Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
The study found that physicians who helped create plans for physical activity and followed up with patients were more likely to see increased physical activity. The physical environment also played a significant role, with active individuals reporting shorter walking times to community facilities.
A recent study published in Diabetes journal found that minocycline limits retinal damage caused by microglia cells in diabetic rats. The antibiotic reduces neuroinflammation and activation of microglia, resulting in less nerve cell death and improved vision outcomes.
A study found high rates of untreated eye disease among older adults with diabetes, particularly in managed care networks. Managed care patients were more likely to have cataract and glaucoma, highlighting the need for improved access to eye care.
Researchers have discovered that a faulty body clock can wreak havoc on the body's metabolism, increasing the risk of obesity and diabetes. In a study published in Science, scientists found that mice with a misaligned internal timepiece gained weight and developed metabolic abnormalities when fed regular or high-fat diets.
A study by Cardiff University explores the reactions of 38 parents whose children were newly diagnosed, finding that intense emotions and insecurity prevail for up to 12 months after diagnosis. The parents' comments reveal ongoing fear and anxiety about their child's condition and its impact on daily life.
A Umeå research team has made a breakthrough in understanding how obesity causes diabetes, fatty liver, and blood-fat disturbances. The study found that mice lacking a specific receptor, GPR40, are protected from these complications when fed a calorie-rich diet.
Researchers found that simvastatin prevents or reverses vascular injury by vasoprotective means, protecting against diabetes-induced endothelial cell dysfunction. The study suggests a potential role for statins in treating diabetic patients.
Research reveals employees with diabetes can be valuable workers in a favorable environment. The burden of fatigue is largely determined by the individual's self-management capabilities and outlook on their disease and work situation.
A study by University of Illinois Chicago researchers reveals that continuous positive airway pressure therapy can significantly reduce glucose levels in diabetic patients. This reduction in glucose levels can help prevent late-stage complications such as cardiovascular and kidney disease.
Researchers found that deleting pro-inflammatory enzyme IkB kinase â (Ikk-â) from immune cells' macrophages improves insulin sensitivity, offering hope for new type II diabetes treatments. The study suggests targeting myeloid cells and their macrophages as a potential strategy for treating the disease.
A single brain region, the hypothalamic arcuate nucleus (ARH), is sufficient for normal control of blood sugar and activity level by the fat hormone leptin. Restoration of leptin signaling in mice improves glucose homeostasis and locomotor activity.
Orphan nuclear receptors are structurally related to well-known hormone receptors but lack known ligands. Dr. Forman's work identifies novel signaling pathways and regulatory molecules that contribute to critical diseases, including fat cell formation, insulin sensitivity, and cholesterol homeostasis.
A large cohort study found that elevated fasting serum glucose levels and diabetes are associated with an increased risk of all cancers and specific cancers, including pancreatic cancer, in men and women in Korea. The study suggests that hyperinsulinemia may be a pathway by which obesity increases cancer risk.
A 10-year study of 1,298,385 Koreans found that high sugar levels were associated with higher death rates from all cancers combined. The strongest associations were for pancreatic cancer in men and liver and cervix cancers in women.
A recent study by Group Health Research Institute has identified key risk factors for kidney infections in women under 50. The research found that frequent sexual intercourse, recent urinary tract infections, new sex partners, family history of UTIs, and spermicide use are associated with a higher risk of kidney infection.
A recent study published in the Archives of Internal Medicine found that aspirin use is underutilized among diabetic women and young adults. The researchers discovered a significant disparity in aspirin use between men and women with diabetes, with only 34% of women using aspirin regularly compared to 42% of men.
Chronic kidney disease affects over 7.4 million Americans with less than half the kidney function of a healthy adult, while an additional 11.3 million have at least half normal function but persistent protein in their urine. Raising awareness and controlling diabetes and hypertension are critical to reducing progression and complications.
A study found that only 9% of adults with moderately decreased kidney function reported being told they had weakened or failing kidneys, highlighting a need for increased awareness and diagnosis. The researchers suggest that control of diabetes and hypertension are critical in reducing the rate of progression and complications of chron...
A study of over 9,600 participants found that those who were severely obese in young adulthood had significantly higher Medicare charges at age 65 compared to non-overweight peers. The average annual Medicare charges for severely obese individuals were $6,192 more than for non-overweight men and $5,618 more than for non-overweight women.
Researchers found that diabetics with mental disorders were more likely to have poorer diabetes control and experience complications. The study's findings highlight the need for comprehensive care that addresses both physical and mental health needs.
