Research on how cancer spreads through the body. Covers metastasis monitoring, bone metastasis, and nanoparticle treatments.
Researchers at the University of Granada have identified genetic and phenotypic changes that lead to tumor progression and metastasis. Circulating tumor cells can adapt to hostile environments and resist treatment, causing metastasis.
Researchers have developed targeted, fluorescent molecular imaging probes that can non-invasively detect breast cancer lymph node metastases, improving breast cancer staging and prognosis. CAIX and CAXII cell surface markers are highly expressed in breast cancer lymph node metastases.
Research finds that ISG15 pathway disrupts cytoskeletal architecture in breast cancer cells, promoting cell migration and invasion. The study suggests that targeting the ISG15 pathway could provide a therapeutic advantage for patients with metastatic tumors.
Scientists at Thomas Jefferson University's Center for Translational Medicine have found that reducing N-cadherin levels in pancreatic cancer cells can slow down their mobility and prolong survival in mice by 25 percent. This discovery could lead to new targeted therapies for pancreatic cancer.
Researchers found that increasing EET levels promotes tumor growth and metastasis, even in cancers that rarely spread. Blocking EETs, however, could reduce tumor growth and metastasis, suggesting a potential new avenue for cancer treatment.
A team of researchers found that raising levels of epoxyeicosatrienoic acids (EETs) in mice stimulated primary tumor growth and metastasis, suggesting potential risks for humans. EET antagonists may provide a new approach to preventing and treating cancer-related metastasis.
Researchers found that EET-enhancing drugs promote tumor growth and metastasis in mice, raising concerns about their use in humans. The findings suggest that these drugs could also worsen cardiovascular diseases.
Researchers found that blocking EETs production can eliminate blood vessels that feed cancer tumors, promoting metastasis. Increasing EET levels may help patients with vascular conditions, but excessive levels promote tumor growth and metastasis.
Combining bevacizumab with standard chemoradiation therapy prolongs survival and delays disease progression in patients with advanced nasopharyngeal carcinoma. The study results show over 90% of patients surviving 2 years without distant metastases.
Researchers found that tumors with high microRNA-200c levels are more likely to spread and those with lower levels may benefit from focused local treatment. This discovery could help identify patients who can benefit from aggressive, targeted radiation therapy and move them away from whole-body treatments.
Researchers at Moffitt Cancer Center have identified a chemical disrupter of the Rb-Raf-1 interaction, which may be vulnerable to targeting to prevent cancer cell proliferation and tumor growth. The study found that this disruption can limit metastasis in test mice, suggesting a potential new approach for combating metastatic disease.
Women with newly diagnosed inflammatory breast cancer who have stray tumor cells in their blood should receive aggressive treatment, regardless of imaging results. Researchers found no correlation between circulating tumor cells and survival rates in these patients.
Scientists isolated a protein called periostin that plays a major role in metastasis development. Blocking this protein can prevent the formation of secondary cancers, offering a promising therapeutic option for late-stage cancers.
A recent study found that clodronate had a low incidence of adverse events and toxicity among patients with breast cancer. The treatment modestly reduced the incidence of distant metastases in postmenopausal women, with a relative reduction of 9% compared to placebo.
Researchers have discovered a drug that can alter the DNA of uveal melanoma cells, rendering them less aggressive. The treatment, known as histone deacetylase inhibitors, may slow or prevent tumor growth in patients with metastatic eye cancer.
A team of UNC scientists has identified P-Rex1 protein as a crucial factor in the movement of melanoblasts, leading to melanoma development. The study found that mice lacking this protein are resistant to melanoma metastasis, suggesting P-Rex1 plays an important role in cancer spread.
A new study from the University of Hawaii Cancer Center found that PEA-15 protein enhances tumor formation in kidney cells carrying a mutation in the cancer-promoting gene H-Ras. The discovery suggests caution in pursuing PEA-15 as an anti-cancer therapeutic, highlighting its dual role in cancer growth and suppression.
A study by MIT cancer biologists reveals that platelets release chemical signals inducing tumor cells to become more invasive and form new tumors. The findings suggest that direct physical contact between platelets and tumor cells is necessary for metastasis, highlighting potential targets for drug development.
A clinical trial found that denosumab treatment increases bone-metastasis-free survival by an average of four months in men with prostate cancer. The drug targets the bone microenvironment to prevent tumor spread.
A study published in The Lancet shows denosumab can delay time to bone metastasis in men with castration-resistant prostate cancer. Denosumab significantly increases bone-metastasis-free survival by over four months compared to placebo, with improved outcomes also seen in delayed first bone metastasis.
