Articles tagged with Eye Diseases
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Dr. Jason I. Comander has received a $250,000 Research to Prevent Blindness Career Development Award to study patients with inherited retinal degenerations, including retinitis pigmentosa. The award aims to develop techniques for high-throughput functional characterization of human genetic variation and mutation in retinitis pigmentosa.
The probability of blindness from glaucoma has decreased by nearly half since 1980, with advances in diagnosis and therapy likely contributing to the reduction. However, a significant proportion of patients still progress to blindness, emphasizing the need for continued research and vigilant eye exams.
A special issue of IOVS addresses the aging eye, focusing on unmet needs and accelerating clinical care. The issue features new research on genetics, biology, and prevention/treatment of age-related diseases such as cataracts and macular degeneration.
Researchers from Penn Vet found a shared cell death pathway involved in inherited vision diseases, including rod cone dysplasia and X-linked progressive retinal atrophy. The study suggests that targeting this pathway with TNF-inhibitors could slow disease progression or complement gene therapies.
Scientists have developed a new technique to visualize the silencing of one X chromosome in females, revealing wide-ranging variation in patterns across tissues and individuals. The study's findings offer insights into genetic diversity and disease causes, particularly for X-linked variations like hemophilia and color blindness.
Researchers identify azithromycin as a potential therapy for meibomian gland dysfunction, leading to improved treatment options for dry eye disease. The study suggests that topical azithromycin could directly stimulate the function of human meibomian gland epithelial cells.
Researchers have developed a nonsense suppression drug that can restore function in mice with aniridia, a progressive disease affecting the eyes and brain. The treatment, ataluren, was administered topically to postnatal aniridia mice and successfully reversed eye deformations and restored vision.
Researchers identified a fungal surface protein that promotes host cell invasion in mucormycosis, while others found that melanocytes from light-skinned humans secrete a molecule promoting angiogenesis. These findings could lead to new treatments and biomarkers for diseases associated with increased vascularization.
A new hand-held optical device can scan a patient's entire retina in seconds, detecting early signs of diabetic retinopathy, glaucoma and macular degeneration. This innovation enables primary care physicians to screen a wider population outside traditional specialist offices.
Researchers at UBC-VCH have developed a potential cure for aniridia, a rare eye disease affecting 5,000 people in North America. They formulated the drug Ataluren into eye drops and found it restored normal vision in mice with the condition.
A new study reveals that nearly half of Americans with diabetes are unaware of the link between the disease and visual impairment, while only six in ten have had their eyes fully examined. The research highlights the need for improved patient education and access to eye care specialists to prevent vision loss.
Two studies examine the effects of spaceflight on mouse eyes, revealing oxidative stress as a key mechanism behind eye damage. Researchers found genes involved in response to oxidative stress and potential indicators of optic nerve damage, highlighting the need for countermeasures to protect astronauts' vision.
Cardiovascular complications and hypoglycemia are common nonfatal complications in older adults with diabetes. The study found that patients with diabetes for a longer duration had higher rates of all outcomes, including mortality.
Researchers analyzed minute movements to diagnose autism and determine its severity in children and young adults. The study found that fluctuations in hand movements can indicate the degree of autism spectrum disorder, allowing for subtyping and improved diagnosis. This breakthrough may lead to more tailored treatments.
Research found that women who used oral contraceptives for three or more years are 2.05 times more likely to have glaucoma, a leading cause of blindness. The study suggests long-term use of birth control may be a risk factor for glaucoma, particularly in combination with other factors such as ethnicity and family history.
The IRIS Registry is a centralized collection and reporting software tool that enables ophthalmologists to statistically analyze their own care, compare it to peers, and pinpoint opportunities for improvement. The database will be populated with data from over 18 million patients by 2016.
A new retinal implant system called the Argus II has shown positive results in helping people with retinitis pigmentosa recognize common objects. The device uses a miniature camera and electrodes to stimulate cells in the retina, creating patterns of light perception.
A Mayo Clinic study published in the Journal of Bone and Mineral Research found that patients with type 2 diabetes have lower bone material strength, highlighting the need for conventional measurements to be reevaluated. The research suggests potential detrimental effects of poor glucose control on bone quality.
A Swedish study found that birth before 32 weeks is associated with increased risks of retinal detachment in childhood, adolescence and young adult life. The research indicates the need for ophthalmologic follow-up in children and adults born extremely and very prematurely.
McGill University has made its online game Phylo available globally to connect thousands of scientists with hundreds of thousands of gamer-citizens scientists. Players have already contributed over 4,000 puzzle solutions based on genomic data.
