Articles tagged with Drug Development
Researchers at MD Anderson Cancer Center have discovered that adding copper-loaded agents to radiotherapy can overcome radioresistance in preclinical models of thoracic cancer. A novel blood-based biomarker, OSMR, has also been identified in patients with acute myeloid leukemia (AML), which shows prognostic potential and can help ident...
Researchers from the International Institute of Molecular and Cell Biology in Warsaw discovered a crucial role of enzyme TENT5A in extending poly(A) tails of therapeutic mRNA molecules, making them more stable and effective. Macrophages play a key role in vaccine effectiveness, capturing and neutralizing 'intruders' after administration.
The University of Missouri is partnering with a consortium to design and license a new research reactor, NextGen MURR, which will produce critical medical isotopes for cancer treatment. The project aims to enhance Missouri's role as a leader in nuclear science and medical research.
A novel cannula delivery system allows repeated, nondisruptive delivery of imaging agents to the mouse brain during long-term multiphoton microscopy. This innovation enhances longitudinal studies on brain function, disease progression, and potential treatments.
A team of experts at Cincinnati Children's reports achieving a milestone in growing human liver organoid tissue that faithfully reproduces key zones, nearly doubling rodent survival rate. This breakthrough paves the way for studying human liver biology and disease, accelerating drug development and potentially leading to repair tissues.
A new, easier-to-administer sustained-release formulation of flucytosine has entered Phase II clinical trials in Malawi and Tanzania. The trial aims to address the growing concern of cryptococcal meningitis, a major health threat to people with weakened immune systems, particularly those with advanced HIV.
A landmark study found that over 3 million children worldwide lost their lives in 2022 due to antimicrobial resistance (AMR)-related infections. The study data also revealed a sharp rise in the use of Watch and Reserve antibiotics, posing serious long-term risks.
Researchers used CRISPR interference to examine every gene in the human genome and discovered a new set of genes contributing to Parkinson's disease risk. The study identified the Commander complex, which regulates lysosomal function and is implicated in PD risk, offering opportunities for new treatments.
The journal is inviting submissions on AI for engineering, focusing on novel methodologies and applications to solve real-world problems. Submissions can cover various areas such as intelligent manufacturing, energy, transportation, and medicine.
Researchers have identified a potential precision medicine approach to prevent chronic kidney disease progression by targeting type 5 collagen, a minor component of scar tissue. A repurposed anti-cancer drug, Cilengitide, has been shown to slow kidney scarring and disease progression in high-risk individuals.
Scientists at City of Hope have identified a new molecular target for treating pancreatic cancer, using an experimental drug to slow tumor growth and damage tumor cells. The approach showed promise in clinical trials with two patients, resulting in up to a 49% shrinkage in liver metastases.
Researchers at Mayo Clinic developed a personalized deep brain stimulation platform to treat drug-resistant epilepsy. The study found that this approach reduced seizures while also improving memory and sleep in patients with temporal lobe epilepsy.
Neuro-immunologist Stephen Hauser has won the 2025 Breakthrough Prize in Life Sciences for his role in identifying the immune system's primary driver of damage to nerve cells in multiple sclerosis. His B-cell theory has led to the development of therapies that have transformed treatment, reducing relapses and improving prognosis.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.
A clinical study confirms that early treatment with fosdenopterin/rcPMP significantly reduces the risk of early death and promotes healthy brain development in infants with MoCD type A. The therapy restores the missing molybdenum cofactor, leading to improved developmental milestones.
Researchers at MIT have developed a method to mass manufacture nanoparticles that target cancer cells, eliminating the need for manual polymer mixing and streamlining production. This approach integrates good manufacturing practice (GMP)-compliant processes, making it suitable for large-scale production of cancer treatments.
Scientists at ISTA create a new brain organoid model that incorporates microglia to study viral infections, such as Rubella, and test the effectiveness of ibuprofen. The results show that microglia play a crucial role in inflammatory reactions and that ibuprofen exerts its protective effects by inhibiting two inflammatory enzymes.
Researchers identified a new way to fight infections like Lyme and syphilis by disrupting the bacteria's 'motor', preventing it from spreading through the body. The findings could have wide-ranging impacts on the treatment of infections in the future as concern about antibiotic-resistant strains grows.