Adults with diabetes have experienced a 50% reduction in the rate of incident CVD, while those without diabetes saw a 35% reduction. Patients with diabetes have benefited from similar declines as those without, with substantial room for further progress to reduce high CVD event risks.
Dr. Veillette's team identified a basic mechanism controlling antibody production in B lymphocytes, which are hyperactive in autoimmune diseases. This breakthrough provides new therapeutic targets for reducing attacks on organs like the pancreas and kidneys.
A study published in Health Services Research found that diabetes associated with early retirement, disability, and work absenteeism resulted in estimated losses of $2,800 to $22,100 per person. The total economic toll was $133.5 billion over the lifetime of this age group.
Joslin and Stanford researchers have made a breakthrough discovery about muscle regeneration, identifying the specific cells that can give rise to new muscle fibers. Contrary to previous studies, these cells are located near muscle fibers and not in blood-forming tissues like bone marrow.
A University of Edinburgh health study found that people with previously undiagnosed diabetes are at a similar increased risk of death from cardiovascular disease as those with known diabetes. The researchers suggest using simple fasting blood sugar tests to identify individuals at high risk of heart disease and stroke.
Research from the Look AHEAD study reveals that individuals with diabetes who are overweight or obese have poorer control of cardiovascular disease risk factors. The findings highlight the importance of weight loss programs as part of preventing cardiovascular disease in people with diabetes.
Researchers found that molecular clock genes Bmal1 and Clock play a crucial role in regulating glucose levels, with suppressing these molecules eliminating diurnal variation. A mutated Clock gene also protected mice from diabetes induced by high-fat diets, suggesting altering meal timing may reduce disease risk.
A new theory proposes that hyperglycemia and hypoxia contribute to diabetic complications by disrupting NADH recycling. This process produces free radicals that cause damage to tissues, including those in the eyes, heart, nerves, and kidneys. The study suggests that glycolysis and the sorbitol pathway play a crucial role in this process.
A new clinical trial has found that high skin sterol levels are associated with an increased risk of heart disease in patients with coronary artery disease. The study, published by IMI International Medical Innovations, used a prospective registry to examine the relationship between skin sterol and cardiovascular risk factors.
Researchers at Université de Montréal found that diabetes patients are three times more likely to develop liver cancer and twice as likely to get pancreatic cancer. The study analyzed data from over 3,000 cancer patients and healthy individuals.
Scientists have discovered a new mechanism underlying muscle wasting in various diseases, including cancer and diabetes. Blocking the NF-kB pathway can prevent muscle atrophy and prolong survival in mouse models of disease.
A new study, ORCADES, will investigate the roles of inheritance and environment in causing three major killer diseases. The study aims to identify genes that predispose individuals to illness and understand the impact of lifestyle factors on disease development.
A U-M team, led by Dr. Stephen Feinberg, is engineering tissue grafts to treat mouth wounds in patients with diabetes or undergoing chemotherapy. The grafts, made from a combination of mucosal cells and AlloDerm, show promise for smaller donor sites and faster healing times.
The study suggests that monitoring glycated hemoglobin levels can help identify individuals at increased risk of developing cardiovascular disease. Researchers found a significant association between elevated glycated hemoglobin levels and increased risk of large-vessel cardiovascular disease among people with type II diabetes.
Researchers at Stanford University School of Medicine have discovered a primordial pancreas in fruit flies that produces both insulin and glucagon, two hormones crucial for regulating blood sugar levels. This breakthrough could lead to the development of new drugs for treating diabetes.
The study found that approximately 1 in 5 subjects had previously undiagnosed diabetes, while over 1 in 4 had impaired glucose tolerance. Lifestyle changes and medication may help prevent the progression of impaired glucose tolerance to full-blown diabetes and its associated complications.
The Euro Heart Survey on diabetes and the heart found abnormal glucose regulation is common in patients with coronary artery disease. Patients with diabetes face a dismal prognosis, but those without known diabetes can benefit from improved treatment standards.
Following guidelines improved acute reperfusion and adjunctive treatment of STEMI in diabetics, leading to a 36% relative reduction in hospital mortality. Diabetes mellitus significantly increases the risk of developing coronary artery disease.
Women with diabetes having acute coronary syndrome are at a higher risk of presenting with ST-elevation-ACS and dying in hospital, compared to men. Diabetes has a differential effect on the pathophysiology of ACS based on patient sex.
A large-scale study validates the benefits of low-GI diets in rats, showing significant reductions in body fat, blood glucose and insulin levels. The study suggests that glycemic index is an independent factor contributing to major chronic diseases.