Researchers at Scripps Research Institute have developed a promising technique for treating human eye disease by targeting microRNAs, which can stop abnormal blood vessel growth. The approach shows promise in preventing blindness in diseases like neovascular macular degeneration and diabetic retinopathy.
Researchers at Bascom Palmer Eye Institute have discovered a key marker in blood and urine that can identify people who carry genetic mutations causing retinitis pigmentosa, a blinding disease. The test is non-invasive and easy to perform, especially for young children.
Researchers used whole genome sequencing to identify unique mutations and a previously undescribed disease gene NEK2 associated with retinitis pigmentosa. The study highlights the importance of rare structural DNA variations in Mendelian diseases.
Researchers from the American Academy of Ophthalmology found a 40% lower long-term mortality risk among patients who had their vision corrected through cataract surgery. The study, which followed over 350 participants, suggests that correcting cataract-related visual impairment results in improved outcomes beyond just eye health.
Researchers developed an animal model simulating eye complications associated with Graves' disease, paving the way for better treatments. The condition causes the thyroid gland to become overactive and produce too much thyroid hormone, leading to eye problems like swelling of tissue behind the eyes causing them to bulge outward.
Researchers identified critical inhibitory neurons responsible for vision development in children. A new treatment approach uses an experimental drug compound to reopen the critical-period window and correct central vision disorders.
A recent study published in PLoS One reveals that impaired autophagy is linked to age-related macular degeneration, a leading cause of visual impairment. The researchers found that the lysosomal clean-up mechanism, or autophagy, plays a crucial role in clearing harmful protein accumulations behind the retina, which lead to vision loss.
New research shows that vegetable oil fatty acids can increase plasma membrane fluidity in retina cells, reducing the risk of retinopathy and age-related macular degeneration. A diet rich in omega-3 fatty acids and olive oil may also contribute to preventing retina diseases.
A study published in Human Molecular Genetics found that the complement system plays a critical role in early macular degeneration. The researchers used mice genetically engineered to have an inherited form of the disease and found that turning off the complement system prevented the disease from progressing.
Researchers found that people with sleep apnea are at a significantly higher risk of developing open-angle glaucoma compared to those without the condition. The study recommends clinicians alert patients about this association to encourage treatment.
A multicenter clinical trial found daily omega fatty acid supplementation to be effective in improving ocular irritation symptoms and halting inflammation progression in moderate to severe dry eye patients. HydroEye clearly had a positive impact on these patients, providing safe and cost-effective relief.
A team of researchers at Mass Eye and Ear has created the most comprehensive description of gene expression in the human retina. The study identified over 30,000 novel exons and more than 100 potential new genes that were not previously known to be expressed in the retina.
A Michigan State University study reveals that 90% of patients with eye diseases are willing to donate their eyes, but only a fraction follow through. The study suggests that educating the public about eye donation and streamlining the donation process could increase donations.
Researchers at Cedars-Sinai Medical Center are developing a new stem cell therapy approach to treat limbal epithelial stem cell deficiency, a common cause of corneal blindness. The goal is to create a corneal cell source for transplantation using induced pluripotent stem cells from patients' own eyes.
Research at the University of Alberta found that rats with low birth weights are more susceptible to age-related vision loss. The team's findings suggest a potential link between low birth weights and complex diseases like age-related eye disorders.
A novel songbird disease has rapidly evolved to become more harmful to its host in just two decades, according to a new study. The research found that the disease became more virulent in both regions studied, with birds exposed to later disease strains developing more swollen eyes that took longer to heal.
A comprehensive online database of human phosphatases and their substrates has been created to aid researchers in understanding cellular reactions. The database, DEPOD, groups phosphatases into families based on three-dimensional structure, enabling the identification of known substrates and suggestion of new ones.
A team of researchers has successfully developed a method to breach the blood-brain barrier using the nasal lining, allowing for higher molecular weight drug delivery to the central nervous system. This breakthrough opens up new treatment options for neurodegenerative and CNS diseases affecting millions of people worldwide.
A study analyzing 203 children with retinoblastoma found that delays in diagnosis led to more invasive and life-threatening disease courses in non-white, Hispanic, or uninsured patients. The researchers aim to explore the causes of these delays and eliminate them.
A research team led by Dr. Robert Hess used Tetris to train both eyes to work together, alleviating suppression of the weaker eye and increasing brain plasticity. The treatment showed dramatic improvements in vision and 3-D depth perception in adults with amblyopia.