A novel AI-based method called scNET combines gene expression data with networks of possible gene interactions to identify biological patterns in response to drug treatments. The system reveals complex mechanisms underlying cellular behavior, providing insights for new therapeutic approaches.
A new paper highlights emerging alternatives to traditional diabetes medicines, such as continuous glucose monitors and lifestyle interventions like GEM, which can improve patient adherence and long-term health outcomes.
Researchers developed new AI models, InstaNovo and InstaNovo+, to vastly improve accuracy and discovery in protein science. These models excel in tasks such as de novo peptide sequencing, identifying microorganisms, and discovering novel peptides, with implications for personalized medicine, cancer immunology, and beyond.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
Researchers have identified six promising biomarkers that can detect drug-induced kidney injury earlier than traditional markers, enabling more timely monitoring during drug development. These biomarkers could lead to the development of safer medications and improve patient outcomes.
Researchers propose GLDH as a more liver-specific biomarker for detecting liver injury, offering greater specificity than current ALT and AST tests. The test performed similarly to ALT for detecting liver injury but was not impacted by associated muscle injury.
Researchers discovered TBX2 drives therapy resistance by shifting signaling from the androgen receptor to the glucocorticoid receptor. The study identified a strategy to target this switch, potentially predicting patient risk and offering new treatment approaches.
Yali Dou, a molecular biologist at Keck School of Medicine of USC, has been elected as an AAAS fellow for her groundbreaking work in understanding leukemia and cancer. Her research on mixed-lineage leukemia proteins has led to the development of potential cancer treatments and a deeper understanding of epigenetics.
A new medical database automatically compiles patient records of obese individuals, offering insights for health promotion and drug development. The J-ORBIT database reveals strong links between obesity and various diseases, including diabetes, hypertension, and coronary heart disease.
The ISS National Lab's new podcast, 'Between a Rocket & a Hard Space', offers exclusive insights from scientists, engineers, and visionaries on the future of space research. The first episode explores the groundbreaking science happening on the International Space Station, including its impact on medicine, technology, and industry.
A team of scientists has created a new method to selectively modify specific proteins in complex biological environments. They achieved this using aptamers and deoxyoxanosine, allowing precise conjugation of desired sites on target proteins. This breakthrough technology has the potential to revolutionize cancer diagnosis and treatment.
Researchers developed a sensor platform that tracks multiple metabolites continuously, offering a window into disease onset and health status. The technology harnesses natural biochemical processes, enabling reliable detection of over 800 metabolites, with potential applications in diagnosing metabolic disorders and optimizing fitness.
Researchers developed a universal vaccine that removes sugar molecules from coronavirus spike proteins, creating effective antibodies. The vaccine showed improved protection against various variants and potential applications for cancer treatment.
A growing body of evidence suggests a significant link between human papillomavirus (HPV) and heart disease. Researchers pooled data from nearly 250,000 patients in seven studies, finding HPV-positive individuals had a 40% higher likelihood of developing cardiovascular disease.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have discovered a new class of antibiotics derived from frog secretions, which show promise in targeting harmful bacteria without affecting human cells or beneficial gut bacteria. The synthetic peptides were developed using structure-guided design a...
The researchers have created a way to deliver certain drugs in higher doses with less pain by injecting them as a suspension of tiny crystals. This approach can enable long-term delivery of contraceptives or treatments for diseases such as HIV, reducing the need for frequent injections.
A team of biologists has discovered an ancient neurohormone called bombesin that controls appetite in humans and other vertebrates. The study also found that bombesin-like neurohormones are present in starfish, revealing a common ancestor of appetite regulation dating back over half a billion years.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A study by the University of the Basque Country has detected potential biomarkers in the blood that could help predict the risk of developing schizophrenia due to cannabis use. The researchers found significant differences in fatty acid content between cannabis users, individuals with schizophrenia, and those with dual diagnoses.
Researchers discovered that a drug-resistant type of bacteria has adapted to produce antimicrobial genetic tools, eliminating its cousins and replacing them as the dominant strain. The finding validates a system developed at Pitt and UPMC for detecting infectious disease outbreaks.
Dr. Owen Witte has been awarded the 12th annual Harrington Prize for Innovation in Medicine for his groundbreaking work on leukemia, lymphoma, and other cancers. His discoveries have led to life-saving therapies like Gleevec and ibrutinib, transforming cancer treatment.
