Articles tagged with T Lymphocytes
Researchers at Gwangju Institute of Science and Technology have developed a new bioinformatics pipeline, CRESSP, to investigate the mechanism underlying autoimmune diseases following SARS-CoV-2 infection. The tool identified potential epitopes responsible for COVID-related autoimmune diseases and predicted cross-reactive epitopes of di...
A University of Washington model found that the body's ability to create cloned immune cells falls significantly with age, leading to increased susceptibility to COVID-19 in the elderly. The study suggests that genetic limits on cell division may play a role in the devastating effects of COVID-19 on older adults.
Researchers at Karolinska Institutet have developed a method to identify the immune cells involved in autoimmune diseases and identified four new target molecules for personalized treatment of multiple sclerosis. This approach could lead to more precise treatments with fewer side effects, potentially benefiting other autoimmune diseases.
The study found that T-cell immunity was effective against Omicron variants in approximately 90% of vaccinated Europeans. The researchers identified a specific HLA-DRB1*03:01 variant that allowed the virus to evade immune recognition, particularly affecting individuals with this genetic variation.
Researchers at TU Darmstadt found that x-rays trigger a calcium signalling cascade in T-cells, stimulating the immune response. This discovery could lead to improved cancer treatment by enhancing the killing effect of ionising radiation on tumour cells.
Researchers at Karolinska Institutet study how the immune system protects against malaria, finding that people who have contracted the disease before develop a tolerance that prevents severe disease. This knowledge can aid in the development of more effective vaccines.
Researchers at Gladstone Institutes and UC San Francisco have developed a comprehensive rule book for designing therapeutic cells with improved specificity and safety. The new receptor system, dubbed SNIPRs, is small enough for cost-effective engineering into human cells and can detect and respond to even small amounts of its target. T...
Researchers found that APC gene mutations in colon cancer patients disrupt T lymphocyte migration to tumors, making it harder for the immune system to combat cancer. The study provides new insights into the mechanisms of antitumor immune defense.
A study by University of Helsinki researchers found that the immune system attacks itself in rare type of blood cancer. The immune system plays a role in the development and growth of cancer cells, making current therapies less effective.
A new CAR T-cell product targeting CLDN6 showed acceptable safety and early signs of efficacy in a phase I/II clinical trial. The therapy combined with an mRNA vaccine expanded transferred CAR T cells and improved tumor cell killing.
A study published by the University of Alabama at Birmingham found that T cell-derived interleukin-22 plays a crucial role in antibacterial defense of colonic crypts. The researchers discovered that two types of immune cells, innate and adaptive, have distinct roles in defending against pathogenic bacteria.
Researchers at Tel Aviv University developed a drug delivery system based on lipid nanoparticles that utilize RNA to boost personalized cancer care. The nanodrug enhances chemotherapy effectiveness and reinvigorates the immune system, increasing sensitivity to cancer cells.
Researchers at Northwestern University used CRISPR to identify human genes important for HIV infection in blood cells, finding 86 genes that may play a role in replication and disease. The study proposes a new map for understanding how HIV integrates into the DNA and establishes chronic infections.
Researchers at Penn Medicine have developed a new approach to alter immune cells for CAR T cell therapy in just 24 hours, cutting manufacturing time from nine to 14 days. This could make the therapy more cost-effective and accessible to more patients.
A University of Gothenburg study found that IgA antibodies present in the respiratory tract protected healthcare workers from contracting COVID-19. The research, published in the European Journal of Immunology, suggests that these antibodies may play a crucial role in preventing severe illness and hospitalization.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
Human immune cells occupy certain tissues and remain there for years, contrary to previous belief. T cells found to be optimally adapted to their local environment, potentially supporting barrier function.
Researchers have revealed that during Type 1 Diabetes development, pancreatic duct cells reprogram to suppress autoimmune T cell responses. This discovery advances understanding of the disease by creating a map of pancreatic islet cells over time.
Researchers discovered a viral infection can trigger autoimmunity in mice by disrupting the thymus's screening process for self-destructive T cells. Infection with murine roseolovirus led to autoimmune gastritis months later, highlighting a previously unknown way viruses can trigger autoimmunity.
A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.
A new graft strategy has reduced chronic graft-versus-host disease in leukemia patients by depleting naïve T cells from donor blood. The approach has shown promising results, with only 7% of patients developing chronic GVHD compared to 30-60% with standard treatment.
