Researchers have discovered a way to bring cancer-killing T cells to bear against a specific type of colorectal cancer, showing promising results. The findings may represent a therapeutic strategy to target other types of cancers, and the next step is to further explore how T cells become activated in the tumor environment.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalJournal of Experimental Medicine·DateOct 8, 2021
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers analyzed fecal metagenomic DNA sequencing data to see if specific donor strains correlated with successful treatment outcomes. They found no correlation between donor strains and response to anti-PD-1 therapy in melanoma patients.
SourceUniversity of Alabama at Birmingham·JournalBMC Microbiology·TypeComputational simulation/modeling·DateOct 7, 2021
Researchers developed a gel made of fibrin that improved the effectiveness of CAR-T cell immunotherapy for glioblastoma by enhancing T cell distribution and preventing tumor recurrence. In mouse studies, the gel showed promising results, with 64% of treated mice being tumor-free after 94 days.
SourceUNC Lineberger Comprehensive Cancer Center·JournalScience Advances·TypeExperimental study·DateOct 6, 2021
Researchers at CNIO and 12 de Octubre Hospital have developed a new cancer treatment called CAR-NK-cell immunotherapy, which uses natural killer cells to target cancerous cells. The treatment has shown promising results in mice with multiple myeloma, with 25% of treated mice remaining disease-free.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalBlood Cancer Journal·TypeExperimental study·DateOct 6, 2021
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A recent study found that non-Hispanic Black patients who received immunotherapy for advanced-stage non-small cell lung cancer had a lower risk of death compared to non-Hispanic white patients. The researchers controlled for access-related issues and found disparities persisted in certain populations.
SourceAmerican Association for Cancer Research·DateOct 6, 2021
Researchers have identified a common mutation in gliomas that sensitizes them to immunotherapy, which can lead to improved survival rates and tumor-free periods. The discovery may have broader therapeutic implications for all glioma patients, offering new hope for treatment.
SourceMichigan Medicine - University of Michigan·JournalScience Advances·TypeExperimental study·DateSep 29, 2021
A high-fat diet increases the incidence of colorectal cancer by suppressing MHC-II levels in intestinal cells. This disruption allows cancer cells to grow unchecked. Researchers hope that reconfiguring the gut microbiome and boosting immune recognition molecules can help combat cancer.
SourceCold Spring Harbor Laboratory·JournalCell Stem Cell·DateSep 28, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers found that antidepressants inhibit the growth of pancreatic and colon cancers in mice by blocking a mechanism used by cancer cells to evade the immune system. The findings suggest a promising approach for combining antidepressant drugs with immunotherapy to treat incurable cancers.
SourceUniversity of Zurich·JournalScience Translational Medicine·DateSep 28, 2021
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
SourceAlphaMed Press·JournalStem Cells Translational Medicine·TypeRandomized controlled/clinical trial·DateSep 28, 2021
Researchers at Johns Hopkins Kimmel Cancer Center discovered differences in gene activity between immune cells from patients with lung cancer who responded and did not respond to immunotherapies. The findings suggest that non-responders' immune cells can be reprogrammed to act more like responders', potentially leading to new treatment...
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
The IMpower010 trial demonstrates that atezolizumab significantly improves disease-free survival in resected, early-stage NSCLC patients compared to best supportive care. Tumors expressing PD-L1 > 50% show a greater benefit of treatment.
The KEYNOTE-826 study found that adding immunotherapy to standard first-line treatment increases overall survival by eight months for patients with recurrent, persistent or metastatic cervical cancer. The addition of pembrolizumab to chemotherapy also reduced the risk of death and disease progression by 33%.
SourceEuropean Society for Medical Oncology·JournalAnnals of Oncology·DateSep 18, 2021
Scientists at Hokkaido University have developed a lipid nanoparticle that delivers immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy. This approach has shown promise in mice experiments and could lead to the development of an adjuvant treatment for cancer patients.
SourceHokkaido University·JournalJournal for ImmunoTherapy of Cancer·TypeExperimental study·DateSep 17, 2021
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Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A survey of 5,589 cancer patients found widespread unawareness about immunotherapy's mechanism, efficacy, and cost. Non-oncology doctors also face challenges in keeping up with the latest developments in oncology.
SourceEuropean Society for Medical Oncology·JournalAnnals of Oncology·DateSep 16, 2021
A novel population of long-lived T cells, called 'lymph node resident memory T cells,' provides protection against melanoma by persisting in lymph nodes. These cells were found to counteract melanoma spreading in mice and predicted better outcomes for human melanoma patients with lymph node metastases.
