Articles tagged with Chronic Obstructive Pulmonary Disease
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A new study highlights the importance of diagnosing depression and anxiety in people with chronic obstructive pulmonary disease (COPD) to address gaps in care. The study found that fewer than half of those meeting the criteria for a depression or anxiety diagnosis were receiving mental health counseling or using antidepressants.
The collaboration aims to close gaps in early recognition and management of IPF by equipping healthcare providers, public health professionals, and patients with necessary resources. The organizations will employ designated activities to build a knowledge base, develop survey tools, and create educational and awareness assets.
PRISm is a form of Pre-Chronic Obstructive Pulmonary Disease (Pre-COPD) characterized by respiratory symptoms and reduced lung function. Imaging assessments, such as computed tomography scans and magnetic resonance imaging, play a crucial role in diagnosing and predicting the prognosis of PRISm.
A retrospective study found that smoking negatively affects respiratory rehabilitation efficacy in COPD patients, leading to inferior pulmonary function improvements and reduced quality of life compared to non-smokers. Non-smokers showed significant gains in exercise capacity and sleep quality post-rehabilitation.
A U-shaped relationship between admission peripheral oxygen saturation and all-cause hospital mortality was observed in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The lowest mortality rate occurred at an SpO2 of 89.5%, indicating that lower oxygen levels are associated with increased risk.
The American College of Chest Physicians (CHEST) has developed an educational program and formal certification exam for nurse practitioners and physician assistants/associates in critical care. The program validates clinical expertise and demonstrates professional acumen, aiming to improve patient care.
Macrophages expressing high Spp1 levels are found in emphysema patients and those exposed to cigarette smoke or soot-like particles. This study highlights Spp1 as a crucial mediator of environmental particle pollution-related COPD development, offering potential preventive targets.
Sodium-glucose cotransporter-2 inhibitors and GLP-1RAs show reduced risk of moderate/severe COPD exacerbations compared to dipeptidyl peptidase 4 inhibitors. This finding may inform glucose-lowering medication prescribing for patients with type 2 diabetes and active COPD.
Arnulfo Duarte, a first-year fellow, will receive the APCCMPD and CHEST Medical Educator Scholar Diversity Fellowship for a second year. The program aims to improve diversity in pulmonary and critical care education by providing mentorship and training opportunities.
A new study has developed a polygenic risk score for COPD that improves identification of individuals with the disease in the community. The test uses genetic samples from a cheek swab or blood test, and when combined with a case-finding questionnaire, it identifies undiagnosed cases more accurately.
The TARIPH Centre will conduct patient-centric translational research on respiratory health in collaboration with nine institutions, focusing on factors unique to Asia. The five-year programme aims to provide a clearer understanding of lung disease in Asians and develop effective national strategies for improvement.
According to the CDC's latest report, COPD ranks as the sixth leading cause of death in the US, claiming over 30 million Americans. The disease affects women more than men, with a higher burden of deaths among females.
Researchers discover how cigarette smoke alters the function of mucosal-associated invariant T (MAIT) cells, a key type of immune cell in the lungs. This impairment increases susceptibility to respiratory infections and worsens chronic obstructive pulmonary disease (COPD).
A new study published in the COPD Foundation journal found that people with chronic obstructive pulmonary disease (COPD) are at a higher risk of falls and related injuries when taking commonly prescribed medications. The likelihood of falls increases relative to the number of fall-risk increasing drugs used.
Additional research is required to explore the relationship between COPD and metabolic syndrome, focusing on outcomes, intervention trials, and health services research. This will help shift from a COPD-focused approach to an integrated care approach considering all comorbidities.
A study published in ERJ Open Research found that women are less likely to receive a lung transplant and wait an average of six weeks longer for one. Despite this, women who undergo transplantation have higher survival rates five years post-transplant.
A recent study published in the Journal of the COPD Foundation found that childhood smoking before age 15 significantly increases a person's risk of developing chronic obstructive pulmonary disease (COPD) later in life. The research examined a nationally representative sample of adults and accounted for secondhand smoke exposure, highl...
John Howington, MD, MBA, FCCP, is the new President of CHEST, succeeding Neil S. Freedman, who will be President-Elect in 2026. Dr. Howington has extensive leadership experience and has published over 49 research publications.
A deep learning model developed by researchers at San Diego State University can accurately diagnose chronic obstructive pulmonary disease (COPD) using a single inhalation lung CT scan. The study found that the model performed similarly to traditional two-phase CT measurements, with added clinical data improving accuracy.
