Articles tagged with Orthopedics
Researchers from Osaka University found that fibroblasts in cholesteatoma tissues express activin A, a protein causing local bone erosion. This discovery may lead to new treatments for managing cholesteatomas.
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
Research discusses challenges and future directions for porous metallic implant fabrication, focusing on microstructure, biocompatibility, and mechanical properties. The review aims to promote metabolite and nutrient exchange, bone ingrowth, and improved implant-tissue anchorage.
A new study by the University of Bristol highlights significant variations in healthcare spending and care delivery across NHS hospitals following hip fracture. The research found that patients who received timely orthogeriatrician assessment and physiotherapy had lower costs and reduced risk of delirium.
Patients undergoing bilateral total knee arthroplasty are at a higher risk of complications such as pulmonary embolism, stroke, and blood loss anemia compared to those undergoing unilateral TKA. The study found that the risks of these complications were approximately doubled in the bilateral TKA group.
A second-generation all-inside meniscal repair system demonstrates a high successful repair rate of 84-88% at 10 years, with low failure rates and no correlation to patient characteristics or surgical techniques. Patient-reported outcomes improve after meniscal repair and ACL reconstruction.
Researchers found that treatment with tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO), a common complication of abnormal bone formation. The study showed a significant reduction in HO risk, with an odds ratio of 0.49 and a 50% lower risk compared to patients not receiving TXA.
A novel study found that honokiol promotes healing of rotator cuff injury and may be an effective treatment for humans. The study suggests that SIRT3 activation plays a protective role in alleviating aging-induced fibrocartilage degeneration and promoting rotator cuff healing.
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
Researchers found bacterial DNA in surgical specimens of patients with hip and knee arthritis, revealing a microbiome in previously assumed sterile sites. The most common bacteria were Escherichia, Cutibacterium, Staphylococcus, Acinetobacter, and Pseudomonas.
The new FRAXplus beta version offers a more user-friendly platform to refine risk factor information, allowing clinicians to explore the impact on individual patients. The tool provides helpful features such as saved data and export options to facilitate sharing.
A new Johns Hopkins Medicine study found that patients with low pain self-efficacy are more likely to use daily prescribed opioids before surgery. Surgeons can use pain self-efficacy scores to identify high-risk patients and provide education and counseling to improve post-surgery outcomes.
Researchers developed 'smart' coatings that monitor strain on implants to prevent infection and provide early failure warning. The coatings, inspired by dragonfly and cicada wings, integrate flexible sensors with antibacterial surfaces.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
The Build Better Bones platform provides practical guidance on strengthening bones through targeted exercises and bone-healthy nutrition. The platform also offers helpful information for caregivers, including support with daily tasks and medical specialty knowledge.
A study of joint replacements in England finds socio-economic inequalities remain, with those living in deprived areas having the least access to surgery. The findings highlight the need for healthcare commissioners to address disparities in joint replacement provision.
A new study from Lund University estimates that regression to the mean can account for up to 1 point improvement in pain scores among osteoarthritis patients. This natural phenomenon can lead to false positives in clinical trials, masking the true efficacy of treatments.
A study found that sleeve gastrectomy decreases bone mineral density and strength in adolescents and young adults. Participants who underwent weight loss surgery lost significant amounts of weight and experienced reductions in abdominal fat tissue and muscle mass.
Patients with low sodium levels before or after total knee or hip arthroplasty are at increased risk of complications and adverse outcomes. Postoperative hyponatremia was linked to longer hospital stays, higher rates of discharge to rehabilitation centers, and readmission within 90 days.
Researchers found that preserving the meniscus with sutures is more effective in protecting cartilage from future damage in younger patients. Meniscectomies, which remove more than half of the meniscus, were more likely to progress cartilage degeneration.
A research team at HKUMed has invented a non-invasive technology to effectively reduce methicillin-resistant Staphylococcus aureus (MRSA) infection in bony tissue. The novel antibacterial nano-sheets can release ROS subject to ultrasound stimulation, eliminating MRSA bacteria deeply seated in bony tissue with 99.72% efficacy.
Researchers have found a potential treatment for osteoarthritis by targeting the GP130 immune receptor, which causes hyper-inflammation in joints. The new compound R805/CX-011 showed promising results in animal studies, reducing joint pain and stiffness, and may lead to Phase 1 and 2A clinical trials.
A new way to identify higher-risk groups of older surgical patients can help surgeons make better care decisions and compare hospital performance. The new definitions label fewer patients as multimorbid and specify high-risk comorbidity combinations, which contribute to patient risk.
Higher body mass index patients undergoing unicompartmental knee replacement (UKR) experience lower revision rates with cementless implants, according to a new study. Cementless fixation is preferred in higher-BMI patients, reducing the risk of revision surgery by up to 40%.
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
A novel surgical pain management strategy has been developed to reduce opioid use after total knee arthroplasty. The study found that changing prescriptions for opioids at discharge from automatic to upon request dramatically decreased opioid use, with over half of patients recovering without opioid use.
A systematic review of 18 studies found that muscle relaxants and non-steroidal anti-inflammatory drugs (NSAIDs) can effectively reduce symptoms. Combining NSAIDs with paracetamol showed a greater improvement than using NSAIDs alone.
Researchers found that young adults post-ACLR who exhibited lower patellofemoral joint (PFJ) loading during hopping were more likely to develop PFJ osteoarthritis at 1-year and worsening PFJ osteoarthritis between 1-5 years. Lower PFJ contact force was linked to increased risk of early osteoarthritis.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
A new study finds that age-related abdominal fat is associated with lower muscle density, leading to less effective muscle function. This accumulation of visceral adipose tissue may represent a modifiable risk factor for poor musculoskeletal outcomes with aging.