SourceDartmouth Health·JournalImmunity·TypeComputational simulation/modeling·DateSep 14, 2021
Researchers developed a treatment using cowpea mosaic virus nanoparticles that target lung tumors, slowing tumor growth and preventing cancer spread. The treatment showed efficacy against aggressive cancer cell lines and may offer protection to patients at high risk of metastatic disease.
SourceUniversity of California - San Diego·JournalAdvanced Science·TypeExperimental study·DateSep 14, 2021
Patients treated with immune checkpoint inhibitors show better quality of life and reduced symptoms compared to those without immunotherapy. The study analyzed self-reported outcomes of 26 published studies and found that patients' global quality of life was stable or improved, but breathing difficulties increased
SourceH. Lee Moffitt Cancer Center & Research Institute·TypeMeta-analysis·DateSep 14, 2021
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers at Kyoto University designed a synthetic molecular code, EnPGC-1, that activates mitochondrial biogenesis in T cells, increasing their numbers and longevity. The approach enhances anti-tumor immunity in mice and improves survival.
SourceKyoto University·JournalCell Chemical Biology·DateSep 13, 2021
A phase II trial found that high-dose cytarabine followed by pembrolizumab improved cancer remission rates in AML patients, with a complete remission rate of 38%. The treatment also showed promise for patients who had not benefited from standard therapy.
SourceUNC Lineberger Comprehensive Cancer Center·JournalBlood Cancer Discovery·TypeRandomized controlled/clinical trial·DateSep 10, 2021
Researchers analyzed large datasets to find biomarkers that could help select immunotherapy treatment for older patients. The analysis suggests that factors such as mutational burden and immune checkpoint protein expression are associated with increased response to immunotherapies in older patients, despite lower general immunity.
SourceJohns Hopkins Medicine·JournalCell Reports·DateSep 7, 2021
A nationally representative survey found that 72% of people with food allergies were unaware of oral immunotherapy as a treatment option. The study highlights the need for more accessible and equitable outreach efforts to ensure all patients can benefit from recent advances in food allergy treatments.
SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalJournal of Allergy and Clinical Immunology·DateSep 2, 2021
Researchers at the University of Gothenburg have developed a simple blood test to detect treatment-triggered encephalitis in patients undergoing immunotherapy. The study found that markers such as S-100B and NFL can act as early warnings for encephalitis, allowing for timely administration of anti-inflammatory drugs.
SourceUniversity of Gothenburg·JournalJournal for ImmunoTherapy of Cancer·TypeCase study·DateSep 2, 2021
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new combination treatment has shown significant tumor shrinkage and prolonged survival in patients with metastatic uveal melanoma. The treatment, which targets HDAC and PD-1 proteins, was found to work better in tumors with active BAP1 genes, a key discovery that may lead to improved survival rates.
SourceUniversity of Gothenburg·JournalNature Communications·TypeRandomized controlled/clinical trial·DateAug 30, 2021
The FDA has granted orphan drug status to Octagam 10%, the first and only IVIg treatment for adult dermatomyositis. The therapy is expected to become the first treatment option for adults with this rare disease, which affects approximately 10 out of every million U.S. residents.
A new study suggests that a treatment for canine glioblastoma may also be effective in humans, with some dogs experiencing significant tumor shrinkage. The treatment uses an immunotherapy drug called STING agonist, which induced a robust immune response against cancer cells.
SourceNorthwestern University·JournalClinical Cancer Research·DateAug 25, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers found a safe and tolerable combination of entinostat and immunotherapy, increasing CD8/FoxP3 gene expression and resulting in 16% objective response rate. The study showed promising results for patients with advanced cancers that have not responded to traditional therapy.
SourceJohns Hopkins Medicine·JournalClinical Cancer Research·DateAug 18, 2021
Scientists investigated a method to enhance immunotherapy for lung cancer and found that combining it with certain chemotherapy drugs could eliminate harmful immune cells. This approach showed promising results in preclinical studies, inducing the regression of about 70% of tumors.
SourceEcole Polytechnique Fédérale de Lausanne·JournalScience Translational Medicine·DateAug 11, 2021
Researchers at City of Hope found that advanced colorectal cancer patients with no liver metastases respond to checkpoint inhibitors, achieving a major response in 20% of cases. In contrast, patients with liver metastases showed no positive response to immunotherapy.
SourceCity of Hope·JournalJAMA Network Open·TypeSystematic review·DateAug 9, 2021
Researchers have developed an immunotherapy strategy that combines three drugs to boost the immune system against tumors. The new therapy showed promising results in mice, with pancreatic tumors shrinking or disappearing completely in about half of the animals.
SourceMassachusetts Institute of Technology·JournalCancer Cell·DateAug 6, 2021
A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
SourceBroad Institute of MIT and Harvard·JournalCell·TypeComputational simulation/modeling·DateAug 5, 2021
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A research team at Kansas State University is working on a three-year project to monitor a cancerous tumor's immune state to assess immunotherapy interventions. The goal is to drive more tumors into a favorable state, ultimately contributing to improved cancer immunotherapy treatment.