High-flow nasal oxygen was found to be more effective than noninvasive ventilation in preventing endotracheal intubation or death within 7 days in four of five patient groups with acute respiratory failure. However, the results were sensitive to analysis models and may require further study in specific patient populations.
The COPD Foundation's PIVOT initiative aims to integrate patient-inspired health concepts into clinical trials for COPD. This framework improves research study design, enhances treatment benefit communication, and accelerates access to new therapies.
The surgical team led by Stephanie H. Chang performed the groundbreaking procedure using da Vinci Xi robotic system at NYU Langone Transplant Institute. The successful transplant marks a significant milestone in lung transplantation surgery, offering hope to patients with chronic obstructive pulmonary disease (COPD) like Cheryl Mehrkar.
A new study from the University of Copenhagen found that nicotinamide riboside can reduce lung inflammation in COPD patients, leading to a significant drop in inflammation markers and improved lung function. The treatment also showed signs of delaying cellular aging.
Researchers use AI to predict COPD flare-ups based on daily urine tests, potentially allowing for proactive treatment and prevention. The study identifies biomarkers in urine that can forecast a flare-up seven days prior to symptoms.
Researchers are conducting a multi-year study to understand small airway abnormalities and their role in emphysema development. The SPIROMICS Study of Early Disease Progression (SOURCE) aims to provide novel insights into COPD progression and inform the development of new therapies.
A new editorial suggests using syndemic theory approach to address disparities in COPD treatment, emphasizing the importance of considering comorbidities and socioeconomic factors. The authors aim to promote holistic care and increase research participation from minority populations.
A team of researchers at Vanderbilt University has developed robotic sensory cilia that can monitor mucus conditions in human airways, detecting infection, obstruction, and disease severity. The technology leverages external magnetic fields to sense mucus viscosity and layer thickness, paving the way for real-time monitoring and early ...
A new study from the University of Toronto finds that childhood neglect is associated with a range of mental and physical health problems in adulthood. The presence of a supportive adult and higher socioeconomic status largely attenuate this relationship.
A cohort study reveals that AATD patients with COPD have a unique liver transcriptomic profile, with upregulated pathways related to fibrosis and inflammation. Histopathological analysis confirms higher levels of fibrosis and hepatocellular damage in these individuals.
Researchers found that reducing sialic acid levels on MUC5B mucin protein can alter its structure, leading to entangled polymers and impaired mucus transport. This study identifies a possible therapeutic strategy for treating cystic fibrosis and other muco-obstructive diseases.
A large multicentre study found no differences in quality of life, symptoms, or mortality between patients receiving 24-hour and 15-hour oxygen therapy at home. This is significant for patients with chronic obstructive pulmonary disease undergoing long-term oxygen therapy.
A new study found that cystic fibrosis patients with more severe disease characteristics exhibit shorter leukocyte telomere length and greater LTL attrition. This association may accelerate aging and increase susceptibility to age-related diseases, emphasizing the importance of early CF diagnosis and timely therapeutic intervention.
A new preclinical blood test identifies adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease (COPD), by analyzing 32 proteins that accurately predict lung health data. The risk score indicates a high likelihood of hospital care, COPD development, and respiratory disease death.
A pilot study found that voice changes recorded on a smartphone can signal an impending flare-up of COPD symptoms. Researchers analyzed the voices of 28 people with COPD and discovered higher pitched tones and 'jitter' before an exacerbation occurred.
Two studies found that long-term exposure to air pollution increases the risk of hospitalization for respiratory conditions, including asthma and COPD. Green spaces may actually increase emergency room visits for respiratory issues when combined with hay fever.
A new smart mask prototype, EBCare, analyzes chemicals in exhaled breath in real-time, offering personalized health monitoring for respiratory ailments like asthma and COPD. The device's self-cooling system allows for daily wear, while its low cost makes it a promising tool for remote health assessments.
Inhalation of live Lactobacilli bacteria attenuates pulmonary inflammation, improves lung function, and structure for COPD and bronchopulmonary dysplasia. The treatment reduces neutrophilic inflammation, MMP-9, and pro-inflammatory markers.
A recent study found that approximately two-thirds of inhalers used by patients hospitalized with COPD were misused, leading to inadequate medication delivery and increased exacerbations. Regular therapeutic education and proper inhaler technique can improve health outcomes.
A new perspective article highlights the impact of wildfires on individuals with COPD and asthma. The five-part Population Health Approach, developed by the University of California, Davis Health, identifies high-risk patients and provides interventions to mitigate poor air quality's negative effects.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed with the Directory of Open Access Journals (DOAJ), enhancing their open access content's accessibility and usage. The indexation is attributed to strong editorial boards led by Hayley Gershengorn and Matthew Miles.
