Articles tagged with Drug Interactions
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Scientists have developed a rapid method to distinguish between left- and right-handed molecules in a mixture, offering potential breakthroughs in drug development and disease diagnosis. The Mass-Selected PhotoElectron Circular Dichroism technique can identify molecule handedness with high accuracy, even in complex mixtures.
Researchers at TSRI devised a set of chemical methods to study protein interactions with lipids, identifying thousands of lipid-protein interactions and discovering small molecules that selectively block these interactions. The findings suggest a wider range of proteins can be targeted with small-molecule ligands than previously thought.
Researchers developed a microfabricated device to evaluate the efficacy and toxicity of drugs metabolized through the liver, simplifying the process and overcoming limitations of existing systems. The device enables separate culture of primary liver cells and cancer cells, allowing for analysis of metabolic conversion and toxic effects.
A new trial design, called a two-by-two trial, can account for behavior-treatment interactions and provide more accurate efficacy results. By randomizing both treatment and probability of treatment, researchers can quantify the effects of treatment, behavior, and their interaction.
A study by the American Heart Association found that culturally tailored educational materials can decrease racial disparities in stroke preparedness outcomes. Interactive interventions and enhanced educational materials led to a significant increase in patients arriving at emergency departments within three hours of symptom onset.
A new study proposes a two-by-two blind trial design that considers interactions between behavior and treatment. The researchers found that participants who felt confident about receiving treatment changed their behaviors in ways that improved health outcomes and made the drug more effective.
Scientists and policymakers are reevaluating policies regarding contact with emerging isolated tribes in South America. The spread of diseases via outsiders is a major concern, while anthropologists warn that governments may not be prepared to protect these groups.
Researchers compiled summaries of 71 leading cardiovascular drugs and their interactions with genetic variations to improve prescribing decisions. The study found that seven frequently prescribed medications warrant pharmacogenomic guidelines, which can help prevent adverse drug reactions and treatment non-response.
Pharmacy Doctorate students from University of Houston won awards for clinical skills and disease state management at the Texas Society of Health-System Pharmacists Meeting. The teams demonstrated their abilities in patient consultation and developed therapeutic plans to identify problems, strategy, and monitoring.
Researchers have developed a new method for studying protein motion by freezing and then slowly 'waking' them up with increasing temperature. This approach, using variable-temperature solid-state NMR, reveals a hierarchical sequence of protein motions, allowing scientists to study individual motions and their interactions.
A multi-year study by Olga Troyanskaya and her team identified 144 functional gene interaction networks for organs as diverse as the kidney, liver, and whole brain. The technique, NetWAS, combines quantitative genetics with functional genomics to increase the power of GWAS and identify genes underlying complex human diseases.
Researchers found that Veterans Health Administration patients managed by pharmacists who educated and monitored them showed improved adherence rates. Pharmacist-led patient management was key to this success, involving regular education and follow-up to ensure medication was taken as prescribed.
Researchers at UCSF have visualized the TRPA1 protein, also known as the 'wasabi receptor', at near-atomic resolution. This discovery provides valuable insight into how anti-inflammatory pain drugs can be designed to target this receptor.
The American Geriatrics Society and AARP have developed a free guide to help older Chinese-Americans manage their health. The guide highlights common health concerns and provides practical recommendations for discussing cultural issues with healthcare providers.
A University of York student has helped develop a new drug release gel that may help avoid some of the side effects of painkillers such as ibuprofen and naproxen. The gel is based on small molecules that self-assemble into nanofibers, allowing for precise control over drug release.
Researchers at Penn Medicine have discovered a new class of receptors that ketamine binds to, which may underlie its diverse effects. This finding opens the door for designing drugs that interact specifically with these receptors, potentially leading to more targeted treatments.
Researchers at Michigan Medicine have developed a new compound that shows promise in treating acute leukemia and may also play a role in prostate cancer. The MLL-menin interaction is a key driver of the disease, and blocking this interaction has shown potential in laboratory studies.
Researchers have identified two mechanisms by which a blood thinning agent interacts with a protein that acts as a natural HIV barrier, shedding light on the degradation of the virus. The study aims to develop drugs that inhibit HIV infection without harming langerin's protective function.
Researchers discovered a new cellular factor critical to Ebola virus infection and identified Tetrandrine as a potent small molecule inhibiting the virus's entry into human white blood cells. The compound showed efficacy in preventing Ebola virus disease in mice without obvious side effects.