A new study using a microfluidic device found that certain infections may not be as resistant to antibiotics as previously thought. The researchers tested three different antibiotic agents against Pseudomonas aeruginosa and found a gradient of antibiotic activity dependent on the flow rate.
A Rice University statistician has received a $1 million CPRIT award to advance AI-powered precision medicine for prostate cancer. The project aims to identify lethal forms of prostate cancer earlier and improve treatment selection using AI tools and advanced imaging techniques.
Researchers at the University of Zurich have developed a technology to test 25 antibodies simultaneously in a single mouse, greatly reducing the number of laboratory animals required. The method uses protein fragments as barcodes for analysis, allowing for high-quality preclinical data on multiple antibody candidates.
The WIN Consortium is transforming cancer care through personalized medicine, leveraging AI, molecular profiling, and clinical trials. The organization's innovations, including N-of-1 clinical trials and WINTHER and WINGPO trials, are helping clinicians make more precise treatment decisions and improving outcomes for cancer patients.
Researchers at the University of Birmingham have developed a new method for rapid scalable preparation of uniform nanostructures directly from block polymers, significantly reducing processing time from weeks to just minutes.
Researchers developed CeSPIACE, a 39-amino-acid peptide drug candidate that binds to the spike protein, blocking viral entry. It demonstrates strong binding to major SARS-CoV-2 variants and shows efficacy against multiple strains in vivo and in vitro experiments.
Researchers have discovered how severe COVID-19 can destroy immune cells' ability to repair the lungs, leading to lingering effects of long COVID. By enhancing damaged organelles using a FDA-approved drug, they found improved lung healing and reduced inflammation.
A new diagnostic method called flicker optoretinography (f-ORG) analyzes the retina's reaction to light, helping to detect danger before symptoms appear. The technique detects even minor changes in photoreceptors, providing valuable insights into retinal health.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
A UMass Amherst Ph.D. student has been awarded a €20,000 grant to investigate a new therapeutic target for Lyme disease by targeting the GuaB enzyme necessary for Borrelia burgdorferi replication in mammals.
The Crew-10 mission will support cutting-edge biomedical investigations and NSF-funded physical science projects through the ISS National Lab. Astronauts will conduct experiments on the International Space Station, with findings benefiting humanity and driving commerce in low Earth orbit.
The study highlights the role of the Nwd1 gene in liver disease and its potential as a therapeutic target. Mice with Nwd1 gene deletion exhibited liver pathologies mirroring MASH, including excessive lipid accumulation and increased ER stress.
A new study suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer. Researchers found that both stress-related neurotransmitters and obesity-related hormones activate a protein called CREB, which is linked to cancer cell growth.
Researchers at Cornell University have found a new way that transposons, or 'jumping genes', can survive and propagate in bacteria with linear DNA. The study reveals that these genes can target and insert themselves at the ends of linear chromosomes, called telomeres, which is essential for their survival.
A new study published in the European Journal of Preventive Cardiology found that a type of diabetes medication called SGLT2 inhibitors can significantly lower the risk of heart failure and hospital visits related to heart failure in cancer patients. The benefits were particularly promising for breast cancer patients receiving anthracy...
Researchers found that aspirin prevents cancers from spreading by decreasing a clotting factor called thromboxane A2 and releasing T cells from suppression. This discovery could lead to the development of targeted treatments to prevent cancer metastasis, making aspirin potentially less expensive than antibody-based therapies.
The new AI model leverages hypergraphs to quickly and accurately identify therapeutic gene targets for diseases. HIT outperformed existing models in all tested metrics, demonstrating its accuracy in classifying therapeutic gene targets with great precision.
PARP inhibitors have been found to be effective in treating cancers with BRCA1/2 mutations by blocking DNA repair pathways. The combination of PARPis with chemotherapeutic drugs can also improve treatment efficacy, increasing DNA damage and blocking repair processes.
Richard Willson, a University of Houston professor, has been elected Fellow of the Royal Society of Chemistry for his contributions to the chemical sciences. He has developed innovative methods to detect viruses and other biological threats using glow-in-the-dark nanoparticles.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
Researchers at UTEP secured a patent for anti-malarial drug pyronaridine, which slows cancer cell growth and induces programmed cell death, sparing healthy cells.