Articles tagged with Diabetes
A study of 906 breast cancer patients found that comorbidities such as diabetes and hypertension contributed to racial disparities in survival rates. Black patients had shorter overall survival rates, while whites were more likely to die from competing causes.
US kidney failure rates have stabilized over the past two decades, with diabetes and high blood pressure remaining leading causes. Despite progress, racial disparities persist, particularly among African Americans, who continue to experience higher rates of new cases.
The PROactive study found that Takeda's ACTOS (pioglitazone HCl) significantly reduced the combined risk of non-fatal heart attacks, strokes, and deaths by 16% in high-risk patients with type-2 diabetes. This led to a 10% reduction in the primary combination endpoint of seven different macrovascular events.
Researchers at Mayo Clinic found nerve damage due to high blood sugar levels can begin as early as 20 years into the disease. The study of over 500 patients showed steady worsening of nerve conduction tests even in those with normal values, highlighting the importance of controlling diabetes from onset.
Researchers found that smokers had a significantly higher incidence of developing diabetes compared to non-smokers, even after adjusting for other risk factors. The study suggests another poor health outcome associated with cigarette smoking, supporting current surgeon general's warnings.
Researchers have identified a potential new treatment for insulin-dependent diabetes by targeting natural killer T cells. The study shows that multiple doses of alpha-galactosylceramide can reduce the production of interferon-gamma, which helps destroy transplanted islet cells.
High insulin levels block stress hormones, leading to excessive fat storage and energy imbalance. The study provides new understanding of insulin resistance in Type II diabetes and its potential link to obesity.
The partnership aims to stimulate and accelerate European research into beta cell function and survival, aiming to move towards a cure for diabetes. Approximately 194 million people worldwide suffer from diabetes, with the number expected to exceed 333 million by 2025.
A study of over 16,000 participants found a graded association between high blood glucose levels and increasing coronary heart disease risk. Non-diabetic individuals with elevated HbA1c levels were at significantly increased risk of heart disease.
A diet high in soy protein prevents the accumulation of triglycerides and cholesterol in the liver despite obesity and hyperinsulinemia. This is achieved through reduced expression of genes involved in lipid production and increased breakdown of fatty acids.
Researchers have discovered that malfunctioning bone marrow cells can cause premature cell death and dysfunction in nerve cells, leading to neuropathy. The study provides a basis for understanding the dangerous nerve condition in diabetics and may eventually lead to a treatment.
A recent study found that diabetics who underwent ankle fracture surgery had significantly longer hospital stays and higher mortality rates compared to non-diabetic patients. The researchers estimated that diabetic patients experienced an additional day of hospitalization and costs approximately 20% higher.
Only about 0.06% of health plan members receive a diagnosis for alcohol dependence, compared to 40% for depression, 65% for diabetics, and 70% for those with hypertension. This failure to identify and treat alcohol dependence begins with inadequate screening and follow-up care.
A study found that insulin resistance is a predictor of congestive heart failure (CHF) in elderly men, independent of diabetes and other established risk factors. Insulin resistance was also associated with more severe disease and a worse prognosis in patients with CHF.
A new study suggests that ACE inhibitors, which reduce blood pressure and prevent diabetes-related complications, should be made available at no cost to seniors with diabetes. This could lead to increased use of the medication and significant savings for Medicare, with estimates suggesting $1,606 in lifetime savings per recipient.
A national survey reveals that many Americans take high doses of vitamin E supplements, despite potential risks, and a study shows that test results are frequently forgotten after hospital discharge. A new study suggests that full coverage for ACE inhibitors would improve health outcomes and save Medicare money.
A recent study published in Archives of Internal Medicine found diuretics to be equally protective against fatal coronary heart disease or non-fatal heart attacks among people with diabetes. Additionally, diuretics were shown to be more effective in lowering systolic blood pressure and reducing the risk of congestive heart failure.
A new study suggests that minor surgery plus antibiotics can prevent foot-bone infections and amputations. Patients with diabetes are at high risk, especially those with poor circulation and kidney problems.
A new study published in New England Journal of Medicine shows that treatment for mild gestational diabetes reduces maternal glucose levels and improves health outcomes for both mothers and babies. The ACHOIS trial, the largest of its kind, recruited 1000 women and 1030 babies from Australia and the UK.
A Joslin study finds that maintaining a controlled diet and preventing weight gain can prevent the development of glucose intolerance in individuals born with low birth weight. The researchers observed improved insulin sensitivity and reduced risk of diabetes in mice on calorie-restricted diets compared to those allowed to eat freely.
