A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
A team of Canadian scientists has discovered a molecule produced by microbes in the gut that fuels the liver to make more glucose and fat than necessary. Trapping this molecule using a safe, biodegradable polymer improves blood sugar control and reduces fatty liver disease in mice with obesity.
The American Heart Association has launched a nationwide initiative to tackle cardiovascular disease, focusing on 15 regions across the US. The Cardiovascular-Kidney-Metabolic Health Initiative aims to improve treatment of interconnected conditions leading to heart disease and stroke.
The conference will feature keynote speakers Donna Ryan and Erik Wilson, as well as informative presentations and breakout sessions on the latest advances in obesity research. The Louisiana Obesity Society aims to support healthcare providers treating obesity through education and networking.
The 2025 Critical Path Institute Global Impact Conference will bring together industry, regulatory agencies, academia, and patient advocacy groups to discuss pressing challenges in drug development. The event aims to foster cross-sector collaboration to advance medical innovation and improve treatment outcomes for patients.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
Research warns that GLP-1 drugs may not provide the long-term health benefit of improved heart and lung function. While they help with weight loss, patients may experience significant muscle loss, which can increase cardiovascular disease risk. Doctors are urging additional research to better understand the effects of these drugs.
A new study identified neurobeachin as a genetic predictor of weight loss response to GLP-1RAs. The findings have the potential to advance obesity care and provide more effective, personalized treatment options.
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
Research reveals a direct connection between diabetic peripheral neuropathy and skeletal health, linking nerve damage to reduced cell signaling. The study shows that diabetic mice with nerve damage had weakened bones due to impaired nerve-bone communication.
A University of Cincinnati researcher is investigating how excess sugar impacts cardiovascular structure and function in people with diabetes. The study focuses on a protein called GLUT1, which becomes overactive in diabetes, leading to harmful changes at the cellular level.
The study found a significant increase in extremely severe obesity among US children and adolescents, leading to severe metabolic and cardiovascular complications. Extremely severe obesity was linked to conditions like metabolic dysfunction-associated steatotic liver disease, prediabetes or diabetes, and metabolic syndrome.
The bariatric weight reduction surgery medical tourism industry lacks regulation, posing safety, ethical, and legal risks for patients. Many patients self-refer for the procedure due to high costs in their home country, and there's often a lack of preoperative and postoperative follow-up.
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
SourcePenn State·JournalCurrent Developments in Nutrition·TypeRandomized controlled/clinical trial·DateJul 14, 2025
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.
A new study found that intermittent energy restriction significantly improved fasting blood glucose and triglycerides, while also increasing insulin sensitivity. The IER group showed the greatest advantages in reducing these markers compared to time-restricted eating and continuous energy restriction groups.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
A long-term study of healthy men found that minimally elevated blood sugar levels can lead to declines in sperm movement and erectile function. The study suggests that lifestyle choices and medical interventions can help preserve or revive reproductive health in aging men.
A real-world study of 120 postmenopausal women found that using tirzepatide and menopause hormone therapy simultaneously led to superior total body weight loss percentage compared to using tirzepatide alone. This combined treatment also resulted in a higher percentage of participants achieving at least 20% weight loss.
A small study found that consuming more protein may help prevent muscle loss in adults with obesity taking semaglutide, an anti-obesity medication. The researchers noted that older adults and women may be at higher risk for muscle loss, emphasizing the importance of preserving muscle during weight loss with this medication.
This study found that sleep fragmentation-induced testicular damage in T2DM is mediated by melatonin receptor 1a, which activates FGFR1 to suppress TAB1/TAK1 complex. Melatonin and its agonist improved lipid homeostasis, highlighting a promising therapeutic approach for male infertility in T2DM.
Researchers identified TMEM9B-AS1, a long non-coding RNA that regulates cellular functions, as significantly reduced in skeletal muscles of people with type 2 diabetes. Its absence disrupts protein production, leading to muscle weakness and loss.
A recent study published in Nature reveals that weight loss triggers the breakdown and recycling of fats called lipids, potentially leading to improved health outcomes. Weight loss also clears out senescent cells, which are ageing and damaged cells that accumulate in tissues, reducing inflammation and scarring.
A recent survey found that 39% of respondents incorrectly identified all processed foods as unhealthy. However, the Physicians Committee for Responsible Medicine reports that it is not processed plant foods but rather meat consumption associated with an increased risk of type 2 diabetes and cardiovascular disease.
Michael Karin, renowned for his work on chronic inflammation and cancer, will lead the Center for Metabolic and Liver Diseases at Sanford Burnham Prebys. He aims to develop new treatments for metabolic and liver diseases, which affect millions of patients worldwide.
A new nutritional epigenetics study protocol aims to reduce lead and mercury exposures in pregnant women to prevent childhood autism and ADHD. The protocol provides a valid method for measuring changes in ultra-processed food intake and diet, which may impact child neurodevelopment.
A study found that a grandmaternal age difference of ≤-9 years significantly increases the risk of pregnancy cardiometabolic disorders. The researchers analyzed data from 2,235 grandmother-mother pairs and discovered a nonlinear association between age differences and CMDs.
A new potential drug treatment has shown promising results in reducing blood sugar levels and increasing fat burning in people with type 2 diabetes and obesity. The treatment activates metabolism in skeletal muscle, promoting healthy weight loss and preserving muscle mass, a key factor in metabolic health.