A new study found that using race-neutral equations for lung function test interpretation accurately predicted risk of death and COPD flare-ups, especially for African Americans. The study suggests reclassifications can allow those most in need to gain eligibility for specialized treatments like lung transplant.
Researchers report that dupilumab substantially decreases exacerbation frequency and improves lung function as well as symptom burden in COPD patients with type 2 inflammation. The study's findings are promising for these patients, who have a high risk of exacerbations.
Research found that race-neutral spirometry equations tend to decrease severity for white patients and increase severity for Black patients, leading to higher enrollment rates of Black patients in COPD clinical trials. This shift resulted in more Black subjects meeting typical inclusion criteria, while fewer white subjects were eligible.
Treatment with bisoprolol did not reduce self-reported COPD exacerbations, contradicting previous expectations. Researchers found bisoprolol effective for cardiovascular conditions but noted physician reluctance to prescribe it for COPD patients.
A world-first clinical trial found that finding and treating people with undiagnosed asthma or COPD improves their health and reduces healthcare visits. The study, which involved 508 patients, showed that those treated by a lung specialist and educator averaged fewer healthcare visits and improved symptoms compared to usual care.
Researchers developed CT-Derived Functional Imaging, a software program that calculates lung volume changes and blood mass without contrast dye. The technology has improved diagnoses for up to 30% of patients who couldn't tolerate contrast dye, and also benefits all patients with lung issues such as COPD and cancer.
A new study found that progressive lung abnormalities in smokers are associated with increased frequency and severity of acute respiratory diseases, highlighting the need for closer monitoring and earlier intervention.
The Lundquist Institute has been awarded a four-year, $2.6 million grant to develop wearable multiplex biosensors that can monitor exacerbation risk in COPD. The proposed sensors have the potential to revolutionize COPD management and transform chronic disease management by providing real-time, non-invasive monitoring.
Researchers found that patients with lung disease have a higher risk of developing heart disease, regardless of age or smoking status. The study, published in Orphanet Journal of Rare Diseases, suggests that Proteinase 3 enzyme may play a key role in this increased risk.
Researchers found that Indigenous communities in California were exposed to 1.7 times more wildfire smoke than expected, with the average annual exposure being a critical factor in understanding long-term health effects. The study proposes new metrics to measure cumulative exposure and duration of smoke exposure.
Research published in Thorax found a link between age of menarche and increased COPD risk, with early menarche increasing the risk by 17%. Women who experienced infertility or had multiple miscarriages were also at higher risk. Menopause before age 40 was associated with a significant increase in COPD risk.
Cadmium exposure from cigarette smoke can lead to increased ANO1 expression in airway epithelial cells, exacerbating COPD. MicroRNA-381 negatively regulates ANO1, but its downregulation by cadmium could worsen disease severity.
A new study by the University of Technology Sydney suggests that office air conditioning can reduce the risk of harm from wildfire smoke. The researchers found that air conditioning filters in UTS Buildings 4 and 7 captured a significant portion of wildfire smoke, reducing exposure to toxic particles for staff and students.
Researchers found that a team intervention provided by phone leads to persistent improvements in depression, anxiety, and quality of life for people managing chronic illnesses. The program demonstrated early, persistent, and clinically meaningful improvements in adults with COPD, HF, or ILD.
A clinical trial found that trazodone and cognitive behavioral therapy for insomnia were no more effective than placebo in improving insomnia symptoms among long-term dialysis patients. Serious adverse events also occurred more frequently with trazodone use. More trials are needed to investigate additional therapies for this condition.
A new study reveals that bacteria associated with gum disease promote COPD through the activation of γδ T cells and M2 macrophages in the immune system. Researchers found that mice infected with periodontitis and COPD had worse progression, highlighting a potential new strategy for treating COPD.
The ATS 2024 International Conference in San Diego will feature scientific sessions and expert interviews on the latest developments in pulmonary, critical care, and sleep medicine. The conference will cover key subjects such as COVID-19, asthma, COPD, and air pollution.
A ground-breaking study published in Nature Communications sheds light on the intricate mechanisms underlying the virulence of Aspergillus fumigatus, specifically focusing on the crucial role of mycotoxin gliotoxin production. The research team identified pivotal roles played by GliT oxidoreductase and GtmA methyltransferase in the sel...
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
A 12-week beetroot juice supplement reduced systolic blood pressure by 4.5mmHg and increased walking distance by 30 meters in COPD patients. The nitrate-rich supplement improved cardiovascular risk markers, suggesting potential benefits for everyday life and heart disease prevention.