Articles tagged with Metabolic Disorders
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A new review analyzes the efficacy of current non-invasive methods for assessing non-alcoholic fatty liver disease (NAFLD) and associated conditions. Blood-based biomarker tests and imaging methods are explored, with some showing promise in early diagnosis and staging liver disorders.
A recent study published in the Journal of Endocrinology suggests that lowering blood glucose levels can partially restore reproductive hormone levels and ovulation in female mice with obesity. The study used dapagliflozin, a common type 2 diabetes medication, to treat the mice, resulting in improved fertility outcomes.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
Researchers studied cavefish genome-wide map of liver tissue to understand metabolism evolution and its potential applications for humans. The study found striking similarities in metabolic adaptations among cavefish populations, raising questions about universal adaptation mechanisms that could be triggered in other species like humans.
A Brazilian study analyzing data from 3,875 elderly men and women found that weak muscles combined with abdominal obesity can indicate an early sign of functional decline. The study suggests that monitoring simple actions such as sitting down, standing up, walking short distances may help identify this condition.
A new study has found that adults with asthma are more likely to become obese later in life. The research, which included over 8,700 participants from 11 European countries and Australia, revealed that non-allergic asthma, longer disease duration, and corticosteroid treatment were associated with increased obesity risk.
Researchers have developed a new optical microscopy platform that allows them to visually track the timing and location of fat storage within intact cells of fruit flies. The tool is being used to untangle links between diet and phenomena like obesity, diabetes, and aging.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
Researchers found that alterations in gut microbiota can help treat pancreatic and hormonal dysfunction in diabetes patients. The study showed that antibiotics treatment can improve insulin sensitivity and reduce glucose intolerance in obese mice and humans.
A digital training program improved movement behavior, physical activity, and mental well-being in participants, while also reducing anxiety levels. The study, conducted by Goethe University Frankfurt, found that the program was particularly effective when used with professional trainers and regular questionnaires.
Dr Nicholas Fuggle, a UK researcher, has been awarded the prestigious ESCEO-IOF Pierre Meunier Young Scientist Award for his significant contributions to research in musculoskeletal ageing. He is recognized for his work on determinants of musculoskeletal ageing and digital healthcare.
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
The IOF Skeletal Rare Diseases Academy has awarded grants to six young researchers for their outstanding work on rare skeletal disorders. The awards recognize the importance of advancing knowledge and diagnosis for these conditions.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
Researchers found that female mice produce more of the FPR2 protein, which helps prevent NAFLD, and that estrogen mediates its production. This discovery highlights the need for sex-balanced animal experiments and could lead to novel treatments and gender-based therapies for NASH
A large US survey found a strong association between e-cigarette use and prediabetes, with users having higher prevalence of high-risk lifestyle factors and worse health status. The study's findings challenge the promotion of e-cigarettes as a safer smoking alternative.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A study found that specific bacterial groups from the Lachnospiraceae family were associated with an increased risk of developing type 2 diabetes. The research used machine learning techniques and analyzed fecal samples from a large Finnish population cohort, identifying microbial biomarkers that predicted disease incidence.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.
A new federally funded study will use machine learning to create a first-of-its-kind algorithm predicting individual responses to food and dietary routines. The National Institutes of Health's All of Us Research Program will recruit 10,000 participants nationwide.
A Cleveland Clinic study found that prior weight loss achieved with bariatric surgery was associated with a 60% lower risk of developing severe COVID-19. Patients who underwent weight-loss surgery had better clinical outcomes, including reduced hospitalization and need for supplemental oxygen.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
A study led by Children's Hospital of Philadelphia researchers used stem cells to implicate several genes involved in bodily functions associated with the hypothalamus. The findings could help clinicians identify potential causes of dysfunction for traits regulated by the hypothalamus, such as sleep and stress.
Researchers from the University of Tsukuba found that lifestyle factors such as smoking, alcohol consumption, and sedentary behavior significantly increase the risk of developing metabolic syndrome in non-obese individuals. Similar risk factors were identified for both obese and lean individuals, highlighting the importance of healthy ...
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers discovered that childhood cancer patients treated with abdominal or total body irradiation exhibit abnormalities in their adipose tissue, similar to those found in obese individuals with cardiometabolic disease. This suggests that strategies to reduce radiation dose to fat may be necessary to prevent long-term dysfunction i...
Research suggests COVID-19 pandemic has adverse effects on women's menstrual cycles due to stress and sleep disturbance. Women are experiencing increased rates of depression, anxiety, and poor sleep.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
The Society for Endocrinology's annual conference will feature world-leading scientific and clinical research on endocrine clinical practice. The event will showcase the latest innovations in endocrine medicine, including Medal and Award lectures by renowned experts.
The Rutgers-NYU Center for Asian Health Promotion and Equity aims to address significant disparities in the Asian community's relationship with heart health and mental health. The center will focus on cardiometabolic disease and mental health research to inform practice and policy at local, regional, and national levels.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
A controlled trial found that consuming an avocado daily for 12 weeks reduced visceral abdominal fat and the ratio of visceral to subcutaneous fat in female participants. The benefits were primarily seen in females, with no impact on glucose tolerance or male participants.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
A recent study found that rates of minor lower extremity amputations increased between 2009 and 2017 in rural and Western American residents, Native Americans, and Asian Americans/Pacific Islanders. Major LEAs rates remained steady during the period with notable increases in White populations and rural areas.
