Articles tagged with Metabolic Disorders
A study published in Nature reveals that cysteine depletion disrupts metabolic pathways, forcing cells to rapidly burn fat stores. The research also highlights the role of coenzyme A (CoA) in shaping metabolism and provides insights into potential future obesity solutions.
A study found that children exposed to higher levels of air pollution experienced rapid weight gain and higher BMI by age 13, leading to increased insulin resistance in their mid-20s. The study suggests early interventions can help reduce the risk of chronic disease.
A study published in Cell Metabolism finds that a combination of gut bacteria and acetate reduces obesity in mice. The researchers discovered that the specific combination of Bacteroides species and acetate leads to increased fat burning and reduced sugar storage, resulting in weight loss.
A child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy, showcasing the power of tailored gene editing to treat patients. The infant is now growing well and thriving after receiving three doses of the therapy with no serious side effects.
A study by Leipzig University researchers has provided high-resolution insights into the energy balance of brain neurons during spreading depolarizations. The findings show that even in 'healthy' brain tissue, these waves cause a temporary drop in ATP levels.
Researchers at the University of Oklahoma discovered that FGF21 can reverse fatty liver disease in mice by sending signals to both the brain and liver. The study provides valuable insight into the mechanism of action of FGF21, a target for a new class of highly anticipated drugs.
Researchers at Wayne State University are developing a new treatment to prevent diabetic corneal complications, which can lead to vision loss and poor healing. The project combines two naturally occurring peptides to target inflammation, delayed healing, and nerve degeneration.
A new University of Georgia study found that Black Americans with high blood pressure and diabetes in midlife had significantly higher levels of a dementia-related biomarker over an 11-year period. Early intervention for these chronic health conditions could protect brain health and reduce neurodegenerative diseases later in life.
A 72-week clinical trial found tirzepatide to be more effective than semaglutide in reducing body weight and waist circumference. The study demonstrated that tirzepatide's dual mechanism of action, mimicking both GLP-1 and GIP hormones, is key to its superior performance.
Estrogen-related receptors play a crucial role in regulating muscle cell metabolism and energy production. Researchers discovered that these receptors can increase mitochondrial numbers and enhance energetic output when muscles need more energy, making them a promising therapeutic target for metabolic disorders.
Women who experience menopause before age 50 are at higher risk of developing fatty liver disease and its related metabolic risk factors. The study found that early menopause is associated with increased risks of pre-diabetes, obesity, hypertension, and dyslipidemia.
Pregnant women with fatty liver disease are at an increased risk of giving birth prematurely, with a threefold higher risk compared to the general population. The study also found that women with fatty liver disease had a 63% higher risk of caesarean section.
A new NIH study found that maternal cardiometabolic health before and during pregnancy is associated with higher blood pressure in children. The study analyzed data from 12,480 mother-child pairs and identified three key risk factors: pre-pregnancy obesity, gestational diabetes, and high blood pressure during pregnancy.
The American Society for Nutrition's annual conference will showcase the latest research on nutrition science and its applications. NUTRITION 2025 will highlight key areas such as chronic pain, ultra-processed foods, obesity medicines, and adolescent health, featuring expert discussions and research updates.
A cohort study of 12,480 mother-offspring pairs found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy are associated with increased offspring blood pressure. These risk factors may also promote a faster rate of blood pressure change from age 2 to 18 years.
A new study from the Keck School of Medicine of USC found that children born to mothers with obesity, gestational diabetes, and hypertensive disorders have higher systolic and diastolic blood pressure. The study's findings suggest that early blood pressure interventions could start as early as pregnancy.
Researchers found that silencing Mitch, a key regulator of mitochondrial fusion, increases cellular respiration and burns more fats and carbohydrates. In human cells, deleting Mitch leads to increased muscular endurance and a decrease in fat accumulation.
A systematic review of 46 clinical studies with 4,113 participants found that automated insulin delivery (AID) systems improved time in target range and reduced elevated glucose values compared to conventional pump therapy. However, low efficacy was observed during periods with very low glucose levels.
