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Good news on blocking a virus considered a global threat

Researchers developed an antibody cocktail effective against a Hendra virus variant, neutralizing its ability to mutate and evade recognition. The combination of four antibodies leaves the virus with minimal ability to further evolve, providing significant protection against this global biosecurity threat.

SourceOhio State University·JournalProceedings of the National Academy of Sciences·DateJun 13, 2022

Higher rate of COVID-19 death before vaccination linked to certain common inflammatory immune conditions

A study analyzing 17 million patient GP records in England found that people with certain inflammatory immune conditions were at higher risk of dying or needing hospital care from COVID-19. The analysis suggests that targeting prevention strategies and early interventions towards those most at risk can help inform evidence-based policy.

SourceLondon School of Hygiene & Tropical Medicine·JournalThe Lancet Rheumatology·DateJun 8, 2022

THE LANCET INFECTIOUS DISEASES: Study reports first use of antivirals in monkeypox patients, highlighting challenges in understanding and treating this rare disease

A new retrospective study analyzed seven patients with monkeypox in the UK between 2018 and 2021, suggesting potential benefits of antiviral medications like tecovirimat. However, brincidofovir showed little clinical benefit and raised concerns about liver toxicity.

SourceThe Lancet·JournalThe Lancet Infectious Diseases·TypeCase study·DateMay 24, 2022

Genetic options ensure rust resistance is toast

Researchers at King Abdullah University of Science & Technology (KAUST) have identified a stem rust resistance gene in Aegilops sharonensis and transferred it to common wheat. The new transgenic wheat lines show high levels of resistance to the stem rust pathogen, providing hope for mitigating the devastating effects of climate change.

SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Communications·TypeExperimental study·DateMay 9, 2022

A pre-Easter surprise: massive recall of chocolate products due to outbreak of monophasic Salmonella Typhimurium in 10 European countries

A multistate outbreak in 10 European countries linked to chocolate products has been linked to monophasic Salmonella Typhimurium, primarily affecting young children. The outbreak strain demonstrated a multidrug-resistant profile, highlighting the importance of including uncommon AMR profiles in early international communications.

SourceEuropean Centre for Disease Prevention and Control (ECDC)·JournalEurosurveillance·TypeObservational study·DateApr 14, 2022

Vehicles Play Important Role in PRRSV Transmission

Researchers from North Carolina State University found that trucks transporting pigs and farm workers can spread porcine reproductive and respiratory syndrome virus (PRRSV) among farms. The model estimated that vehicle movements contributed up to 20% of PRRSV transmissions, highlighting the importance of enhancing biosecurity measures ...

SourceNorth Carolina State University·JournalTransboundary and Emerging Diseases·TypeComputational simulation/modeling·DateMar 7, 2022

COVID-19 restrictions linked to nearly 750,000 fewer dengue cases in 2020

A new study found a strong association between school closures and declines in non-residential trips during COVID-19, leading to reduced risk of dengue transmission. Reduced time spent in public areas was closely associated with reduced dengue risk in countries where COVID-19 restriction measures began at the peak of dengue season.

SourceLondon School of Hygiene & Tropical Medicine·JournalThe Lancet Infectious Diseases·DateMar 2, 2022

Study identifies virus responsible for high mortality rate among pigeons in São Paulo City

A study found that a subtype of Newcastle disease virus caused the deaths of dozens of pigeons in São Paulo City. The researchers sequenced the viral genome and identified tissue wounds to determine the cause of death, revealing subgenotype VI.2.1.2 as the responsible pathogen. The risk to humans and poultry is considered low.

CityU research estimates vaccine donation from high to low- and middle-income countries will help end COVID-19 pandemic

A team led by City University of Hong Kong researcher Dr Zhang Qingpeng found that donating 46% to 80% of COVID-19 vaccines to low- and middle-income countries can significantly reduce infection rates and mortality. The study suggests prioritizing vaccines for countries with high incidence, prevalence, and mortality rates.

SourceCity University of Hong Kong·JournalNature Human Behaviour·TypeData/statistical analysis·DateMar 1, 2022

Harvard Chan research shows actions to prevent pandemics cost 5% of lives lost every year from emerging infectious diseases

Researchers provide cost-effective actions to prevent pandemics, including better surveillance and wildlife management, with estimated annual costs under $20 billion. These 'primary pandemic prevention' actions can help prevent future pandemics and have substantial co-benefits for human health, environment, and economic development.

