Articles tagged with Metabolic Disorders
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
A recent study from Houston Methodist reveals how Alzheimer's can disrupt the connection between nerves and blood vessels in fat tissue, worsening heart and metabolic conditions. The research highlights a potential link between neurodegeneration and cardiovascular and metabolic disorders.
The Louisiana ECHO program, which focuses on pre-, peri- and postnatal outcomes, obesity, and other areas, will continue its efforts to expand access to clinical trials for Louisiana children. The grant renewal supports the collaboration between researchers from Pennington Biomedical and Ochsner Health System, as well as two free-stand...
A new study from Virginia Tech found that weightlifting outmuscles running for blood sugar control in diabetes models. The research compared the effects of endurance and resistance exercise in mice fed a high-fat diet and found that weightlifting was more effective in reducing subcutaneous and visceral fat, improving glucose tolerance,...
The European Society of Endocrinology (ESE) has announced the winners of the 2026 ESE Awards, which recognize outstanding contributions to improving knowledge and expertise in endocrinology. This year's winners include Martin Reincke for his work on neuroendocrinology and Maria-Christina Zennaro for her research on hypertension.
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
Researchers have discovered that HSL plays an unexpected role in the nucleus of fat cells, helping maintain healthy adipose tissue. This new understanding challenges 60 years of certainty about fat metabolism and offers avenues for better understanding metabolic diseases such as obesity.
The National Institutes of Health has renewed Pennington Biomedical's Metabolic Basis of Disease Center for five years, providing $2.2M per year to support research on the mechanisms of metabolic health. The center aims to address the obesity epidemic and its related illnesses.
Researchers developed innovative 3D dynamic cell co-culture models to simulate MASLD progression stages, addressing traditional 2D culture limitations. Pro-inflammatory macrophages were identified as drivers of hepatocyte lipid metabolism disruption.
A study published in Science Advances found that the ketogenic diet can have potentially dangerous impacts on metabolic health, including impaired blood sugar regulation and fatty liver disease. Mice fed the diet developed severe metabolic complications, with some changes starting within days.
A new study has identified a leptin-sensitive brain circuit in the lateral hypothalamus that helps animals overcome anxiety to perform essential behaviors such as eating, exploring, and limiting maladaptive hyperactivity. Boosting the activity of these neurons can restore adaptive choices even under conditions that cause anxiety.
Researchers developed innovative blood-based biomarkers to predict long-term blood pressure improvements after bariatric surgery. The study analyzed pre-surgery blood tests and identified top 10 molecules linked to improved blood pressure outcomes.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
Researchers have identified a cellular mechanism that transmits mitochondrial DNA mutations, which can cause serious and incurable diseases. A potential treatment is proposed to target the enzyme USP30, reducing the risk of mitochondrial disease transmission.
The four-day training program equipped postdoctoral fellows with state-of-the-art methods for clinical research in obesity, metabolism and nutrition. Participants deepened their skills in gold-standard methodologies crucial for advancing clinical and translational research.
A new study shows that just 30 minutes of less sitting per day can improve the body's ability to utilize fats and carbohydrates for energy production. Participants who successfully reduced sedentary time showed improvements in metabolic flexibility and fat burning during light-intensity exercise.
Researchers have developed a new mRNA vaccine technology using albumin-recruiting lipid nanoparticles to deliver vaccines precisely to lymph nodes, avoiding liver toxicity. The approach outperformed traditional delivery systems in laboratory tests, producing strong antitumor T-cell responses and high levels of neutralizing antibodies.
A study of 5,794 adults found that different types of depression are associated with varying levels of risk for cardiometabolic diseases. Those with atypical/energy-related symptoms were more likely to develop Type-2 diabetes, while those with melancholic symptoms were at higher risk for cardiovascular disease.
A growing number of patients on GLP-1 receptor agonists may experience altered FDG uptake patterns on oncological PET-CT scans, potentially leading to misdiagnosis. Researchers recommend documenting medication histories to inform interpretation and developing national guidance.
