Articles tagged with Smallpox
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Public Health Alerts provide concise, data-driven information on disease outbreaks and urgent health events. The new series, launched by NEJM Evidence and CIDRAP, offers expert-reviewed reports to support public health evidence-based care.
Researchers at Lancaster University discovered a new type of vaccine-specific scepticism, where some people perceive COVID-19 vaccines as 'not a vaccine' compared to MMR. This phenomenon may also apply to the flu vaccine, highlighting the need for clear public health messaging.
A collaborative research effort has provided new insights into the likelihood of mpox spreading by airborne respiratory particles, comparing it to SARS-CoV-2 and smallpox. The study suggests that future viral evolution could alter this dynamic, underscoring the need for continued surveillance.
Scientists have developed an experimental vaccine that combines the benefits of both vaccine strategies, using a horsepox virus to confer safety in a single shot. The new vaccine is substantially more attenuated than the vaccinia virus used in existing vaccines, reducing the risk of side effects and triggering systemic infections.
The authors emphasize the importance of increasing vaccination rates to combat decreasing rates globally. They also highlight emerging challenges such as a highly virulent strain of influenza and measles outbreaks, particularly in areas with low vaccination rates.
A European study found that prior smallpox vaccination in childhood could offer protection against infections caused by monkeypox virus (MPXV) clade II in men. The estimated degree of protection varied among countries, highlighting the need for further research.
Researchers found that Mpox antibodies decrease significantly within a year of MVA-BN vaccination, especially in individuals without prior smallpox vaccination. In contrast, antibody levels remained high in those with childhood smallpox vaccination, suggesting long-term protection.
A Swedish study reveals that neutralising antibodies to the monkeypox virus decline significantly after two doses of the MVA-BN vaccine within the first month. The findings suggest that a booster dose may be necessary to maintain immunity, emphasizing the need for scientific evidence before policy decisions are made.
Researchers found that intradermal administration of the JYNNEOS smallpox vaccine induces an efficient immune response, protecting people living with HIV from contracting the monkeypox virus. Individuals with low CD4 T cell levels require a booster dose to compensate for their immunosuppressed status.
Researchers identified a new approach to treat poxviruses by targeting a cellular protein, making the virus more susceptible to natural defences. Existing immunosuppressive drugs can restrict replication and spread of poxviruses.
A survey of over 20,000 respondents in Japan found that 23% of male and 13% of female respondents were willing to receive the smallpox vaccine for Mpox prevention. Higher vaccination rates were observed among homosexual men compared to their heterosexual counterparts.
Researchers from Karolinska Institutet in Sweden report that individuals vaccinated against smallpox decades ago retain cross-reactive immunity to mpox. The study found that previous smallpox vaccination provides about 80% protection against mpox.
A new study reveals that smallpox originated more than 3,800 years ago, confirming historical sources and shedding light on the disease's history. The researchers used genetic analysis to trace the evolution of the virus, finding that different strains descended from a single common ancestor.
Researchers at La Jolla Institute for Immunology have confirmed that the smallpox vaccine MVA-BN (JYNNEOS) can teach T cells to recognize and fight the mpox virus. The study suggests that the JYNNEOS vaccine may provide protection against severe disease and could be effective in immunocompromised individuals.
Scientists have identified a protein complex called Ku that helps human cells detect viral DNA, and discovered how viral proteins can block this detection. The findings offer a new approach to improving the response to infections caused by viruses like monkeypox.
According to a review by Petra Zimmermann and Nigel Curtis, children under 8 are at higher risk of complications from monkeypox disease. The authors emphasize the need for smallpox vaccination as an effective way to prevent the spread of monkeypox among young children.
This review examines the known neurologic complications of smallpox and monkeypox, including their complications from vaccination. The study highlights the importance of understanding these neurological effects to improve treatment and prevention strategies.
A UC Davis Health study found that tecovirimat appears to be safe and effective for treating monkeypox symptoms and skin lesions. The study, which included 25 patients with confirmed monkeypox infection, showed that 92% of patients had lesions in their genital or anal area, while 40% healed from their lesions within a week of treatment.
A new study identifies pox virus proteins that directly interfere with the body's innate immune system, allowing it to evade the host's defense mechanisms. The research team has discovered five 'redox' proteins that interact with Reactive Oxygen Species, which play a key role in destroying pathogens identified by the immune system.