Researchers identified six risk groups for cardiometabolic complications in older people without type 2 diabetes, with a special high-risk group characterized by inflammation and insulin resistance. The study emphasizes the need for precise early detection and prevention strategies.
Research found that bad habits like smoking, heavy drinking, and lack of exercise can lead to declines in health as young as 36, with effects more pronounced over the long-term. The study tracked hundreds of people for 30 years and found that three unhealthy behaviors were linked to poorer mental and physical health.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
A study published in Journal of Proteome Research reveals that inflammation and aging contribute to the development of non-viral liver cancer. Researchers analyzed gene expression and metabolites in normal and affected samples, identifying potential therapeutic targets for chemoprevention.
Researchers discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective treatment. Restoring this mechanism prevents progression of HFpEF and alleviates lipid overload in heart cells, providing molecular evidence for a promising therapeutic...
Twelve young researchers from around the world receive ESCEO-IOF Young Investigator Awards for their groundbreaking studies on osteoporosis. The prestigious awards were presented during the World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2025) in Rome, Italy.
AMMOM has been recognized by the IOF for its significant contributions to osteoporosis awareness and bone health in Mexico. The organization has collaborated extensively with the IOF on various initiatives, including joint scientific meetings and advocacy efforts.
A clinical study confirms that early treatment with fosdenopterin/rcPMP significantly reduces the risk of early death and promotes healthy brain development in infants with MoCD type A. The therapy restores the missing molybdenum cofactor, leading to improved developmental milestones.
The American College of Physicians has awarded $260,000 in grants to support regional programs addressing equity challenges in obesity care. Thirteen grantees will implement collaborative outreach projects to train medical professionals and their patients to combat misinformation and improve clinical capacity for obesity care.
A new imaging technology has been developed that combines super-resolution imaging with artificial intelligence to reveal subcellular structures and dynamics in living cells. This breakthrough enables scientists to better understand the root causes of diseases, leading to improved treatments.
A team of Chinese researchers identified a novel intercellular signaling mechanism between adipocytes and hepatocytes in endoplasmic reticulum stress response. The study reveals that ceramide, a fat molecule, plays a key role in activating the unfolded protein response pathway in hepatocytes.
A new consensus paper emphasizes the role of bone turnover markers (BTMs) in diagnosing and managing osteoporosis. BTMs, such as procollagen type I N propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX-I), are invaluable tools for predicting fracture risk and monitoring treatment adherence.
A comprehensive study found that people with fatty liver disease have almost twice the mortality rate of the general population. The disease is caused by overweight or obesity and increases the risk of dying from various causes, including liver disease, cancer, cardiovascular disease, and infections.
A new study reveals that inhibiting gut cannabinoid receptor 1 (CB1R) can help protect the gut barrier and prevent alcohol-induced intestinal permeability. By targeting CB1R, researchers hope to develop a novel therapeutic approach for treating alcohol-related digestive disorders.
This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
A new study suggests that statins can reduce chest muscle loss in smokers, while aspirin may contribute to increased muscle loss. The study examined data from 4,191 participants and found that statins protected pectoralis muscle area and density, whereas aspirin led to decreased muscle mass.
Researchers found that a Western-style diet high in glycogen can fuel lung cancer tumors, leading to faster growth and worse outcomes. A nutrient-rich diet, active lifestyle, and reduced alcohol intake are recommended for lung cancer prevention.
Researchers have developed a powerful imaging technology to study cellular metabolism, enabling the visualization of biomolecules' synthesis and turnover in live cells and organisms. Heavy-water probing allows for the tracking of metabolic dynamics, providing insights into aging and age-related diseases.
Researchers found that PRP treatment increased gene expression related to metabolism, cell survival, and communication between cells in cumulus cells. This suggests that PRP may help support egg development and fertility in women with poor ovarian response.
The Shimadzu – DxD Hub Diagnomics Centre aims to accelerate the development of high-quality, cost-effective diagnostic solutions. It focuses on three key areas: infectious diseases, cancer, and metabolic disorders, with efforts to develop solutions for early disease detection and precision medicine approaches.