A new report highlights the potential of precision medicine to improve obesity prevention and treatment by identifying high-risk individuals and tailoring interventions. The authors emphasize the need for rigorous clinical trials to empirically determine the effectiveness of precision-based treatments.
Research presents evidence suggesting that metabolically active visceral fat is associated with more advanced stages of endometrial cancer and lymph node metastases. The study found no strong correlation between visceral fat volume and its metabolic activity.
A repeated cross-sectional study shows that cardiometabolic risk factors in Spanish children have improved over the last 30 years, with decreases in excess weight, lipid parameters, and blood pressure. The study provides valuable insights into the evolution of cardiometabolic risk in children.
Researchers exploring how exercise stress affects cellular adaptations and disease risk, focusing on mitochondrial energy sensing and AMPK activation. The study aims to determine if increasing mitoAMPK activity can mitigate diabetes in skeletal muscle.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
A simple blood analysis can predict the risk of developing severe liver disease, enabling earlier detection and potentially improving treatment outcomes. The CORE model, developed by Karolinska Institutet researchers, is based on three routine blood tests and has been shown to be highly accurate in predicting liver disease risk.
The study reveals that Christensenella tenuis significantly reduces LPS levels and improves glucose and lipid metabolism in diet-induced obesity mice. It achieves this through a distinct bile acids-LPS interaction, preventing LPS from translocating into the bloodstream.
The latest Global Burden of Disease study reveals a significant increase in cardiovascular disease (CVD) burden worldwide, with CVD causing one in three deaths globally. The report estimates that 79.6% of all CVD deaths are attributable to modifiable risk factors, which has increased globally by 97.4 million since 1990.
Zhiqiang Lin, Ph.D., receives a $300,000 AHA grant to investigate VGLL4's role in protecting the liver from fatty liver disease. The study aims to slow MASH progression to liver failure, potentially improving quality of life for millions suffering from the illness.
Researchers have identified a new population of hypothalamic neurons, Crabp1 neurons, that play a critical role in regulating energy expenditure. Silencing these neurons leads to reduced energy expenditure and obesity, while activating them enhances locomotor activity and protects against high-fat diet-induced weight gain.
A new study published in JAMA Network Open shows that regular phone support after losing weight is crucial for maintaining weight loss. Participants who received monthly phone calls maintained an average of 8% weight loss from their starting weight, with about 60% keeping off at least 5% of their initial weight.
A recent study analyzing data from the Mexican National Health and Nutrition Surveys (2016-2023) found that cardiovascular disease risk increased in Mexico between 2016 and 2023. The average 10-year CVD risk was estimated at 9.5% using region-specific tools, highlighting the need for accurate models to predict local disease burden.
A new study found that high blood pressure, pre-diabetes or Type 2 diabetes, and low HDL cholesterol are the three deadliest cardiometabolic risk factors for MASLD patients, with risks of death increasing by 40%, 25%, and 15% respectively. The study used data from the National Health and Nutrition Examination Survey to reach its conclu...
Metabolic bariatric surgery shows promise as a cost-effective weight loss option for class II and III obesity patients. The study found bariatric surgery resulted in greater weight loss compared to GLP-1 receptor agonists.
A Cleveland Clinic study found that bariatric surgery offers greater long-term benefits compared to GLP-1 medicines, including lower risks of death, heart disease, and kidney failure. Patients who underwent weight-loss surgery experienced better blood sugar control and relied less on diabetes medications over 10 years.
A study reveals how PGC-1α protein and estrogen work together to boost thermogenesis in females, outperforming males. This finding highlights a sex-specific mechanism of energy metabolism and suggests new therapeutic targets for obesity and diabetes prevention.
Researchers found that four common PFAS triggered fat buildup and cancer-related changes, with effects differing by sex. Liver cells from male and female donors responded differently to PFAS exposure.