Researchers at Peking University created a comprehensive single-cell landscape of tumor-infiltrating T cells across 21 cancer types, revealing heterogeneity and dynamics. This study provides an immune-typing scheme that could inform targeted therapy.
A new study published in Nature found that valine is essential for the growth of T cell acute lymphoblastic leukemia, a type of childhood blood cancer. Blocking valine-linked genes led to decreased valine levels and stalled tumor cells from growing.
A novel approach may reduce the serious adverse effect of cytokine release syndrome associated with chimeric antigen receptor (CAR) T-cell therapy. Supressing interferon gamma (IFNγ) appears to prevent activation of macrophages and other immune cells that drive the syndrome without impacting CAR T-cell efficacy.
IN8bio is developing a genetically modified gamma-delta T cell technology to treat glioblastoma multiforme. Preclinical studies published in Scientific Reports show significant improvement in survival outcomes, and a Phase I clinical trial is underway at UAB.
Researchers create a porous microneedle to deliver CAR T cells into solid tumors, improving anti-tumor effects. The strategy showed enhanced tumor infiltration and amplification of CAR T cells in melanoma models.
A recent study led by Okayama University scientists found that metformin activates a subset of immune cells called CD8+ T-lymphocytes to attack and kill tumor cells. The study revealed that metformin increases the production of reactive oxygen species in these cells, which activates growth pathways and allows for proliferation.
Researchers are developing a transformative technology called Multiscale Intelligent Convergence (MusIC) to map the complexity of T cells and identify attributes essential for patient benefit. The goal is to create more reliable biomanufacturing of T cell infusion products and engineering potent immune cells.
Researchers found that high levels of immune cells in tumors correlate with better outcomes for esophageal cancer patients. The study used the Immunoscore to evaluate tumor-infiltrating lymphocytes and found a strong association between high scores and long-term survival rates.
A team of scientists from the University of Pittsburgh and National Cancer Institute discovered why HIV is rarely the direct cause of cancer. The research found that it requires a specific series of events involving changes in HIV and additional mutations in human genes, resulting in T cell lymphomas. However, the occurrence is rare, a...
Researchers have discovered a way to bring cancer-killing T cells to bear against a specific type of colorectal cancer, showing promising results. The findings may represent a therapeutic strategy to target other types of cancers, and the next step is to further explore how T cells become activated in the tumor environment.
A clinical trial found that obese prostate cancer patients who underwent regular exercise training for 12 weeks had increased levels of anti-cancer myokines, which suppressed tumour growth and helped fight cancerous cells. The study suggests exercise may be a key weapon in cancer patients' battle against the disease.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.
Researchers discovered that stem-like T cells in nearby lymph nodes can resupply and refresh the immune system's attack on tumors, potentially slowing cancer growth. The study supports the development of therapies targeting these cells to improve immunotherapy responses.
A recent study by researchers at the University of Helsinki found that low-density granulocytes (LDG) play a significant role in weakening the immune response in covid-19 patients. The study revealed that LDGs inhibit T lymphocyte division, leading to suppressed adaptive immunity against the virus.
A new approach has identified T cells in Covid-19 patients, revealing their appearance, number, and activity level against SARS-CoV-2. The study distinguishes between active and dormant T cells, enabling a better understanding of the immune response to the virus.
Researchers at the University of Pennsylvania School of Medicine have identified a new mechanism of resistance in advanced chronic lymphocytic leukemia (CLL) patients to CAR T cell therapy. They found that inhibiting the BET protein with the small molecule inhibitor JQ1 can reinvigorate exhausted T cells and increase their production.
Researchers found that local delivery of tumor-specific T-cells is an efficient option to convert tumors unresponsive to checkpoint inhibitors to permit tumor cures. Locally delivered T-cells showed similar control of established tumors as intravenous adoptive T-cell transfer.
Researchers used mass cytometry and machine learning to discover 'immune signatures' that differentiate between symptomatic and asymptomatic Plasmodium vivax malaria infections. The study found a previously unrecognised role for immune CD4 T cells in preventing serious disease and controlling asymptomatic infection.
A study by Ludwig-Maximilians-Universität München's researchers found that the CD40L/CD40 interaction plays a crucial role in atherogenesis. The team showed that inhibition of this interaction can reduce atherosclerosis-associated clot formation and stabilize plaques, offering new therapeutic strategies for cardiovascular disease.
