comments were negative, with sadness and fear prevalent. The study highlights the need for integrated care approaches to support vulnerable young patients managing complex medical conditions.
A Danish study finds that HPV vaccination has reduced prevalence of high-risk HPV types among vaccinated women, suggesting population immunity. However, non-vaccine types remain common and new infections occur more frequently in vaccinated women than unvaccinated women.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
A new breast scan system combines photoacoustic and ultrasound imaging to produce clear 3D images of common breast cancer subtypes. The system, called OneTouch-PAT, takes less than a minute to complete and excels at detecting suspicious lesions in women with dense breast tissue.
An international study has shown that BrECADD preserves fertility significantly better than eBEACOPP without worsening recovery chances. After treatment, 95% of women and 86% of men had normal hormone levels, enabling more pregnancies and births.
The American Society for Nutrition (ASN) has announced that NUTRITION 2026 will be held in National Harbor, Maryland, near Washington, DC. The meeting will showcase the latest developments in nutrition science and feature top experts in the field. Abstract submissions open this fall, and award nominations will also be accepted.
A recent analysis of 16 years of data on Japanese adults reveals a strong association between socioeconomic status and the incidence of five common cancers. Communities with low employment rates or low incomes show higher cancer rates compared to those with higher socioeconomic status.
A new study published in BioScience found that cancer is incredibly rare in turtles, affecting only about 1% of individuals. The research, led by the University of Nottingham, analyzed medical records and necropsies from hundreds of zoo turtles, revealing tumours rarely spread.
Researchers at Vanderbilt University Medical Center have developed a safe and effective fluorescent imaging agent that can assist surgeons in visualizing nerves during head and neck surgery. The agent, bevonescein, allows for intraoperative nerve-specific fluorescence visualization, reducing the risk of nerve injury.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.
A new multi-institutional clinical trial will test zipalertinib, an investigational drug targeting specific EGFR mutations in early-stage non-small cell lung cancer. The goal is to prevent recurrence and improve long-term outcomes for patients with limited treatment options.
Researchers at Boston University have found that exosomes released by obese tissues can turn slow-moving TNBC cells into highly mobile and invasive ones. This discovery could lead to the development of non-invasive biomarkers for metastatic risk and new drug targets like Rho-protein inhibitors.
The study highlights a significant increase in early-onset colorectal cancer rates globally, particularly in high-income countries. Younger patients are more likely to receive aggressive treatment without survival advantage, and survivors often report problems with anxiety, body image, and sexual dysfunction.
A recent survey found that 39% of respondents incorrectly identified all processed foods as unhealthy. However, the Physicians Committee for Responsible Medicine reports that it is not processed plant foods but rather meat consumption associated with an increased risk of type 2 diabetes and cardiovascular disease.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
Cancer cells utilize more energy from a less efficient pathway, but researchers found that power-generating waves on the cell membrane could be used to stage cancers and target drugs. Measuring these waves may help stage cancers in a standardized way.
A new prototype imaging system combines light-emitting diodes (LEDs) with hyperspectral imaging technology to create detailed maps of tissue properties invisible to conventional cameras. The system shows promise for cancer detection during endoscopy, achieving real-time speeds and high-quality data comparable to reference systems.
A new study from the University of Michigan Rogel Cancer Center identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment. The researchers found that docetaxel could be a good option earlier on in patients whose tumor harbors a specific gene program linked to extreme no...
A compound called NSC51349 has shown promise as an antiviral treatment against cutaneous human papillomaviruses (HPVs), reducing viral load without harming host cells. The discovery offers new potential for treating skin infections and cancers in immunocompromised individuals.