Articles tagged with Psychosis
Early intervention services are being developed or expanded in 48 US states to improve treatment outcomes for young people with psychosis. Coordinated specialty care (CSC) programs use a team of specialists to create personalized treatment plans, resulting in improved symptoms, interpersonal relationships, and quality of life.
Studies suggest inflammatory cytokines are associated with increased rates of depression and psychosis. Anti-cytokine treatment has been shown to reduce symptoms of depression in clinical trials, regardless of physical illness improvement.
Researchers found thickening of the left carotid artery, indicating blood vessel inflammation and potential cardiovascular risk. This study suggests that blood vessels may be affected in childhood and adolescence, sparking hope for new treatment strategies.
Researchers found that taurine supplementation improved symptoms in patients with first episode psychosis, particularly in depression and overall functioning. However, cognitive function remained unchanged.
Researchers developed a new probability model to detect psychosis risk with 70% accuracy, combining medical history, clinical assessment, and biomarkers of fatty acids. This could lead to timely treatment and prevention of psychotic episodes.
A large international study found that people with psychosis have lower levels of physical activity, increasing cardiovascular disease risk. Barriers include mobility difficulties, pain, depression, and cognitive impairment.
A study of 204,186 people across 46 low- and middle-income countries found that low physical activity is associated with a diagnosis of psychosis, particularly among males. However, psychotic-like symptoms without a diagnosis are not linked to inactivity.
A study found that individuals with smaller hippocampi are more likely to have a combination of genetic risk factors associated with an increased risk of psychosis. This discovery may lead to the development of personalized treatment strategies for schizophrenia.
A systematic review of 35 studies found that longer duration of untreated childhood schizophrenia-spectrum psychosis is associated with poorer functional improvement. Children and adolescents with EOS often experience frequent pre- and co-morbid conditions, leading to worse outcomes.
A new clinical calculator assesses individual risk of psychosis after early warning signs of schizophrenia, such as hearing voices. Symptoms like unusual thought content and social functioning decline contribute significantly to the risk of developing psychosis.
Researchers found that patients with psychosis fail to produce cortisol after waking, indicating a potential biomarker for early detection. Cortisol levels may also predict risk for other chronic diseases.
A study published in The BMJ found that refugees have a substantially higher risk of psychotic disorders, including schizophrenia. Refugees were up to 3.6 times more likely to develop psychosis than the Swedish-born population, with incidence rates of 1264 per million.
Researchers have found a link between the AKT1 gene and psychotic-like symptoms in young people who use cannabis. The study suggests that individuals with this gene variant are more susceptible to the mind-altering effects of smoking cannabis, even if they are otherwise healthy.
A professor of psychiatry argues that schizophrenia should be replaced with 'psychosis spectrum syndrome' due to the complexity and heterogeneity of psychotic illness. The current classification system uses outdated language and may lead to misdiagnosis or overemphasis on this condition.
A new analysis shows that team-based coordinated specialty care (CSC) is more cost-effective than typical community care for young people with first episode psychosis. CSC produces better clinical and quality of life outcomes, making it a better value despite modestly higher costs.
Research finds that repeated traumatic experiences during infancy and adolescence multiply the risk of psychosis by 7. Heavy cannabis use also significantly raises this risk, with a 6x multiplier. Neuroticism levels are associated with a 30% increased risk.
Researchers found that people with Alzheimer's who had more physical signs of the disease were also more likely to have psychosis. However, when they looked at those whose autopsies confirmed Alzheimer's, psychosis did not correlate with physical evidence of the disease. Instead, it was linked to vascular risk factors and cerebral inju...
A UTSW-led study identified three neurobiologically distinct biotypes of psychoses, which do not always match conventional clinical diagnoses. The findings suggest that the term 'psychosis' might describe unique psychiatric disorders with distinctive mechanisms and treatments.
A new study finds that biomarkers outperform symptoms in identifying distinct psychosis subgroups, suggesting a more precise diagnosis may lead to improved treatments. The research used 1,872 participants and identified three biotypes, each with unique patterns of brain function and structure.
A team of researchers has identified biological markers that can classify mental disorders with greater precision, using neurobiological measures to differentiate conditions. The findings may lead to improved diagnostics and treatments for those suffering from mental illness.
A team-based, coordinated specialty care approach produces better clinical and functional outcomes than typical community care for people with first episode psychosis. Treatment is most effective when provided soon after psychotic symptoms begin.