Researchers found no subgroup of patients who benefit from surgery for a torn meniscus, suggesting it should only be performed in cases of obvious complaints. A personalized approach focusing on prevention and physiotherapy is recommended to save healthcare costs and improve quality of life.
The Geriatric Fracture Program at Cedars-Sinai Medical Center has been shown to reduce hospital stays by 2.12 days and lower hospital-related costs by $5,316 for patients aged 65 and older. The program's comprehensive care approach, including bone strength assessments and fall prevention strategies, is effective in improving outcomes.
A recent study found that Black and Hispanic veterans experienced longer wait times for cardiology and orthopedic services compared to white veterans, highlighting racial disparities in healthcare access
A new clinical trial of over 12,000 patients found that inexpensive aspirin is just as effective as injectable blood thinners in preventing life-threatening blood clots and other complications. The study suggests that surgeons may change their practice to administer aspirin to patients hospitalized with bone fractures.
Researchers found that knee extension velocity, not quadriceps strength, is a strong predictor of walking performance in elderly patients after total knee arthroplasty. This study suggests that training to enhance knee extension velocity could be effective in recovering gait function.
A new study published in BMJ Open found no significant difference between older and newer knee replacement implants six months after surgery. This is a breakthrough for patients, as it suggests that older designs with proven track records can provide similar patient-reported outcomes to more modern designs.
A randomized trial shows that patients undergoing partial knee arthroplasty (UKA) experience faster functional recovery in walking speed and mobility tests compared to those who had total knee arthroplasty (TKA). UKA also resulted in shorter operative times, reduced blood loss, and improved functional outcomes.
Bicycle-related injuries in the US decreased over time, with an increasing rate of injuries among older patients, particularly head injuries and fractures. Helmet wearing is crucial regardless of age to prevent such injuries.
Researchers developed an AI-based neural network to detect early knee osteoarthritis from x-ray images, matching doctors' diagnoses in 87% of cases. This method could help reduce unnecessary examinations, treatments, and even knee joint replacement surgery.
A study found that joint replacement prices are not associated with quality of care, but rather with the type of insurer. The study analyzed publicly available data from 18 hospitals in California and found significant price differences between different payer types.
A study published in The Journal of Arthroplasty found that prescribing smaller initial opioid prescriptions can reduce the risk of refill in patients after surgery. This approach also creates an opportunity for doctors and patients to discuss the risks of continuing opioids if needed.
A study published in the American Journal of Preventive Medicine estimates the economic burden of acute firearm injuries at a Level I Trauma Center in New Orleans, resulting in a net loss of $20.3 million over four years. The study highlights the significant financial impact of gun violence on healthcare systems and society.
The IOF and ESCEO position paper recommends retaining the current WHO diagnostic criteria for osteoporosis, which has served the field well. The paper suggests that distinguishing between diagnostic and intervention thresholds can help improve treatment of patients at high risk of fractures.
A study by Osaka Metropolitan University found that teaching fall prevention using home floor plans reduced falls in older hospital patients by 97% compared to a control group. The intervention group had no falls within two months of discharge, while the control group experienced 7.7% falls.
Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.
A study found that patient-reported outcome measures (PROMs) were infrequently accessed by clinicians, even when integrated into electronic health records. The data collection rate was high, but the use of PROMs among surgeons and care teams was nearly non-existent.
Researchers at FAU aim to empower amputees to maximize their individual potential for controlling the full dexterity of artificial hands using a novel bimodal skin sensor and machine learning algorithms. The project will develop customized prosthetic sockets and training programs to overcome limitations with current sensing technology.
A randomized clinical trial involving over 1,600 patients found that two antiseptic solutions are equally effective in preventing post-surgical infections. The study provides reassurance to orthopedic surgeons and helps improve practice of evidence-based medicine.
A landmark study published in The Lancet found that chlorhexidine gluconate and povidone-iodine aqueous solutions are equally effective in preventing surgical site infections in patients with open fractures. This finding has significant implications for healthcare practitioners and may reduce costs associated with accessing these antis...
A new study found that hormone therapy may protect against adhesive capsulitis, a painful orthopedic disorder affecting perimenopausal women. The research suggests estrogen plays a role in musculoskeletal function and reducing inflammation, supporting the hypothesis that hormone therapy is protective against the disorder.
A study found that excessive physical activity during adolescence is associated with abnormal leg alignment, which can develop into a physiological adaptation to load where the shin bone meets the knee. This abnormal alignment may increase the risk of future injuries and osteoarthritis if modified during critical periods of growth.
A McMaster University study found that switching to non-opioid painkillers after surgery can significantly reduce opioid consumption and improve patient outcomes. The six-week study enrolled 193 patients who received either standard opioid-based painkillers or a combination therapy of naproxen, acetaminophen, and pantoprazole.
A new day-case surgical procedure for diabetic foot ulcers has been shown to accelerate effective healing, reduce recurrence, and prevent amputations. The procedure, which involves adjusting the mechanics of the foot, was found to be effective in treating up to 19 patients with successful ulcer resolution in just 3-4 weeks.
A study of 543 children and teenagers found that those whose parents preferred a language other than English were twice as likely to wait more than 90 days for surgery. The researchers urge orthopedic departments to provide more equitable care for non-English speaking families.
A group of researchers from Osaka Metropolitan University found that administering parathyroid hormone to rat Achilles tendons increased the production of cartilaginous matrix and promoted chondrogenic differentiation. This breakthrough discovery may lead to improved outcomes for meniscal reconstruction surgery, protecting knee cartila...
Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.