Articles tagged with Risk Factors
Researchers have identified a gene called LHPP that interacts with stress to mediate aspects of treatment-resistant MDD in an animal model. Increased expression of LHPP aggravated depression-like behaviors by dephosphorylating two protein kinases, CaMKIIα and ERK.
Research at the University of Gothenburg found that even low-active IBD patients have a higher risk of serious infections due to microscopic intestinal inflammation. Achieving a fully healed intestinal mucosa may reduce this risk, contributing to lower morbidity and mortality in IBD patients.
A new study from Tulane University found that frequent salt consumption is associated with a higher risk of developing Type 2 diabetes. The study surveyed over 400,000 adults and found participants who regularly added salt had a 13% to 39% increased risk of developing the disease compared to those who never or rarely used salt.
Researchers developed a community-based intervention to address food insecurity and transportation difficulties, which did not increase discrimination experiences among families. The study suggests that well-designed interventions can be provided without stigmatizing patients or families, paving the way for future research.
A recent study found that people living in areas with high levels of fine particulate matter have a 56% greater risk of developing Parkinson's disease. The Mississippi-Ohio River Valley and parts of Texas, Kansas, and eastern Michigan were identified as regions with higher rates of the disease.
A three-year USDA grant will train healthcare and social workers in five high-risk rural Missouri counties to address childhood trauma and reduce opioid overdoses. The training covers topics such as ACEs, positive childhood experiences, and trauma-informed care.
A new study has identified 16 major risk factors for severe RSV infection in children under one year of age. The researchers created a clinical prediction model that performed well in both Finland and Sweden, highlighting the need for targeted prevention measures for high-risk infants.
A randomized clinical trial of 524 trauma patients found that adding sigh breaths to mechanical ventilation did not increase ventilator-free days. However, prespecified secondary data suggest that sighs are well-tolerated and may improve clinical outcomes in this patient population.
A study by Nagoya University found that children with a genetic predisposition to autism spectrum disorder (ASD) used screens for longer periods. Children with attention deficit hyperactivity disorder (ADHD) also increased their screen time as they grew older, suggesting a potential link between genetic risk and excessive screen use.
A study of 9,479 participants identified racial and ethnic disparities in breast cancer survival, highlighting the need for targeted interventions to improve outcomes for at-risk subgroups. The findings suggest that focused care approaches can address these disparities and promote more equitable treatment.
A study of 2,361 mother-child pairs found that prenatal lead exposure is associated with an increased risk of cognitive developmental delay (CDD) in children, particularly those with a high genetic risk. This suggests that integrating genetic factors into assessments of CDD risk may improve children's cognitive ability.
Weight gain in females with a family history of mood disorders begins before the onset of mood disorders, highlighting the need for childhood interventions. Early interventions can prevent adverse mental and physical outcomes in this vulnerable group.
The study, which analyzed data from older adults with peptic ulcer disease, revealed that approximately 1 in 8 individuals developed depression for the first time during the pandemic. Women, those who felt lonely, and those with functional limitations were at higher risk of depression. Targeted screening and intervention are being reco...
A study by Dr Veronica Lamarche discovered that equal consumption was more important than levels of drunkenness in perceiving consensual sex. Hook-ups where one partner is drunker are more likely to be seen as non-consensual, coercive, and dangerous.
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
A study of 340,000 pregnant women in southern California found a significant association between long-term exposure to antepartum and postpartum air pollution and increased risks of postpartum depression. The findings highlight the importance of identifying modifiable environmental risk factors to improve maternal mental health.
A recent analysis found that assisted reproductive technology cycles using a gestational carrier resulted in higher live birth rates and an increased risk of twins. Despite national recommendations, more than one-quarter of embryo transfers involved two or more embryos, highlighting the need for improved guidelines.
A simple MRI scan and a new metric for prostatic urethra length may help identify men at risk of chronic urinary side effects after radiation therapy. The study found that longer prostatic urethras are associated with a higher likelihood of these symptoms, which can impact quality of life.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
Researchers found that polygenic risk scores identify only 11% of individuals who develop disease and generate 5% false positives. The scores contribute little health benefit while adding cost and complexity to healthcare systems.
A new study reveals a reversal in the trend of early-onset lung cancer, now affecting younger women and middle-aged adults. The increased incidence in women is attributed to rising rates among those born in the 1960s, without higher smoking prevalence.
