A new Harvard-led research suggests that the thymus, often considered expendable in adults, actually plays a crucial role in maintaining adult immune health and preventing cancer. The study found that patients who had their thymus removed had a nearly threefold higher risk of death from various causes, including cancer.
SourceHarvard University Department of Stem Cell and Regenerative Biology·JournalNew England Journal of Medicine·TypeObservational study·DateAug 3, 2023
A recent study published in Immunity has found that ketone bodies, produced by the liver during fasting or low glucose levels, power immune cells and improve T cell function. This discovery may pave the way for personalized dietary recommendations to augment treatments for infection, cancer, and other diseases.
SourceVan Andel Research Institute·JournalImmunity·TypeExperimental study·DateJul 28, 2023
A new study found that individuals vaccinated with the newer pertussis vaccine show similar immune responses to antigens present and absent from the vaccine, suggesting that asymptomatic infections drive T cell response. This could lead to the spread of the bacteria to vulnerable populations.
SourceLa Jolla Institute for Immunology·JournalCell Host & Microbe·TypeExperimental study·DateJul 26, 2023
Researchers found that CD4+ T cells initiate fat wasting, while CD8+ T cells induce muscle wasting, which surprisingly helps the mice fight infection and survive. The study sheds light on the complex relationship between immune cells and wasting responses.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at UCL and Stanford University create a three-component anti-cancer therapy using click chemistry, improving cancer-killing efficiency with sialidase enzyme, and exploring potential for next-generation agents.
SourceUniversity College London·JournalNature Chemistry·TypeExperimental study·DateJul 24, 2023
The IBS-KAI Conference will focus on viral diseases and immunology, featuring over 20 international experts. The conference aims to prepare for responses to future infectious diseases, including those with pandemic potentials.
Research identifies beneficial changes in immune system during pregnancy, which can lead to new treatment strategies for MS. Women with MS experience a 70% decrease in relapses during the last third of pregnancy, possibly due to epigenetic changes and hormone regulation.
SourceLinköping University·JournalJournal of Neuroinflammation·TypeObservational study·DateJun 13, 2023
Researchers found that targeting CD69 boosts the differentiation of tumor-specific CD8+ T cells in lymph nodes, promoting enhanced anti-tumor activity. This discovery identifies CD69 as a promising therapeutic target for future cancer immunotherapies.
SourceChiba University·JournalCancer Immunology Research·TypeExperimental study·DateJun 13, 2023
A new study published in Science Advances has found that certain antibodies against the Epstein-Barr virus can mistakenly target the brain and spinal cord, causing damage in multiple sclerosis patients. The research reveals a potential link between EBV infection and MS, with implications for personalized therapies.
SourceKarolinska Institutet·JournalScience Advances·DateMay 17, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.
SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateMay 16, 2023
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateMay 16, 2023
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
SourceCactus Communications·JournalChinese Medical Journal·DateMay 16, 2023
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
SourceUniversity of Freiburg·JournalCancer Immunology Research·DateMay 4, 2023
Moffitt researchers develop CAR T cells that target prostate cancer biomarker PSCA, killing cancer cells and preserving bone health. Zoledronate treatment enhances antitumor activity with minimal toxicity.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalScience Advances·TypeExperimental study·DateMay 3, 2023
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Research found that specific gut bacteria enhance response to PD-1 checkpoint blockade by altering immune molecules PD-L2 and RGMb. This leads to improved detection and destruction of cancer cells, offering potential for enhanced immunotherapy treatment outcomes.
SourceHarvard Medical School·JournalNature·TypeExperimental study·DateMay 3, 2023
Researchers at NIH have characterized idiopathic CD4 lymphocytopenia, a rare immune deficiency that affects the body's ability to fight off infections. People with severe cases of ICL are at higher risk of acquiring or developing multiple diseases, including cancers and autoimmune disorders.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateMay 3, 2023
Researchers at Sanford Burnham Prebys have found a way to revive exhausted T cells, which are crucial for destroying cancerous cells. The new approach targets PSGL-1 protein and slows down T cell exhaustion, significantly reducing tumor growth in mice with immunotherapy-resistant melanoma.
SourceSanford Burnham Prebys·JournalCell Reports·DateMay 3, 2023
Researchers at the University of Colorado Cancer Center have made a breakthrough in treating pancreatic cancer by combining radiation and immunotherapy. The treatment eradicates tumors while stopping the cancer from spreading, offering new hope for patients. Clinical trials are planned to further develop this therapy.
