Articles tagged with Diabetes
Researchers discovered a novel gut-brain-liver circuit that lowers blood sugar when activated, providing a potential new approach to treat diabetes. The discovery suggests stimulating the gut's sensing mechanism may slow down sugar production and lower blood sugar levels.
Geisinger's Electronic Health Record program improves blood sugar and cholesterol levels, increases vaccination compliance, and boosts tobacco cessation rates. The program also enhances patient engagement through its Internet portal, MyGeisinger.
A study analyzing brain tissue of volunteers found that small vessel disease accounted for 33% of dementia risk, while Alzheimer's treatments remain investigational. Researchers suggest reducing hypertension and diabetes as effective ways to mitigate this risk.
Scientists have discovered a way to genetically manipulate embryonic stem cells into insulin-producing pancreatic tissue, potentially treating type-1 and type-2 diabetes. The team found that the transcription factor PAX4 encouraged high numbers of stem cells to become beta cells with insulin-producing capabilities.
A Kaiser Permanente study found that people with larger stomachs in their 40s have a higher risk of dementia by age 70. The study showed that abdominal obesity in midlife is a strong predictor of dementia risk.
Researchers at Joslin Diabetes Center have found that insulin inhibits a master gene regulator protein, SKN-1, which controls the Phase 2 detoxification pathway. Increased SKN-1 activity increases lifespan, providing potential insights into increasing resistance to chronic diseases and influencing longevity.
A genetic clue has been uncovered for Parkinson's disease, a progressive movement disorder affecting millions worldwide. GIGYF2 mutations have been found to be directly linked to the development of Parkinson's in people with a family history of the disease.
A new study published in JAMA found that a lack of regular physical activity can cause many diseases, with effects visible within two weeks. The researchers discovered that reducing daily physical activity led to higher glucose and fat levels in the blood, increasing the risk of chronic diseases.
A study by the American Heart Association found that minority and financially vulnerable adults with insulin-treated diabetes are less likely to monitor their blood glucose levels. The disparities were greatest for low-income Hispanics, with significantly lower rates of daily self-monitoring compared to whites.
Researchers discovered that diabetes drives inflammation and slows blood flow, accelerating atherosclerosis through interference with ERK5 signaling. The study identifies advanced glycation end products (AGEs) as key molecules sabotaging this protective mechanism.
Scientists develop a new, lean mouse model by crossing mice deficient in protein kinase C beta (PKCB) with the C57 black mouse. The hybrid mice have less fat distribution, less fat tissue overall, and increased ability to burn fat, suggesting a potential strategy for treating obesity and disorders associated with excess weight.
A study published in Cell Metabolism found that the PPAR gamma protein regulates blood pressure and vascular function, shedding light on why certain diabetes medications also lower blood pressure. The discovery may lead to more specific treatments for cardiovascular diseases associated with type II diabetes.
A recent study suggests that current FPG thresholds for diagnosing diabetes may not accurately detect diabetic retinopathy, which can lead to blindness. The researchers found that over 60% of retinopathy cases were missed by the widely used diabetes cutoff of 7.0mmol/L.
Researchers analyzed over 3.6 million patient records to find thousands of cases of probable undiagnosed diabetes in the UK. The study suggests that tens of thousands of people may be at risk of diabetes and require further assessment.
Researchers found that Hispanic patients with diabetes have approximately 0.5% higher levels on the A1C test compared to non-Hispanic white patients. This study highlights the need for strategies to reduce disparities in diabetes control among minority groups.
Scientists have discovered a single molecule regulating both glucose and fatty acid metabolism in cells. This finding has the potential to revolutionize our understanding of diabetes and develop new therapeutic agents.
Research finds that men who exercised regularly and had a healthy lifestyle were more likely to live to age 90. In contrast, those with smoking, obesity, or hypertension had reduced longevity. Additionally, centenarians with certain health conditions developed them at an older age tended to have better mental and physical function.
A study discovered a 'fat-burning' gene that plays a crucial role in insulin sensitivity. When this gene is impaired, it can lead to increased risk of obesity and worsening diabetes.
The ACP and ACPF Diabetes Initiative has seen statistically significant improvements in clinical measures, including a nearly 50% reduction in office visits for diabetes patients. The team-based approach has also led to increased awareness of high-quality diabetes care among physicians.
