Articles tagged with Metabolic Disorders
Researchers from University of South Australia found that porous silica can prevent fats and carbohydrates from being adsorbed in the body. Engineered particles of purified sand are designed to soak up digestive enzymes, fats, and sugars within the gastrointestinal tract.
The new guidelines, issued by the American Society for Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), recommend metabolic and bariatric surgery for individuals with a BMI of 35 or more, regardless of obesity-related conditions. The guidelines also endo...
The Vilcek Foundation has awarded $250,000 in prizes to four leading immigrant scientists: Alejandro Sánchez Alvarado, Edward Chouchani, Biyu J. He, and Shixin Liu. They received the 2023 Vilcek Foundation Prizes in Biomedical Science for their groundbreaking work in regeneration, metabolic disease, cognitive neuroscience, and nanoscal...
Researchers at the University of Cincinnati found a significant link between poor metabolic health and low breast milk production. Women with conditions like insulin resistance, high blood pressure, and obesity were more likely to experience persistent low milk supply despite best breastfeeding practices.
Children with obesity who lose weight show increased hunger-related brain activity, despite changes in gut hormone levels. This disconnect may underlie why many people regain weight after a strict diet, highlighting the need for targeted treatments.
People with diabetes face higher risk of hospitalization during extreme heat events due to dehydration and blood glucose imbalance. Research reveals a link between extreme heat and emergency hospitalizations for hypo- and hyperglycemia-related conditions.
Researchers at Tokyo Metropolitan University discovered that a protein excreted by type I muscle fibers can differentiate surrounding myoblasts into type I fibers, upending the notion that fiber ratios are fixed at birth. This finding has significant implications for treating conditions such as type 2 diabetes and aging populations.
A study by University of Basel researchers found that insufficient insulin production contributes to overweight, challenging the long-held belief that poor nutrition and lack of exercise cause weight gain. The research revealed a key enzyme's role in hormone activation, leading to severe hunger and obesity.
Researchers have identified a stream of messages between fat tissue and the brain, revealing a previously unknown pathway for adipose tissue to communicate with the brain. The discovery suggests that sensory neurons play a crucial role in regulating fat metabolism and may hold potential for treating obesity and metabolic diseases.
A team from the University of Tsukuba has developed a mouse model carrying a disease-associated mitochondrial mutation, which reveals that faulty RNA processing is responsible for metabolic disorders. The study provides new avenues for scientific discovery in understanding mitochondria and multiple diseases.
A study published in Cell found that a Western-style diet high in sugar alters the gut microbiome, leading to metabolic disease, pre-diabetes, and weight gain. Eliminating sugar from the diet restored the protective effects of Th17 immune cells, which were depleted by the sugar.
Researchers at Duke-NUS Medical School found that high levels of homocysteine in the liver correlate with severity of non-alcoholic steatohepatitis. Supplementing vitamin B12 and folic acid reversed inflammation and fibrosis in preclinical models.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
Researchers at University of Basel found that the sight and smell of a meal stimulate an inflammatory response in the brain, which affects insulin secretion. In overweight individuals, this response is excessive and can impair insulin function.
The International Osteoporosis Foundation proposes a screening strategy to identify women at high risk of hip fracture, which could lead to a reduction in treatment gaps and improved identification of fractures. The approach combines low-cost assessment with targeted intervention using low-cost generic treatments.
A recent study examined changes in Korean adults' diet quality and cardiometabolic risk factors from 2007 to 2018. The research found declining trends in diet quality and increasing risks of obesity, hypertension, and type 2 diabetes.
Research on wild Assamese macaques reveals that their gut bacteria composition changes uniquely with age, despite similar lifestyles. This finding suggests that the process is part of natural aging and not due to lifestyle changes, with potential implications for developing personalized therapies against intestinal diseases.
A cluster-randomised trial in Singapore showed a low-cost, multi-pronged intervention improved BP control, reduced cardiovascular risk and increased use of antihypertensive medications. The intervention could cut hypertension-linked morbidity and mortality globally with rapid scalability.
A new review analyzes the efficacy of current non-invasive methods for assessing non-alcoholic fatty liver disease (NAFLD) and associated conditions. Blood-based biomarker tests and imaging methods are explored, with some showing promise in early diagnosis and staging liver disorders.
A recent study published in the Journal of Endocrinology suggests that lowering blood glucose levels can partially restore reproductive hormone levels and ovulation in female mice with obesity. The study used dapagliflozin, a common type 2 diabetes medication, to treat the mice, resulting in improved fertility outcomes.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
Researchers studied cavefish genome-wide map of liver tissue to understand metabolism evolution and its potential applications for humans. The study found striking similarities in metabolic adaptations among cavefish populations, raising questions about universal adaptation mechanisms that could be triggered in other species like humans.
A Brazilian study analyzing data from 3,875 elderly men and women found that weak muscles combined with abdominal obesity can indicate an early sign of functional decline. The study suggests that monitoring simple actions such as sitting down, standing up, walking short distances may help identify this condition.
A new study has found that adults with asthma are more likely to become obese later in life. The research, which included over 8,700 participants from 11 European countries and Australia, revealed that non-allergic asthma, longer disease duration, and corticosteroid treatment were associated with increased obesity risk.
