Articles tagged with Metastasis
Researchers at Dana-Farber Cancer Institute found six abnormal genes that are both cancer-causing and metastasis-promoting in melanoma skin cancer. These genes can be used to predict whether human melanoma tumors are likely to spread, enabling doctors to cure the disease by intervening early.
Researchers discovered that specific microRNAs play a crucial role in melanoma metastasis by suppressing the immune system and promoting cell invasion. The study found that these miRNAs can serve as biomarkers for more aggressive tumors, suggesting new therapeutic targets for battling the deadliest form of skin cancer.
Researchers have identified a way to exploit brain's self-repair mechanism to protect nerve cells and enhance brain repair after stroke. Estradiol has been shown to protect male rats against beta-cell failure in rodent models of type 2 diabetes, suggesting estrogen receptors as a viable therapeutic target.
Leeds researchers investigate the effectiveness of pure Eicosapentaenoic Acid (EPA) in preventing the spread of bowel cancer to the liver. Previous studies have shown that EPA may prevent large bowel polyps, a precursor to colorectal cancer.
Scientists have discovered that niclosamide, a drug previously used to treat tapeworm infections, can silence a gene that triggers colon cancer metastasis. In mouse studies, the compound inhibited the formation of metastases in colon cancer cells.
Researchers used time-lapse video microscopic technology to observe early stages of ovarian cancer metastasis. The study identified the force-dependent processes necessary for tumor cells to attach to and proliferate on organs in the peritoneum.
Van Andel Research Institute scientists found a protein that predicts the spread of nasopharyngeal carcinoma, a deadly head and neck cancer common in southern China and Southeast Asia. Higher levels of serglycin correlate with poor prognosis and increased metastasis, suggesting it as a therapeutic target to stop disease progression.
Researchers at Einstein College of Medicine identified a key player in breast cancer spread, CCL2, which recruits immune cells to facilitate tumor growth. By blocking CCL2 signaling, they found potential for halting or slowing metastatic disease.
Researchers developed a new alpha-emitter-based therapy that effectively targets and cures neuroendocrine tumors without harming healthy tissues. The treatment, called 213Bi-DOTATOC peptide receptor alpha-therapy, showed promising results in patients with liver metastases resistant to beta-particle peptide therapy.
Scientists have identified heparan sulfate as a crucial molecule in the growth of lymphatic vessels that allow cancer cells to metastasize. By inhibiting heparan sulfate production, researchers may be able to develop new therapies to slow or stop cancer spread.
A blood test has identified seven plasma biomarkers that can predict the risk of metastasis in melanoma patients. The test was tested on 216 individuals and showed a high accuracy rate of 0.898, indicating its potential for use in clinical settings.
Breast cancer patients whose cells use ketones and lactate as a food supply can be identified by gene profiling, predicting recurrence, metastasis, and poor clinical outcome. The researchers propose using this approach, called Metabolo-Genomics, to target oxidative mitochondrial metabolism with new anti-cancer drugs.
Researchers have discovered a protein that improves vascular regeneration in mice with heart attacks, and found that manipulating this protein could be used to treat various vascular diseases. Additionally, studies on mouse models have revealed plasticity in the pathways that control insulin secretion, offering new insights into diabet...
Researchers at UCSF have discovered a link between inflammation and the early formation of pancreatic cancer. They found that two molecular signals produced in the pancreas during inflammation can help initiate the early stages of cancer, while another protein may be a clinical indicator of cancer stage.
Researchers at Albert Einstein College of Medicine have identified two molecules that help cancer cells spread inside the body. The study found that these molecules regulate RhoC activity, which is positively correlated with increased invasion and motility of tumor cells.
Researchers at MIT have identified a genetic change that helps lung tumors metastasize, with reduced NKX2-1 activity associated with higher death rates for lung-cancer patients. Understanding this gene's role may help scientists develop drugs to counteract its loss.
Researchers discovered that ionizing radiation drives overexpression and activity of MET through the ATM and NF-κB signaling pathways, making some tumor cells resistant to radiation. Inhibiting MET counteracted this increased invasiveness, promoting apoptosis in tumor cells and enhancing the effect of radiation.
The new TNM 7 lung cancer staging system better predicts local or regional recurrence after surgery, according to a study published in the Journal of Thoracic Oncology. The updated system improved accuracy for predicting disease recurrence among patients with non-small cell lung cancer.
A study published by Scottsdale Healthcare and TGen identified microRNA-328 as a biomarker that can predict lung cancer patients' risk of developing brain metastasis. The study found that over-expression of microRNA-328 resulted in increased cancer cell migration, suggesting its involvement in 'brain-seeking' metastatic potential.