SourceHarvard Chan C-CHANGE·JournalScience Advances·DateFeb 4, 2022

New commentary in European Journal of Clinical Nutrition makes case for adopting ‘blue zone’ diet to stave off COVID-19

A plant-based diet has been shown to lower the risk of COVID-19 infection and severe illness, with some studies suggesting a 9% lower risk and 73% lower risk among healthcare workers. The 'blue zone' diet, prevalent in Okinawa, Japan, may also provide benefits.

SourcePhysicians Committee for Responsible Medicine·JournalEuropean Journal of Clinical Nutrition·DateJan 31, 2022

Sediments a likely culprit in spread of deadly disease on Florida coral reefs, study finds

A new study found that seafloor sediments can transmit a deadly pathogen to local corals, contributing to the persistence of a devastating coral disease outbreak. Coastal construction activities like dredging and beach renourishment may further spread the disease.

SourceUniversity of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science·JournalFrontiers in Marine Science·TypeExperimental study·DateJan 25, 2022

Researchers identify a set of cellular receptors in humans and other species for the eastern equine encephalitis virus, other members of the alphavirus family

A new study identifies a set of cellular receptors for eastern equine encephalitis virus and other alphaviruses shared across mosquitoes, humans, and animals. The researchers tested a decoy molecule that successfully prevented infection and slowed disease progression in cell and animal models.

SourceHarvard Medical School·JournalNature·TypeExperimental study·DateJan 14, 2022

Chicago study finds individual housing dramatically reduced coronavirus rates in at-risk people experiencing homelessness

A Chicago study found that providing individual hotel rooms and medical support to high-risk homeless individuals reduced SARS-CoV-2 infection rates by 75% compared to citywide rates in shelters. The intervention also led to improvements in health measures such as blood pressure and glycemic control, with over half of participants movi...

SourceUniversity of Chicago Medical Center·JournalJAMA Network Open·DateDec 13, 2021

Early warning signals could help monitor disease outbreaks

Researchers developed a novel sequential analysis method to detect EWSs in daily COVID-19 case data across 24 countries, finding warnings were regularly detectable prior to exponential cases changes. The reliability of these signals depended on the time between successive waves and mathematical likelihood of critical transition.

SourceUniversity of Bristol·JournalBiology Letters·TypeComputational simulation/modeling·DateDec 7, 2021

Which COVID-19 vaccine works better?

The study found that the Moderna vaccine offered a lower risk of documented infection (21% reduced), symptomatic COVID-19 (44% reduced), hospitalization (55% reduced), ICU admission (10% reduced), and death (2% reduced) compared to the Pfizer vaccine. The results suggest that either vaccine is effective, but Moderna may be slightly mor...

SourceVeterans Affairs Research Communications·JournalNew England Journal of Medicine·TypeNews article·DateDec 1, 2021

UK study suggests COVID-19 became much more lethal in late 2020

A new statistical analysis supports the notion that COVID-19 became more lethal in the UK in late 2020, with increased lethality attributed to factors beyond just the alpha variant of the virus. The study used Bayesian inference to draw stronger conclusions from weekly data on cases and deaths.

SourcePLOS·JournalPLOS ONE·TypeComputational simulation/modeling·DateNov 24, 2021

Warning over antibiotic-resistant bacteria

A study by Anglia Ruskin University has identified potentially dangerous Pseudomonas bacteria in 21% of wild bird faeces collected from locations near the River Cam. The bacteria, which can be passed on to humans through cross-contamination, were resistant to multiple antibiotics.

SourceAnglia Ruskin University·JournalEcology and Evolution·DateNov 17, 2021

Georgia State researchers develop rapid computer software to track pandemics as they happen

A team of researchers at Georgia State University has created a lightning-fast computer software that can process over 200,000 novel virus genomes in under two hours. The software provides valuable information for countries making early decisions about lockdowns, quarantines, and testing during infectious disease outbreaks.

SourceGeorgia State University·JournalJournal of Computational Biology·TypeComputational simulation/modeling·DateNov 16, 2021

Does previous SARS experience help healthcare workers cope with COVID-19?

A new study published in PLOS ONE found that over half of surveyed healthcare workers reported PTSD symptoms during the COVID-19 pandemic, regardless of previous SARS experience. Healthcare workers with prior SARS experience showed lower scores of PTSD and depression, but this effect disappeared after correcting for other factors.

SourcePLOS·JournalPLOS ONE·TypeSurvey·DateNov 10, 2021

Change in vaccination strategy averted outbreak of urban yellow fever in São Paulo State, scientists say

An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.