Articles tagged with Heart Disease
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Researchers developed CrossDome, a tool that uses genetic and biochemical information to predict T-cell immunotherapy's impact on healthy cells. The tool identified high-risk candidates in cases where treatments mistakenly attacked heart cells.
A new study found that elevated Lipoprotein(a) levels are a significant predictor of recurrent coronary heart disease (CHD) in people over 60. The study suggests current cholesterol-lowering medications may not be effective in reducing the risk of recurrent CHD, highlighting the need for novel therapeutics to target elevated Lp(a).
Researchers found immune markers associated with myocardial injury in hypertensive patients with Covid-19, including altered cytokine levels and immune cell activation. These findings suggest a key role for immune dysregulation in the development of cardiac muscle injury.
Researchers used machine learning to build predictive models for nine common diseases based on genetic information and blood biomarkers. Blood biomarkers provided better prediction in nearly all cases, especially for near-term risk, suggesting direct links between some measures and the pre-symptomatic phase of disease.
The new scientific statement highlights the importance of identifying the root cause of pediatric cardiomyopathy to develop effective treatment strategies. Genetic testing is recommended for all children with cardiomyopathy, which may lead to financial and emotional cost savings.
A new study shows that saracatinib reduces inflammation in patients with atherosclerotic cardiovascular disease by more than 90% and boosts genes that help clean up plaque deposits. The experimental cancer drug may offer an effective therapy for cases where standard treatment fails to help.
A groundbreaking study has shown that a devastating heart condition can spontaneously reverse in three men, who are now free of symptoms. The condition, transthyretin cardiac amyloidosis, is progressive and previously considered irreversible.
A new study published in Hypertension found that oral estrogen hormone therapy may increase the risk of high blood pressure in women, while transdermal and vaginal formulations appeared to have a lower impact. The research involved over 112,000 women aged 45 years and older who took estrogen-only hormone therapy.
Researchers have developed a test to detect 'zombie' cells in donor blood, which may help increase the number of suitable hearts available for transplant. The test targets proteins associated with senescent cells, which can impact heart health.
A new American Heart Association scientific statement highlights the disproportionate burden of cardiovascular disease on AI/AN women. The study reveals that more than 60% of these women have suboptimal heart health when pregnant, increasing their risk of heart disease later in life.
A new study published in the Journal of the American Heart Association found that elevated levels of two protein biomarkers associated with heart damage were linked to undetected or symptomless cardiovascular disease in adults with Type 2 diabetes. The study analyzed health information and blood samples from over 10,300 adults and foun...
Researchers developed an AI system, Geneformer, to predict how disruptions in human gene connections cause disease. The model, trained on data from thousands of genes, can identify potential drug targets for diseases like heart disease and cancer.
Researchers discovered that vascular toxicity linked to these drugs is unrelated to angiogenesis-related genes, but rather due to changes in vascular architecture. This new understanding will help select the most effective and safe way to modulate angiogenesis in ischemic tissues or cancer.
Researchers identified five subtypes of heart failure using machine learning, including early onset and atrial fibrillation related. These subtypes have different mortality risks, with some patients at higher risk of dying within a year after diagnosis.
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
Researchers found that genetic predisposition to lipids, Alzheimer's, and heart disease in the MLXIPL gene locus is shaped by exogenous exposures. Minor alleles of certain variants associated with high triglyceride levels and lower HDL-C levels, which may provide protective effects against Alzheimer's risk.
Women with short or long menstrual cycles are at increased risk of cardiovascular disease events such as heart attack or AFib. The study analyzed data from over 58,000 women and found that irregular menstrual cycle length was associated with higher risks of CVD, independent of other factors.
Increasing physical activity, particularly daily 20-minute walks, can improve cardiovascular health and reduce disparities in heart health. Despite this, only one in four American adults meet the recommended physical activity levels, with certain groups facing additional barriers to accessibility.
A new study from the University of South Australia shows that the Mediterranean diet is not only good for health but also for your weekly budget. Compared to the typical Australian Western diet, the Mediterranean diet costs less, with a family of four saving $28 per week and nearly $1500 per year
A new Northwestern University study finds that CT scans are more effective than genetics in predicting the risk of heart disease in middle-aged individuals. The study used data from over 3,200 adults and found that adding CT scan data to conventional risk factors improved the accuracy of risk prediction.