Healthcare workers must be vigilant in detecting and managing suspected monkeypox cases while avoiding stigmatization of affected communities. The authors stress the importance of careful infection control practices and community allyship with men who have sex with men to combat the outbreak.
The current monkeypox outbreak is more widespread than previous ones outside of Africa, with significant cases reported in Europe, the UK, and North America. A notable increase in cases among men who have sex with men has been observed, although the cause remains unclear.
Researchers at Medical University of South Carolina found that blocking the enzyme polymerase reduces the virus's ability to multiply. This discovery exposes an Achilles' heel that could be targeted with a therapeutic. Polymerase is a key tool for DNA replication and repair, making the virus vulnerable to disruption.
Researchers found a 1000-fold increase in skin microbiota and larger lesions after smallpox vaccination, but all groups had equal protection from re-infection. The study suggests that manipulating commensal skin microbiota might enhance the efficacy of intradermal vaccines.
The study reveals the structure of D13 and its role in assembling into a protein scaffold, which is critical for virus replication. The researchers discovered two ways the proteins interact to form a spherical honeycomb lattice, with a small helix structure playing a key role in assembly.
Researchers have successfully reconstructed the atomic structure of poxvirus RNA polymerase, which can produce mRNA independently. This breakthrough could lead to the development of new antiviral drugs and a better understanding of zoonotic diseases.
The study suggests that COVID-19 eradication is technically possible due to the availability of safe vaccines, lifelong immunity, and effective government management. However, securing high vaccine coverage and responding quickly to variants are major challenges.
Smallpox epidemics showed significant changes in frequency and seasonality over three centuries, with the introduction of vaccination and control measures leading to eradication. The analysis provides new insights into infectious disease ecology.
Researchers analyzed weekly smallpox mortality records from 1664 to 1930 to identify historical events influencing disease dynamics. They found that introduction of better control measures, especially vaccination, led to decreased mortality and eventual eradication.
Scientists discovered extinct strains of smallpox in Viking skeletons, proving the killer disease plagued humanity for at least 1400 years. The ancient strains were genetically different from modern smallpox, and their presence pushes back the confirmed existence of smallpox by a thousand years.
A new study pushes back the earliest evidence for smallpox infection by nearly 1,000 years to the 7th century in northern Europe. The discovery of a previously unknown clade of the smallpox virus suggests it may have been widespread throughout Viking Age Europe.
A new study reveals that the Vikings suffered from smallpox, dating back to the 7th century, and that the disease was more widespread than previously thought. The researchers found distinct viruses circulating during the Viking Age, which share a common ancestor with modern-day smallpox.
Researchers at McMaster University have traced the origins of old virus strains used as vaccination strains during the American Civil War, contributing to the eradication of smallpox. The study highlights the importance of understanding the history and evolution of viruses in vaccine development.
A study published in the Journal of Infectious Diseases found that HIV-positive women who received a childhood smallpox vaccine still retained some immunity to the virus, despite receiving antiretroviral therapy. This limited response suggests that while HIV treatment can boost overall immune function, it may not restore specific memor...
The US FDA has approved a new smallpox vaccine called JYNNEOS, which is non-replicating and can be used to protect against both smallpox and monkeypox diseases. The vaccine developed by Bavarian Nordic was shown to have a superior immune response compared to the existing ACAM2000 vaccine.
A smallpox outbreak could have devastating consequences in cities with high rates of immunosuppression. Experts warn that children and young people aged 0-19 years are most at risk, while older adults over 45 may experience severe disease and death.
A Phase 3 clinical trial demonstrates the safety and efficacy of IMVAMUNE, a non-replicating smallpox vaccine. The study showed twofold higher neutralizing antibodies compared to ACAM2000, a statistically superior immune response.
UAlberta researchers created a synthetic horsepox virus that can provide vaccine protection against smallpox. The discovery demonstrates the potential of synthetic DNA technology in advancing public health measures.
Researchers sequenced ancient HBV genome from 16th-century mummified child, confirming pathogen's long history in humans. The findings suggest the evolution of this virus is complex and has changed little over 450 years.
Researchers have discovered that the virus used in the early smallpox vaccine was closely related to horsepox, contradicting centuries-long assumptions that cowpox was used. The finding has significant implications for our understanding of vaccine development and its applications in modern medicine.
Researchers explore the origins of the smallpox vaccine, tracing its development from cowpox virus to modern vaccinia virus. The study sheds light on the intricate relationships between different types of viruses and lymphs involved in the vaccine's evolution.