Researchers found that individuals with early signs of psychosis relied more heavily on prior knowledge to interpret ambiguous images, leading to improved task performance. This suggests an altered balance in normal brain functions contributing to the emergence of mental illness symptoms.
A new analysis identified illogical thoughts as most predictive of schizophrenia risk in teens experiencing attenuated psychosis symptoms. Suspiciousness and unusual thought content were found to be the most informative symptoms, while perceptual disturbances - common features of schizophrenia - were not predictive.
A new study found that people with Parkinson's disease psychosis who took antipsychotic medication were four times more likely to die than those who didn't. The treatment also led to serious health issues such as cognitive decline and worsening of Parkinson's symptoms.
A study by Columbia University's Mailman School of Public Health found that young people identified as 'at risk' for mental problems described feeling stigmatized by symptoms, but not the label itself. Early intervention benefits may outweigh stigma concerns.
A study published in Neuropsychopharmacology found lower conflict-related brain activity in adolescents at high risk for psychosis, indicating a potential predictor of psychotic disorders. The researchers used fMRI scans to measure cognitive flexibility and detected reduced activation in key brain regions.
Researchers found marginalized Vancouver residents are dying at 8.29 times the national average, with psychosis and hepatitis C-related liver dysfunction being significant risk factors for mortality. The study highlights the need for improved detection and treatment of these conditions in marginalized populations.
Researchers used fMRI to distinguish first-episode psychotic patients from healthy controls while watching the movie. They found significant differences in brain activity, particularly in the precuneus region, which is associated with memory and self-awareness.
A study published in NPJ-Schizophrenia found that an automated speech analysis program accurately predicted psychosis onset in high-risk youths. The analysis, which measured semantic coherence and syntactic structure, correctly differentiated between individuals who developed psychosis and those who did not.
A study by UCLA and University of Pittsburgh researchers has isolated specific genetic differences between people with DiGeorge syndrome who have autism and those who have psychosis. The findings suggest a potential way to determine which child is at risk for which disorder, allowing for early intervention and improvement.
A new study from UC Berkeley shows hallucinations and delusions associated with psychiatric disorders seldom foreshadow acts of aggression. Only 12% of violent incidents were preceded by psychosis, contradicting the media-fueled stereotype of homicidal mayhem.
A UK study reveals extremely high rates of cardiovascular risk factors in people with psychosis, including obesity and metabolic syndrome. The research highlights the importance of incorporating weight and cardiovascular risk assessment into routine care, as well as promoting healthy lifestyles.
A recent study found that a good therapeutic alliance is crucial for improving wellbeing, while poor relationships can harm treatment outcomes. The researchers discovered that patients who received effective therapy benefited from the therapist-patient connection, regardless of the therapy type.
Researchers detected antibodies to dopamine D2 receptor and N-methyl-D-aspartate (NMDA) glutamate receptor among children experiencing their first episode of psychosis. The finding suggests a distinct subgroup where autoimmunity plays a role in their illness, paving the way for more specific diagnosis and effective interventions.
A new study has identified antibodies targeting dopamine D2 receptors and NMDA glutamate receptors in children experiencing their first episode of psychosis. This finding suggests that autoimmunity may play a role in the development of psychosis, offering hope for new treatment approaches.
A recent study found that adolescents with psychological symptoms often exhibit visual distortions and hallucinations before developing a full-blown mental disorder. The researchers also discovered that these symptoms are strongly linked to self-destructive thought processes, which can increase the risk of suicide.
A new study finds that gray matter loss in the brain is a precursor to psychosis, with increased inflammation accelerating this process. Researchers analyzed brain scans of young adults at clinical high risk for psychosis and healthy controls, revealing a significant correlation between proinflammatory cytokines and gray matter thinning.
Almost 40% of people with first-episode psychosis in community clinics may benefit from medication treatment changes. Current prescribing practices highlight the need for more education on first-episode specific medication practices at community facilities.
Patients with first episode psychosis face elevated risks of heart disease and metabolic issues due to mental illness, unhealthy lifestyle behaviors, and antipsychotic medications. A team-based healthcare approach is necessary to address these needs and improve overall health.
Researchers at University of North Carolina Health Care developed a blood test that identifies individuals at high risk for developing psychosis. The test measures immune and hormonal system imbalances, as well as oxidative stress, and shows promise in predicting the development of severe mental disorders like schizophrenia.