A literature review found that dietary nitrate from vegetables may prevent cardiovascular disease, while nitrate from meat and water may pose a cancer risk. Experts emphasize the need for clarification in current guidelines and more research to distinguish fact from fiction.
Researchers have developed a pharmacological treatment that improves cardiac function in patients with stiff-heart syndrome, a condition caused by amyloid protein deposition. The new drug reduces amyloid protein deposits and shows promise in reversing established disease symptoms.
Researchers developed a new tool to predict heart disease risk in those over 40 based on their total exposure to heart disease risk factors. The study found that black patients have a 46% greater risk of developing heart disease compared to white patients.
A new study found an initial decline in diabetes mellitus plus cardiovascular disease-related mortality, but it reversed from 2014 to 2019. The researchers emphasized the need for primary prevention of diabetes and early diagnosis to prevent cardiovascular complications and mortality.
A UK study of over 420,000 adults reveals that those with existing cardiovascular disease and overweight or obesity are five times more likely to suffer a stroke and four times more likely to have a heart attack than those with extreme obesity. The study highlights the substantial impact of living with both conditions on individuals, p...
The latest clinical evidence on TAVI in younger patients with aortic stenosis will be discussed, including factors that determine the choice between TAVI and surgical aortic valve replacement. Valve design and implantation technique can also influence long-term outcomes and future treatment options.
TVT 2023 will feature 15 Late-Breaking Clinical Science studies highlighting advances in transcatheter aortic valve replacement and mitral, tricuspid, and left atrial appendage occlusion therapies. The meeting aims to guide the selection of patients who will benefit from these procedures and define optimal treatment strategies.
Researchers found that high-fat diets increase levels of gut-derived bacterial toxins and systemic inflammation, promoting atherosclerosis. The study suggests targeting interventions for individuals at risk of developing heart disease.
The study used magnetic resonance imaging (MRI) to measure acute pressure changes inside the heart, discovering that pressure increases when patients receive a specific medication called adenosine. This technology can help doctors better diagnose and monitor patients with heart disease and heart failure.
A study published by the European Respiratory Society found that around 20.2% of French adults are likely to have obstructive sleep apnoea (OSA), with only 3.5% being treated for the condition. OSA is more common in men, older adults, and those with cardiovascular disease.
A new study finds that one-time genomic screening of adults aged 20-60 for hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia is cost-effective based on quality-adjusted life-year measures. The study suggests that this approach could improve disease management and reduce healthcare costs.
A retrospective cohort study of U.S. veterans found that adding a GLP1 receptor agonist to diabetes treatment reduced the risk of major adverse cardiovascular events and heart failure hospitalization by about 20% compared to DPP4 inhibitors. The study's findings will aid clinicians in choosing a diabetes drug regimen for older patients.
Researchers found that solriamfetol, armodafinil–modafinil, and pitolisant reduce excessive daytime sleepiness in patients with obstructive sleep apnea already using conventional therapy. However, patients may be more likely to discontinue the use of these medications due to adverse events including headache, anxiety, and insomnia.
A Chinese Medical Journal review highlights the health hazards of air pollution, particularly from fine particulate matter (PM2.5), which is associated with increased risks of cardiovascular disease, hospitalization, and respiratory mortality. The study suggests that reducing PM2.5 levels through government interventions and individual...
A new study found that young adults with advanced heart disease desire to be actively involved in their medical care decisions, despite their parents' preference for a shared decision-making approach. The research highlights the importance of understanding individual preferences and personalizing communication methods with each patient.
A team of researchers from The Ohio State University, University of California Davis, and Virginia Commonwealth University will investigate the biological mechanisms of chronic stress's effect on cardiovascular health. They aim to identify specific interventions that can help reduce health risks associated with chronic stress.
The program guide for TVT 2023 showcases over 200 world-renowned faculty experts, with a focus on clinical decision-making and strategies for treating valvular heart disease. The summit highlights the latest advances in transcatheter valve therapy and nonsurgical procedures.
Researchers analyzed data from over 20,000 US adults, finding that those who lost at least 5% of their body weight showed higher diet quality and more moderate physical activity. However, the study also found that many individuals relied on unsustainable non-evidence-based approaches for weight loss, highlighting the need for a paradig...
A new study reveals delayed diagnosis of HoFH leads to premature cardiovascular disease, highlighting the need for increased lipid screening and aggressive treatment. Despite available therapies, most patients require further lipid-lowering treatments.