Scientists discovered that variant forms of tyrosine can slow tumor growth and prevent metastasis. This finding could lead to a simple and safe type of therapy to manage malignant disease.
Researchers found that elevated TGF beta levels lead to fascin overexpression, promoting tumor metastasis. High fascin expression is associated with poor prognosis.
The National Cancer Institute has awarded Albert Einstein College of Medicine two grants totaling $8 million to study the microenvironments that drive the spread of cancer. The research aims to understand the complex process of metastasis, which is responsible for most cancer-related deaths.
Scientists propose 'Lance Armstrong effect' to overcome resistance in pancreatic and other cancers, with promising results in testicular cancer patients who beat metastatic disease despite low survival rates elsewhere. Researchers explore nanoparticle therapies to target tumors with high temperatures.
A University of Rochester analysis found that older men are more likely to die from prostate cancer due to late-stage diagnosis. The study's lead author notes that overall health plays a significant role in life expectancy following a cancer diagnosis.
Researchers at Medical College of Wisconsin show that CXCL12 protein inhibits metastasis in colon and melanoma cancers. The protein, naturally expressed in bone marrow and other organs prone to cancer metastasis, effectively blocks tumor growth and improves survival time.
Studies reveal the role of Sirt1 in improving insulin sensitivity through caloric restriction. Researchers also identify a potential treatment approach for KRAS mutant colorectal cancers by combining receptor tyrosine kinase inhibitors with MEK inhibitors. Additionally, new insights into the cellular defects of Huntington disease are p...
Researchers found widespread disagreement among scientists studying cancer metastasis, with no two scenarios identical. The study suggests making assumptions explicit can improve biomedical modeling and create new opportunities for understanding alternative theories.
A U-M study has identified the p38-gamma molecule as a key regulator of aggressive breast cancer cell movement. By understanding how this molecule influences cell motion, researchers hope to develop targeted therapies that can improve treatment outcomes.
A new study uses the Tilman model of competition between invasive species to understand how prostate cells invade bone marrow and take over the microenvironment. The research reveals that cancer cells follow a similar path to ecological invasions, highlighting the potential for ecological modeling to understand metastasis.
A new trial shows that a single dose of the drug ibandronate is as effective in controlling pain from prostate cancer bone metastases as a single dose of radiotherapy. The study found no long-term difference in pain relief between the two treatments.
Researchers have developed a new bone-targeting drug that can delay the onset of metastases in hormone-resistant prostate cancer patients. The study showed that denosumab prolonged bone metastasis-free survival significantly compared to placebo, improving patient quality of life.
A Phase III trial of Radium-223 Chloride has shown improved survival rates among patients with bone metastases from advanced prostate cancer. The study found that patients taking radium-223 had a 30% lower rate of death compared to those receiving placebo.
A new treatment, percutaneous hepatic perfusion (PHP), has been shown to significantly extend the time patients with liver-dominant metastatic melanoma can live without disease progression. On average, PHP patients survived for 8.1 months, compared to 1.6 months in the control group.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a gene-based imaging system that can detect castration-resistant prostate cancer earlier than conventional methods. The system uses specific genes and reporter genes to accurately identify the spread of the disease, giving oncologists more time to treat it and pot...
Researchers found that soy peptide lunasin binds to receptors in highly metastatic colon cancer cells, preventing them from attaching to the liver. Combining lunasin with chemotherapy drug oxaliplatin resulted in a sixfold reduction in new tumor sites.
Researchers have identified a protein that plays a critical role in heart development and may also be a therapeutic target for halting colon cancer metastasis. BVES expression was found to be low in all stages of colon cancer and decreased levels were observed in many other types of epithelial cancers.
Researchers found that breast tumor cells can evade NK cell antitumor activity by promoting self-tolerance. The study suggests that restoring NK cell function could benefit individuals with breast cancer.
Researchers have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional targets for preventing and treating the disease. A novel vaccine for HER2+ breast cancer is also being developed to address a particularly aggressive form of the disease.
A study found no association between occult metastases in lymph nodes and overall survival among women with early-stage breast cancer. Researchers detected micro-metastases using immunohistochemical staining but did not find significant impact on death or recurrence rates.
A high-throughput screen identified several compounds that inhibit invadopodia formation, a key step in cancer cell invasion. In contrast, another compound, paclitaxel, was found to promote invadopodia formation and cancer cell invasion.