A study of 36 studies found that minority populations received fewer preventive care measures for diabetes, including flu vaccinations and cholesterol tests. Socioeconomic factors, language differences, and potential bias in healthcare may contribute to these disparities.
A Harvard study finds that diabetics experience impaired blood vessel function on days with high sulfate and black carbon particle pollution, increasing heart attack risk. The research highlights a biological mechanism linking particle pollution to cardiovascular disease.
A study by researchers at Duke University Medical Center found that improved disease knowledge alone does not translate into improved blood sugar control, cholesterol levels, weight management, or mortality rates among diabetics. Despite this, education is still an important aspect of diabetes care.
Researchers found that exposure to fine particles in air pollution impairs blood vessel reactivity in people with diabetes, leading to a higher risk of heart problems. The study also suggests that this association may help explain previous findings on the link between air pollution and cardiovascular issues in diabetics.
Researchers at Cedars-Sinai Medical Center found that patients with metabolic syndrome and moderate coronary calcium have a greater chance of having blockage in their arteries. The study analyzed 1,043 patients without known heart disease and found that those with metabolic syndrome had a significantly higher risk of ischemia during st...
Research found a strong association between depression severity and poor glycemic control among Hispanics with diabetes, particularly those with moderate-severe depression. This underlines the importance of identifying and treating depression to improve diabetic outcomes in this high-risk population.
Researchers analyzed voting patterns and committee memberships to find the most partisan committees, including the Select Committee on Homeland Security. They also developed a mathematical tool to identify Representatives' partisanship and cooperativity. Additionally, they created insulin-producing cells from human liver cells that can...
Researchers found that non-dippers had higher fasting glucose levels and were more likely to develop diabetes. Monitoring glucose levels is crucial for these patients to prevent cardiovascular problems.
The study found that physicians who helped create plans for physical activity and followed up with patients were more likely to see increased physical activity. The physical environment also played a significant role, with active individuals reporting shorter walking times to community facilities.
A recent study published in Diabetes journal found that minocycline limits retinal damage caused by microglia cells in diabetic rats. The antibiotic reduces neuroinflammation and activation of microglia, resulting in less nerve cell death and improved vision outcomes.
A study found high rates of untreated eye disease among older adults with diabetes, particularly in managed care networks. Managed care patients were more likely to have cataract and glaucoma, highlighting the need for improved access to eye care.
Researchers have discovered that a faulty body clock can wreak havoc on the body's metabolism, increasing the risk of obesity and diabetes. In a study published in Science, scientists found that mice with a misaligned internal timepiece gained weight and developed metabolic abnormalities when fed regular or high-fat diets.
A study by Cardiff University explores the reactions of 38 parents whose children were newly diagnosed, finding that intense emotions and insecurity prevail for up to 12 months after diagnosis. The parents' comments reveal ongoing fear and anxiety about their child's condition and its impact on daily life.
A Umeå research team has made a breakthrough in understanding how obesity causes diabetes, fatty liver, and blood-fat disturbances. The study found that mice lacking a specific receptor, GPR40, are protected from these complications when fed a calorie-rich diet.
Researchers found that simvastatin prevents or reverses vascular injury by vasoprotective means, protecting against diabetes-induced endothelial cell dysfunction. The study suggests a potential role for statins in treating diabetic patients.
Research reveals employees with diabetes can be valuable workers in a favorable environment. The burden of fatigue is largely determined by the individual's self-management capabilities and outlook on their disease and work situation.
A study by University of Illinois Chicago researchers reveals that continuous positive airway pressure therapy can significantly reduce glucose levels in diabetic patients. This reduction in glucose levels can help prevent late-stage complications such as cardiovascular and kidney disease.
Researchers found that deleting pro-inflammatory enzyme IkB kinase â (Ikk-â) from immune cells' macrophages improves insulin sensitivity, offering hope for new type II diabetes treatments. The study suggests targeting myeloid cells and their macrophages as a potential strategy for treating the disease.
A single brain region, the hypothalamic arcuate nucleus (ARH), is sufficient for normal control of blood sugar and activity level by the fat hormone leptin. Restoration of leptin signaling in mice improves glucose homeostasis and locomotor activity.
Orphan nuclear receptors are structurally related to well-known hormone receptors but lack known ligands. Dr. Forman's work identifies novel signaling pathways and regulatory molecules that contribute to critical diseases, including fat cell formation, insulin sensitivity, and cholesterol homeostasis.