Researchers found low Rho GDI-alpha protein levels in tamoxifen-resistant breast cancer tumors, predicting recurrence. MTA2 protein levels rose with declining Rho GDI-alpha, combining to predict tumor progression.
A new microfluidic device, developed by MIT researchers, can detect single cancer cells in a blood sample and also identify viruses like HIV. This device has the potential to revolutionize cancer diagnosis and make it more accessible in developing countries.
Researchers at the University of Pittsburgh discovered a new nitric oxide pathway that protects against intimal hyperplasia in rats. The study found that supplementing rats with nitrate before vessel injury markedly limited damage, while a diet low in nitrate exacerbated it.
A Wayne State University researcher has found that continuous restructuring of the extracellular matrix, which supports tumor weight, enables highly invasive cancer cells to spread to other parts of the body. The study identified fibronectin and cofilin as crucial components required for this mechanical response.
Researchers at Boston University School of Medicine have identified Neuropilin-2 as a potential biomarker and therapeutic target for melanoma. The novel cell screening method clarifies the process behind tumor metastasis and may allow the identification of biomarkers for other aggressive cancers.
The authors refine the original six hallmarks using information from transgenic animals and biochemical assays, adding two new categories: enabling characteristics and emerging hallmarks. This updated review provides a solid basis for cancer research and identifies therapeutic targets.
Researchers have discovered that T cells from elite HIV controllers upregulate a protein called p21, which inhibits viral replication. This finding may inform the development of new treatments for patients susceptible to HIV's devastating effects. Meanwhile, two new studies shed light on pediatric brain tumors and lung cancer metastasis.
Researchers at UCSD School of Medicine identified Twist1's role in promoting invadopodia formation and matrix degradation in tumor cells. This process facilitates the spread of cancer to surrounding tissues and other parts of the body.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
Trapping prostate cancer stem cells with self-assembling nanomaterials inhibits colony formation and cell division in vitro. The approach may offer a new treatment strategy for metastatic hormone-refractory prostate cancer by targeting cancer stem cells, which are thought to be the origin of tumor metastasis.
Researchers used gas chromatography/mass spectrometry (GC/MS) technology to study urinary metabolite changes in mice with gastric cancer. The study identified low molecular weight biomarkers that may play a significant role in early diagnosis and screening of metastasis or recurrence.
A cohort study found that hepatitis B virus (HBV) infection decreases the percentage of metastases in colorectal cancer patients, while increasing extrahepatic metastases. This suggests HBV may serve as a prognostic factor for hepatic metastasis formation in CRC patients.
A UCLA research team has developed a device using Velcro-like nanoscale technology to efficiently identify and capture circulating tumor cells, or CTCs, in blood samples. The new approach captures a greater number of CTCs than existing methods and could enable early detection and diagnosis of cancer.
A recent study discovered a blood protein linked to lung adenocarcinoma, which could serve as a diagnostic marker for the disease. Elevated levels of serum amyloid A (SAA) were found in patients with lung cancer, making it a promising target for developing drugs that stop cancer spread.
Researchers discovered that zoledronic acid can prevent lung cancer metastases from recruiting new blood vessels. The drug showed a statistically significant reduction in VEGF and b-FGF levels, suggesting potential anti-angiogenic effects.
A new gene expression test distinguishes between metastasizing and non-metastasizing head and neck cancers with high accuracy. The test was validated in a large multi-center cohort, predicting the absence of metastasis in 89% of cases.
A newly discovered biological pathway transforms normal cells into aggressive tumors by regulating the epithelial-mesenchymal transition (EMT) process. This mechanism involves a specific molecular factor called hnRNP E1, which can be used as a diagnostic approach for cancer.
Research at University of California, San Diego School of Medicine identifies regulatory T cells as primary source of RANKL protein, accelerating breast cancer spread. Interfering with RANKL interaction with cancer cells may block tumor progression, offering potential target for drug therapy.
Researchers identified a new role for focal adhesion kinase in producing vascular leakiness in lung tissue, increasing expression of E-selectin and attracting cancer cells. Blocking FAK activity reduced both vascular permeability and metastatic cell adhesion.
Researchers found that photodynamic therapy can eliminate tumor-associated lymphatic vessels and in-transit tumor cells, reducing metastasis. This approach could be combined with existing surgical techniques to destroy lymphatic vessels draining from tumors.
A study found that removing only the first lymph node (sentinel lymph node dissection) did not impact overall survival for women with early-stage breast cancer. The use of this method resulted in fewer complications compared to more extensive axillary lymph node dissection.
