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Aspirin as effective as blood thinner injections to prevent deadly complications in patients hospitalized with bone fractures

A new clinical trial of over 12,000 patients found that inexpensive aspirin is just as effective as injectable blood thinners in preventing life-threatening blood clots and other complications. The study suggests that surgeons may change their practice to administer aspirin to patients hospitalized with bone fractures.

SourceUniversity of Maryland School of Medicine·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJan 18, 2023

Faster knee for better walking

Researchers found that knee extension velocity, not quadriceps strength, is a strong predictor of walking performance in elderly patients after total knee arthroplasty. This study suggests that training to enhance knee extension velocity could be effective in recovering gait function.

SourceOsaka Metropolitan University·JournalPLOS ONE·TypeObservational study·DateJan 12, 2023

Artificial Intelligence searches an early sign of osteoarthritis from an x-ray image – might save from unnecessary treatments and examination

Researchers developed an AI-based neural network to detect early knee osteoarthritis from x-ray images, matching doctors' diagnoses in 87% of cases. This method could help reduce unnecessary examinations, treatments, and even knee joint replacement surgery.

SourceUniversity of Jyväskylä - Jyväskylän yliopisto·JournalDiagnostics·TypeObservational study·DateDec 15, 2022

Reducing opioids prescribed after total knee and hip arthroplasty can be beneficial for patients and doctors

A study published in The Journal of Arthroplasty found that prescribing smaller initial opioid prescriptions can reduce the risk of refill in patients after surgery. This approach also creates an opportunity for doctors and patients to discuss the risks of continuing opioids if needed.

SourceMichigan Medicine - University of Michigan·JournalThe Journal of Arthroplasty·TypeSurvey·DateDec 13, 2022

LSU Health New Orleans study reveals economic burden of gun violence

A study published in the American Journal of Preventive Medicine estimates the economic burden of acute firearm injuries at a Level I Trauma Center in New Orleans, resulting in a net loss of $20.3 million over four years. The study highlights the significant financial impact of gun violence on healthcare systems and society.

SourceLouisiana State University Health Sciences Center·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateNov 14, 2022

Go home safe: fall prevention for older hospital patients after discharge

A study by Osaka Metropolitan University found that teaching fall prevention using home floor plans reduced falls in older hospital patients by 97% compared to a control group. The intervention group had no falls within two months of discharge, while the control group experienced 7.7% falls.

SourceOsaka Metropolitan University·JournalInternational Journal of Environmental Research and Public Health·TypeRandomized controlled/clinical trial·DateNov 10, 2022

Researchers find treatment options for patients whose blood cancer relapses after CAR-T

Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.

Landmark study finds antisepsis agents interchangeable in reducing infection risk in open fracture surgeries

A landmark study published in The Lancet found that chlorhexidine gluconate and povidone-iodine aqueous solutions are equally effective in preventing surgical site infections in patients with open fractures. This finding has significant implications for healthcare practitioners and may reduce costs associated with accessing these antis...

SourceLouisiana State University Health Sciences Center·JournalThe Lancet·TypeRandomized controlled/clinical trial·DateOct 14, 2022

Orthopedic surgery patients do fine without opioid painkillers

A McMaster University study found that switching to non-opioid painkillers after surgery can significantly reduce opioid consumption and improve patient outcomes. The six-week study enrolled 193 patients who received either standard opioid-based painkillers or a combination therapy of naproxen, acetaminophen, and pantoprazole.

SourceMcMaster University·JournalJAMA·TypeRandomized controlled/clinical trial·DateOct 4, 2022

Tendon tissue plus parathyroid hormone reproduces a normal meniscus

A group of researchers from Osaka Metropolitan University found that administering parathyroid hormone to rat Achilles tendons increased the production of cartilaginous matrix and promoted chondrogenic differentiation. This breakthrough discovery may lead to improved outcomes for meniscal reconstruction surgery, protecting knee cartila...

SourceOsaka Metropolitan University·JournalThe American Journal of Sports Medicine·TypeExperimental study·DateAug 26, 2022

The locked library: Disease causes cells to reorder their DNA incorrectly

Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.

SourceUniversity of Pennsylvania School of Medicine·JournalNature Biomedical Engineering·TypeExperimental study·DateAug 22, 2022

A new way to control pain after knee replacement surgery

Researchers at Houston Methodist found that injecting morphine into the tibia during knee replacement surgery reduces postoperative pain and the need for pain medication. This method, known as intraosseous infusion, may also facilitate a swifter recovery of the knee joint.

SourceHouston Methodist·JournalThe Journal of Arthroplasty·TypeRandomized controlled/clinical trial·DateAug 12, 2022

ACL reconstruction goes under the microscope

Researchers at Osaka Metropolitan University evaluated ACL reconstruction options and found that quadriceps tendon-patellar bone (QTB) grafts have greater similarity to the ACL at femoral insertion sites, indicating they are a more suitable option. This study contributes to potential improvement in ACL injury treatment by reducing the ...

SourceOsaka Metropolitan University·JournalThe American Journal of Sports Medicine·TypeExperimental study·DateAug 7, 2022

Children and teens getting spinal surgery don’t need so many opioids, study suggests

A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.

SourceMichigan Medicine - University of Michigan·JournalJournal of Pediatric Orthopaedics·TypeRandomized controlled/clinical trial·DateAug 3, 2022

LSU Health New Orleans analysis highlights importance of including demographic data in human research papers to reduce health disparities

A recent study published in The Journal of Bone and Joint Surgery found that only 35.9% of articles reported patient race, 15.4% reported ethnicity, and 8.3% reported income. Including demographics in multivariable analyses is crucial to determine the applicability of study results to diverse patient populations.

