Articles tagged with T Lymphocytes
Dr. Sanjana's research uses high-throughput genome engineering technologies to identify genes that can boost the effectiveness of CAR T-cell therapy for pancreatic ductal adenocarcinoma. The project aims to overcome immunosuppression in pancreatic cancer and potentially lead to improved immunotherapies.
Researchers discovered that tumour T cells produce immunosuppressive steroids to evade the immune system, reducing tumour growth in mice. Preventing steroid production using a key gene or drug significantly slowed tumour formation and progression, suggesting new drug targets for cancer immunotherapy.
A novel cell therapy using patient T cells has shown preliminary effectiveness in treating relapsed or treatment-resistant multiple myeloma. The treatment, which is safer than existing CAR T cells, improved survival rates and objective clinical responses in patients with active disease.
Researchers used multiomics analysis to investigate HIV-1-infected cells in humanized mice. The study identified multiple characteristics of HIV-1-producing cells, including viral genome and transcriptomic profiles, which could provide insights for developing an HIV-1 cure.
The OneChain Immunotherapeutics spin-off aims to develop CAR-T therapies for rare leukaemia subtypes like coT-ALL, which affects children and has a poor prognosis. The spin-off is funded by €3M and will enable the transfer of research knowledge from academia to clinical use.
Researchers found that CAR T cells targeting the HER2 protein on cancer cells led to a sustained tumor response. The child's immune system was recruited to act against the tumor, suggesting a potential novel approach to fighting difficult-to-treat cancers.
Sylvester researchers have identified a potential protein target, STING, that may help mitigate graft versus host disease in stem cell transplants. In preclinical models, inhibiting the STING pathway reduced symptoms of GVHD.
Researchers developed a vaccine targeting aged immune cells, which accumulated in fat tissues of obese individuals and caused chronic inflammation. Vaccination improved glucose metabolism, insulin resistance, and overall organ function in obese mice by removing senescent T cells.
A new study found that T cells targeting the SARS-CoV-2 virus can help fight COVID-19, even in severe cases. The research also reveals similar responses to the virus among Dutch and American patients.
A study published in Nature found that blood cell mutations linked to leukemias become inevitable as people age, especially in the Japanese population. The research identified genetic variations associated with increased risk of these mutations, which can be detected through a simple blood test.
Researchers at the German Cancer Research Center found that CAR T cell production can be significantly reduced in an academic setting, from EUR 320,000 to around EUR 60,000. This could lead to substantial cost savings and faster treatment times for patients, as well as increased accessibility of this life-saving therapy.
Researchers at Memorial Sloan Kettering have engineered CAR T cells to recognize and eliminate senescent cells, which contribute to various debilitating diseases. The uPAR-directed approach has shown promise in mouse models of liver fibrosis and lung cancer, offering hope for new treatments.
The use of CAR-T immunotherapy against acute myeloid leukemia is being reevaluated due to concerns over its impact on healthy hematopoietic stem and progenitor cells. Studies have shown that anti-CD123 CAR T-cells can inhibit normal hematopoiesis, leading to irreversible impairment in blood cell formation.
Rice University researchers suggest that T cell relaxation time is key to immune response, explaining how invaders prompt the immune system. The approach helps explain why T cells can react so fast and selectively, despite self-ligand imposters outnumbering invaders by a factor of 100,000.
A novel intracellular biopsy technique developed by City University of Hong Kong isolates targeted miRNAs from living cells within 10 minutes using diamond nanoneedles. This technique simplifies the experimental operation, reducing processing time from hours to minutes and enabling quasi-single-cell miRNA analysis.
Researchers at La Jolla Institute for Immunology discovered that antibodies against one virus can make another more severe. However, a specific type of T cell can counteract this effect. The study suggests the need for future vaccines to elicit a balanced response from both antibodies and T cells.
Researchers identified microglia as key immune cells protecting the brain from airborne viral infections, limiting damage to neurons. CD8 T cells engaged microglia to present virus particles, triggering an antiviral response without killing neurons.
Researchers found that T cells increase their metabolism to survive, contradicting previous assumptions about immune function. The study suggests that targeted interventions like vaccines or immunotherapies could boost T cell immunity in the elderly.
Researchers at Hollings Cancer Center have developed a novel flow cytometry technique to quantify protein production in T-cells. This study reveals that T cells with robust protein production are more effective at controlling tumor growth.