A study found that Acinetobacter baumannii and Candida auris were common among patients receiving mechanical ventilation, particularly in long-term care facilities. These pathogens pose a significant risk to this vulnerable population, highlighting the need for targeted surveillance and prevention efforts.
The UK Biobank study found that racial minority status increased dementia risk by 24%, with socio-economic status attenuating this effect. Lifestyle factors such as diet, smoking, physical activity, and sleep were identified as crucial in reducing racial and socio-economic disparities in dementia.
A new study published in Obstetrics & Gynecology found that birthing people who died during pregnancy or postpartum had received significant amounts of hospital care. The study identified factors such as severe maternal morbidity, opioid use, and prior hospitalization as linked to pregnancy-associated deaths.
A new study analyzing English primary care records found that hypertension, obesity, diabetes, and low HDL cholesterol confer a higher risk of dementia in South Asian and Black people compared to White individuals. The results suggest tailored dementia prevention efforts should be targeted towards minority ethnic groups.
A new study found that pre-pregnancy obesity is a primary driver of future cardiovascular disease risk, rather than pregnancy complications. The research followed 4,216 individuals from early pregnancy to postpartum and found those with overweight or obese BMI had a higher risk of developing hypertensive disorders during pregnancy.
Middle-aged Chinese surgery patients experience subjective cognitive impairment within 12 months after surgery, with identified risk factors. Preoperative psychological interventions and optimized perioperative management may help prevent postoperative cognitive impairment.
A University of Minnesota Medical School professor is receiving a $4.39 million grant to study atrial myopathy, a heart condition associated with increased risk of dementia and vascular brain injury. The project aims to characterize the progression of atrial myopathy and its relationship to dementia and mild cognitive impairment.
A new study found that an alternative model to identify patients with lung cancer eligible for screening was more accurate than the currently used method based on the United States Preventive Services Task Force (USPSTF) criteria. The PLCOm2012 models had higher sensitivity and identified more people with lung cancer eligible for scree...
A study of 23,000 adults found a significant link between depressive symptoms and increased mortality from cardiovascular disease. Public health efforts can support nationwide strategies to reduce depression's burden.
A new American Heart Association advisory introduces the concept of cardiovascular-kidney-metabolic (CKM) syndrome, which affects nearly every major organ. The approach highlights the importance of screening for CKM-related conditions and addressing social factors to prevent progression.
Research reveals that faster placental growth increases the risk of preeclampsia and shorter pregnancy duration. Genetic variations affecting placental size also influence baby weight and mother's health.
A recent human study found that grape consumption improved key markers of eye health in older adults, including increased Macular Pigment Optical Density (MPOD) and reduced AGEs. Regular grape intake was also shown to increase plasma antioxidant capacity and total phenolic content.
Research suggests that trans men and women have a higher risk of cardiovascular disease, while the link to diabetes remains uncertain. Testosterone therapy may contribute to increased cardiovascular risk in trans men, whereas hormone treatments for trans women do not explain this association.
A new study examines cannabis use patterns, motivations, and risk factors among college students at a large public university in the southeastern US. The researchers found that top reasons for cannabis use were relaxation and social pressure, while daily users reported higher quantity of cannabis per day.
A new study aims to identify environmental and social factors contributing to Alzheimer's disease in older Black adults, who are up to two times more likely to develop the condition. Using remote cognitive assessments and biomarkers, researchers hope to gain a better understanding of the biopsychosocial factors behind this disparity.
A study published in Diabetes Care found that obesity, hypertension, and dyslipidemia alter cardiac energy production by interfering with metabolic substrate uptake. The research reveals early changes in apparently healthy middle-aged individuals, highlighting the importance of identifying mechanisms involved in heart disease onset.
A meta-analysis found that CPAP treatment adherence is associated with a lower risk of recurrent cardiovascular events in patients with obstructive sleep apnea. Adherence to CPAP therapy may be a key factor in secondary cardiovascular prevention.
A large study of 491,000 participants found that loneliness was associated with an increased risk of developing Parkinson's disease. The findings suggest that loneliness is a significant psychosocial determinant of health and may contribute to the development of the neurodegenerative disorder.
A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
A new study from Tulane University found that walking more than five flights of stairs daily can cut the risk of heart disease by 20%. The study, published in Atherosclerosis, used UK Biobank data from 450,000 adults and found that stair climbing reduced cardiovascular disease risk in those with multiple risk factors.
