Articles tagged with Metabolic Disorders
A repeated cross-sectional study shows that cardiometabolic risk factors in Spanish children have improved over the last 30 years, with decreases in excess weight, lipid parameters, and blood pressure. The study provides valuable insights into the evolution of cardiometabolic risk in children.
Researchers exploring how exercise stress affects cellular adaptations and disease risk, focusing on mitochondrial energy sensing and AMPK activation. The study aims to determine if increasing mitoAMPK activity can mitigate diabetes in skeletal muscle.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
A simple blood analysis can predict the risk of developing severe liver disease, enabling earlier detection and potentially improving treatment outcomes. The CORE model, developed by Karolinska Institutet researchers, is based on three routine blood tests and has been shown to be highly accurate in predicting liver disease risk.
The study reveals that Christensenella tenuis significantly reduces LPS levels and improves glucose and lipid metabolism in diet-induced obesity mice. It achieves this through a distinct bile acids-LPS interaction, preventing LPS from translocating into the bloodstream.
The latest Global Burden of Disease study reveals a significant increase in cardiovascular disease (CVD) burden worldwide, with CVD causing one in three deaths globally. The report estimates that 79.6% of all CVD deaths are attributable to modifiable risk factors, which has increased globally by 97.4 million since 1990.
Researchers have identified a new population of hypothalamic neurons, Crabp1 neurons, that play a critical role in regulating energy expenditure. Silencing these neurons leads to reduced energy expenditure and obesity, while activating them enhances locomotor activity and protects against high-fat diet-induced weight gain.
Zhiqiang Lin, Ph.D., receives a $300,000 AHA grant to investigate VGLL4's role in protecting the liver from fatty liver disease. The study aims to slow MASH progression to liver failure, potentially improving quality of life for millions suffering from the illness.
A new study published in JAMA Network Open shows that regular phone support after losing weight is crucial for maintaining weight loss. Participants who received monthly phone calls maintained an average of 8% weight loss from their starting weight, with about 60% keeping off at least 5% of their initial weight.
A new study found that high blood pressure, pre-diabetes or Type 2 diabetes, and low HDL cholesterol are the three deadliest cardiometabolic risk factors for MASLD patients, with risks of death increasing by 40%, 25%, and 15% respectively. The study used data from the National Health and Nutrition Examination Survey to reach its conclu...
A recent study analyzing data from the Mexican National Health and Nutrition Surveys (2016-2023) found that cardiovascular disease risk increased in Mexico between 2016 and 2023. The average 10-year CVD risk was estimated at 9.5% using region-specific tools, highlighting the need for accurate models to predict local disease burden.
Metabolic bariatric surgery shows promise as a cost-effective weight loss option for class II and III obesity patients. The study found bariatric surgery resulted in greater weight loss compared to GLP-1 receptor agonists.
A Cleveland Clinic study found that bariatric surgery offers greater long-term benefits compared to GLP-1 medicines, including lower risks of death, heart disease, and kidney failure. Patients who underwent weight-loss surgery experienced better blood sugar control and relied less on diabetes medications over 10 years.
A study reveals how PGC-1α protein and estrogen work together to boost thermogenesis in females, outperforming males. This finding highlights a sex-specific mechanism of energy metabolism and suggests new therapeutic targets for obesity and diabetes prevention.
Researchers found that four common PFAS triggered fat buildup and cancer-related changes, with effects differing by sex. Liver cells from male and female donors responded differently to PFAS exposure.
The 2025 Childhood Obesity Conference, hosted by Pennington Biomedical's Greaux Health initiative, aims to educate healthcare providers and promote healthier futures for Louisiana's children through cutting-edge research and evidence-based strategies. Participants can earn up to 7.5 CMEs and gain practical tools to support healthier fu...
UCSF researchers develop a new strategy to prime CAR T cell therapy by combining it with diabetes drugs, increasing the efficacy of NECTIN4-CAR T cells in treating urothelial carcinoma. The study shows that using thiazolidinediones enhances NECTIN4 expression, making tumor cells more susceptible to the treatment.
A recent study found that green tea extract improved glucose sensitivity and insulin resistance in obese mice, preserving muscle morphology. The treatment reduced body weight by up to 30% and increased the expression of genes related to glucose metabolism, suggesting a selective effect on excess body fat.
Researchers at King's College London have discovered that cells use electricity to selectively target and eliminate the weakest neighbours, helping to maintain a balanced and healthy protective layer. This process, known as extrusion, is crucial for balancing cell division and death, and disrupting it can lead to disease.
A new 'metabolic clock' uses data from over 13,500 participants to predict a person's biological age and detect early markers of disease. The tool analyzes blood samples using NMR metabolomics and machine learning to estimate health parameters.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
Cachexia affects connections between brain and immune system, reducing motivation in cancer patients. Patient-reported symptoms are invaluable data points that may help researchers better understand disease progression.