Researchers have developed a new optical microscopy platform that allows them to visually track the timing and location of fat storage within intact cells of fruit flies. The tool is being used to untangle links between diet and phenomena like obesity, diabetes, and aging.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
Researchers found that alterations in gut microbiota can help treat pancreatic and hormonal dysfunction in diabetes patients. The study showed that antibiotics treatment can improve insulin sensitivity and reduce glucose intolerance in obese mice and humans.
A digital training program improved movement behavior, physical activity, and mental well-being in participants, while also reducing anxiety levels. The study, conducted by Goethe University Frankfurt, found that the program was particularly effective when used with professional trainers and regular questionnaires.
Dr Nicholas Fuggle, a UK researcher, has been awarded the prestigious ESCEO-IOF Pierre Meunier Young Scientist Award for his significant contributions to research in musculoskeletal ageing. He is recognized for his work on determinants of musculoskeletal ageing and digital healthcare.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
The IOF Skeletal Rare Diseases Academy has awarded grants to six young researchers for their outstanding work on rare skeletal disorders. The awards recognize the importance of advancing knowledge and diagnosis for these conditions.
Researchers found that female mice produce more of the FPR2 protein, which helps prevent NAFLD, and that estrogen mediates its production. This discovery highlights the need for sex-balanced animal experiments and could lead to novel treatments and gender-based therapies for NASH
A large US survey found a strong association between e-cigarette use and prediabetes, with users having higher prevalence of high-risk lifestyle factors and worse health status. The study's findings challenge the promotion of e-cigarettes as a safer smoking alternative.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A study found that specific bacterial groups from the Lachnospiraceae family were associated with an increased risk of developing type 2 diabetes. The research used machine learning techniques and analyzed fecal samples from a large Finnish population cohort, identifying microbial biomarkers that predicted disease incidence.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.
A new federally funded study will use machine learning to create a first-of-its-kind algorithm predicting individual responses to food and dietary routines. The National Institutes of Health's All of Us Research Program will recruit 10,000 participants nationwide.
A Cleveland Clinic study found that prior weight loss achieved with bariatric surgery was associated with a 60% lower risk of developing severe COVID-19. Patients who underwent weight-loss surgery had better clinical outcomes, including reduced hospitalization and need for supplemental oxygen.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
A study led by Children's Hospital of Philadelphia researchers used stem cells to implicate several genes involved in bodily functions associated with the hypothalamus. The findings could help clinicians identify potential causes of dysfunction for traits regulated by the hypothalamus, such as sleep and stress.
Researchers from the University of Tsukuba found that lifestyle factors such as smoking, alcohol consumption, and sedentary behavior significantly increase the risk of developing metabolic syndrome in non-obese individuals. Similar risk factors were identified for both obese and lean individuals, highlighting the importance of healthy ...
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers discovered that childhood cancer patients treated with abdominal or total body irradiation exhibit abnormalities in their adipose tissue, similar to those found in obese individuals with cardiometabolic disease. This suggests that strategies to reduce radiation dose to fat may be necessary to prevent long-term dysfunction i...
Research suggests COVID-19 pandemic has adverse effects on women's menstrual cycles due to stress and sleep disturbance. Women are experiencing increased rates of depression, anxiety, and poor sleep.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
The Society for Endocrinology's annual conference will feature world-leading scientific and clinical research on endocrine clinical practice. The event will showcase the latest innovations in endocrine medicine, including Medal and Award lectures by renowned experts.
The Rutgers-NYU Center for Asian Health Promotion and Equity aims to address significant disparities in the Asian community's relationship with heart health and mental health. The center will focus on cardiometabolic disease and mental health research to inform practice and policy at local, regional, and national levels.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
A controlled trial found that consuming an avocado daily for 12 weeks reduced visceral abdominal fat and the ratio of visceral to subcutaneous fat in female participants. The benefits were primarily seen in females, with no impact on glucose tolerance or male participants.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
A recent study found that rates of minor lower extremity amputations increased between 2009 and 2017 in rural and Western American residents, Native Americans, and Asian Americans/Pacific Islanders. Major LEAs rates remained steady during the period with notable increases in White populations and rural areas.
Researchers at Radboud University have identified new biomarkers for pyridoxine-dependent epilepsy, enabling better and earlier treatment of the disease. The discovery could lead to optimized treatment and improved chances of preventing cognitive disability.
Researchers at Heidelberg University successfully introduced a rare genetic mutation into a fish model to study the causes of complex metabolic diseases. The study found that supplying fully functional ALG2 mRNA could reverse the genetic defect, allowing analysis of individual function areas of the enzyme.
Scientists have developed a Japanese rice fish model to study congenital disorders of glycosylation, including ALG2-CDG. The model replicates symptoms such as neuronal problems and retinitis pigmentosa, and demonstrates that supplying fully-functional Alg2 can prevent defects.
An international team identified an error in the cytochrome P450 oxidoreductase (POR) gene as the cause of aromatase deficiency, a rare metabolic disorder. This discovery enables precise therapy and prevents side effects associated with steroid supplementation.
Researchers have identified acid ceramidase as a key enzyme in the production of psychosine, a toxic glycolipid that accumulates in people with Krabbe disease. Removing or inhibiting this enzyme has been shown to decrease or eliminate psychosine production and disease symptoms.
A large-scale genome-wide association study identifies eight genetic variants associated with anorexia nervosa, suggesting a combination of metabolic and psychiatric components. The findings encourage considering metabolism in understanding the disorder's causes and improving treatment approaches.