SourceUniversity of Colorado Anschutz Medical Campus·JournalCancer Cell·DateApr 27, 2023
Researchers at Moffitt Cancer Center found that tumor-associated macrophage clustering in the stromal compartment is associated with poor outcomes. The study developed a score based on gene expression to predict macrophage clustering, which also predicted disease stage and survival.
SourceH. Lee Moffitt Cancer Center & Research Institute·TypeExperimental study·DateApr 26, 2023
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Researchers found that probiotic bacteria Lactobacillus reuteri stimulates cancer-killing T cells by secreting indole-3-aldehyde, which activates a receptor in CD8 cells. A diet rich in tryptophan enhances the effect of immunotherapy on shrinking tumors and prolonging survival.
SourceUniversity of Pittsburgh·JournalCell·TypeExperimental study·DateApr 6, 2023
Researchers found that neutrophils activated by T cell-based immunotherapy can kill tumor cells that evade targeted therapies. This unexpected antitumor response could lead to new immunotherapies that harness this potent immune mechanism.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
SourceKarolinska Institutet·JournalProceedings of the National Academy of Sciences·DateMar 30, 2023
Researchers found that immune checkpoint inhibitors increase the mobilization of overlapping tumor-reactive CD8+ T cells, leading to antitumor effects. The diverse subset of T-cell clones plays a key role in this response, with polyclonal clones exhibiting more proliferative potential and contributing to effective treatment outcomes.
SourceTokyo University of Science·JournalCancer Immunology Research·TypeExperimental study·DateMar 29, 2023
Researchers at the University of Wisconsin-Madison have identified a specific cell population, called CD4/CD8 double positive T cells, that causes graft-versus-host disease in bone marrow transplants. The team's findings may lead to targeted treatments and improved patient outcomes.
SourceUniversity of Wisconsin-Madison·JournalScience Advances·DateMar 24, 2023
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
SourceCell Press·JournalStem Cell Reports·TypeExperimental study·DateMar 23, 2023
Researchers found that immunotherapy can activate tumor-fighting T cells in nearby lymph nodes, potentially boosting efficacy against solid tumors. The study suggests leaving lymph nodes intact until after immunotherapy could improve treatment outcomes for patients with head and neck cancers.
SourceUniversity of California - San Francisco·JournalCell·DateMar 20, 2023
A comprehensive analysis of invasive ER+ breast cancers found macrophages as dominant immune cells infiltrating tumors. The study identified distinct immune cell 'neighborhoods' associated with good patient outcomes and highlights the need for tailored immunotherapies targeting macrophages.
SourceUniversity of Pittsburgh·JournalNature Cancer·TypeExperimental study·DateMar 16, 2023
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A study by Washington University School of Medicine suggests targeting T cells to prevent neurodegeneration and treat Alzheimer's disease. The research indicates that microglia partner with T cells to cause brain damage in the disease, and blocking their entry can avoid most neurodegeneration.
SourceWashU Medicine·JournalNature·TypeExperimental study·DateMar 8, 2023
A new study discovered that maternal γδ T cells influence the transfer of microorganisms during birth and nursing, impacting lung immune response in newborns. This discovery highlights the role of gut microbiota in modulating lung immunity and has implications for understanding the first breath response.
SourceInstituto de Medicina Molecular·JournalCell Reports·TypeExperimental study·DateFeb 13, 2023
A study published in the Journal of Biological Chemistry found that a fish oil derivative called DHEA can reduce inflammation and disease severity in mice with multiple sclerosis. By supplementing the diet of mice with DHEA, researchers noticed a decrease in MS-like disease symptoms and an improvement in the immune system's response.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalJournal of Biological Chemistry·TypeExperimental study·DateFeb 8, 2023
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Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A team of scientists led by Thomas Blankenstein presents a mechanism that prevents the immune response from overshooting its mark. The KRKR motif, a short sequence of four amino acids, is crucial in binding to connective tissue and preventing interferon-gamma from spreading throughout the body.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalNature Immunology·TypeExperimental study·DateFeb 3, 2023
A new Pitt study reframes understanding of graft-versus-host disease, suggesting that GVHD is locally maintained by donor T cells in target tissues. The research, published in Immunity, offers an alternative model that could guide development of novel therapies and improve outcomes for stem cell recipients.