A study by Penn State researchers found that consuming whole grains can lead to significant weight loss and reduced risk of chronic diseases. The study showed that the whole grain group experienced a lower body weight, lower blood pressure, and increased intake of fiber and magnesium compared to the refined grain group.
The prevalence of diabetes mellitus is increasing due to population aging and existing high rates, leading to complications and premature death. Most patients experience at least one complication within six years after diagnosis.
Researchers found significant differences in the quality of care delivered to Jewish and Arab patients with diabetes in Jerusalem. Arab patients received less diet counseling, physical activity support, and medication prescriptions compared to their Jewish counterparts.
A team of researchers has identified pancreatic stem cells with the capacity to generate new insulin-producing beta cells in adult mice. These findings represent a significant breakthrough in understanding the pancreas's ability to regenerate beta cells, a crucial step towards developing effective treatments for diabetes.
A meta-analysis of 18,686 individuals with diabetes and 71,370 without diabetes found a significant reduction in all-cause mortality and major vascular events with statin therapy. The study suggests that most people with diabetes should now be considered for statin therapy.
A new study found that reducing drug co-pays for employees with chronic illnesses increased the use of preventive medicines, leading to fewer hospitalizations and emergency room visits. The study involved over 35,000 employees and showed significant increases in use of important medications.
A systematic review of published research explores the benefits of seven key behaviors (AADE7) in diabetes management. The studies were rigorously reviewed to identify effective strategies and remaining gaps in knowledge, providing direction for future researchers.
A study found that nearly three-fourths of American adults with conditions increasing cardiovascular disease risk also have hypertension. Despite treatment, only one-third to one-half of these individuals reach their blood pressure goals.
Researchers found that older adults with diabetes and depression who receive depression care management live half as long as those who don't. The study, published in Diabetes Care, suggests integrating depression evaluation and treatment into diabetes management in primary care.
Researchers found that activating a protein in muscle tissue increased average lifespan and prevented some age-related diseases in mice. The protein, uncoupling protein-1, converts energy from food into heat and mimics the effects of exercise.
A University of Missouri-Columbia study found that weight gain, not the type of diet, is a key factor in developing diabetes in cats. The researchers compared glucose-tolerance tests between cats fed dry food and those fed canned food, finding no significant difference.
Researchers at the University of Utah Health found that lung transplantation rarely extends children's survival and can even increase their risk of dying. The study analyzed data from 514 patients with cystic fibrosis and found that only one patient showed a clear benefit from transplantation, while others were at a higher risk of death.
Scientists at the University of Pennsylvania School of Medicine have found a protein called Rev-erb that coordinates the body's daily oxygen cycle to maintain correct metabolism. This discovery provides new pathways for treating metabolic disorders like obesity and diabetes.
A new study finds that 92% of older adults with diabetes have at least one other major chronic condition, and nearly half have three or more. The severity and type of co-existing condition matter, decreasing patients' ability to manage their diabetes.
A new study found that dieters who eat in response to emotions, rather than social situations, tend to lose less weight and experience more weight regain. Emotional eating was associated with lower weight loss and higher likelihood of regaining weight in successful losers.
Researchers found that fasting was associated with lower odds of being diagnosed with coronary artery disease (CAD) in patients who fasted. Fasting was linked to healthier arteries, even in people with diabetes, although the study does not recommend skipping meals for diabetics.
The estimated prevalence of chronic kidney disease in US adults has increased from 10% to 13%, driven by rising diabetes and hypertension rates. The prevalence of earlier stages of CKD accounts for most individuals with the condition, highlighting the need for cardiovascular risk factor management.
Researchers at Mayo Clinic found no link between diabetes treatment and survival rates after a heart attack. The study, which analyzed data from over 2,700 patients, suggests that commonly used medications for managing blood sugar levels do not reduce the likelihood of survival after a heart attack.
Researchers at Stanford University School of Medicine have identified a protein called menin as a key regulator of gestational diabetes. The study suggests that understanding the mechanisms of regulating menin could lead to new ways of growing islets for transplantation and new treatments for diabetes in pregnant women and obese adults.
A study found HIV-infected African Americans are at a higher risk of developing end-stage renal disease (ESRD) than white patients with HIV, with rates similar to those with diabetes
Patients with severe psychiatric illness lose 25-30 years of life expectancy due to increased risk of cardiovascular disease, diabetes, heart disease, and stroke. Lifestyle interventions like healthy eating and exercise can be challenging for this population.
