Articles tagged with Metastasis
A study published in The Lancet shows denosumab can delay time to bone metastasis in men with castration-resistant prostate cancer. Denosumab significantly increases bone-metastasis-free survival by over four months compared to placebo, with improved outcomes also seen in delayed first bone metastasis.
A study by MIT cancer biologists reveals that platelets release chemical signals inducing tumor cells to become more invasive and form new tumors. The findings suggest that direct physical contact between platelets and tumor cells is necessary for metastasis, highlighting potential targets for drug development.
A clinical trial found that denosumab treatment increases bone-metastasis-free survival by an average of four months in men with prostate cancer. The drug targets the bone microenvironment to prevent tumor spread.
Scientists discovered that variant forms of tyrosine can slow tumor growth and prevent metastasis. This finding could lead to a simple and safe type of therapy to manage malignant disease.
Researchers found that elevated TGF beta levels lead to fascin overexpression, promoting tumor metastasis. High fascin expression is associated with poor prognosis.
The National Cancer Institute has awarded Albert Einstein College of Medicine two grants totaling $8 million to study the microenvironments that drive the spread of cancer. The research aims to understand the complex process of metastasis, which is responsible for most cancer-related deaths.
A University of Rochester analysis found that older men are more likely to die from prostate cancer due to late-stage diagnosis. The study's lead author notes that overall health plays a significant role in life expectancy following a cancer diagnosis.
Scientists propose 'Lance Armstrong effect' to overcome resistance in pancreatic and other cancers, with promising results in testicular cancer patients who beat metastatic disease despite low survival rates elsewhere. Researchers explore nanoparticle therapies to target tumors with high temperatures.
Studies reveal the role of Sirt1 in improving insulin sensitivity through caloric restriction. Researchers also identify a potential treatment approach for KRAS mutant colorectal cancers by combining receptor tyrosine kinase inhibitors with MEK inhibitors. Additionally, new insights into the cellular defects of Huntington disease are p...
Researchers at Medical College of Wisconsin show that CXCL12 protein inhibits metastasis in colon and melanoma cancers. The protein, naturally expressed in bone marrow and other organs prone to cancer metastasis, effectively blocks tumor growth and improves survival time.
Researchers found widespread disagreement among scientists studying cancer metastasis, with no two scenarios identical. The study suggests making assumptions explicit can improve biomedical modeling and create new opportunities for understanding alternative theories.
A U-M study has identified the p38-gamma molecule as a key regulator of aggressive breast cancer cell movement. By understanding how this molecule influences cell motion, researchers hope to develop targeted therapies that can improve treatment outcomes.
A new study uses the Tilman model of competition between invasive species to understand how prostate cells invade bone marrow and take over the microenvironment. The research reveals that cancer cells follow a similar path to ecological invasions, highlighting the potential for ecological modeling to understand metastasis.
A new trial shows that a single dose of the drug ibandronate is as effective in controlling pain from prostate cancer bone metastases as a single dose of radiotherapy. The study found no long-term difference in pain relief between the two treatments.
Researchers have developed a new bone-targeting drug that can delay the onset of metastases in hormone-resistant prostate cancer patients. The study showed that denosumab prolonged bone metastasis-free survival significantly compared to placebo, improving patient quality of life.
A new treatment, percutaneous hepatic perfusion (PHP), has been shown to significantly extend the time patients with liver-dominant metastatic melanoma can live without disease progression. On average, PHP patients survived for 8.1 months, compared to 1.6 months in the control group.
A Phase III trial of Radium-223 Chloride has shown improved survival rates among patients with bone metastases from advanced prostate cancer. The study found that patients taking radium-223 had a 30% lower rate of death compared to those receiving placebo.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a gene-based imaging system that can detect castration-resistant prostate cancer earlier than conventional methods. The system uses specific genes and reporter genes to accurately identify the spread of the disease, giving oncologists more time to treat it and pot...
Researchers found that soy peptide lunasin binds to receptors in highly metastatic colon cancer cells, preventing them from attaching to the liver. Combining lunasin with chemotherapy drug oxaliplatin resulted in a sixfold reduction in new tumor sites.
Researchers have identified a protein that plays a critical role in heart development and may also be a therapeutic target for halting colon cancer metastasis. BVES expression was found to be low in all stages of colon cancer and decreased levels were observed in many other types of epithelial cancers.
Researchers found that breast tumor cells can evade NK cell antitumor activity by promoting self-tolerance. The study suggests that restoring NK cell function could benefit individuals with breast cancer.
