Articles tagged with Diabetes
A U-M team, led by Dr. Stephen Feinberg, is engineering tissue grafts to treat mouth wounds in patients with diabetes or undergoing chemotherapy. The grafts, made from a combination of mucosal cells and AlloDerm, show promise for smaller donor sites and faster healing times.
The study suggests that monitoring glycated hemoglobin levels can help identify individuals at increased risk of developing cardiovascular disease. Researchers found a significant association between elevated glycated hemoglobin levels and increased risk of large-vessel cardiovascular disease among people with type II diabetes.
Researchers at Stanford University School of Medicine have discovered a primordial pancreas in fruit flies that produces both insulin and glucagon, two hormones crucial for regulating blood sugar levels. This breakthrough could lead to the development of new drugs for treating diabetes.
The study found that approximately 1 in 5 subjects had previously undiagnosed diabetes, while over 1 in 4 had impaired glucose tolerance. Lifestyle changes and medication may help prevent the progression of impaired glucose tolerance to full-blown diabetes and its associated complications.
The Euro Heart Survey on diabetes and the heart found abnormal glucose regulation is common in patients with coronary artery disease. Patients with diabetes face a dismal prognosis, but those without known diabetes can benefit from improved treatment standards.
Following guidelines improved acute reperfusion and adjunctive treatment of STEMI in diabetics, leading to a 36% relative reduction in hospital mortality. Diabetes mellitus significantly increases the risk of developing coronary artery disease.
Women with diabetes having acute coronary syndrome are at a higher risk of presenting with ST-elevation-ACS and dying in hospital, compared to men. Diabetes has a differential effect on the pathophysiology of ACS based on patient sex.
A large-scale study validates the benefits of low-GI diets in rats, showing significant reductions in body fat, blood glucose and insulin levels. The study suggests that glycemic index is an independent factor contributing to major chronic diseases.
Researchers found VA patients received standard processes of care more often, including recommended tests and services, and had better diabetes control. The study suggests the VA's national system provides excellent quality care due to its integrated care and tracking mechanisms.
The study reveals alarming rates of eye diseases among Latinos, including open-angle glaucoma, diabetic retinopathy, and cataracts. These findings underscore the importance of developing tailored prevention and treatment strategies for this underserved population.
A study of 2060 children reveals that maternal obesity is a major predictor of cardiac and minor malformations, while gestational diabetes only predicts skeletal malformations. The authors suggest that excess energy and insulin resistance contribute to malformations.
A new study using combined PET/CT imaging has effectively diagnosed diabetes-related osteomyelitis of the foot. The technique provides a precise location of infection, enabling easier treatment strategy definition and improved patient outcomes.
Research finds that rosiglitazone effectively treats PCOS symptoms, while valproate increases incidence of PCOS in women. Carotid artery thickness is also linked to increased risk for heart disease in women with PCOS. Furthermore, sleep apnea may increase risk for diabetes in women with PCOS.
A new treatment approach has been developed to prevent autoimmune diabetes in mice by blocking the interaction between NKG2D on T cells and proteins found on abnormal cells. This breakthrough finding suggests a potential therapeutic strategy for preventing or controlling type 1 diabetes.
Patients with diabetes, females over 70, or obesity are more likely to develop postoperative mediastinitis caused by methicillin-resistant S. aureus. Identifying these risk factors enables the design of preventive strategies.
A study of 19,537 patients found that those taking cholesterol-lowering drugs statins before admission had better hospital outcomes than non-statin users. Meanwhile, researchers discovered limited information on the effectiveness of bioterrorism surveillance systems in detecting illnesses and emerging infections.
Researchers found that insulin and glucose in type-2 diabetics' urine increases E. coli's adherence, leading to a greater risk of UTIs. Insulin also affects the bacteria's surface characteristics, potentially providing some protection against antibiotics.
A recent study found that diabetes-related mortality may increase in relative importance among the elderly population, with a 10% per year mortality rate among those with diabetes. The study suggests that prevention of diabetes among the elderly should be a priority, as demonstrated by the Diabetes Prevention Program.
Researchers found that a strong preference for female physicians delays colonoscopy procedures and increases costs. Additionally, a study revealed a significant association between diabetes mellitus and an increased risk of developing colon cancer. These findings highlight the need for interventions to address these barriers to care.
A long-term study found that people with diabetes are at a 65% increased risk of developing Alzheimer's disease compared to those without the condition. The study also showed that cognitive decline in perceptual speed was associated with diabetes, but not other cognitive systems.
