Articles tagged with Metabolic Disorders
Researchers at Karolinska Institutet have identified two types of metabolic-associated fatty liver disease, a liver-specific type and a systemic type that affects other organs. The discovery could lead to improved diagnosis and treatment of this growing patient group, with potential benefits for cardiovascular health.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
Researchers at Wake Forest University School of Medicine found a strong association between living in disadvantaged neighborhoods and higher blood pressure and lower cognitive scores. The study analyzed data from over 500 adults aged 55+ and used the Area Deprivation Index to measure neighborhood disadvantage.
A new study proves a suspected link between poor sleep and MASLD, a liver disorder that affects 30% of adults. Patients with MASLD experience significant sleep fragmentation, waking up 55% more often at night.
Researchers created an animal model with a targeted mtDNA mutation to advance understanding of mitochondrial genetic disorders. The study found significant changes in brain structure and function, as well as metabolic abnormalities, linking mitochondrial dysfunction to cognitive-metabolic impairments.
Researchers at St. Jude Children's Research Hospital identified a key role for glutamine in red blood cell development and disease. Glutamine metabolism plays a critical role in removing toxic byproducts, such as ammonium, that can accumulate during heme production.
Dr. Philip Gold's landmark paper reveals depression's full-body impact, documenting structural brain changes and disruptions in hormone systems. His analysis highlights interconnected mechanisms underlying the disease, opening new therapeutic possibilities for innovative treatments targeting neuroendocrine dysfunction.
Researchers from UAB have developed a gene therapy that reverses metabolic dysfunction-associated steatohepatitis (MASH) in mice, and most obese and type 2 diabetic patients could benefit from this treatment. The therapy, based on the fibroblast growth factor 21 protein, mediates long-term reversal of liver fibrosis and MASH.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
A new study found compositional and functional differences in the gut microbiota of Chinese long-living adults (over 90 years) compared to elderly adults (65–74 years). The researchers noted lower relative abundances of bacteria in certain genera, which may regulate biological processes like autophagy and telomere maintenance. These fi...
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers developed a mouse model mimicking the liver symptoms of myotonic dystrophy type 1, revealing fatty liver disease and hypersensitivity to medications. The study found that a gene regulating fat synthesis is misspliced in affected livers, providing potential treatment pathways.
Researchers found inhibiting ACMSD increases NAD+ levels, reducing inflammation and fibrosis in mouse models of MASLD/MASH. Boosting NAD+ production could protect against severe liver damage and cirrhosis.
A team of scientists from NTU Singapore and HKU found that electro-acupuncture can reverse the effects of obesity in obese individuals and mice on a high fat diet. The treatment targets osteoprotegerin, a protein linked to fat cell formation and obesity development.
A recent study published in Liver Cancer found that patients with diabetes mellitus and comorbid obesity are at a higher risk of liver cancer recurrence after resection. The risk is significantly higher for those with comorbid obesity, increasing by approximately 3.8 times over five years postoperatively.
A randomized controlled trial found that time-restricted eating (TRE) led to greater improvements in glucose control, weight loss, and fat reduction compared to standard nutrition counseling in adults with metabolic syndrome. TRE resulted in a lower risk of muscle mass loss during weight loss.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
A new study found that childhood trauma can have specific consequences for biological health and risk of developing 20 major diseases later in life. The study's findings differ by sex and type of stressor, highlighting the need for a precision medicine approach based on patients' sex and specific stress profile.
A study found that every 1% decrease in BMI leads to a 4% reduction in cardiovascular risk. Blood sugar control also lowers the risk of chronic kidney disease independently of weight change.
Scientists at St. Jude Children's Research Hospital have elucidated the structural mechanism of URAT1, a protein linked to gout, using cryo-electron microscopy. The findings reveal how URAT1 transports urate and offer new insights for developing more effective treatments for gout.
Researchers at the University of Copenhagen have identified a protein called OSER1 that influences longevity in various animals and humans. The discovery opens up possibilities for understanding age-related diseases and developing new drug targets.
Scientists discovered the highest natural blood sugar levels in mammals, found in a species of bats that can survive on a diet rich in sugars. The study's findings suggest that these bats have evolved unique strategies for glucose regulation, which may hold potential for managing metabolic diseases in humans.
A study published in Annals of Internal Medicine found that approximately 61% of Medicare-eligible adults have a BMI of 27 or higher, making them eligible for semaglutide. However, the number of patients who will be eligible depends on how cardiovascular disease is defined, with narrow definitions resulting in only 3.6 million people b...
Scientists at IOCB Prague have developed a new compound that suppresses appetite and protects the brain against Alzheimer's disease. The modified molecule, derived from the neuropeptide CART, is effective in reducing pathology associated with Alzheimer's.
A nationwide cohort study of 254,670 Chinese adults aged 40-80 years reveals significant interactions between age, gender, and sleep duration on lipid levels. The study highlights the importance of considering age in studies of gender differences in metabolic diseases and advocates for personalized prevention and management strategies.
A smartphone healthcare application was found to be more effective for weight loss among non-walkers. Participants who did not have a walking habit at baseline were more likely to achieve successful weight loss with the app, possibly due to increased physical activity triggered by notifications.
The study compared FDG-PET/CT and CT for evaluating treatment response in unresectable malignant pleural mesothelioma patients. The results showed that both imaging modalities provided accurate findings for tumor response evaluation, with high concordance between the two methods.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Nutrition 2024 will explore the role of diet in exercise performance, brain health, and disease prevention. Researchers will share emerging findings on the relationships between specific foods and chronic diseases.