Genetic analysis of ancient DNA reveals that the evolution of smallpox occurred far more recently than previously believed, with all available strains having an ancestor no older than 1580. Researchers found two circulating strains of the virus, variola major and minor, after English physician Edward Jenner developed a vaccine in 1796.
Researchers discovered a 17th-century variola virus in a child mummy, providing a more accurate timeline for the evolution of smallpox. The study suggests that smallpox may have appeared in humans more recently than previously thought, and its evolutionary history was influenced by human migration and colonization.
Dr. Andrea Ferrante is studying the molecular processes governing vaccine efficacy with a $1.6 million grant. Her goal is to create safer and more effective vaccines by understanding the role of dendritic cells in triggering an immune response.
Researchers at UT Health Science Center discover how poxviruses outsmart the body's immune system by targeting a key restriction factor called SAMD9. This finding has significant implications for cancer treatment and therapy, as SAMD9 also suppresses tumors.
Researchers uncover interesting revelations about the vaccinia virus through DNA sequencing data and historical accounts. The study suggests that the Brazilian VACV-IOC strain may have originated from a French Beaugency strain, challenging previous assumptions.
A Kansas State University research project will investigate the interaction between viruses and the immune system, focusing on poxviruses that could potentially become deadly diseases like smallpox. The study aims to predict future host ranges and develop new strategies for disease control.
Scientists have isolated a mutated polio virus that can evade the immune system and render vaccinations ineffective. This discovery is alarming as it threatens to undermine progress made in eradicating polio, which has been nearly eradicated thanks to effective vaccination.
International scientists argue that crucial scientific questions remain unanswered and important public health goals unmet in the case of smallpox. Research on live variola virus remains vital due to recent advances in synthetic biology and ongoing knowledge gaps, making its destruction less meaningful.
Children conceived during a severe epidemic show increased resistance to later diseases, a phenomenon known as functional trans-generational effect. This discovery suggests that parents can prepare their children for future diseases, and the underlying mechanism may be linked to an optimized immune response in high-pathogen environments.
Mayo Clinic researchers found that genetic differences affect immunity to smallpox vaccine. The study identified new targets for developing personalized vaccines, potentially benefiting non-responders.
Poxviruses evolve to adapt against host defenses by expanding their genome and overcoming immune mechanisms, providing a potent means of adaptation. This discovery offers insights into infectious-disease transmission between animals and humans and has implications for developing better antiviral strategies.
Researchers discovered that poxviruses can rapidly produce multiple copies of a gene to counter host defenses, allowing them to quickly adapt and evolve. The study provides new insight into the mechanisms of adaptation for large double-stranded DNA viruses.
Despite significant progress, polio eradication remains complex due to asymptomatic infections and vaccine limitations. Experts emphasize the need for further research on virus-host interactions and vaccine usage in the final stages of the program.
A recent study has reclassified cowpox virus into distinct species, challenging the long-held assumption of a single causative agent. The research also found that commercial smallpox vaccines are derived from central or eastern Europe, rather than Jenner's original English strain.
The destruction of live smallpox samples is crucial for further research, as the last naturally occurring case occurred in 1977. New vaccines have been developed, but full development is essential for global security and public health.
A recent study suggests that the monkeypox virus can cause significant lung damage by decreasing production of proteins involved in maintaining lung tissue structure and lubrication. This finding may lead to new approaches for treating conditions such as bronchitis, emphysema, and other lung diseases.
Researchers at UCLA report a 20-fold increase in human monkeypox cases in the Democratic Republic of Congo since smallpox vaccinations ended in 1980. The virus has become more common due to lack of health infrastructure and no surveillance, posing a risk for wider spread into animal populations.
Researchers discovered how smallpox kills by targeting molecules that block viral replication, paving the way for new therapeutics. The study sheds light on the molecular mechanisms causing disease in other viral infections, offering hope for prevention and treatment of pox viruses.
Researchers at La Jolla Institute have identified a cellular defect that increases the risk of severe reactions to the smallpox vaccine in people with eczema. Boosting Natural Killer cell activity may help prevent such reactions.
Researchers have identified a key interaction between smallpox virus and human protein human nuclear factor kappa-B1, which inhibits inflammation pathways. This finding may reveal new strategies for developing treatments for smallpox and understanding the human immune system.