Researchers identified mismatch negativity as a potential biomarker of psychosis risk, suggesting that deficits in this brain signal may precede the onset of psychosis. The study found that individuals at clinical high risk for psychosis who developed a psychotic disorder had reduced mismatch negativity compared to those who did not.
Researchers at Penn Medicine developed a method to assess and diagnose psychosis in young children by analyzing cognitive development. The study found that children with psychotic symptoms had lower chronological ages than predicted, indicating a significant lag in cognitive development.
Research finds a link between childhood death of a nuclear family member and increased risk of psychosis. Exposure to suicide has the highest risk, especially in early childhood.
A study published in Neural Regeneration Research found that Parkinson's patients with psychosis had greater white-matter fiber injury than those without psychosis. This difference may explain why psychosis often occurs in Parkinson's disease patients.
A new study published in SAGE Open found that people with psychotic disorders such as schizophrenia are more likely to be left-handed. The research team studied 107 individuals from a public outpatient psychiatric clinic and found that 40% of those with schizophrenia were left-handed, compared to 11% of those with mood disorders.
A new drug, pimavanserin, has shown significant improvement in reducing psychotic symptoms in Parkinson's disease patients. The study found a 37% improvement in psychotic symptoms compared to placebo, with no worsening of motor symptoms reported.
Researchers identified neuroimaging markers in the brain that can help predict which people with psychosis will respond to antipsychotic medications. Cortical folding defects were found in individuals who did not respond to treatment, while those who responded had brain structures similar to healthy controls.
A study published in International Journal of Drug Policy found a significant increase in cannabis psychosis hospital admissions following cannabis reclassification in 2009. The study challenges the government's claim that stronger forms of cannabis cause mental health problems.
A new review published in The Obstetrician & Gynaecologist recommends that all women be asked about postpartum psychosis risk factors before conception to ensure early recognition and prompt treatment. Women with bipolar disorder are at high risk of developing postpartum psychosis, with a 1 in 4 chance.
Researchers at the University of Helsinki have found that high doses of famotidine can penetrate the blood-brain barrier and affect the histamine system in the brain. After four weeks of treatment, symptoms of schizophrenia decreased statistically significantly in patients who received famotidine.
Researchers from the University of Manchester found that early access to cognitive behavioral therapy (CBT) significantly reduced the risk of developing a full-blown psychotic illness. CBT was shown to reduce the risk by more than half at six, 12, and 18-24 months after treatment started.
Researchers at Karolinska Institutet have identified a gene variant associated with higher production of kynurenic acid, which may explain psychotic features in bipolar disorder. The study suggests that inflammation and stress trigger the production of KYNA, leading to increased levels in patients' brains.
Research at Tel Aviv University finds that Parkinson's patients taking dopamine-enhancing medications are developing artistic talents, including painting, sculpting, and writing. The study suggests a link between dopamine levels and creativity, with some patients exhibiting increased impulsivity and lower inhibitions.
Individuals with epilepsy have a higher risk of schizophrenia and bipolar disorder, as well as an increased likelihood of developing psychosis. A Finnish study found that families with a history of epilepsy were more likely to experience both conditions.
Researchers in British Journal of Ophthalmology reveal that self-inflicted blinding is a rare complication of severe psychosis, such as schizophrenia. The phenomenon has been mistakenly attributed to sexual guilt and the Oedipus complex, but cultural beliefs are not a plausible explanation for this behavior.
Researchers have developed a computer algorithm that can analyze brain scans to predict the severity of future psychotic episodes. The study found that the algorithm was able to differentiate between patients who would develop continuous psychosis and those with more benign forms in seven out of ten cases.
A new meta-analysis of over 20,000 patients shows that cannabis use is associated with an earlier onset of psychotic illness by up to 2.7 years, with possible life-long consequences for brain development and mental health outcomes.
A meta-analysis of 83 studies suggests that cannabis users develop psychosis about 2.7 years younger than non-users. The study supports the view that cannabis precipitates schizophrenia and other psychotic disorders, potentially through genetic and environmental interactions or disrupting brain development.
This special issue of Biological Psychiatry highlights the benefits and challenges of postmortem research in studying psychosis, schizophrenia, and other psychiatric disorders. Advances in science and technology have expanded the scope of postmortem work, allowing for more detailed studies of brain structure and function.
A study of 203,829 individuals in Sweden found that urban living is associated with a higher incidence of schizophrenia and other nonaffective psychoses. Social fragmentation and deprivation were key factors explaining the association.