Human cells use a synchronized traffic control system to monitor nutrient levels and precisely control cellular energy balance, blood sugar levels, and energy management. This finding offers promising new targets for treating diabetes and cancer.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
Researchers discovered mutations in the SPNS1 gene disrupt cellular recycling, leading to progressive liver and muscle damage. The study offers fresh hope for treatment and sheds light on the importance of phospholipid recycling in maintaining energy balance.
Researchers used CRISPR gene editing to bring back a human lost gene that breaks down uric acid, a waste product causing gout and related health issues. The study showed promising results in lowering uric acid levels and preventing fat buildup in liver cells.
Researchers developed a sensor that detects acetone levels in breath to diagnose diabetes and prediabetes. The sensor can provide results in a few minutes without requiring a visit to a doctor's office or lab work.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
Researchers have identified over 400 genes linked to accelerated aging, including subtypes such as cognitive decline and metabolic problems. The findings support the 'geroscience hypothesis' and suggest that treating aging itself may be key to preventing chronic illnesses.
Researchers discovered a significant association between metabolic syndrome and an increased risk of Parkinson's disease. The study found that people with metabolic syndrome were about 40% more likely to develop the disease than those without it.
Researchers at UVA Health System are developing AI-based systems that can automatically detect meals and deliver insulin doses. The goal is to create fully automated artificial pancreas systems that require minimal user interaction.
Researchers uncover a critical endocrine link between brown adipocytes and pancreatic β-cells, revealing the ZNF638-RBP4-retinol-ATRA pathway's role in T1D pathogenesis. Targeting this axis may halt disease progression.
A new study found that adolescents with higher blood levels of per- and polyfluoroalkyl substances (PFAS) prior to bariatric surgery regained more weight and had greater increases in waist circumference up to five years after surgery. Researchers believe PFAS exposure disrupts endocrine and metabolic processes, leading to weight regain.
A University of Houston study found that positive childhood experiences, such as supportive relationships and regular household routines, can protect against disordered eating behaviors in college students. Adverse childhood experiences, including abuse and neglect, were also linked to increased risk factors for disordered eating.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
Researchers have developed a groundbreaking method to observe lysosomes in live suspended cells—quantitatively, in 3D, and without the use of chemical labels. The technology uses holographic tomography in flow cytometry configuration (HTFC) to identify morphological and spatial lysosomal changes in models of lysosomal storage diseases.
A technology expert predicts AI-based medicine will revolutionise care for Alzheimer’s and diabetes, but access must be made available to all patients. The author highlights key innovations such as diagnostic imaging and surgical robots that will aid in more accurate diagnoses and treatments.
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
A team of Canadian scientists has discovered a molecule produced by microbes in the gut that fuels the liver to make more glucose and fat than necessary. Trapping this molecule using a safe, biodegradable polymer improves blood sugar control and reduces fatty liver disease in mice with obesity.
The American Heart Association has launched a nationwide initiative to tackle cardiovascular disease, focusing on 15 regions across the US. The Cardiovascular-Kidney-Metabolic Health Initiative aims to improve treatment of interconnected conditions leading to heart disease and stroke.
The conference will feature keynote speakers Donna Ryan and Erik Wilson, as well as informative presentations and breakout sessions on the latest advances in obesity research. The Louisiana Obesity Society aims to support healthcare providers treating obesity through education and networking.
The 2025 Critical Path Institute Global Impact Conference will bring together industry, regulatory agencies, academia, and patient advocacy groups to discuss pressing challenges in drug development. The event aims to foster cross-sector collaboration to advance medical innovation and improve treatment outcomes for patients.
A new study identified neurobeachin as a genetic predictor of weight loss response to GLP-1RAs. The findings have the potential to advance obesity care and provide more effective, personalized treatment options.
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
Research warns that GLP-1 drugs may not provide the long-term health benefit of improved heart and lung function. While they help with weight loss, patients may experience significant muscle loss, which can increase cardiovascular disease risk. Doctors are urging additional research to better understand the effects of these drugs.
Research reveals a direct connection between diabetic peripheral neuropathy and skeletal health, linking nerve damage to reduced cell signaling. The study shows that diabetic mice with nerve damage had weakened bones due to impaired nerve-bone communication.
A University of Cincinnati researcher is investigating how excess sugar impacts cardiovascular structure and function in people with diabetes. The study focuses on a protein called GLUT1, which becomes overactive in diabetes, leading to harmful changes at the cellular level.
The study found a significant increase in extremely severe obesity among US children and adolescents, leading to severe metabolic and cardiovascular complications. Extremely severe obesity was linked to conditions like metabolic dysfunction-associated steatotic liver disease, prediabetes or diabetes, and metabolic syndrome.
The bariatric weight reduction surgery medical tourism industry lacks regulation, posing safety, ethical, and legal risks for patients. Many patients self-refer for the procedure due to high costs in their home country, and there's often a lack of preoperative and postoperative follow-up.
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
A new study found that intermittent energy restriction significantly improved fasting blood glucose and triglycerides, while also increasing insulin sensitivity. The IER group showed the greatest advantages in reducing these markers compared to time-restricted eating and continuous energy restriction groups.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.