Researchers from Rush University Medical Center have discovered that diabetics are at a significantly higher risk of developing Alzheimer's disease. The study, which followed over 800 Catholic nuns and priests for five years, found a 65% increase in the risk of AD among those with diabetes.
The US task force recommends targeted screening of healthy women over 70 with mammography and Pap tests, as there is limited evidence to support universal screening for lung cancer. Meanwhile, a study reveals that managing drug care for older adults requires improvement, with failures in educating patients on medication use and underus...
A study found that long-term calorie restriction significantly reduces risk of atherosclerosis, diabetes, and high blood pressure. Participants on low-calorie diets had lower cholesterol, triglyceride, and fasting glucose levels compared to those on typical Western diets.
Researchers found that about 20% of un diagnosed participants were at risk for diabetes and 3.4% were diabetic. Shelter residents had lower hemoglobin A1c levels than those screened elsewhere, suggesting better health outcomes.
Researchers at UCSB are studying cinnamon's effects on mice with diabetes, finding a compound that has insulin-like activity and may help alleviate the condition. The study aims to explore the potential of cinnamon as a natural treatment for type II diabetes, which affects over 170 million people worldwide.
A study published in Endocrine Practice found that continuous insulin monitoring and endocrinologist involvement did not increase the cost of treating diabetic patients undergoing CABG surgery. The protocol showed significantly better glycemic control, leading to shorter hospital stays and fewer deep sternal wound infections.
The UPMC Community Medicine initiative improved HbA1c levels by 0.83 percent and reduced blood pressure and cholesterol below target ranges in a large proportion of patients. Physician compliance with evidence-based guidelines was significantly increased through data tracking and education.
Researchers at the Eleanor Roosevelt Institute have patented a new treatment for type II diabetes, focusing on regulating insulin resistance by manipulating melanocyte-stimulating hormone (MSH) levels. The approach has shown promise in genetically engineered mice and may offer a new direction in understanding and treating the disease.
Diabetic women carrying two copies of the haptoglobin-2 gene are at risk of accelerated artery narrowing when taking antioxidant vitamins C and E. In contrast, those carrying the haptoglobin-1 variant experience a decreased rate of atherosclerosis when taking these vitamins.
Researchers at UT Southwestern have made significant progress in understanding lipodystrophies, rare disorders characterized by partial or total loss of fat tissues. Recent studies have identified gene mutations and novel therapeutic approaches for these patients, which may also be applicable to obese individuals with abnormal fat dist...
A study published in Diabetes Care found that diabetes reduces life expectancy by 12 years, with men living 64.7 years and women 70.7 years compared to the general population. Eradicating diabetes would increase life expectancy by 2.8 years for men and 2.6 years for women.
Researchers found a link between the two diseases, with mutations in HNF-1a protein interfering with PKHD1 gene transcription. This discovery may lead to similar therapeutic approaches for both MODY5 and polycystic kidney disease.
A researcher is studying how diabetes affects ganglion cells and developing a potential treatment using sigma receptor ligands. The goal is to prevent ganglion cell death and the growth of new blood vessels that obstruct vision.
Patients who develop diabetes after kidney transplant experience poorer outcomes, including higher rates of infection and recurrent infections. Tight control of glucose levels is crucial for these patients to remain healthy.
Researchers found that achieving basal growth hormone levels of less than 2.5 µg/liter and glucose-suppressed GH levels of less than one µg/liter may not minimize cardiovascular risks in acromegaly patients. Instead, these patients are at increased risk for conditions like hypertension, diabetes, and osteoarthritis.
A large cohort study reveals that diabetes significantly increases the risk of developing chronic liver disease and liver cancer. Regular testing of liver enzymes is recommended for patients with diabetes to monitor for potential toxicity.
Research by Martin Muurling found that mice on low-fat diets were more sensitive to insulin, suggesting a low-fat diet may be a more effective remedy for diabetes. The study also showed that consuming fish oil had no positive effects on reduced insulin sensitivity.
A study examining trends in adults with diagnosed diabetes found that only a small percentage met recommended targets for HbA1c, blood pressure, and total cholesterol. The authors highlight the need for ongoing monitoring, empowering clinicians and patients to improve care quality and reduce vascular disease risk.
Researchers have discovered a link between the ratio of two energy-compounds and increased blood flow in brain cells. By modulating this ratio, scientists can better understand how blood circulation is activated in the brain, potentially leading to new treatments for diseases like Alzheimer's and diabetes.
Low cardiorespiratory fitness in young adulthood is associated with a higher risk of developing diabetes, hypertension, and the metabolic syndrome. Improving fitness over 7 years was linked to reduced risk, but weight changes may have offset this benefit.