The 2025 Childhood Obesity Conference, hosted by Pennington Biomedical's Greaux Health initiative, aims to educate healthcare providers and promote healthier futures for Louisiana's children through cutting-edge research and evidence-based strategies. Participants can earn up to 7.5 CMEs and gain practical tools to support healthier fu...
UCSF researchers develop a new strategy to prime CAR T cell therapy by combining it with diabetes drugs, increasing the efficacy of NECTIN4-CAR T cells in treating urothelial carcinoma. The study shows that using thiazolidinediones enhances NECTIN4 expression, making tumor cells more susceptible to the treatment.
A recent study found that green tea extract improved glucose sensitivity and insulin resistance in obese mice, preserving muscle morphology. The treatment reduced body weight by up to 30% and increased the expression of genes related to glucose metabolism, suggesting a selective effect on excess body fat.
Researchers at King's College London have discovered that cells use electricity to selectively target and eliminate the weakest neighbours, helping to maintain a balanced and healthy protective layer. This process, known as extrusion, is crucial for balancing cell division and death, and disrupting it can lead to disease.
A new 'metabolic clock' uses data from over 13,500 participants to predict a person's biological age and detect early markers of disease. The tool analyzes blood samples using NMR metabolomics and machine learning to estimate health parameters.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
Cachexia affects connections between brain and immune system, reducing motivation in cancer patients. Patient-reported symptoms are invaluable data points that may help researchers better understand disease progression.
Human cells use a synchronized traffic control system to monitor nutrient levels and precisely control cellular energy balance, blood sugar levels, and energy management. This finding offers promising new targets for treating diabetes and cancer.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
Researchers discovered mutations in the SPNS1 gene disrupt cellular recycling, leading to progressive liver and muscle damage. The study offers fresh hope for treatment and sheds light on the importance of phospholipid recycling in maintaining energy balance.
Researchers used CRISPR gene editing to bring back a human lost gene that breaks down uric acid, a waste product causing gout and related health issues. The study showed promising results in lowering uric acid levels and preventing fat buildup in liver cells.
Researchers developed a sensor that detects acetone levels in breath to diagnose diabetes and prediabetes. The sensor can provide results in a few minutes without requiring a visit to a doctor's office or lab work.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
Researchers have identified over 400 genes linked to accelerated aging, including subtypes such as cognitive decline and metabolic problems. The findings support the 'geroscience hypothesis' and suggest that treating aging itself may be key to preventing chronic illnesses.
Researchers discovered a significant association between metabolic syndrome and an increased risk of Parkinson's disease. The study found that people with metabolic syndrome were about 40% more likely to develop the disease than those without it.
Researchers at UVA Health System are developing AI-based systems that can automatically detect meals and deliver insulin doses. The goal is to create fully automated artificial pancreas systems that require minimal user interaction.
Researchers uncover a critical endocrine link between brown adipocytes and pancreatic β-cells, revealing the ZNF638-RBP4-retinol-ATRA pathway's role in T1D pathogenesis. Targeting this axis may halt disease progression.
A new study found that adolescents with higher blood levels of per- and polyfluoroalkyl substances (PFAS) prior to bariatric surgery regained more weight and had greater increases in waist circumference up to five years after surgery. Researchers believe PFAS exposure disrupts endocrine and metabolic processes, leading to weight regain.
A University of Houston study found that positive childhood experiences, such as supportive relationships and regular household routines, can protect against disordered eating behaviors in college students. Adverse childhood experiences, including abuse and neglect, were also linked to increased risk factors for disordered eating.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
Researchers have developed a groundbreaking method to observe lysosomes in live suspended cells—quantitatively, in 3D, and without the use of chemical labels. The technology uses holographic tomography in flow cytometry configuration (HTFC) to identify morphological and spatial lysosomal changes in models of lysosomal storage diseases.
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.