Articles tagged with Metabolic Disorders
Research in mice found that early-life gut microbes shape insulin-producing cell development and reduce long-term changes in metabolism and diabetes risk. Exposure to a fungus called Candida dubliniensis during infancy may also promote lifelong metabolic health by supporting the growth of insulin-producing cells.
Women with disturbed eating behaviours and low physical activity have more central body fat and increased risk of metabolic inflammation, which can lead to cardiovascular disease. Exercise and flexible eating habits may reduce visceral fat and prevent disease when combined.
Researchers discovered a gene called Plvap enables the body's metabolic shift from burning sugar to fat when fasting. When Plvap is turned off, the liver continues burning sugar, potentially increasing the effectiveness of weight-loss and diabetes medications.
Researchers developed Janus-type supramolecules that form stable ribbon-type assemblies, guiding the arrangement of ion channels across lipid membranes. The supramolecular channels mediate efficient and selective K+ transport, disrupting cancer cell balance and inducing apoptosis.
A national poll found that three-fourths of employees with chronic conditions need to manage their health during work hours, but a majority have not told their employer. The poll highlights challenges such as missed opportunities and stigma, as well as difficulties in caring for family members with chronic conditions.
A new study from the Salk Institute has discovered that a protein called BCL6 plays a crucial role in maintaining healthy muscle mass. Increasing BCL6 levels successfully reversed muscle losses in mice, suggesting that pairing GLP-1 medications with a BCL6-boosting drug could help counteract unwanted muscle loss.
Research reveals that normal term birth triggers a cellular process involving glutamine metabolism in neural stem cells, which is impaired by preterm birth. This process affects postnatal neurogenesis and may contribute to worse neurodevelopmental outcomes in preterm infants.
A team of researchers at Georgia State University has identified a novel group of neurons controlling the brain-heart-gut axis that can be activated to induce a hypometabolic state resembling hibernation. This discovery could have wide-ranging impacts on scientific fields, including obesity and cardiometabolic health.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.
A recent study discovered that assessing an individual's perceived walking speed relative to peers can identify those at risk of metabolic diseases. Faster walkers had lower risks of diabetes, hypertension, and dyslipidemia.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
Researchers used STOC-T to visualize retinal microcirculation in real-time, providing insights into the mechanisms of retinal function. The study offers a groundbreaking opportunity for precise monitoring of hemodynamic changes in the retina, enabling early detection and treatment of diseases such as Alzheimer's and Parkinson's.
Dr. Gerta Hoxhaj has been recognized with the 2025 Mary Beth Maddox Award and Lectureship for her groundbreaking work on cancer metabolism. Her research focuses on understanding the connections between signaling networks and metabolic pathways in cancer cells, revealing new mechanisms crucial for tumor growth.
Researchers at Université de Montréal's CRCHUM discovered that inhibiting a key brain enzyme can reduce body weight and improve physical activity in mice. The study suggests that targeting specific neuronal pathways in the brain could be crucial for fighting obesity and metabolic disorders.
Researchers at Karolinska Institutet have identified two types of metabolic-associated fatty liver disease, a liver-specific type and a systemic type that affects other organs. The discovery could lead to improved diagnosis and treatment of this growing patient group, with potential benefits for cardiovascular health.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
Researchers at Wake Forest University School of Medicine found a strong association between living in disadvantaged neighborhoods and higher blood pressure and lower cognitive scores. The study analyzed data from over 500 adults aged 55+ and used the Area Deprivation Index to measure neighborhood disadvantage.
A new study proves a suspected link between poor sleep and MASLD, a liver disorder that affects 30% of adults. Patients with MASLD experience significant sleep fragmentation, waking up 55% more often at night.
Researchers created an animal model with a targeted mtDNA mutation to advance understanding of mitochondrial genetic disorders. The study found significant changes in brain structure and function, as well as metabolic abnormalities, linking mitochondrial dysfunction to cognitive-metabolic impairments.
Researchers at St. Jude Children's Research Hospital identified a key role for glutamine in red blood cell development and disease. Glutamine metabolism plays a critical role in removing toxic byproducts, such as ammonium, that can accumulate during heme production.
Dr. Philip Gold's landmark paper reveals depression's full-body impact, documenting structural brain changes and disruptions in hormone systems. His analysis highlights interconnected mechanisms underlying the disease, opening new therapeutic possibilities for innovative treatments targeting neuroendocrine dysfunction.
Researchers from UAB have developed a gene therapy that reverses metabolic dysfunction-associated steatohepatitis (MASH) in mice, and most obese and type 2 diabetic patients could benefit from this treatment. The therapy, based on the fibroblast growth factor 21 protein, mediates long-term reversal of liver fibrosis and MASH.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
A new study found compositional and functional differences in the gut microbiota of Chinese long-living adults (over 90 years) compared to elderly adults (65–74 years). The researchers noted lower relative abundances of bacteria in certain genera, which may regulate biological processes like autophagy and telomere maintenance. These fi...
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers developed a mouse model mimicking the liver symptoms of myotonic dystrophy type 1, revealing fatty liver disease and hypersensitivity to medications. The study found that a gene regulating fat synthesis is misspliced in affected livers, providing potential treatment pathways.
Researchers found inhibiting ACMSD increases NAD+ levels, reducing inflammation and fibrosis in mouse models of MASLD/MASH. Boosting NAD+ production could protect against severe liver damage and cirrhosis.