SourceLouisiana State University Health Sciences Center·JournalJournal of Bone and Joint Surgery·TypeMeta-analysis·DateJul 26, 2022

Knee replacement surgery decreased after NHS policies on patient’s weight were introduced, worsening health inequalities, study finds

New research reveals NHS weight policies are associated with a decline in knee replacement surgery rates, disproportionately affecting less affluent groups. The study found that regions introducing BMI-based policies saw a decrease in surgery, potentially worsening health inequalities.

SourceUniversity of Bristol·JournalPLOS ONE·TypeObservational study·DateJun 29, 2022

Researchers explore biomechanical “Rule of Thirds” after second ACL injury

After examining documented cases of second ACL injuries, researchers found that patients can be divided into three functional subgroups based on the Rule of Thirds concept. This biomechanical classification may help identify athletes at risk for further injury and accelerate their return to play after ACL reconstruction.

SourceMarshall University Joan C. Edwards School of Medicine·JournalJournal of Orthopaedics·TypeData/statistical analysis·DateJun 18, 2022

Malnutrition links kidney disease, weaker muscles

A study published in Frontiers in Nutrition found that malnutrition contributes to sarcopenia in hemodialysis patients, characterized by muscle mass, strength, and function losses. The Nutrition Risk Index (NRI) is a simple and convenient metric developed in Japan, which shows significant relationships between NRI score and sarcopenia,...

SourceOsaka Metropolitan University·JournalFrontiers in Nutrition·TypeObservational study·DateJun 1, 2022

A new approach to medical guidelines, taking inspiration from Wikipedia

Researchers developed a novel 'Wikiguideline' approach to establish medical guidelines, leveraging online collaboration and high-quality data. The method was tested using osteomyelitis, an infection of the bone, and found sufficient data for only two recommendations: increasing oral antibiotic therapy and limiting therapy duration.

SourceMichigan Medicine - University of Michigan·JournalJAMA Network Open·TypeSystematic review·DateMay 10, 2022

Program issuing mailed kits doubles rate of leftover opioids disposal

A study by researchers at the University of Pennsylvania School of Medicine found that mailing opioid disposal kits doubled the rate of safe disposal among patients who received them. The kits were provided to 235 patients after orthopedic or urologic procedures and resulted in the safe disposal of 480 unused tablets.

SourceUniversity of Pennsylvania School of Medicine·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateMay 6, 2022

UK National Osteoporosis Guideline Group publishes new guidance

The UK National Osteoporosis Guideline Group has published a new guideline for the prevention and treatment of osteoporosis, which includes updated recommendations for vertebral fracture detection and anabolic treatment options. The guidance aims to improve service provision in both primary and secondary care settings.

SourceInternational Osteoporosis Foundation·JournalArchives of Osteoporosis·TypeLiterature review·DateApr 20, 2022

Comprehensive care program helped reduce some racial disparities after hip and knee replacement

A bundled care Medicare program has led to reductions in some outcome disparities for Black patients compared to White patients undergoing hip and knee replacement surgery. The Comprehensive Care for Joint Replacement (CJR) Model has improved key outcomes such as hospital readmission rates, length of stay, and Medicare payments.

SourceWolters Kluwer Health·JournalJournal of Bone and Joint Surgery·DateApr 18, 2022

Bioprinting for bone repair improved with genes

An international team of engineers has successfully bioprinted bone along with two growth factor encoding genes that help incorporate cells and heal defects in rats. The researchers used gene encoding PDGF-B and BMP-2, which encouraged cell multiplication and migration, resulting in a 40% increase in bone tissue creation.

SourcePenn State·JournalBiomaterials·DateApr 12, 2022

Continuation versus discontinuation of anti-rheumatic biologics during the perioperative period: What does the evidence support?

Patients who discontinue biologic disease-modifying anti-rheumatic drugs (bDMARDs) before orthopaedic surgery are more likely to experience a disease flare following surgery. However, discontinuing bDMARDs does not appear to increase the risk of surgical site infections or delayed wound healing. The review and meta-analysis highlights ...

SourceWolters Kluwer Health·JournalJournal of Bone and Joint Surgery·DateFeb 17, 2022

Managing pain after knee, shoulder surgeries without opioids

Researchers at Mayo Clinic developed a non-opioid pain management approach that provides equivalent or better pain control and patient satisfaction compared to traditional opioid regimens. This approach eliminates opioids after common sports surgeries, such as knee and shoulder procedures.

SourceMayo Clinic·JournalArthroscopy The Journal of Arthroscopic and Related Surgery·DateFeb 7, 2022

Marshall University researchers explore use of robotic arm technology in revision total knee arthroplasty

Researchers at Marshall University's Joan C. Edwards School of Medicine have successfully applied robotic arm technology to revision total knee arthroplasty, achieving well-aligned components and excellent range of motion in patients. The study utilizes computer-assisted technology to improve component positioning and reduce the burden...

For young people with meniscal tears, surgery and exercise are equally effective

A new study published in NEJM Evidence reveals that exercise and patient education can provide similar results as surgery for young people with meniscal tears. The research compared surgical and non-surgical treatment options among 121 young individuals and found no significant difference in outcomes between the two groups.

SourceUniversity of Southern Denmark Faculty of Health Sciences·JournalNEJM Evidence·TypeRandomized controlled/clinical trial·DateFeb 2, 2022

New expert review of the global approach to rehabilitation following fragility fracture

A new review by the International Osteoporosis Foundation highlights the importance of comprehensive post-fracture care, including exercise, nutrition, physiotherapy, and patient education. The study concludes that individualized exercise approaches can improve recovery and reduce future fracture risk.

SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeLiterature review·DateFeb 2, 2022