Research found that certain heart rate variability patterns can predict future health conditions, including stroke, depression, and cognitive dysfunction. The study suggests that nocturnal HRV provides a unique window into how the body functions during sleep.
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
The National Urea Cycle Disorders Foundation is establishing a multistakeholder Partner Network to guide health care decisions and build a sustainable infrastructure for UCD research. The project aims to empower the broad UCD community to work together effectively, identify research needs, and create a roadmap for future studies.
The American College of Lifestyle Medicine has published a comprehensive guideline on lifestyle interventions for treating and remitting type 2 diabetes and prediabetes. The guideline offers evidence-based strategies for optimizing lifestyle behaviors, sustaining changes, and reducing medication needs.
The AMA has passed a resolution calling for easier access to anti-obesity medications, which have been shown to help adults lose an average of 15-20% of their weight. Improved access could benefit millions nationwide, reducing obesity-related medical costs estimated at $173 billion annually.
A new study published in npj Digital Medicine found that an interactive artificial pancreas system, using digital twins, improved blood sugar control and reduced hemoglobin A1c levels in type 1 diabetes patients. The system adapts to users' changing bodies and allows them to test changes to the system's parameters in a safe simulation ...
A new study from Karolinska Institutet found that infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence. Children with neurological health problems had almost six times the risk of death compared to healthy children.
A University of Oxford study found that an intensive low-energy diet programme significantly improved eating disorder symptoms in people with type 2 diabetes and excess weight at risk of developing eating disorders. The programme showed benefits persisting six months after completion.
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
The small intestine's epithelial cells and immune cells work together to maintain gut integrity and regulate immune responses. Dysfunction in these cellular networks is linked to systemic diseases such as obesity, insulin resistance, and autoimmune conditions.
Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.
New research shows that weight stigma and not weight itself have the biggest impact on mental health and healthy behaviors in patients after weight-loss surgery. This reduction in weight stigma is linked to improvements in both mental and physical health, including lower levels of anxiety and depression.
The Greaux Healthy initiative aims to prevent and treat childhood obesity through partnerships with healthcare providers, educators, and families. The program has developed tools and resources for four priority populations, including expectant families, preschool-aged children, school-aged children, and adolescents and young adults.
A new study found that nearly one-third of individuals adopting healthy diets didn't lose weight but still experienced significant improvements in cardiometabolic markers, including increased HDL cholesterol and reduced visceral fat. The research suggests a healthy diet can have benefits beyond weight loss.
The Endocrine Society supports the bipartisan legislation to ensure people living with obesity have access to effective treatments. The bill will cover anti-obesity medications and intensive behavioral therapy, addressing the chronic disease's complications like cancer, type 2 diabetes, and heart disease.
The CONFIDENCE trial demonstrates that combination therapy with finerenone and empagliflozin leads to significantly greater reductions in albuminuria than either agent alone. The study shows a 52% median reduction in urinary albumin-to-creatinine ratio, achieving the ADA-recommended target for 70% of patients.
Scientists have uncovered fast chemical reactions in living cells that may protect against cell damage. These reactions involve the amino acid cysteine and could lead to new anti-aging strategies.
A new study found that excessive oleic acid in olive oil drives fat cell growth, increasing the risk of obesity. High levels of oleic acid stimulate the proliferation of precursor cells that form new fat cells, leading to a larger capacity for storing excess nutrients.
A new study published in Nature Medicine suggests that individual differences in blood sugar responses to various carbohydrates can indicate specific metabolic health subtypes. These subtypes are associated with different levels of insulin resistance or beta-cell dysfunction, which can contribute to prediabetes and Type 2 diabetes.
A large study has found that cholesterol-lowering drugs do not have an antidepressive effect, contradicting previous small studies. The research, published in JAMA Psychiatry, involved 161 patients with depression and obesity, who received either statins or a placebo for 12 weeks.
Researchers have discovered a key marker, FXYD2, that identifies functional maturity and heterogeneity of stem cell-derived islet organoids. This breakthrough enables quality control for production of transplantable islets, advancing the field toward safer and more effective islet replacement therapies.
Researchers at Weizmann Institute of Science discovered that nerve cells can sense mechanical forces in fat tissue, regulating brown fat activity and influencing energy balance. Mice lacking this sensing ability were resistant to obesity and metabolic conditions.
A 12-week study found that chickpea consumption improved cholesterol levels, while eating black beans reduced inflammation in adults with prediabetes. The researchers suggest incorporating beans into daily diets as a simple way to reduce chronic disease risk.
A new study published in the American Society for Nutrition found that higher linoleic acid levels were associated with lower risks of heart disease and type 2 diabetes. The research used blood markers to measure linoleic acid levels in nearly 1,900 people, suggesting that this omega-6 fatty acid may support cardiometabolic health.
A Japanese study found that choosing the right type of meal can extend meal duration and encourage more mindful eating. Researchers discovered that traditional bento-style meals with individual components promoted longer meal times and more chewing compared to fast food.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
The study analyzed 14.7 million excess US deaths from 1980 to 2023, finding that rates remained higher than pre-pandemic levels. Excess deaths during and after the pandemic were largely driven by pre-existing causes such as drug overdose, firearm injury, and cardiometabolic disease.