A team of scientists from NTU Singapore and HKU found that electro-acupuncture can reverse the effects of obesity in obese individuals and mice on a high fat diet. The treatment targets osteoprotegerin, a protein linked to fat cell formation and obesity development.
A recent study published in Liver Cancer found that patients with diabetes mellitus and comorbid obesity are at a higher risk of liver cancer recurrence after resection. The risk is significantly higher for those with comorbid obesity, increasing by approximately 3.8 times over five years postoperatively.
A randomized controlled trial found that time-restricted eating (TRE) led to greater improvements in glucose control, weight loss, and fat reduction compared to standard nutrition counseling in adults with metabolic syndrome. TRE resulted in a lower risk of muscle mass loss during weight loss.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
A new study found that childhood trauma can have specific consequences for biological health and risk of developing 20 major diseases later in life. The study's findings differ by sex and type of stressor, highlighting the need for a precision medicine approach based on patients' sex and specific stress profile.
A study found that every 1% decrease in BMI leads to a 4% reduction in cardiovascular risk. Blood sugar control also lowers the risk of chronic kidney disease independently of weight change.
Scientists at St. Jude Children's Research Hospital have elucidated the structural mechanism of URAT1, a protein linked to gout, using cryo-electron microscopy. The findings reveal how URAT1 transports urate and offer new insights for developing more effective treatments for gout.
Researchers at the University of Copenhagen have identified a protein called OSER1 that influences longevity in various animals and humans. The discovery opens up possibilities for understanding age-related diseases and developing new drug targets.
Scientists discovered the highest natural blood sugar levels in mammals, found in a species of bats that can survive on a diet rich in sugars. The study's findings suggest that these bats have evolved unique strategies for glucose regulation, which may hold potential for managing metabolic diseases in humans.
A study published in Annals of Internal Medicine found that approximately 61% of Medicare-eligible adults have a BMI of 27 or higher, making them eligible for semaglutide. However, the number of patients who will be eligible depends on how cardiovascular disease is defined, with narrow definitions resulting in only 3.6 million people b...
Scientists at IOCB Prague have developed a new compound that suppresses appetite and protects the brain against Alzheimer's disease. The modified molecule, derived from the neuropeptide CART, is effective in reducing pathology associated with Alzheimer's.
A nationwide cohort study of 254,670 Chinese adults aged 40-80 years reveals significant interactions between age, gender, and sleep duration on lipid levels. The study highlights the importance of considering age in studies of gender differences in metabolic diseases and advocates for personalized prevention and management strategies.
A smartphone healthcare application was found to be more effective for weight loss among non-walkers. Participants who did not have a walking habit at baseline were more likely to achieve successful weight loss with the app, possibly due to increased physical activity triggered by notifications.
The study compared FDG-PET/CT and CT for evaluating treatment response in unresectable malignant pleural mesothelioma patients. The results showed that both imaging modalities provided accurate findings for tumor response evaluation, with high concordance between the two methods.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Nutrition 2024 will explore the role of diet in exercise performance, brain health, and disease prevention. Researchers will share emerging findings on the relationships between specific foods and chronic diseases.
Researchers emphasize the importance of addressing socioeconomic, cultural, and epigenetic factors in the Latin American obesity epidemic. The study suggests that public policies and strategies must acknowledge these drivers for effective weight loss.
The SELECT Trial found semaglutide to significantly reduce the risk of kidney-related complications and improve kidney function in individuals with overweight or obesity and cardiovascular disease. The study revealed that semaglutide's ability to prevent macroalbuminuria was a key factor in reducing kidney-related events.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
Researchers evaluated anemia cases using stringent clinical and laboratory criteria, identifying rare congenital sideroblastic anemias and nonsideroblastic iron defects with pathogenic gene mutations. This study highlights the importance of active screening and awareness for these conditions in the Indian subcontinent.
A new study reveals that high consumption of ultraprocessed foods among young children is strongly associated with increased adiposity and other cardiometabolic risk factors. The findings highlight the need for targeted public health initiatives to encourage healthier eating habits and reduce the burden of diet-related diseases.
Researchers are studying the early brain development of babies born to mothers with diabetes to understand the link between prenatal exposure and later childhood obesity. They aim to identify key differences in brain structure and function that may contribute to the increased risk of obesity.
Global life expectancy is forecasted to increase from 73.6 years in 2022 to 78.1 years in 2050, with a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and other communicable diseases.
Researchers at Karolinska Institutet have discovered a new class of drugs that block mitochondrial function and reverse diet-induced obesity, fatty liver, and diabetes in mice. The treatment increased fat metabolism, leading to drastic weight loss and restored glucose tolerance.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A massive study of over 200,000 participants found associations between metabolic dysregulation and long-term risk of depression, anxiety, and stress-related disorders. These findings suggest that individuals with metabolic issues may require closer follow-up for psychiatric diagnosis prevention.
The American Society for Nutrition is offering complimentary press passes to its annual flagship meeting, NUTRITION 2024. The event will explore cutting-edge advances in nutrition research, practice, and policy.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
Researchers found that a high-fat diet suppresses the expression of a key protein in the gut, leading to inflammation and increased risk of Alzheimer's. Managing diabetes may be key to preventing or slowing down dementia symptoms.