Researchers have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional targets for preventing and treating the disease. A novel vaccine for HER2+ breast cancer is also being developed to address a particularly aggressive form of the disease.
A study found no association between occult metastases in lymph nodes and overall survival among women with early-stage breast cancer. Researchers detected micro-metastases using immunohistochemical staining but did not find significant impact on death or recurrence rates.
A high-throughput screen identified several compounds that inhibit invadopodia formation, a key step in cancer cell invasion. In contrast, another compound, paclitaxel, was found to promote invadopodia formation and cancer cell invasion.
A study published in Clinical Cancer Research found that trastuzumab, chemotherapy, and surgery significantly improved overall survival in HER2-positive breast and brain cancer patients. Treatment with these therapies led to improved survival rates of up to 20 months for those with central nervous system metastases.
Researchers at Dana-Farber Cancer Institute found six abnormal genes that are both cancer-causing and metastasis-promoting in melanoma skin cancer. These genes can be used to predict whether human melanoma tumors are likely to spread, enabling doctors to cure the disease by intervening early.
The European Commission has approved YERVOY (ipilimumab) for treating adult patients with previously-treated advanced melanoma. The treatment showed long-term survival rates of 46% and 24% at 1 and 2 years, respectively. YERVOY works by stimulating the immune system to recognize and destroy cancer cells.
Researchers have identified a way to exploit brain's self-repair mechanism to protect nerve cells and enhance brain repair after stroke. Estradiol has been shown to protect male rats against beta-cell failure in rodent models of type 2 diabetes, suggesting estrogen receptors as a viable therapeutic target.
Researchers discovered that specific microRNAs play a crucial role in melanoma metastasis by suppressing the immune system and promoting cell invasion. The study found that these miRNAs can serve as biomarkers for more aggressive tumors, suggesting new therapeutic targets for battling the deadliest form of skin cancer.
Leeds researchers investigate the effectiveness of pure Eicosapentaenoic Acid (EPA) in preventing the spread of bowel cancer to the liver. Previous studies have shown that EPA may prevent large bowel polyps, a precursor to colorectal cancer.
Scientists have discovered that niclosamide, a drug previously used to treat tapeworm infections, can silence a gene that triggers colon cancer metastasis. In mouse studies, the compound inhibited the formation of metastases in colon cancer cells.
Van Andel Research Institute scientists found a protein that predicts the spread of nasopharyngeal carcinoma, a deadly head and neck cancer common in southern China and Southeast Asia. Higher levels of serglycin correlate with poor prognosis and increased metastasis, suggesting it as a therapeutic target to stop disease progression.
Researchers used time-lapse video microscopic technology to observe early stages of ovarian cancer metastasis. The study identified the force-dependent processes necessary for tumor cells to attach to and proliferate on organs in the peritoneum.
Researchers at Einstein College of Medicine identified a key player in breast cancer spread, CCL2, which recruits immune cells to facilitate tumor growth. By blocking CCL2 signaling, they found potential for halting or slowing metastatic disease.
Researchers developed a new alpha-emitter-based therapy that effectively targets and cures neuroendocrine tumors without harming healthy tissues. The treatment, called 213Bi-DOTATOC peptide receptor alpha-therapy, showed promising results in patients with liver metastases resistant to beta-particle peptide therapy.
Scientists have identified heparan sulfate as a crucial molecule in the growth of lymphatic vessels that allow cancer cells to metastasize. By inhibiting heparan sulfate production, researchers may be able to develop new therapies to slow or stop cancer spread.
Breast cancer patients whose cells use ketones and lactate as a food supply can be identified by gene profiling, predicting recurrence, metastasis, and poor clinical outcome. The researchers propose using this approach, called Metabolo-Genomics, to target oxidative mitochondrial metabolism with new anti-cancer drugs.
A blood test has identified seven plasma biomarkers that can predict the risk of metastasis in melanoma patients. The test was tested on 216 individuals and showed a high accuracy rate of 0.898, indicating its potential for use in clinical settings.
Researchers have discovered a protein that improves vascular regeneration in mice with heart attacks, and found that manipulating this protein could be used to treat various vascular diseases. Additionally, studies on mouse models have revealed plasticity in the pathways that control insulin secretion, offering new insights into diabet...
Researchers at UCSF have discovered a link between inflammation and the early formation of pancreatic cancer. They found that two molecular signals produced in the pancreas during inflammation can help initiate the early stages of cancer, while another protein may be a clinical indicator of cancer stage.