Researchers found that coronavirus cases have significantly low T cell counts, negatively correlated with case severity. T cell exhaustion leaves patients more vulnerable to secondary infection. The study suggests targeting treatment for COVID-19 based on T cell counts and function.
Researchers have identified a new potential reservoir of latent HIV, specifically CD127 cells in tissues, which harbor the virus's genetic material but silence its expression. These cells may be targeted for an HIV cure, offering hope for developing an effective treatment.
Researchers develop novel approach to deliver CAR T cell therapy directly into cerebrospinal fluid, effectively treating medulloblastoma and ependymoma in mouse models. Combining immunotherapy with azacytidine significantly enhances treatment efficacy.
Researchers from Duke-NUS Medical School are exploring a new therapy using patient's own immune cells to target infectious diseases, including COVID-19. The therapy involves engineering virus-targeting receptors onto T lymphocytes, allowing them to recognize and kill infected cells.
A new method developed by UC Santa Cruz researchers allows for the creation of libraries of probes for high-throughput assessments of T cell repertoires in blood samples. This technology has the potential to accelerate research and diagnostics in immunology, cancer immunotherapy, and COVID-19 response.
Researchers found signs of autoimmunity in Parkinson's patients years before diagnosis, providing potential for early detection and treatment. The study also showed that immune responses change over time, with more aggressive cells initially causing damage.
Researchers found that distinct microbiomes composed of different types of bacteria contribute to varying levels of colorectal cancer in genetically identical mice. The study suggests that certain bacteria promote inflammation and exhaust immune cells, increasing susceptibility to cancer.
A new analysis supports prior reports that people with sickle cell disease experience lower rates of HIV infection. However, the molecular characteristics of immune system cells do not explain the reduced risk.
A team of researchers from the University of Washington School Medicine has created artificial proteins that function as molecular logic gates, allowing for the programming of complex biological systems. This breakthrough has implications for future medicines and synthetic biology, particularly in the development of cell-based therapies.
Scientists have engineered T-cells to target multiple sites on leukemia cells, offering a more effective treatment for resistant acute lymphoblastic leukemia. The new CAR-T therapy, TriCAR T-cells, targeting CD-19/20/22, demonstrate improved efficacy compared to single-antigen therapies.
Researchers at Kazan Federal University have made significant progress in developing CAR T-cell therapy for solid tumors. The treatment uses genetically modified lymphocytes to target and destroy tumor cells, showing promising results in animal models.
Researchers developed a new CAR T cell therapy using chlorotoxin, a component of scorpion venom, to target glioblastoma cells. The therapy showed promise in killing tumor cells while ignoring healthy tissue.
A study published in eLife has identified two strategies used by cancer to survive treatment with immunotherapies, including one that disables energy production in cancer-killing T-cells. Researchers found that some human cancer cells release molecules that inhibit the activity of energy-producing mitochondria in T-cells.
Researchers developed nanoparticles containing gliadin to treat celiac disease by restoring immune tolerance. In mouse models, these nanoparticles reduced inflammation and tissue damage, inducing gene expression profiles associated with immune tolerance.
Researchers have identified a rare immune cell type that expresses both alpha-beta and gamma-delta T-cell receptors, which can both protect against infection and trigger autoimmune responses.
Researchers at UC San Diego developed a system to control CAR T cells using blue light, destroying skin tumors without harming healthy tissue. In tests, the treatment reduced tumor size by 8-9 fold in 90% of mice.
Researchers report no negative side effects and persistent engineered T cells in advanced cancer patients. The study's findings suggest the gene editing approach is safe and feasible, paving the way for further development of this innovative cancer treatment.
A new protein-based method, STOP-CAR, switches off modified T cells on command, reducing toxicity and organ damage in cancer patients. This breakthrough could speed the clinical development of new CAR therapies.
A team of UPenn researchers is developing a new CAR T-cell gene therapy treatment for advanced metastatic prostate cancer, with the goal of overcoming resistance to current treatments. The ACGT-funded study aims to re-engineer T-cells to induce safe, long-term remission in patients.
Research suggests that a ketogenic diet provides health benefits in short-term, but negative effects occur after about a week. The keto diet works best in small doses, increasing tissue-protective cells called gamma delta T-cells, which lower diabetes risk and inflammation.
Researchers have successfully disrupted viral latency in monkeys and mice, a crucial step towards an HIV cure. The approach uses a combination of immune stimulation and depletion to reactivate the dormant virus, offering new avenues for treatment.
