Articles tagged with Metabolic Disorders
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
Professor Thierry Chevalley has received the prestigious IOF President's Award for his significant contributions to advancing bone health and osteoporosis prevention. With extensive research expertise in geriatrics and bone health, he serves on various scientific committees and leads efforts to develop fracture liaison services.
Research suggests that exercising at a time that matches an individual's natural chronotype (morning or evening alertness) can lower cardiovascular disease risk. The study found that chronotype-aligned exercise improved blood pressure, fasting glucose, cholesterol levels, and sleep quality more effectively than mismatched timing.
The Pennington Generation study aims to explore the impact of physical activity, nutrition, and sleep on children's health and growth. The study will examine how these behaviors relate to weight gain and obesity over time.
Research in mice suggests artificial sweeteners can affect gut microbiome and gene expression, potentially impacting metabolic health. The study found that offspring of mice fed sucralose or stevia had altered gene expression linked to inflammation and metabolism.
Researchers compare viral and MASLD cirrhosis pathogenic mechanisms, identifying shared pathways and diagnostic differences. The study aims to establish a framework for prevention, diagnosis, treatment, and monitoring of MASLD cirrhosis.
Salk Institute researchers have developed a new biological platform for studying mitochondrial DNA in human physiology, adaptation, and therapeutic development. The platform allows scientists to investigate mitochondrial DNA variation in health and disease, enabling therapeutic innovation for mitochondrial disorders.
A team from SickKids discovered a therapeutic target in fat tissue that improves cellular function and reduces inflammation. Low-dose homoharringtonine treatment selectively eliminates senescent cells, improving metabolic problems and preserving lean mass.
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
The new brain–heart clinical practice guideline provides a holistic approach to managing chronic diseases by integrating neurologic and mental health evidence with cardiovascular guidance. The guideline aims to improve the management of patients with concurrent brain and heart diseases, which often co-occur and share similar risk factors.
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
A study found that late sleep schedules are linked to unhealthy eating habits, including increased calorie intake and snacking, as well as reduced physical activity, particularly during school hours. The researchers suggest that parents should pay attention to their children's sleep timing during adolescence.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
The Endocrine Society supports the INSULIN Act to address insulin affordability, setting a $35 monthly cap for people with private insurance and creating a program for uninsured individuals. The bill aims to reduce insulin prices by encouraging competition in the market.
A new study by Finnish researchers found that lower hemoglobin levels within the normal range may be beneficial for glucose metabolism and cardiovascular health. The study, conducted on 64 adults, revealed an association between lower hemoglobin levels and improved physical fitness, heart health, and reduced liver fat.
Researchers have identified a key protein that activates brown fat by expanding blood vessels and nerves, which can regulate body temperature and is linked to weight loss. The findings suggest a new approach to treating obesity that deviates from suppressing appetite.
A new study published in JAMA Pediatrics finds that children with obesity but without metabolic complications still face a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life. Treatment can greatly benefit these children, reducing the risk of future diseases.
Children with metabolically healthy obesity at treatment initiation have an increased risk of type 2 diabetes, hypertension, and dyslipidemia. Reduction in BMI z score is associated with reduced cardiometabolic risk, suggesting treatment should be recommended for these children as well.
A Korea University study reveals that liver metabolic disease is a key risk factor for heart failure in older adults with atrial fibrillation, with MASLD having the lowest risk and ALD carrying the highest risk. The study highlights the importance of liver health in cardiovascular disease management.
Maintaining a healthy lifestyle, including a high-quality diet, moderate exercise, and low alcohol consumption, was associated with lower cardiometabolic disease risk. The study found that adhering to these healthy behaviors reduced the risk of major cardiometabolic diseases independent of medication use.
Activation of hypoxia signaling improved metabolism and limited fat accumulation in obese mice, while preserving vascular networks and bone health. The intervention also enhanced fracture healing and glucose tolerance, suggesting a dual beneficial effect on metabolism and bone integrity.
Researchers developed an expert consensus to standardize the use of ultrasound-derived fat fraction for assessing liver steatosis. The study found that UDFF showed strong correlations with histological steatosis grades and MRI-PDFF, demonstrating excellent reliability and robust diagnostic accuracy.
A concerning rise in adolescent obesity has been found, with overall rates climbing to 15.9% in 2023. Obesity patterns also reveal a decline in weight-loss attempts, with females more likely to attempt weight loss but fewer adolescents reporting efforts in 2023.
A Japanese registry study reveals widespread underdiagnosis and undertreatment of metabolic acidosis in chronic kidney disease patients. Nearly half of patients with bicarbonate measured had metabolic acidosis, and diagnosis and treatment rates were low, highlighting a need for routine bicarbonate testing in CKD care.
Researchers developed a comprehensive genetic risk calculator for metabolic disease by integrating genetic data from hundreds of thousands of people worldwide. The polygenic risk score outperformed existing disease-prediction models and predicted downstream morbidity and clinical interventions, particularly in non-European populations.
A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide does not lead to significant weight regain in clinical practice. Many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
Women with cardiometabolic risk factors such as type 2 diabetes and high waist circumference face a higher risk of liver fibrosis, with rates increasing 11-fold and 2.8-fold compared to men. The study highlights the importance of managing these risk factors for liver health beyond heart disease prevention.
The Greaux Healthy initiative, launched by Pennington Biomedical Research Center, aims to prevent and treat childhood obesity in Louisiana. Studies show that childhood obesity is a national healthcare crisis in Louisiana, with over 1 in 3 children living with overweight or obesity.