A large cohort study found that elevated fasting serum glucose levels and diabetes are associated with an increased risk of all cancers and specific cancers, including pancreatic cancer, in men and women in Korea. The study suggests that hyperinsulinemia may be a pathway by which obesity increases cancer risk.
A 10-year study of 1,298,385 Koreans found that high sugar levels were associated with higher death rates from all cancers combined. The strongest associations were for pancreatic cancer in men and liver and cervix cancers in women.
A recent study by Group Health Research Institute has identified key risk factors for kidney infections in women under 50. The research found that frequent sexual intercourse, recent urinary tract infections, new sex partners, family history of UTIs, and spermicide use are associated with a higher risk of kidney infection.
A recent study published in the Archives of Internal Medicine found that aspirin use is underutilized among diabetic women and young adults. The researchers discovered a significant disparity in aspirin use between men and women with diabetes, with only 34% of women using aspirin regularly compared to 42% of men.
Chronic kidney disease affects over 7.4 million Americans with less than half the kidney function of a healthy adult, while an additional 11.3 million have at least half normal function but persistent protein in their urine. Raising awareness and controlling diabetes and hypertension are critical to reducing progression and complications.
A study found that only 9% of adults with moderately decreased kidney function reported being told they had weakened or failing kidneys, highlighting a need for increased awareness and diagnosis. The researchers suggest that control of diabetes and hypertension are critical in reducing the rate of progression and complications of chron...
A study of over 9,600 participants found that those who were severely obese in young adulthood had significantly higher Medicare charges at age 65 compared to non-overweight peers. The average annual Medicare charges for severely obese individuals were $6,192 more than for non-overweight men and $5,618 more than for non-overweight women.
Researchers found that diabetics with mental disorders were more likely to have poorer diabetes control and experience complications. The study's findings highlight the need for comprehensive care that addresses both physical and mental health needs.
Adults with diabetes have experienced a 50% reduction in the rate of incident CVD, while those without diabetes saw a 35% reduction. Patients with diabetes have benefited from similar declines as those without, with substantial room for further progress to reduce high CVD event risks.
Dr. Veillette's team identified a basic mechanism controlling antibody production in B lymphocytes, which are hyperactive in autoimmune diseases. This breakthrough provides new therapeutic targets for reducing attacks on organs like the pancreas and kidneys.
A study published in Health Services Research found that diabetes associated with early retirement, disability, and work absenteeism resulted in estimated losses of $2,800 to $22,100 per person. The total economic toll was $133.5 billion over the lifetime of this age group.
Joslin and Stanford researchers have made a breakthrough discovery about muscle regeneration, identifying the specific cells that can give rise to new muscle fibers. Contrary to previous studies, these cells are located near muscle fibers and not in blood-forming tissues like bone marrow.
A University of Edinburgh health study found that people with previously undiagnosed diabetes are at a similar increased risk of death from cardiovascular disease as those with known diabetes. The researchers suggest using simple fasting blood sugar tests to identify individuals at high risk of heart disease and stroke.
Research from the Look AHEAD study reveals that individuals with diabetes who are overweight or obese have poorer control of cardiovascular disease risk factors. The findings highlight the importance of weight loss programs as part of preventing cardiovascular disease in people with diabetes.
Researchers found that molecular clock genes Bmal1 and Clock play a crucial role in regulating glucose levels, with suppressing these molecules eliminating diurnal variation. A mutated Clock gene also protected mice from diabetes induced by high-fat diets, suggesting altering meal timing may reduce disease risk.
A new theory proposes that hyperglycemia and hypoxia contribute to diabetic complications by disrupting NADH recycling. This process produces free radicals that cause damage to tissues, including those in the eyes, heart, nerves, and kidneys. The study suggests that glycolysis and the sorbitol pathway play a crucial role in this process.
A new clinical trial has found that high skin sterol levels are associated with an increased risk of heart disease in patients with coronary artery disease. The study, published by IMI International Medical Innovations, used a prospective registry to examine the relationship between skin sterol and cardiovascular risk factors.
Researchers at Université de Montréal found that diabetes patients are three times more likely to develop liver cancer and twice as likely to get pancreatic cancer. The study analyzed data from over 3,000 cancer patients and healthy individuals.
Scientists have discovered a new mechanism underlying muscle wasting in various diseases, including cancer and diabetes. Blocking the NF-kB pathway can prevent muscle atrophy and prolong survival in mouse models of disease.
A new study, ORCADES, will investigate the roles of inheritance and environment in causing three major killer diseases. The study aims to identify genes that predispose individuals to illness and understand the impact of lifestyle factors on disease development.