Researchers at Uppsala University discovered lymph node-like structures in brain cancer patients where immune cells can be activated. Immunotherapy enhanced these structure formation in a mouse model, suggesting new ways to regulate the anti-tumour response.
Scientists at UCL have identified a new immunotherapy that targets acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme helping to manage cholesterol levels in cells. Boosting ACAT inhibition boosts specific immune cells fighting both the virus and cancerous tumours, demonstrating its effectiveness as an immunotherapy.
Researchers at Gladstone Institutes have adapted CRISPR-Cas9 technology to edit human monocytes, a type of white blood cell that plays key roles in the immune system. The study shows the potential utility of gene editing for understanding how the human immune system fights viruses and microbes.
A new study reveals that skin's epidermis layer is comprised of an army of immune cells that station themselves at regular intervals across the skin. When necessary, these cells reposition themselves to protect vulnerable areas, forming a dynamic surveillance system.
Researchers observed T cells exerting a tiny force of up to 5 pico-newtons when recognizing antigens, allowing them to determine if the interaction is with the desired antigen. This study provides insights into how T cells function at the molecular level and could lead to significant advances in medicine.
Scientists discovered that elite controllers' myeloid dendritic cells display traits of trained innate immune cells, which enhance their ability to control HIV. The study also found a specific long-noncoding RNA, MIR4435-2HG, that may be an important driver of this enhanced state.
A Phase II trial found that BKV-specific T cells from healthy donors are safe and effective in treating debilitating complications after stem cell transplants. Patients experienced rapid responses, with 81.6% showing improvement after 28 days, and no cases of severe GVHD or toxicities.
A team of researchers from Virginia Tech and City of Hope aim to improve CAR-T cell therapy for glioblastoma multiforme by studying the impact of fluid flow on the treatment's success. They believe they can use fluid flow to encourage T cells to move deeper into tumors and kill invading cancer cells.
The study found that stress impairs immune cells' ability to move and fight diseases by inhibiting their movements. This effect is caused by the neurotransmitter noradrenaline, which activates the sympathetic nervous system, leading to reduced blood flow, oxygen deprivation, and calcium signaling in leukocytes.
Researchers have developed a new generation of CAR T cells that safely target and kill solid tumors in mice with mesothelioma, ovarian cancer, and glioblastoma. The 'prime-and-kill' molecular circuits enable specific recognition of tumor antigens on healthy tissues, reducing the risk of side effects.
Researchers found that a shorter 'linker' on CAR T cells improves their response to B-cell acute lymphoblastic leukemia. The study suggests that modifying the length of linkers can improve CAR T cell function and overcome current limitations.
Researchers at University of Helsinki and Aalto University created an AI model that can predict T cell targets for previously unmapped viruses, including COVID-19. The model helps understand how T cells identify their targets using a key-lock principle.
A recent study has identified two distinct immune profiles in severe asthma patients, which could lead to personalized treatment approaches. The research, conducted by a team of scientists at the University of Pittsburgh and Stanford University, used advanced tools to characterize immune cells within the airways of severe asthma patients.
Researchers used a mouse model to identify the role of autoreactive T cells against transcriptional intermediary factor 1γ (TIF1γ) in dermatomyositis. The study found that autoreactive CD8+ T cells contribute to the pathogenesis of the disease, while autoantibodies are non-pathogenic clinical markers.
Researchers at Monash University have identified a novel T cell lineage, γμ T cells, which use a unique antibody-like structure to recognize pathogens. This discovery expands the immunology 'toolbox' and may lead to new approaches for fighting viral infections such as COVID-19.
Researchers integrated clinical data with mathematical and statistical modeling to study the competition between normal T cells and CAR T cells. The model confirmed that tumor eradication is a random, yet potentially highly probable event, with cures happening early after treatment.
A new method developed by researchers at the University of Missouri uses machine learning to analyze large amounts of biological data from single-cell RNA-sequencing. This allows scientists to identify patterns and make faster conclusions, which can lead to potential treatments for diseases such as Alzheimer's.
Studies found that disrupting interaction between p53 and Mdm2 in tumor cells is less effective than thought, as it can impair immune cell function. New compound APG115 showed promise in boosting T cell activity against cancer, suggesting a potential therapeutic approach.
A study published in the Proceedings of the National Academy of Sciences has identified a synergy between ICOS ligand and interleukin-10 that promotes mutualism with the gut microbiota. The research found that mice deficient in ICOSL had increased frequencies of IL-10-producing CD4+ T cells, which were crucial for preventing severe inf...