A new UCLA study found that vulnerable elderly patients enrolled in Medicare and Medicaid received only 65% of recommended tests and treatments, indicating significant room for improvement. The study examined quality of care for common conditions such as depression, diabetes, hypertension, and heart failure.
A recent study found that workers with diabetic neuropathic symptoms lose an average of 1.4 hours per week due to health-related lost productive time, resulting in $3.65 billion annual costs. Those with diabetes without symptoms still experience a higher likelihood of unemployment compared to their non-diabetic counterparts.
Most diabetes drug trials prioritize reducing blood sugar levels over patient-relevant outcomes like complication risk and quality of life. This can lead to ineffective treatments that cause more harm than good.
A recent study by researchers at the University of Chicago found that many diabetics experience a significant burden from managing their condition, which can be as impactful on quality of life as the disease itself. Patients reported being distressed by end-stage complications and disliked intensive treatments.
Middle-aged and older adults from African American and Latino backgrounds have poorer blood sugar control than their white counterparts, even when taking medications. The study identified medication adherence and emotional distress as key factors contributing to these disparities.
Scientists have discovered a new mechanism by which insulin-secreting cells regulate KATP channels, allowing for timely energy supply and storage of blood sugar. This discovery sheds light on how the human body maintains normal blood glucose levels and prevents diabetes.
A Kaiser Permanente study shows that treating gestational diabetes during pregnancy lowers a child's risk of becoming obese, with children whose moms were treated having the same risk as those with normal blood sugar levels. High maternal sugar levels increase childhood obesity risk, but treatment reduces it.
A recent heart attack increases the risk of developing new-onset diabetes and pre-diabetes by up to four-and-a-half times. Lifestyle factors such as smoking cessation, weight loss, and adherence to a Mediterranean diet can substantially lower this risk.
A study found that morbidly obese mice can gain protection against diabetes by consuming excess calories without developing insulin resistance. The key hormone adiponectin plays a crucial role in this process, and its abundance helps store excess fat in the right places.
Researchers found high levels of reactive compounds in soda sweetened with high-fructose corn syrup, which may contribute to cell and tissue damage that could cause diabetes. Adding tea components like EGCG reduced the levels of these compounds.
Severely obese patients who undergo gastric bypass surgery show significant reductions in mortality rates from coronary heart disease, cancer, and diabetes. The study found a 56% lower mortality rate from coronary heart disease, a 60% lower death rate from cancer, and a 92% lower death rate from diabetes.
Researchers at the University of Liverpool have identified a molecule in the intestine that can detect sugar content, which could lead to new treatments for diabetes and obesity. The sweet taste receptor is not only present in the tongue but also in the intestine, allowing it to monitor dietary sugars.
Patients with diabetes and acute coronary syndromes have a significantly higher risk of death at 30 days and one year compared to those without diabetes. The study found that diabetes increased the risk of death by nearly 80% at 30 days for patients with unstable angina/non-STEMI and 40% for those with STEMI.
Researchers found that sub-standard housing more than doubled diabetes risk among study participants. Despite ruling out other factors, housing conditions remain a significant contributor to the development of diabetes in this population.
A study found that fair or poor housing conditions increase the risk of developing diabetes in urban, middle-aged African-Americans. Housing conditions, such as cleanliness and physical condition, were evaluated to clarify the relationship between environment and health outcomes.
A RAND Corporation study reveals a sharp decline in undiagnosed diabetes cases among American men over the past 25 years, with ethnic disparities largely eliminated. The study also found that education levels play a significant role in diabetes diagnosis, with those having less education being less likely to receive accurate diagnoses.
Research reveals abnormal fat metabolism as a key factor in the development of heart disease among diabetics. Brief caloric restriction can lead to dramatic accumulation of triglycerides and cardiac hemodynamic dysfunction in transgenic myocardium expressing human calcium-independent phospholipase A2γ.
Women with diabetes lose protective effect of estrogen on kidneys, which normally reduces risk of chronic kidney disease. Research suggests that hormone ratio rather than absolute levels determines impact on diabetic kidney disease.
A new study from Northwestern University's Feinberg School of Medicine reveals that older people with inadequate health literacy had a 50 percent higher mortality rate over five years than those with adequate reading skills. Low health literacy was the top predictor of mortality after smoking, surpassing income and years of education.
A study published in Archives of Surgery found that diabetics spend more days in the intensive care unit and have more complications during hospitalization for trauma. Diabetics are also less likely to be discharged home and require skilled nursing care after discharge.