SourceUniversity of Pittsburgh·JournalImmunity·TypeExperimental study·DateJan 30, 2023
Researchers found that certain gene signaling pathways, such as interferon γ and beta-catenin, can lead to tumor hyperprogression after immunotherapy. Targeting these pathways may prevent hyperprogression in preclinical models.
SourceMichigan Medicine - University of Michigan·JournalCancer Cell·TypeExperimental study·DateJan 19, 2023
Researchers from Hospital Universitario 12 de Octubre and Josep Carreras Institute create a cell therapy based on STAb cells for T-Cell Acute Lymphoblastic Leukemia (T-ALL), a rare disease with few treatment options. The new therapy offers an alternative to CAR-T therapies, which have limitations in treating this type of leukemia.
SourceJosep Carreras Leukaemia Research Institute·JournalBMJ·TypeExperimental study·DateJan 16, 2023
Researchers have discovered a new biomarker that predicts the response to CAR-T cell therapy in patients with diffuse large B cell lymphoma. The biomarker identifies differentiated T cells, which can be removed from leukemia products to improve therapy success rates.
SourceMedical University of Vienna·JournalFrontiers in Immunology·DateJan 9, 2023
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers at MD Anderson Cancer Center have discovered a novel triple immunotherapy combination targeting checkpoints in T cells and myeloid suppressor cells, improving anti-tumor responses and survival rates in preclinical models of pancreatic cancer. The study found that neutralizing specific immunosuppressive mechanisms dramatical...
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Cancer·DateDec 30, 2022
Research from Michigan Medicine reveals that high levels of ammonia in colon tumors can lead to reduced T cell growth and immunotherapy resistance. A study published in Cell Metabolism found that using an FDA-approved drug to lower ammonia levels made tumors more sensitive to treatment.
SourceMichigan Medicine - University of Michigan·JournalCell Metabolism·TypeExperimental study·DateDec 23, 2022
A study published in Cancer Research found that the stress response in T cells can hinder cancer immunotherapy. The researchers discovered that targeting key proteins involved in this stress response could help develop more potent cancer immunotherapies.
SourceUniversity of North Carolina Health Care·JournalCancer Research·TypeExperimental study·DateDec 19, 2022
Scientists at UCSF have engineered T cells to produce a potent anti-cancer cytokine that only activates in tumor cells, eliminating melanoma and pancreatic cancer in mice. The treatment uses IL-2, which supercharges T cells to kill cancer cells while protecting against infection, offering a promising new strategy for fighting hard-to-t...
SourceUniversity of California - San Francisco·JournalScience·DateDec 15, 2022
Researchers at La Jolla Institute for Immunology have found that the inflammatory molecule LIGHT leads to airway remodeling and long-term breathing issues in severe asthma. Therapeutics targeting LIGHT could reverse airway and lung damage, offering a potential long-term treatment for asthma.
SourceLa Jolla Institute for Immunology·JournalJournal of Allergy and Clinical Immunology·TypeExperimental study·DateDec 9, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers develop new method to identify crucial protein fragments driving autoimmunity, enabling better diagnostics and therapies. The study finds cross-reactivity between human and microbial proteins drives autoimmunity in at least two diseases.
SourceWashU Medicine·JournalNature·TypeExperimental study·DateDec 7, 2022
A team of researchers discovered that the gut microbiome plays a critical role in driving granulopoiesis, a process formation of granulocytes, in mice models. The study found that alterations in the gut microbiome composition induced by neutropenia stimulate reactive granulopoiesis via interleukin 17A secreted by T cells, promoting neu...
SourceHokkaido University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 21, 2022
The study reveals that coronin proteins regulate T cell population size by promoting survival signals when cells are not too crowded. This mechanism is evolutionarily conserved in both humans and slime molds, opening up new avenues for research.
SourceUniversity of Basel·JournalScience Signaling·DateNov 9, 2022
Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalBlood·DateNov 4, 2022
Researchers found that immune checkpoint blockade therapy may be beneficial for certain cases of severe COVID-19. In pre-clinical trials, treatment with a PD-1 inhibitor restored T cell functionality and reduced inflammation in mice infected by MHV-A59, another betacoronavirus.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScience Advances·DateOct 27, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers found that two-dose CoronaVac vaccination schedules, spaced 2 or 4 weeks apart, elicit similar immune responses against SARS-CoV-2 variants. The study suggests that either schedule can provide equal protection against COVID-19.