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
SourceUniversity of New South Wales·JournalThe Lancet Regional Health - Western Pacific·TypeData/statistical analysis·DateAug 3, 2021
Researchers have found a way to harness the power of immunotherapy for advanced prostate cancer by targeting a protein called PIKfyve. Blocking PIKfyve with the inhibitor ESK981 has been shown to increase tumor death and recruit immune T cells, offering new hope for patients with this challenging form of cancer.
SourceMichigan Medicine - University of Michigan·JournalNature Cancer·TypeExperimental study·DateAug 2, 2021
Researchers have identified a biomarker, MHC-II, that predicts response to immunotherapies in breast cancer patients. The study found that MHC-II expression is associated with response to standard chemotherapy plus durvalumab or pembrolizumab, but not to standard neoadjuvant chemotherapy alone.
SourceVanderbilt University Medical Center·JournalClinical Cancer Research·DateJul 27, 2021
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers found that patients with advanced bladder cancers and FGFR3 mutations respond to immunotherapy just like those without the mutation. The study's findings suggest that FGFR3-mutated tumors can benefit from immunotherapy treatment, providing a new option for patients who previously had limited treatment options.
SourceUNC Lineberger Comprehensive Cancer Center·JournalBritish Journal of Cancer·DateJul 22, 2021
Researchers found that combining low-dose radiation with immunotherapy significantly boosts cancer eradication rates in mice. The treatment approach triggers the immune system to attack cancer cells, even when radiation alone is too weak to destroy them.
SourceUniversity of Pittsburgh·JournalScience Translational Medicine·DateJul 14, 2021
A new study predicts patient responses to immunotherapy using tumor fragments in the lab, offering hope for personalized cancer treatment. The researchers identified specific immune cell markers that can predict treatment response and resistance.
SourceNetherlands Cancer Institute·JournalNature Medicine·DateJul 8, 2021
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Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers discover pharmacological activation of p53 triggers viral mimicry response, abolishing tumor immune evasion and promoting anti-tumor immunity. The findings have potential for developing new combination therapies that can increase cancer patient access to immunotherapy.
SourceKarolinska Institutet·JournalCancer Discovery·DateJul 6, 2021
Researchers from UNIGE and Harvard Medical School have discovered the difference between desired immune responses targeting cancer cells and unwanted responses affecting healthy tissue. By understanding these differences, they aim to develop new therapeutic approaches that minimize toxic side effects and maximize treatment efficacy.
SourceUniversité de Genève·JournalScience Immunology·DateJul 2, 2021
Researchers develop a non-invasive imaging method to track IDO1 activity, providing a promising alternative to invasive biopsies. The study found that IDO1 status in the mesenteric lymph node is a surrogate marker for cancer-immune set point and predicts immunotherapeutic efficacy.
SourceThe National Institutes for Quantum Science and Technology·JournalJournal for ImmunoTherapy of Cancer·DateJul 2, 2021
Researchers found that MET oncogene amplification creates a hostile environment for immunotherapy, making it ineffective in treating some lung cancers. A combination of a MET inhibitor and anti-PD1 immunotherapy was effective in treating cancers with MET amplification.
SourceMayo Clinic·JournalCancer Discovery·DateJul 1, 2021
Researchers used machine learning to analyze tumor microenvironment and identify biomarkers that predict patient response to immunotherapy. The model outperformed current biomarkers, enabling personalized treatment and better understanding of biological mechanisms involved.
SourceEindhoven University of Technology·JournalPatterns·DateJun 30, 2021
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at WashU Medicine have shown that cell-based immunotherapy using natural killer cells may be effective against solid tumors, including melanoma. The therapy has been successful in treating patients with recurrent leukemia and other blood cancers.
SourceWashU Medicine·JournalClinical Cancer Research·DateJun 29, 2021
Researchers have developed an anti-cancer prodrug that targets cancer cells while minimizing toxicity to normal cells. This innovation improves the effectiveness of immunotherapy by boosting patient immunity. The drug exhibits anticancer effects when activated in cancer cells, inducing an active anticancer immune response.
SourceNational Research Council of Science & Technology·JournalBiomaterials·DateJun 28, 2021
A recent study published in the Oncogene Journal revealed that targeting HIF-1α significantly inhibited melanoma growth and amplified immune cell infiltration into tumour microenvironment. The discovery provides a valuable new target for making resistant melanomas more vulnerable to available anti-cancer treatments.