Strokes can be largely prevented through education and lifestyle changes, such as moving more, healthy eating, and managing blood pressure. The American Stroke Association is launching a digital tool to educate people on stroke warning signs and risk factors, particularly for diverse populations.
A large Chinese study found that acute air pollution exposure is associated with an increased risk of arrhythmia, with the strongest link seen in atrial flutter and supraventricular tachycardia. Exposure to pollutants like nitrogen dioxide was found to persist for up to 24 hours after initial exposure.
A study supported by the National Institutes of Health found that younger women are nearly twice as likely to be rehospitalized after a heart attack as men. The disparity is largely due to higher rates of risk factors such as obesity and depression among women, which contribute to more adverse outcomes.
Researchers at UCL have identified proteins in the blood associated with an increased risk of developing heart diseases, including heart failure. The findings could lead to more refined cancer treatments that minimize cardiotoxicity and improve survival rates.
Researchers at the University of Texas at Austin developed an ultrathin, lightweight electronic tattoo for continuous, mobile heart monitoring. The device provides two key measurements: electrocardiogram and seismocardiogram, giving clinicians a better chance to catch red flags for heart disease early.
The American Heart Association scientific statement rates how closely popular dietary patterns align with its guidance for heart-healthy eating. The statement evaluates 10 categories of diets, scoring them from 31 to 100 based on their alignment with the guidance, with some diets receiving high scores while others need improvement.
A long-term analysis reveals that approximately one-third of CTEPH patients also have left heart disease, which can worsen breathing symptoms and requires more comprehensive diagnostic approaches. The study suggests that treatment options for both conditions may overlap, necessitating further research to find effective therapies.
A new study published in the Journal of the American Heart Association found that U.S. adults who experienced workplace discrimination were more likely to develop high blood pressure. The research, which analyzed data from over 1,200 adults, suggests that work-related stress due to discrimination may be an emerging risk factor for card...
Researchers have discovered a novel feature of long intergenic noncoding RNAs (lincRNAs) that can serve as markers indicating specific types of tissue. This finding has the potential to lead to highly specific disease treatments by targeting diseased tissues.
A comprehensive review of 169 clinical trials found that the effect of fructose-containing sugars on adiposity varies among food sources and energy control. High doses of certain sources, like SSBs, lead to increased body weight, while others, such as fruit and honey, show moderate beneficial effects when consumed in moderation.
A new study comparing outcomes between Ontario and New York State found patients in Ontario more likely to die within a month of procedure due to inadequate availability and long wait times. The study suggests that improved access to TAVR may lead to better post-procedural outcomes.
A recent study published in JAMA Pediatrics reveals that individuals born preterm or large for gestational age have a significantly increased risk of developing atrial fibrillation up to middle-age. In contrast, those born small for gestational age only show an increased risk up to the age of 18.
Researchers found deaths from gallstone disease increased in younger populations and those with Medicaid after Medicaid expansion, highlighting the need for proactive prevention over reactive emergency care. A new healthcare model emphasizing primary care and prevention is proposed to address these inequities.
Individuals who experienced depression during pregnancy were more likely to be diagnosed with cardiovascular disease within two years after giving birth. The study found a significant higher risk of developing six major cardiovascular conditions, including heart failure and ischemic heart disease.
Researchers found that people whose depression symptoms improved after psychological treatment had a lower risk of developing cardiovascular disease over three years. The association was strongest in younger adults and suggested that accessing psychological therapy could have long-term physical health benefits.
A new meta-analysis finds that Black patients are 71% more likely to experience heart damage following chemotherapy treatment. The study highlights the need for further research into underlying factors contributing to these disparities to reduce cardiovascular risk associated with chemotherapy.
Researchers develop a new technique to measure blood attenuation using a fluorophore-coated guidewire, improving the accuracy of near-infrared fluorescence in cardiovascular imaging. The method provides accurate information on vessel walls and outperforms existing correction methods.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
New research suggests a way to ward off age-related weight gain by stimulating beige fat cells. Beige fat has thermogenic properties that can reduce blood sugar and fatty acids causing heart disease. The study identifies a specific signaling pathway responsible for suppressing beige fat formation in older mice.
Adult survivors of childhood cancer have a four times higher risk of late mortality compared to the general population. Maintaining a healthy lifestyle can reduce this risk by 20%, according to a new study published in The Lancet.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.