Researchers at Albert Einstein College of Medicine have identified two molecules that help cancer cells spread inside the body. The study found that these molecules regulate RhoC activity, which is positively correlated with increased invasion and motility of tumor cells.
Researchers at MIT have identified a genetic change that helps lung tumors metastasize, with reduced NKX2-1 activity associated with higher death rates for lung-cancer patients. Understanding this gene's role may help scientists develop drugs to counteract its loss.
Researchers discovered that ionizing radiation drives overexpression and activity of MET through the ATM and NF-κB signaling pathways, making some tumor cells resistant to radiation. Inhibiting MET counteracted this increased invasiveness, promoting apoptosis in tumor cells and enhancing the effect of radiation.
The new TNM 7 lung cancer staging system better predicts local or regional recurrence after surgery, according to a study published in the Journal of Thoracic Oncology. The updated system improved accuracy for predicting disease recurrence among patients with non-small cell lung cancer.
A study published by Scottsdale Healthcare and TGen identified microRNA-328 as a biomarker that can predict lung cancer patients' risk of developing brain metastasis. The study found that over-expression of microRNA-328 resulted in increased cancer cell migration, suggesting its involvement in 'brain-seeking' metastatic potential.
Researchers found low Rho GDI-alpha protein levels in tamoxifen-resistant breast cancer tumors, predicting recurrence. MTA2 protein levels rose with declining Rho GDI-alpha, combining to predict tumor progression.
A new microfluidic device, developed by MIT researchers, can detect single cancer cells in a blood sample and also identify viruses like HIV. This device has the potential to revolutionize cancer diagnosis and make it more accessible in developing countries.
Researchers at the University of Pittsburgh discovered a new nitric oxide pathway that protects against intimal hyperplasia in rats. The study found that supplementing rats with nitrate before vessel injury markedly limited damage, while a diet low in nitrate exacerbated it.
A Wayne State University researcher has found that continuous restructuring of the extracellular matrix, which supports tumor weight, enables highly invasive cancer cells to spread to other parts of the body. The study identified fibronectin and cofilin as crucial components required for this mechanical response.
Researchers at Boston University School of Medicine have identified Neuropilin-2 as a potential biomarker and therapeutic target for melanoma. The novel cell screening method clarifies the process behind tumor metastasis and may allow the identification of biomarkers for other aggressive cancers.
The authors refine the original six hallmarks using information from transgenic animals and biochemical assays, adding two new categories: enabling characteristics and emerging hallmarks. This updated review provides a solid basis for cancer research and identifies therapeutic targets.
Researchers at UCSD School of Medicine identified Twist1's role in promoting invadopodia formation and matrix degradation in tumor cells. This process facilitates the spread of cancer to surrounding tissues and other parts of the body.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
Researchers have discovered that T cells from elite HIV controllers upregulate a protein called p21, which inhibits viral replication. This finding may inform the development of new treatments for patients susceptible to HIV's devastating effects. Meanwhile, two new studies shed light on pediatric brain tumors and lung cancer metastasis.
Trapping prostate cancer stem cells with self-assembling nanomaterials inhibits colony formation and cell division in vitro. The approach may offer a new treatment strategy for metastatic hormone-refractory prostate cancer by targeting cancer stem cells, which are thought to be the origin of tumor metastasis.
Researchers used gas chromatography/mass spectrometry (GC/MS) technology to study urinary metabolite changes in mice with gastric cancer. The study identified low molecular weight biomarkers that may play a significant role in early diagnosis and screening of metastasis or recurrence.
A cohort study found that hepatitis B virus (HBV) infection decreases the percentage of metastases in colorectal cancer patients, while increasing extrahepatic metastases. This suggests HBV may serve as a prognostic factor for hepatic metastasis formation in CRC patients.
A UCLA research team has developed a device using Velcro-like nanoscale technology to efficiently identify and capture circulating tumor cells, or CTCs, in blood samples. The new approach captures a greater number of CTCs than existing methods and could enable early detection and diagnosis of cancer.
A recent study discovered a blood protein linked to lung adenocarcinoma, which could serve as a diagnostic marker for the disease. Elevated levels of serum amyloid A (SAA) were found in patients with lung cancer, making it a promising target for developing drugs that stop cancer spread.
Researchers discovered that zoledronic acid can prevent lung cancer metastases from recruiting new blood vessels. The drug showed a statistically significant reduction in VEGF and b-FGF levels, suggesting potential anti-angiogenic effects.