SourceLuxembourg Institute of Health·JournalOncogene·DateJun 21, 2021
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers developed a microparticle-based cancer vaccine that kickstarts an immune response, increasing the proportion of mice cured of tumors to 75%. Combining the vaccine with immune checkpoint inhibitors greatly improves treatment success, offering a promising approach to improving cancer treatment.
SourceUniversity of Konstanz·JournalNature Communications·DateMay 18, 2021
Researchers at Michigan Medicine identified a long noncoding RNA, LIMIT, that promotes the body's immune response against cancer. By activating key genes and pathways, LIMIT boosts T cell infiltration into tumors, offering new potential therapeutic approaches to overcome immune evasion in human cancers.
SourceMichigan Medicine - University of Michigan·JournalNature Cell Biology·DateMay 17, 2021
Cancer immunotherapy using acoustics-based therapies has shown synergistic effects, enhancing the autogenous immune response to cancer tissue. Detailed mechanisms of sonopyrolysis-, sonoporation-, and sonoluminescence-based therapy are discussed to demonstrate its potential in cancer treatment.
SourceCompuscript Ltd·JournalBIO Integration·DateMay 10, 2021
Researchers found that patients with high levels of PDL-1 and a KRAS gene mutation lived longer when treated with immunotherapy alone compared to those without the mutation. Patients without the mutation had better survival with combination therapy, suggesting preferred treatment approaches for this patient group.
SourceUniversity of Pennsylvania School of Medicine·JournalJAMA Oncology·DateApr 15, 2021
A new study suggests that long-term survival data for immunotherapies should be re-analyzed for potential misinterpretation. Researchers propose an adjustment method, Cox-TEL, to correct inaccurate results based on the Cox proportional-hazards model.
SourceVanderbilt University Medical Center·JournalJAMA Oncology·DateApr 15, 2021
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
A team of researchers has developed AI tools to predict which lung cancer patients will respond to immunotherapy, with the goal of improving patient outcomes and reducing costs. The study uses machine learning algorithms to analyze tissue scan patterns and identify previously unseen indicators that can inform treatment decisions.
Chronic side effects among melanoma survivors after anti-PD-1 immunotherapy treatment are more common than previously recognized, affecting 43% of patients. The most frequently affected organs were joints and the endocrine system.
SourceVanderbilt University Medical Center·JournalJAMA Oncology·DateMar 25, 2021
Research found that immunotherapy using checkpoint inhibitors does not benefit patients with NASH-related liver cancer, and may even promote tumor growth. The study identified a biomarker to assess treatment efficacy in these patients.
SourceGerman Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)·JournalNature·DateMar 24, 2021
A Mount Sinai study found immunotherapy to be significantly less effective in liver cancer patients with non-alcoholic steatohepatitis (NASH), while also fueling tumor growth. The research highlights the need for refined therapeutic strategies to treat both tumors and underlying liver disease.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature·DateMar 24, 2021
Researchers at UCLA discovered that deactivating a specific gene in cancer cells can significantly slow tumor growth and enhance the effectiveness of immunotherapy. The findings hold promise for developing more effective treatments for highly invasive head and neck squamous cell cancers.
SourceUniversity of California - Los Angeles·JournalMolecular Cell·DateMar 23, 2021
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers have discovered that bacteria residing within tumor cells can be harnessed to provoke an immune reaction against the tumor. The findings suggest that bacterial peptides presented on tumor cells can serve as potential targets for immunotherapy, enabling immune T cells to recognize and attack cancer cells more precisely.
SourceWeizmann Institute of Science·JournalNature·DateMar 22, 2021
A study analyzing 45 patients with Merkel cell carcinoma found that patients with shorter disease-free intervals and specific genetic mutations, such as ARID2 and NTRK1, may be more likely to benefit from immunotherapy. These findings could inform treatment decisions and future research.
SourceImpact Journals LLC·JournalOncotarget·DateMar 22, 2021
Researchers at Moffitt Cancer Center found that sequential treatment with immunotherapy followed by BRAF and MEK inhibitors promotes anti-tumor immunity and suppresses signaling that leads to drug resistance. The study suggests that this approach may be a potential treatment option for patients with melanoma.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalCancer Immunology Research·DateMar 2, 2021
Researchers at Columbia University Irving Medical Center have developed a new technique that uncovers tricks cancer cells use to evade immunotherapies. The approach identified new mechanisms of resistance and validated existing ones, providing insights into why some melanoma patients don't respond to treatment.
SourceColumbia University Irving Medical Center·JournalNature Genetics·DateMar 1, 2021
A University of Chicago study has identified multiple targets to improve cancer therapy outcomes. By depleting Ter cells and blocking artemin signaling, researchers found enhanced control of tumor burden in mice.
SourceUniversity of Chicago Medical Center·JournalScience Translational Medicine·DateFeb 24, 2021
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.