A study published in Clinical Cancer Research found that trastuzumab, chemotherapy, and surgery significantly improved overall survival in HER2-positive breast and brain cancer patients. Treatment with these therapies led to improved survival rates of up to 20 months for those with central nervous system metastases.
The European Commission has approved YERVOY (ipilimumab) for treating adult patients with previously-treated advanced melanoma. The treatment showed long-term survival rates of 46% and 24% at 1 and 2 years, respectively. YERVOY works by stimulating the immune system to recognize and destroy cancer cells.
Researchers at Dana-Farber Cancer Institute found six abnormal genes that are both cancer-causing and metastasis-promoting in melanoma skin cancer. These genes can be used to predict whether human melanoma tumors are likely to spread, enabling doctors to cure the disease by intervening early.
Researchers have identified a way to exploit brain's self-repair mechanism to protect nerve cells and enhance brain repair after stroke. Estradiol has been shown to protect male rats against beta-cell failure in rodent models of type 2 diabetes, suggesting estrogen receptors as a viable therapeutic target.
Researchers discovered that specific microRNAs play a crucial role in melanoma metastasis by suppressing the immune system and promoting cell invasion. The study found that these miRNAs can serve as biomarkers for more aggressive tumors, suggesting new therapeutic targets for battling the deadliest form of skin cancer.
Leeds researchers investigate the effectiveness of pure Eicosapentaenoic Acid (EPA) in preventing the spread of bowel cancer to the liver. Previous studies have shown that EPA may prevent large bowel polyps, a precursor to colorectal cancer.
Scientists have discovered that niclosamide, a drug previously used to treat tapeworm infections, can silence a gene that triggers colon cancer metastasis. In mouse studies, the compound inhibited the formation of metastases in colon cancer cells.
Researchers used time-lapse video microscopic technology to observe early stages of ovarian cancer metastasis. The study identified the force-dependent processes necessary for tumor cells to attach to and proliferate on organs in the peritoneum.
Van Andel Research Institute scientists found a protein that predicts the spread of nasopharyngeal carcinoma, a deadly head and neck cancer common in southern China and Southeast Asia. Higher levels of serglycin correlate with poor prognosis and increased metastasis, suggesting it as a therapeutic target to stop disease progression.
Researchers at Einstein College of Medicine identified a key player in breast cancer spread, CCL2, which recruits immune cells to facilitate tumor growth. By blocking CCL2 signaling, they found potential for halting or slowing metastatic disease.
Researchers developed a new alpha-emitter-based therapy that effectively targets and cures neuroendocrine tumors without harming healthy tissues. The treatment, called 213Bi-DOTATOC peptide receptor alpha-therapy, showed promising results in patients with liver metastases resistant to beta-particle peptide therapy.
Scientists have identified heparan sulfate as a crucial molecule in the growth of lymphatic vessels that allow cancer cells to metastasize. By inhibiting heparan sulfate production, researchers may be able to develop new therapies to slow or stop cancer spread.
Breast cancer patients whose cells use ketones and lactate as a food supply can be identified by gene profiling, predicting recurrence, metastasis, and poor clinical outcome. The researchers propose using this approach, called Metabolo-Genomics, to target oxidative mitochondrial metabolism with new anti-cancer drugs.
A blood test has identified seven plasma biomarkers that can predict the risk of metastasis in melanoma patients. The test was tested on 216 individuals and showed a high accuracy rate of 0.898, indicating its potential for use in clinical settings.
Researchers have discovered a protein that improves vascular regeneration in mice with heart attacks, and found that manipulating this protein could be used to treat various vascular diseases. Additionally, studies on mouse models have revealed plasticity in the pathways that control insulin secretion, offering new insights into diabet...
Researchers at UCSF have discovered a link between inflammation and the early formation of pancreatic cancer. They found that two molecular signals produced in the pancreas during inflammation can help initiate the early stages of cancer, while another protein may be a clinical indicator of cancer stage.
Researchers at Albert Einstein College of Medicine have identified two molecules that help cancer cells spread inside the body. The study found that these molecules regulate RhoC activity, which is positively correlated with increased invasion and motility of tumor cells.
Researchers at MIT have identified a genetic change that helps lung tumors metastasize, with reduced NKX2-1 activity associated with higher death rates for lung-cancer patients. Understanding this gene's role may help scientists develop drugs to counteract its loss.
Researchers discovered that ionizing radiation drives overexpression and activity of MET through the ATM and NF-κB signaling pathways, making some tumor cells resistant to radiation. Inhibiting MET counteracted this increased invasiveness, promoting apoptosis in tumor cells and enhancing the effect of radiation.