Researchers found VA patients received standard processes of care more often, including recommended tests and services, and had better diabetes control. The study suggests the VA's national system provides excellent quality care due to its integrated care and tracking mechanisms.
The study reveals alarming rates of eye diseases among Latinos, including open-angle glaucoma, diabetic retinopathy, and cataracts. These findings underscore the importance of developing tailored prevention and treatment strategies for this underserved population.
A study of 2060 children reveals that maternal obesity is a major predictor of cardiac and minor malformations, while gestational diabetes only predicts skeletal malformations. The authors suggest that excess energy and insulin resistance contribute to malformations.
A new study using combined PET/CT imaging has effectively diagnosed diabetes-related osteomyelitis of the foot. The technique provides a precise location of infection, enabling easier treatment strategy definition and improved patient outcomes.
Research finds that rosiglitazone effectively treats PCOS symptoms, while valproate increases incidence of PCOS in women. Carotid artery thickness is also linked to increased risk for heart disease in women with PCOS. Furthermore, sleep apnea may increase risk for diabetes in women with PCOS.
A new treatment approach has been developed to prevent autoimmune diabetes in mice by blocking the interaction between NKG2D on T cells and proteins found on abnormal cells. This breakthrough finding suggests a potential therapeutic strategy for preventing or controlling type 1 diabetes.
Patients with diabetes, females over 70, or obesity are more likely to develop postoperative mediastinitis caused by methicillin-resistant S. aureus. Identifying these risk factors enables the design of preventive strategies.
A study of 19,537 patients found that those taking cholesterol-lowering drugs statins before admission had better hospital outcomes than non-statin users. Meanwhile, researchers discovered limited information on the effectiveness of bioterrorism surveillance systems in detecting illnesses and emerging infections.
Researchers found that insulin and glucose in type-2 diabetics' urine increases E. coli's adherence, leading to a greater risk of UTIs. Insulin also affects the bacteria's surface characteristics, potentially providing some protection against antibiotics.
A recent study found that diabetes-related mortality may increase in relative importance among the elderly population, with a 10% per year mortality rate among those with diabetes. The study suggests that prevention of diabetes among the elderly should be a priority, as demonstrated by the Diabetes Prevention Program.
Researchers found that a strong preference for female physicians delays colonoscopy procedures and increases costs. Additionally, a study revealed a significant association between diabetes mellitus and an increased risk of developing colon cancer. These findings highlight the need for interventions to address these barriers to care.
A long-term study found that people with diabetes are at a 65% increased risk of developing Alzheimer's disease compared to those without the condition. The study also showed that cognitive decline in perceptual speed was associated with diabetes, but not other cognitive systems.
Researchers from Rush University Medical Center have discovered that diabetics are at a significantly higher risk of developing Alzheimer's disease. The study, which followed over 800 Catholic nuns and priests for five years, found a 65% increase in the risk of AD among those with diabetes.
The US task force recommends targeted screening of healthy women over 70 with mammography and Pap tests, as there is limited evidence to support universal screening for lung cancer. Meanwhile, a study reveals that managing drug care for older adults requires improvement, with failures in educating patients on medication use and underus...
A study found that long-term calorie restriction significantly reduces risk of atherosclerosis, diabetes, and high blood pressure. Participants on low-calorie diets had lower cholesterol, triglyceride, and fasting glucose levels compared to those on typical Western diets.
Researchers found that about 20% of un diagnosed participants were at risk for diabetes and 3.4% were diabetic. Shelter residents had lower hemoglobin A1c levels than those screened elsewhere, suggesting better health outcomes.
Researchers at UCSB are studying cinnamon's effects on mice with diabetes, finding a compound that has insulin-like activity and may help alleviate the condition. The study aims to explore the potential of cinnamon as a natural treatment for type II diabetes, which affects over 170 million people worldwide.
A study published in Endocrine Practice found that continuous insulin monitoring and endocrinologist involvement did not increase the cost of treating diabetic patients undergoing CABG surgery. The protocol showed significantly better glycemic control, leading to shorter hospital stays and fewer deep sternal wound infections.
The UPMC Community Medicine initiative improved HbA1c levels by 0.83 percent and reduced blood pressure and cholesterol below target ranges in a large proportion of patients. Physician compliance with evidence-based guidelines was significantly increased through data tracking and education.
Researchers at the Eleanor Roosevelt Institute have patented a new treatment for type II diabetes, focusing on regulating insulin resistance by manipulating melanocyte-stimulating hormone (MSH) levels. The approach has shown promise in genetically engineered mice and may offer a new direction in understanding and treating the disease.