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
SourceUniversity of Bonn·JournalJournal of Cell Biology·DateOct 14, 2022
A novel COVID-19 vaccine developed by Brazilian scientists combines two SARS-CoV-2 proteins to trigger a cellular immune response. The vaccine, called SpiN, showed promise in animal trials, protecting against three strains of the virus and reducing viral load by up to 50 times.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNature Communications·TypeRandomized controlled/clinical trial·DateOct 6, 2022
The NCCN Annual Congress on Hematologic Malignancies will address key findings on chronic lymphocytic leukemia management and CAR T-cells in diffuse large B-cell lymphoma. The event also features updates on immunotherapies in multiple myeloma treatment.
SourceNational Comprehensive Cancer Network·DateSep 27, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new intracellular checkpoint gene, CISH, has been found to suppress the ability of human T-cells to recognize and attack cancer cells. When CISH is disabled, T-cells more effectively recognize mutated proteins produced by tumors, making them more responsive to existing checkpoint therapies.
SourceUniversity of Minnesota Medical School·JournalMed·TypeRandomized controlled/clinical trial·DateSep 13, 2022
A study by researchers at Linköping University suggests that severe COVID-19 infection has long-lasting negative effects on the immune system. The results showed that patients developed antibodies against SARS-CoV-2 within 2-3 weeks of symptoms, which then started to fall after six months.
SourceLinköping University·JournalFrontiers in Immunology·TypeExperimental study·DateSep 8, 2022
Researchers at LSU Health New Orleans have identified a critical immunosuppressive pathway and developed an experimental inhibitor to protect T-cells from weakening. The CBL-B inhibitors show great potential in enhancing the efficacy of cancer immunotherapy, making patients' T-cells more effective in killing cancer cells.
SourceLouisiana State University Health Sciences Center·JournalFrontiers in Immunology·TypeExperimental study·DateAug 29, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A combination of immunotherapy and virotherapy using myxoma virus provides new hope for patients with treatment resistant cancers. The approach boosts the immune capacity to effectively target and destroy cancer cells, inducing a form of cell death called autosis.
SourceArizona State University·JournalCancer Cell·TypeExperimental study·DateAug 26, 2022
A new study identifies PDIA3 as a molecule targeted by the immune system in response to stress, contributing to liver damage in type 2 diabetes and obesity. Elevated levels of antibodies for PDIA3 have been found in people with these conditions, but improving diet and weight can reverse this liver condition.
SourceWeill Cornell Medicine·JournalScience Immunology·DateAug 19, 2022
Researchers captured first image of antigen-bound T-cell receptor complex with bound antigen at atomic resolution. The study reveals no significant structural changes in the receptor after antigen binding, sparking further investigation into the signaling pathway activation mechanism.
SourceGoethe University Frankfurt·JournalCell·TypeExperimental study·DateAug 18, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at Terasaki Institute create micro-organospheres for direct viral infection, immune cell penetration, and high-throughput therapeutic drug screening. The technology holds promise for personalized medicine, tumor therapy and rapid drug testing.
SourceTerasaki Institute for Biomedical Innovation·JournalStem Cell Reports·TypeExperimental study·DateAug 18, 2022
Researchers found that immune cells prefer nutrient fuels previously thought to be waste products, including lactate. This discovery could lead to personalized dietary recommendations to supercharge the immune system. The findings also suggest a strong influence of nutrients on T cell function and survival.
SourceVan Andel Research Institute·JournalCell Metabolism·DateAug 17, 2022
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
SourceTel-Aviv University·JournalJournal for ImmunoTherapy of Cancer·DateAug 8, 2022
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A new study from Tel Aviv University found that CRISPR therapeutics can lead to a significant loss of genetic material in treated cells, potentially destabilizing the genome and promoting cancer. The researchers detected up to 10% of cells with lost chromosomes, highlighting the need for extra care when using this technology.
SourceTel-Aviv University·JournalNature Biotechnology·DateJul 24, 2022
Research reveals T cells in colorectal cancer have a double-edged function. Initially protective against tumor growth, they later promote cancer progression by altering their receptors and producing pro-inflammatory cytokines. The study offers new insights into the role of T cells in colorectal cancer and potential avenues for therapy.
SourceRockefeller University·JournalScience·DateJul 22, 2022