Scientists at Georgia Institute of Technology have found a regulatory RNA called miR-429 that can induce metastatic cancer cells to convert back into less invasive forms. This discovery may allow physicians to treat ovarian cancer more effectively with traditional chemotherapy.
Researchers found that high levels of a particular protein in cancer cells can predict cancer spread with high accuracy. The protein, CPE-delta N, was measured in tumors and surrounding tissues from patients with liver and rare tumors, with results showing that it can accurately predict metastasis or recurrence.
A team of researchers has identified a potential biomarker for predicting future metastasis in patients with the most common form of liver cancer. Quantification of the mRNA template for a truncated version of the protein carboxypeptidase E (CPE) was found to predict intrahepatic metastasis with high sensitivity and specificity.
A team of researchers has identified a potential biomarker for predicting future metastasis in patients with the most common form of liver cancer. They also explored a new gene therapy approach to treating the underlying cause of most forms of muscular dystrophy.
Researchers at Virginia Tech have developed a new method to detect the ability of breast cancer cells to metastasize, using specific silicon microdevices. The technology has the potential to provide important diagnostic and prognostic markers unique to the tumor.
VIB-K.U. Leuven scientists have decoded a potential new anti-cancer mechanism by normalizing abnormal tumor blood vessels through HRG, which prevents metastasis and enhances chemotherapy efficiency. This mechanism offers alternative possibilities for cancer treatment.
A new study shows that protein HRG activates specific immune cells to inhibit tumor growth and metastasis. HRG enhances chemotherapy effects and transforms inflammatory cells from promoting to inhibiting tumor growth.
Researchers found that endothelin-A receptor antagonist drugs only reduce tumor growth at metastasis sites, not large tumors. These drugs block the action of protein ET-1, which stimulates cancer cell growth and spread.
A study found that high circulating tumor cells (CTCs) are an independent prognostic marker for poor overall survival in metastatic breast cancer patients undergoing first-line chemotherapy. Persistence of high CTC levels during therapy was also an early marker of poor outcome.
Denosumab was found to delay the time to first skeletal-related event by 18% and the time to first and subsequent event by 22%, while overall survival and disease progression were similar between groups. The treatment also showed a lower rate of jaw osteonecrosis compared to zoledronic acid.
Fox Chase researchers have discovered several tumor characteristics that increase the risk of brain metastases in breast cancer patients. These include high-grade tumors, negative progesterone receptor status, and inflammatory breast cancer. The study aims to identify women at risk for brain metastases, potentially leading to preventiv...
A study found that PET/CT scans can predict local recurrence in lung cancer patients treated with radiofrequency ablation by analyzing lesion size, tumor type, and glucose metabolic activity. This non-invasive tool may help improve diagnosis and treatment of lung cancer.
Researchers found decreased alpha-2 integrin expression predicts tumor dissemination and lower survival rates in breast and prostate cancer. Alpha-2 integrin suppression of metastasis was confirmed using a mouse model and human microarray databases.
A study found that decreased physician reimbursement for hormone therapy reduced its use in low-risk prostate cancer cases by 40%. However, AST usage remained unchanged in patients with metastatic disease. The decrease is attributed to the real effect of reimbursement change.
A new study finds that a less invasive method for determining lung cancer stage improves detection of metastases and reduces surgical procedures. The method, which combines endosonography and ultrasound, was more effective than traditional surgical staging in identifying patients who needed further treatment.
A recent study published in Cancer found that clinical stage does not predict recurrence risk for patients with localized prostate cancer after having their prostate removed. Despite frequent errors in assigning stage, there was no association between clinical stage and prostate cancer recurrence.
Researchers at Washington University School of Medicine identified a gene linked to eye melanoma metastasis. BAP1 mutations were found in 84% of metastatic tumors but rare in non-metastatic ones. The discovery may lead to more effective treatments and insights into cancer cell evolution.
A recent IRCM breakthrough reveals a novel molecular mechanism that regulates cell motility, a key factor in tumour spread. The study identifies the ELMO protein's regulatory feature as critical in preventing uncontrolled cell migration.
Researchers at Mayo Clinic discovered that epithelial cadherin (E-cadherin), a protein believed to be a beneficial tumor suppressor, can act as an oncogene in some lethal brain tumors. This finding suggests E-cadherin expression may promote tumor growth and migration, challenging current understanding of its role in cancer progression.
A new study from Johns Hopkins Medicine finds that pancreatic cancers develop and spread much more slowly than previously thought. The research suggests that there is a potentially broad window for diagnosis and prevention of the disease, with an average progression time of 11.7 years.