Researchers at Radboud University have identified new biomarkers for pyridoxine-dependent epilepsy, enabling better and earlier treatment of the disease. The discovery could lead to optimized treatment and improved chances of preventing cognitive disability.
Researchers at Heidelberg University successfully introduced a rare genetic mutation into a fish model to study the causes of complex metabolic diseases. The study found that supplying fully functional ALG2 mRNA could reverse the genetic defect, allowing analysis of individual function areas of the enzyme.
Scientists have developed a Japanese rice fish model to study congenital disorders of glycosylation, including ALG2-CDG. The model replicates symptoms such as neuronal problems and retinitis pigmentosa, and demonstrates that supplying fully-functional Alg2 can prevent defects.
An international team identified an error in the cytochrome P450 oxidoreductase (POR) gene as the cause of aromatase deficiency, a rare metabolic disorder. This discovery enables precise therapy and prevents side effects associated with steroid supplementation.
Researchers have identified acid ceramidase as a key enzyme in the production of psychosine, a toxic glycolipid that accumulates in people with Krabbe disease. Removing or inhibiting this enzyme has been shown to decrease or eliminate psychosine production and disease symptoms.
A large-scale genome-wide association study identifies eight genetic variants associated with anorexia nervosa, suggesting a combination of metabolic and psychiatric components. The findings encourage considering metabolism in understanding the disorder's causes and improving treatment approaches.
A global genome-wide association study identified eight genetic variants linked to anorexia nervosa, revealing a complex interplay between metabolic and psychiatric factors. The research suggests that integrating metabolic information may help clinicians develop better treatment approaches for this potentially lethal illness.
A study by researchers at the CNIC reveals a new mechanism in intestinal bacteria regulation that prevents inflammation and promotes mutual benefit. The findings suggest that certain bacteria, such as Lactobacillus, strengthen the intestinal barrier through interaction with receptor Mincle.
Grickscheit aims to develop an 'off-the-shelf' stem cell-based therapy that might not require immunosuppression, a substantial step forward for metabolic liver disease. The UPLiFT investigation will test the effective dose and regimen of the therapy.
A new study found that longer daily fasting times improved health and longevity in male mice, with benefits seen across different diets and calorie consumption levels. The researchers also discovered that extended fasting periods enabled repair and maintenance mechanisms, which may help prevent age-related metabolic disorders.
Researchers report that tadpoles and adult female frogs exposed to endocrine disruptors develop metabolic disorders. Exposure leads to delayed metamorphosis, lower reproductive success, and smaller offspring.
Douglas Wallace receives the award for his pioneering work in mitochondrial genetics, leading to insights into human genealogy and implications for treating metabolic and degenerative diseases. The recognition acknowledges the crucial role of mitochondrial DNA genetics and bioenergetics in common disease etiology.
A study of over 189,000 initially healthy women found that working rotating night shifts for 5 years or more was associated with a small increase in coronary heart disease risk. The researchers also discovered waning risk after cessation of shift work and decreased risk among those who quit earlier.
A team of scientists discovered a molecular switch that regulates the body's circadian clock, allowing it to keep time. The 'phosphoswitch' maintains clock speed despite temperature changes and metabolic signals.
Individuals with sex development disorders face challenges forming positive relationships due to physical differences. Researchers suggest raising public awareness of the diverse nature of bodies and providing practical support mechanisms, such as private locker rooms and support groups.
A new review in Nutrition in Clinical Practice outlines main principles of chronic nutrition management of inherited metabolic disorders, highlighting failure to follow specific dietary treatment can lead to complications and death. Registered dietitians play a crucial role in the multi-disciplinary team delivering care to these patients.
MU researchers have catalogued the effects of abnormal enzymes responsible for one type of glycogen storage disease in humans. Their study, published in The Journal of Biological Chemistry, provides promising early-stage results that could aid in patient prognosis and therapeutic development.
A comprehensive computer model of human metabolism has been developed, connecting the dots between the human genome and metabolism. The Recon 2 model advances understanding of human metabolism in health and disease, enabling identification of biomarkers and prediction of drug side effects.
Researchers at VIB and Oxyrane have created a new technology that produces enzymes for metabolic disorders like Pompe disease more efficiently than current treatments. The novel method uses yeast cells instead of mammalian cells, resulting in 17 times more efficient absorption by patient cells.
A team of researchers has discovered a genetic defect in the RMND1 gene linked to severe neurodegenerative disorders. The study reveals mutations in this gene can lead to early death in infants and has implications for understanding later-onset neurological diseases.
A new treatment for argininosuccinic aciduria (ASA) has been discovered through nitric oxide supplementation. The study found long-term heart and neuropsychological improvements in mice and humans afflicted with ASA, a genetic metabolic disorder that causes ammonia accumulation and liver and nervous system damage.
Researchers created a zebrafish model to study Maple Syrup Urine Disease, which causes brain injury and severe dystonia. The model reveals abnormal swimming behavior and neurotransmitter imbalances, shedding light on disease mechanisms.
A new test can identify biomarkers for mucopolysaccharidoses (MPS), a group of inherited metabolic disorders, allowing for earlier diagnosis and potentially more effective treatment. The test detects specific carbohydrate structures in cells, blood, and urine samples, enabling differentiation between forms of the disease.
Scientists have developed flies with genetic changes similar to those found in patients with galactosemia, allowing researchers to study the disease and develop potential treatments. These models can help understand how sugar metabolism leads to disease and open the door to novel drug discovery.