A study published in The Journal of the American Medical Association found that fitness in young adulthood can significantly reduce the risk of developing high blood pressure, diabetes, and metabolic syndrome. Improving fitness levels by 50% or more can decrease these risks by as much as 50%.
Scientists discovered a chemical relay that controls whether the body burns sugars or fats for energy. The discovery may help design better treatments for insulin resistance and ultimately prevent adult-onset diabetes.
A high-saturated-fat diet combined with starch avoidance yielded significant weight loss in a 6-week study, with patients losing 5% of their body weight. The diet restricts calories and focuses on protein from red meat and cheese, while limiting fruits and non-starchy vegetables.
A recent study by Michigan Medicine found that only 5% of patients and physicians agreed on their top three treatment goals, but nearly half shared one strategy. Patients who prioritized their healthcare goals with their doctors reported better diabetes management outcomes.
The JAK2 enzyme plays a dual role, protecting brain cells from Alzheimer's disease and blocking cell death pathways. However, it also causes damage to blood vessels in diabetics, leading to hypertension, kidney failure, and other age-related diseases.
Researchers have discovered that smaller protein structures called protofibrils are more toxic to cells than mature fibrils in type II diabetes and other age-related diseases. The study suggests that targeting earlier stages of protofibril formation may be a more effective approach to developing treatments.
Researchers have discovered a potential therapeutic target for treating hyperglycemic damage in endothelial cells, which is linked to both diabetes and cardiovascular disease. Inhibiting GAPDH activity by poly(ADP-ribose) polymerase could activate three major pathways of damage, providing new avenues for treatment.
A new animal study found that PKC may contribute to reduced erectile response in diabetic-obese Zucker rats. The researchers observed increased protein expression of PKC isozymes and Rho-kinase b in the corpus cavernosum, suggesting a role for PKC in vasoconstriction and reduced erectile function.
Researchers found increased COX-2 protein expression and changes in TXA2 and PGE2 levels in the Obese Zucker rat, which led to kidney damage. The study suggests that COX-2 inhibitors may be beneficial for preventing renal damage in obesity-related type II diabetes.
A study found that people with glaucoma and macular degeneration had lower rates of annual eye exams compared to those with diabetes. The study suggests that changes in medical practice are necessary to improve patient compliance and prevent visual loss.
Researchers have discovered an engineered mouse that can eat a high-fat diet without gaining weight or developing diabetes. The mouse lacks the SCD-1 gene, which affects fat production and glucose regulation. As a result, muscle cells are more sensitive to insulin, enabling them to absorb glucose and regulate blood sugar levels.
A post-hoc analysis of the LIFE study found a close to 50% risk reduction in sudden death among losartan-treated diabetic patients compared to those treated with atenolol. Lars Lindholm comments that the results are exploratory and require confirmation.
A post-hoc analysis of the LIFE study found that losartan significantly reduced sudden cardiac death in diabetic patients with hypertension and left ventricular hypertrophy compared to atenolol. The results showed a nearly 50% risk reduction in sudden death for losartan-treated patients.
A recent study found that providing Medicare coverage to previously uninsured adults increases access to life-saving preventive tests like cancer and cholesterol screenings. The gap in testing rates narrows significantly after eligibility.
Researchers have developed a mouse embryonic stem cell model that can differentiate into pancreatic precursor cells and islet cells producing four types of hormones. This study could provide valuable insights into normal pancreatic development and potentially lead to better stem cell-based therapies for diabetes.
A protein called PPAR-alpha is critical to this process, and the liver plays a key role in explaining the high incidence of diabetes and hypertension in obese individuals. The study suggests that understanding how steroids cause side effects may help prevent these disorders.
Researchers found that 13.5% of patients with heart failure were prescribed metformin or thiazolidinediones in 1998-99, increasing to 24.4% by 2000-01. These medications are recommended against for patients with significant heart failure symptoms due to potential side effects.
Rutgers University has been awarded millions by the NIH for its genetic research efforts, expanding its capabilities to study disease genetics globally. The new funding will support researchers in studying common pools of subjects to identify genes predisposing individuals to diseases.
Pre-diabetic adults with impaired glucose tolerance (IGT) are nearly twice as likely to die from any cancer and four times more likely to die from colon cancer compared to those with normal glucose tolerance. Researchers suggest that high insulin levels may promote the development of cancer cells, but prevention methods are unclear.
A study found that people with diabetes in Saskatchewan accounted for $134.3 million in health care expenditures, with major comorbidities contributing to 36.4% of these costs. Targeted strategies to prevent diabetes could produce substantial savings and improved health outcomes.