Researchers emphasize the importance of addressing socioeconomic, cultural, and epigenetic factors in the Latin American obesity epidemic. The study suggests that public policies and strategies must acknowledge these drivers for effective weight loss.
The SELECT Trial found semaglutide to significantly reduce the risk of kidney-related complications and improve kidney function in individuals with overweight or obesity and cardiovascular disease. The study revealed that semaglutide's ability to prevent macroalbuminuria was a key factor in reducing kidney-related events.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
Researchers evaluated anemia cases using stringent clinical and laboratory criteria, identifying rare congenital sideroblastic anemias and nonsideroblastic iron defects with pathogenic gene mutations. This study highlights the importance of active screening and awareness for these conditions in the Indian subcontinent.
A new study reveals that high consumption of ultraprocessed foods among young children is strongly associated with increased adiposity and other cardiometabolic risk factors. The findings highlight the need for targeted public health initiatives to encourage healthier eating habits and reduce the burden of diet-related diseases.
Researchers are studying the early brain development of babies born to mothers with diabetes to understand the link between prenatal exposure and later childhood obesity. They aim to identify key differences in brain structure and function that may contribute to the increased risk of obesity.
Global life expectancy is forecasted to increase from 73.6 years in 2022 to 78.1 years in 2050, with a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and other communicable diseases.
Researchers at Karolinska Institutet have discovered a new class of drugs that block mitochondrial function and reverse diet-induced obesity, fatty liver, and diabetes in mice. The treatment increased fat metabolism, leading to drastic weight loss and restored glucose tolerance.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A massive study of over 200,000 participants found associations between metabolic dysregulation and long-term risk of depression, anxiety, and stress-related disorders. These findings suggest that individuals with metabolic issues may require closer follow-up for psychiatric diagnosis prevention.
The American Society for Nutrition is offering complimentary press passes to its annual flagship meeting, NUTRITION 2024. The event will explore cutting-edge advances in nutrition research, practice, and policy.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
Researchers found that a high-fat diet suppresses the expression of a key protein in the gut, leading to inflammation and increased risk of Alzheimer's. Managing diabetes may be key to preventing or slowing down dementia symptoms.
A team led by Kristina Petersen and Penny Kris-Etherton found that eating avocados daily significantly increased participants' adherence to dietary guidelines. The study suggested that using avocados as a substitute for refined grains and sodium may play a role in achieving improved diet quality.
Researchers have identified a gene responsible for the development of starvation-induced fatty liver in cavefish, which are able to protect their liver due to reduced fat accumulation. This genetic basis has implications for understanding and addressing liver conditions in humans, including Type 2 diabetes and obesity.
The American Society for Biochemistry and Molecular Biology's annual meeting features exciting research findings on antibacterial compounds, whooping cough infection, nicotine addiction, and more. Complementary on-site press passes will be issued to a limited number of attendees.
Researchers at York University found that women with both high-risk human papillomavirus (HPV) and metabolic syndrome are at a significantly higher risk of mortality. The study analyzed data from over 5,000 individuals and found that those with both conditions had a 2.6 times higher risk for mortality than those without either condition.
A recent study investigated eating habits and physical activity in colorectal cancer (CRC) patients with overweight/obesity. The results show that these patients have higher prevalence of metastasis, recurrence, and death compared to eutrophic patients.
Healthcare providers must prioritize patient experience to improve diabetes care. This includes explaining treatment options and considering each patient's level of health literacy and cultural background.
A study found that 670 nanometres of red light stimulated energy production within mitochondria, leading to increased glucose consumption and a 27.7% reduction in blood glucose levels. This non-invasive technique has the potential to impact diabetes control by reducing damaging fluctuations of blood glucose.
Researchers at Memorial Sloan Kettering Cancer Center have engineered CAR T cells to target senescent cells, which can lead to chronic inflammation with aging. The treatment improved metabolic function in older mice and prevented decline later in life, suggesting potential benefits for diseases associated with aging.
Researchers at Karolinska Institutet developed a method to study liver function and disease using the cornea of mice eyes. They transplanted liver cells into the eyes, creating a non-invasive platform to monitor liver health over time.
A new review suggests that female reproductive characteristics, such as early menstruation and polycystic ovary syndrome, may contribute to later metabolic dysfunction. The study highlights the importance of screening for reproductive risk factors to aid in prevention or treatment of chronic metabolic diseases.
A novel cleavage mechanism of SREBP-1c was elucidated, revealing regulation by saturated and polyunsaturated fatty acids. The RHBDL4-SREBP-1c pathway improves fatty liver pathophysiology in mice with a high-fat diet.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers identified key factors contributing to long-term lung dysfunction in COVID-19 patients, including hypoxia, systemic inflammation and metabolic syndrome. The study highlights the importance of multidisciplinary treatment approaches for individuals with LONG-COVID.
A randomized trial found that consuming tree nuts as snacks reduced waist circumference, improved lipid biomarkers, and decreased insulin levels in young adults. Daily tree nut consumption was associated with a 42% reduction in metabolic syndrome risk in males and a 67% reduction in females.
Researchers have discovered a bidirectional interaction between amyloid-beta protein and sulfatides that may play a key role in the development of Alzheimer