Researchers at University College London discovered that T cells in the liver can 'recycle' material through autophagy, a process enabled by the cytokine IL-15. This breakthrough could lead to more effective immunotherapies for cancer and chronic viral infections.
Researchers identify CD1a as a key player in triggering T cell responses to allergens in personal care products, shedding light on the 'molecular missing link' behind allergic contact dermatitis. The study highlights the importance of fragrance molecules like farnesol in initiating immune responses.
Scientists have discovered a new population of gamma delta T cells that recognize an MHC-like molecule called MR1. Using advanced imaging techniques, researchers found that these T cells bind to MR1 from underneath the molecule, rather than sitting atop it as previously thought.
Researchers have found that a balance between neutrophils and T cells can accurately predict which patients will respond to immunotherapy. A clinical trial is underway to test a drug that reduces neutrophil levels in tumors, boosting the efficacy of checkpoint inhibitors.
Elite controllers, a subset of HIV-positive individuals, have distinct transcriptional profiles and enhanced ribosomal function in their lymphoid tissue CD8+ T cells. This allows them to suppress HIV replication through cytokine production, presenting an alternative approach to traditional viral eradication strategies.
Researchers discovered immune cells inside tumor samples can predict progression-free survival after surgery for kidney cancer. Patients with well-supported immune cells have longer disease control, leading to improved treatment options and potential adjuvant therapy trials.
A new study suggests that Tr1 cells, a type of T cell, can produce a chemical signal to repair the gut barrier and promote mucus production. The researchers found that these cells are capable of reducing inflammation and healing tissue in children with IBD.
Researchers developed a bispecific T-cell engager, AMG 701, to target myeloma cells. Administered with lenalidomide or pomalidomide, it showed promising pre-clinical results in mice implanted with human myeloma cells.
Research on exhausted CD8 T cells provides clues for refining cancer immunotherapy. A new study defines a transitional stage between stem-like and truly exhausted cells, which could be a target for therapy.
Scientists at Scripps Research developed a method to rapidly discover compounds that restore anti-tumor activity in immune cells called T cells. The approach identified 19 compounds that can reawaken exhausted T cells, potentially leading to new combination-immunotherapy regimens against cancers and persistent infections.
A team of researchers found that HIV takes refuge in lymph nodes in the spleen and gut during antiretroviral treatment. These cells, which are part of the immune response, allow the virus to escape treatment by limiting drug flow or eliminating them faster.
Researchers at Children's National Hospital have developed virus-specific T-cells that neutralize six viruses, including CMV and EBV, in patients with primary immune deficiency diseases. The treatment shows promise in preventing and treating multiple viral infections, with partial clinical improvement in critically ill patients.
A new study from Yale University finds that a ketogenic diet can enhance the body's natural response to influenza by activating gamma delta T cells, which produce mucus in lung cell linings. The research suggests that the way the body burns fat may fuel the immune system's ability to fight flu infection.
Researchers genetically engineered CAR T cells with molecular tags, allowing them to be monitored in animal models using PET imaging. This technology enables clinicians to track the number and location of CAR T cells over time, providing a more accurate measure of therapy durability and potential efficacy.
Gajewski's research found that a 'hot' or T cell inflamed tumour microenvironment is key to unlocking immunotherapy efficacy. STING agonists and targeted therapies are being developed to combat 'cold' tumours with limited immune response.
Researchers studied the contents of exosomes released by melanoma cells and found that they selectively package certain proteins and RNAs to influence immune cell response. This finding suggests that cancer cells may use their exosomes to avoid eradication by subduing T cell activity.
A new study by University of Minnesota researcher Ryan Langlois provides insights into the immune response to influenza. The research found that infected cells in the lungs can survive the clearance process and actually divide faster than uninfected cells.
Researchers discovered Hedgehog signaling shuts down chemokine secretion by tumor-associated macrophages, limiting CD8 T-cell infiltration. Blocking hedgehog pathway reverses process, promoting CD8 T-cell infiltration into tumor microenvironment.
Researchers developed a system that allows for spatiotemporal control of CAR T-cell therapy, enabling cancer cells to target specific locations and times. This approach reduces the risk of non-specific targeting of organs and normal tissues, potentially improving treatment outcomes.
A new report suggests that immune cells process glucose differently in living organisms, with implications for therapeutic development and a more complete understanding of immune cell function. The study's findings could lead to breakthroughs in diagnostic and treatment strategies.