Research identifies genetic overlap between schizophrenia and cardiovascular disease (CVD) risk factors, particularly smoking initiation and BMI. The study found that people with schizophrenia have a genetic propensity to smoking and a reduced genetic risk of obesity.
A recent study published in Human Reproduction found a doubling in the chances of pregnancy miscarrying or resulting in a stillbirth following a job loss. The researchers emphasize an association between job loss and increased probability of miscarriage or stillbirth, highlighting potential socioeconomic factors.
A study of 1.84 million US adults from 2008 to 2019 found registered nurses and healthcare support workers were more likely to attempt or die by suicide than non-healthcare workers. The findings highlight the need for improved mental health protections for these workers.
A new study reveals that consanguinity may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder. The research analyzed genomic data from diverse groups to investigate the relationship between autozygosity, or genetic relatedness, and disease prevalence.
Researchers found dementia prevalence among people with ID to be 6.44%, with modifiable risk factors identified as hypertension, depression, stroke, age, severity of ID, duration of education, and traumatic brain injury. These findings can inform better screening and support for individuals with intellectual disabilities.
A global comparative study assesses barriers to participation in cardiovascular rehabilitation programs for men and women, highlighting sex differences and regional variations. The study provides patients with mitigation strategies to address these barriers and improve CR utilization.
A significant burden of cardiovascular disease and cardiometabolic risk factors has been identified among 220,000 American Indian and Alaska Native patients with Medicare insurance. The study emphasizes the critical need for future efforts to prioritize cardiovascular health in this population.
A new study reveals that most healthcare facilities in low- and middle-income countries are unprepared to deliver services for treating cardiovascular disease risk factors, including diabetes and hypertension. However, investing in HIV care may provide a solution by improving readiness.
The study found that type 1 diabetes incidence slightly increased overall, while type 2 diabetes significantly increased after the COVID-19 pandemic. Non-Hispanic Black and Hispanic youth were disproportionately affected.
A new study found that older adults with COPD had a heightened risk of depression during the early stages of the COVID-19 pandemic. Approximately 1 in 2 individuals with COPD and a pre-pandemic history of depression experienced a recurrence of depression.
A new study reveals that people with high social vulnerability are more exposed to wildfires in Oregon and Washington, with the number of exposed individuals tripling between 2011 and 2021. The study highlights the need for tailored wildfire preparation and response strategies for individual communities with different risk factors.
A large study published in Journal of Investigative Dermatology found that patients with severe psoriasis have a high prevalence of coronary microvascular dysfunction, which is associated with increased cardiovascular risk. Psoriasis severity and duration, as well as the presence of psoriatic arthritis, are independently linked to redu...
Historian Dr Philippa Carter argues that jobs like food preparation, childcare, and dairy production left women exposed to witchcraft accusations. These occupations, often performed by women, were perceived as a threat to social order, increasing the likelihood of suspicion and accusation.
A 10-state study from the CDC's VISION Network identified risk factors for critical COVID-19 outcomes in adults hospitalized with the virus. Adults with four or more underlying disease risk factors, including hypertension, diabetes, heart disease, and obesity, are at higher risk of ICU admission and death.
A study of 3,635 female participants found premenstrual disorders are associated with increased risks of early menopause and moderate or severe vasomotor symptoms. This suggests underlying physiology may be linked to earlier menopause and health risks later in life.
A new study from Texas A&M University finds an association between vaping and asthma in US adolescents who have never smoked conventional tobacco products. The study highlights the need for strategies to tackle e-cigarette use and its adverse health effects.
A recent study published in the International Journal of Infectious Diseases found that individuals infected with the Omicron variant have a significantly lower risk of developing long COVID compared to those infected with earlier variants. The study analyzed data from over 11,000 people and found that around half of all wild-type infe...
Climate change exacerbates cardiovascular disease through poor air quality and extreme temperatures, according to a special issue of the Canadian Journal of Cardiology. Experts review environmental influences, exposures, and practical tips for healthcare providers to mitigate these effects.
An analysis of 71,000 shooting incidents in five major US cities found that socioeconomic status and lack of access to a vehicle are strongly linked to increased firearm assaults. Policymakers can use this data to target neighborhoods at risk of firearm violence using the CDC's Social Vulnerability Index.