Researchers have discovered that the surface of the eye produces 'lubricin,' a substance similar to joint lubricant, reducing friction between cornea and conjunctiva. This finding holds promise for treating conditions like dry eye disease, postmenopausal vaginal atrophy, and xerostomia.
Researchers found that topical anakinra significantly reduced dry eye symptoms, eliminating corneal staining and improving signs of ocular surface disease. The treatment was well-tolerated and effective in reducing dry eye symptoms six times more than the current standard treatment.
Age-related macular degeneration is a leading cause of visual impairment in people over 65, affecting over 9.1 million Americans. Regular screening by an ophthalmologist is critical for early detection and treatment.
Researchers at Lund University have developed a new method to investigate the importance of biomechanical factors in the central nervous system. The study found that when the biomechanical balance is disturbed, as happens in eye diseases such as retinal detachment and glaucoma, the normal function of the retina is lost, resulting in se...
A new study from the University of Utah Health has disproved the long-held theory that a lack of fatty acids causes blindness in children with Stargardt type 3 retinal degeneration. The researchers found that mice with reduced fatty acids in their photoreceptor cells maintained normal vision.
A prospective study found that children with low-risk retinoblastoma do not need postoperative chemotherapy to prevent disease recurrence or metastasis. The results suggest that certain patients with intermediate-risk disease can receive less aggressive adjuvant treatment or even forego it altogether.
A recent review of 400 patients with Wolfram syndrome reveals that 15% do not meet current diagnostic criteria, highlighting the need for revision. The study proposes expanding the diagnostic criteria to identify two of four clinical features, which would diagnose up to 98% of patients.
The study demonstrates that EBI-005 binds to its target, IL-1R1, 85-fold more tightly than IL-Ra, providing a 100-fold increase in potency in vivo. Additionally, EBI-005 has been shown to be more thermally stable than IL-1Ra, indicating potential for a room temperature-stable product.
Researchers at the University of York have established a link between Parkinson's and visual problems in an animal model. A study found that a common genetic mutation triggering Parkinson's affects eye nerve cell function, leading to gradual loss of vision.
Researchers at LSU Health Sciences Center have identified a protein, fatty acid transport protein 4 (FATP4), that protects retinal photoreceptor cells from degeneration. The study suggests FATP4 may be a therapeutic target for inherited retinal degenerative diseases and age-related macular degeneration.
A landmark clinical trial published in Ophthalmology found that genetic variants do not predict treatment response to Lucentis and Avastin for wet AMD. The study's findings clarify the value of genetic testing for this serious eye disease, contradicting previous hopes for personalized medicine.
The National Eye Institute has launched new resources to help people with low vision, including a large-print booklet and videos. The materials provide tips for maximizing remaining eyesight and encourage individuals to seek help from a low vision specialist.
Researchers discovered that high-density bands in photoreceptor outer segments are more susceptible to breakage due to their rigidity. This finding supports the idea that mutations causing rhodopsin aggregation can destabilize the outer segment, leading to cell death and blindness.
Scientists at Cincinnati Children's Hospital Medical Center and the University of California, San Francisco, discovered a light-response pathway that controls retinal neuron development during pregnancy. This finding has significant implications for understanding fetal eye development and ocular diseases caused by vascular disorders.
Researchers have identified an early predictor for glaucoma, a condition that affects nearly three million people in the US and 60 million worldwide. The study found that certain changes in blood vessels in the retina can be an early warning sign of increased risk for glaucoma.
A study published in Neurology found that people with MS relapses had faster retinal thinning than those without relapses. The study also showed that participants with worsening disability experienced increased retinal thinning.
A new study found that up to 40-50% of older adults with eye disease limit their activities due to a fear of falling. This fear leads to social isolation and disability in seniors, emphasizing the need for interventions to help them feel more confident about their abilities.
Research found that people with glaucoma show delayed eye movement reaction times by about 15 per cent, even in early stages of the disease. This delay may affect daily activities such as reading, driving, or navigating, highlighting the need for new vision pathways and approaches to measuring vision loss.
Scientists at Sanford-Burnham Medical Research Institute have discovered that carnosic acid, a component of rosemary, promotes eye health and protects retinas from degeneration. The findings suggest a possible new approach for treating age-related macular degeneration.
A Mayo Clinic study finds that a primary treatment for wet macular degeneration is effective even in patients with macular traction problems. This breakthrough may help physicians not give up on treating such patients, and understand the need for more doses of medication.