Salk Institute researchers identified Med14, a protein connected to GLP-1 drug effects on pancreatic beta cells, leading to improved viability, insulin production, and stress resistance. The study suggests a potential molecular link between GLP-1 drugs and broader benefits, including type 2 diabetes susceptibility genes.
Semaglutide and tirzepatide prescriptions increased dramatically between 2018 and 2025, while MBS use rates declined substantially starting in 2023. Recent shifts in MBS use may be more pronounced in certain patient subgroups, such as those seeking sleeve gastrectomy or with lower BMIs.
A recent study has shed light on the processes that drive mitochondrial uptake and its benefits for cells. Isolated mitochondria were found to be taken up by mesenchymal stromal cells, enhancing proliferation and cytoprotection, and improving energy metabolism.
A new study introduces an innovative imaging tracer that identifies shifts in fat usage for energy, shedding light on aggressive cancers' lipid-based metabolism. This discovery could lead to targeted therapeutic interventions and improved patient outcomes.
A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.
A new study has identified an altered expression of specific genes in individuals with obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and liver fibrosis. The research team found that inhibiting the gene expression can reduce liver fibrosis, offering a potential new treatment option.
A ketogenic diet reduced high blood sugar and improved aerobic capacity in mice with hyperglycemia. The diet caused remodeling of their muscles, making them more oxidative and reactive to aerobic exercise. Researchers believe that combining the keto diet with exercise may be key to achieving optimal health benefits.
A new American Heart Association scientific statement projects that nearly 6 in 10 US women will have some type of cardiovascular disease by 2050, driven by rising rates in high blood pressure and other health factors. The economic burden is expected to be at least $200 billion annually.
A new study by Harvard T.H. Chan School of Public Health and the Department of Veterans Affairs Boston Healthcare System found that using GLP-1 receptor agonists in combination with adhering to healthy lifestyle habits significantly reduces cardiovascular risk among individuals with type 2 diabetes. The study showed that these two stra...
Researchers developed an ultrathin mesh of conductive wires to help lab-grown pancreatic cells mature and function properly. The approach, called 'cyborg' transplants, has the potential to expand the supply of new tissue and reduce rejection risk.
A group of nerve cells in the brainstem has been identified as a stabilizing system for blood pressure, preventing fluctuations between daily activities. The study suggests that loss or dysfunction of these cells can lead to unstable blood pressure and is associated with conditions such as multiple system atrophy.
Researchers at Gladstone Institutes discovered that red blood cells act as glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates. This adaptation fuels efficient oxygen delivery to tissues while lowering blood sugar levels.
Syzygium jambolanum extracts demonstrate significant protective and antidiabetic effects, improving glycaemic control and metabolic health. The study reveals a systemic protective effect beyond glucose lowering alone.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
A new Cochrane review suggests that intermittent fasting may not be an effective strategy for weight loss in overweight or obese adults. The study found no meaningful difference in weight loss between intermittent fasting and traditional dietary advice or doing nothing, highlighting the need for more research into this area.
University of Pittsburgh scientists discovered a way to fight insulin resistance and diabetes by protecting a special type of immune cell in fat tissue. By improving insulin sensitivity in mice, the research reveals a potential new treatment path for type 2 diabetes that could supplement GLP-1 drugs.
Researchers at PolyU have identified a key driver of tumour growth in liver cancer and developed a monoclonal antibody that neutralises this protein. The antibody inhibits the growth and proliferation of FABP4-driven cancer stem cells, enhancing immune cell activity.
University of Toronto researchers highlight the importance of studying child obesity, gut bacteria, and metabolic conditions to prevent youth-onset diabetes. They emphasize the need for personalized interventions tailored to individual microbiome profiles.
The collaboration aims to accelerate the development of small molecule inhibitors for treating metabolic diseases. Insilico will utilize its Pharma.AI platform to design and optimize novel molecules, while Qilu will handle subsequent development and commercialization.
A phase 2 clinical trial is comparing three strategies to protect heart health in prostate cancer patients undergoing hormone therapy. The study will assess the impact of intermittent fasting, GLP-1 medication, and nutritional counseling on cardiovascular and metabolic risks associated with androgen deprivation therapy.
Researchers have found a nonlinear dose-response relationship between exercise and hepatic steatosis, indicating that a combination of aerobic and resistance exercises can produce clinically meaningful improvements. The study suggests that exercising above 130 MET-min/week can lead to significant reductions in hepatic steatosis.
The W8Buddy study, a major real-world evaluation of digitally delivered specialist weight management pathways, is recruiting 450 participants from 4 Specialist Weight Management Services across England and Wales. The study aims to assess the long-term health benefits and economic impact of digital tools for obesity care.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
Researchers found that CD47 knockdown improves glucose homeostasis and alleviates dyslipidemia in aged male mice by reducing visceral fat and enhancing brown fat tissue function. This breakthrough suggests CD47 as a key regulator of age-related metabolic dysfunction.
Obesity is a chronic health condition associated with harm to health, affecting more than one-third of the US population. A new American Heart Association scientific statement emphasizes socioeconomic and structural barriers to obesity prevention and management.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
Researchers have discovered a novel drug candidate that can reverse metabolic liver disease and fibrosis, addressing a critical gap in treatment options. The compound, EVT0185, has been shown to control blood sugar levels, reduce cholesterol, and destroy fat build-up that causes liver fibrosis.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
A study published in PNAS found that over 60% of pairs of damaging genetic variants can restore enzyme activity when combined, challenging long-held assumptions about genetics. This phenomenon, known as intragenic complementation, has implications for rare disease diagnosis and treatment.