Researchers investigated the effects of electroacupuncture on gut microbiota and metabolomics in ALS patients, finding a reduction in Eisenbergiella abundance and improvements in Lachnospiraceae levels. The study suggests that this treatment may be beneficial for patients with ALS.
Research in mice found that early-life gut microbes shape insulin-producing cell development and reduce long-term changes in metabolism and diabetes risk. Exposure to a fungus called Candida dubliniensis during infancy may also promote lifelong metabolic health by supporting the growth of insulin-producing cells.
Women with disturbed eating behaviours and low physical activity have more central body fat and increased risk of metabolic inflammation, which can lead to cardiovascular disease. Exercise and flexible eating habits may reduce visceral fat and prevent disease when combined.
Researchers discovered a gene called Plvap enables the body's metabolic shift from burning sugar to fat when fasting. When Plvap is turned off, the liver continues burning sugar, potentially increasing the effectiveness of weight-loss and diabetes medications.
Researchers developed Janus-type supramolecules that form stable ribbon-type assemblies, guiding the arrangement of ion channels across lipid membranes. The supramolecular channels mediate efficient and selective K+ transport, disrupting cancer cell balance and inducing apoptosis.
A national poll found that three-fourths of employees with chronic conditions need to manage their health during work hours, but a majority have not told their employer. The poll highlights challenges such as missed opportunities and stigma, as well as difficulties in caring for family members with chronic conditions.
A new study from the Salk Institute has discovered that a protein called BCL6 plays a crucial role in maintaining healthy muscle mass. Increasing BCL6 levels successfully reversed muscle losses in mice, suggesting that pairing GLP-1 medications with a BCL6-boosting drug could help counteract unwanted muscle loss.
Research reveals that normal term birth triggers a cellular process involving glutamine metabolism in neural stem cells, which is impaired by preterm birth. This process affects postnatal neurogenesis and may contribute to worse neurodevelopmental outcomes in preterm infants.
A team of researchers at Georgia State University has identified a novel group of neurons controlling the brain-heart-gut axis that can be activated to induce a hypometabolic state resembling hibernation. This discovery could have wide-ranging impacts on scientific fields, including obesity and cardiometabolic health.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
A recent study discovered that assessing an individual's perceived walking speed relative to peers can identify those at risk of metabolic diseases. Faster walkers had lower risks of diabetes, hypertension, and dyslipidemia.
Researchers used STOC-T to visualize retinal microcirculation in real-time, providing insights into the mechanisms of retinal function. The study offers a groundbreaking opportunity for precise monitoring of hemodynamic changes in the retina, enabling early detection and treatment of diseases such as Alzheimer's and Parkinson's.
Dr. Gerta Hoxhaj has been recognized with the 2025 Mary Beth Maddox Award and Lectureship for her groundbreaking work on cancer metabolism. Her research focuses on understanding the connections between signaling networks and metabolic pathways in cancer cells, revealing new mechanisms crucial for tumor growth.
Researchers at Université de Montréal's CRCHUM discovered that inhibiting a key brain enzyme can reduce body weight and improve physical activity in mice. The study suggests that targeting specific neuronal pathways in the brain could be crucial for fighting obesity and metabolic disorders.
Researchers at Karolinska Institutet have identified two types of metabolic-associated fatty liver disease, a liver-specific type and a systemic type that affects other organs. The discovery could lead to improved diagnosis and treatment of this growing patient group, with potential benefits for cardiovascular health.
Researchers at Wake Forest University School of Medicine found a strong association between living in disadvantaged neighborhoods and higher blood pressure and lower cognitive scores. The study analyzed data from over 500 adults aged 55+ and used the Area Deprivation Index to measure neighborhood disadvantage.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
A new study proves a suspected link between poor sleep and MASLD, a liver disorder that affects 30% of adults. Patients with MASLD experience significant sleep fragmentation, waking up 55% more often at night.
Researchers created an animal model with a targeted mtDNA mutation to advance understanding of mitochondrial genetic disorders. The study found significant changes in brain structure and function, as well as metabolic abnormalities, linking mitochondrial dysfunction to cognitive-metabolic impairments.