Researchers used a new computational method to predict the interactions between small molecules and thousands of proteins, revealing that many chemical probes are not selective but instead interact with multiple proteins. This study highlights the importance of understanding protein functions to develop more efficient and safer medicines.
A team of NUS researchers developed a novel strategy to prevent inflammation-associated cancers by targeting the interaction between FAT10 and MAD2. This approach facilitates the development of cancer drugs with fewer side effects, as it targets specific pathological functions without affecting other physiological functions.
Researchers analyze patients' genetic makeup to determine potential reactions to medications and reduce adverse effects. The goal is to increase the quality of life for individuals in behavioral health services, reducing emergency room visits and healthcare costs.
University of Illinois journalism professor Matthew Ehrlich compiled hundreds of cat-related tales from the New York Times digital archive, showing a range of stories beyond just cute cat videos. He found hero cats and nuisance cats, as well as concerns over animal treatment and rights.
A team of scientists has deciphered the structural details of a brain protein, TSPO, which has an almost equally strong affinity for Valium as it does for its target protein. The study reveals that TSPO breaks down a compound found in red blood cells, potentially helping regulate oxygen compounds and mitigating side effects.
Researchers at the University of Warwick have developed a new triggered-release mechanism for nanoparticles that could improve drug delivery and reduce side effects. The mechanism uses two nanoparticles to release medication only when taken into cells, potentially leading to more effective treatments with fewer side effects.
Researchers at the University of Copenhagen have designed new peptides that interact with gephyrin to enhance brain signaling, with effects up to 1,000 times stronger than natural counterparts. This breakthrough could lead to more effective treatments for mental disorders with fewer side effects.
Researchers found that combining clarithromycin with certain statins increases the risk of acute kidney injury or high potassium levels, potentially leading to hospital admission. The study suggests that alternative antibiotics like azithromycin may help prevent these adverse events.
A comprehensive review of recent studies provides insight into the causes and consequences of mild cognitive impairment (MCI), offering doctors and patients actionable advice. The guide highlights the importance of aerobic exercise, mental activity, social engagement, and stroke prevention in reducing MCI progression.
A study found that pharmaceutical companies failed to comply with FDA recommendations for pivotal drug study design and primary outcomes in nearly a quarter of cases. The researchers suggested that mandatory FDA review of pivotal trial protocols could optimize study quality.
Research identifies specific glycans on cell surfaces as key targets for bacterial toxins, offering new avenues for blocking toxin action and developing novel treatments. The discovery has major implications for the treatment of diseases caused by bacterial pathogens such as Streptococcus pneumoniae and group A streptococci.
Researchers have uncovered a mechanism that explains why many ALS drugs fail as the disease progresses: the brain's pumps become more active and remove both toxins and medicine. Blocking these pumps improves drug efficacy in mouse models.
Salk scientists unveil a new method that enables detection of fleeting protein interactions, which could dramatically accelerate cancer drug discovery. The ReBiL method, published in Cell Reports, provides an immediate platform to screen for badly needed new drug candidates.
PharmaMar presents results highlighting a pipeline of targeted therapies, including Aplidin, an antitumoral compound targeting eEF1A2, and an ADC combining a marine-derived agent with trastuzumab. The company's pipeline includes multiple compounds in clinical development for various tumor types.
A study published in JAMA found that a device for closing the left atrial appendage significantly reduces the risk of stroke and cardiovascular death in patients with atrial fibrillation. The device was shown to be noninferior and superior to warfarin, a current treatment option for stroke prevention.
GAS5, a long intergenic non-coding RNA, acts as a brake on steroid hormone receptors, preventing them from binding DNA. Researchers have gained insights into how GAS5 RNA interacts with steroid hormone receptors and its potential role in disease.
Researchers at Johns Hopkins University have captured images of the complex, revealing the connection between some genetic mutations and electrical abnormalities in the heart. The study provides a starting point for designing therapies to treat conditions such as long QT syndrome and Brugada syndrome.
A new study has identified high levels of drinking among low-income older adults, with spikes in consumption around social security check dates. The study used a novel approach involving bogus recycling bins to assess alcohol consumption and found that medical conditions like diabetes may reduce drinking rates.
A cross-sectional study found that medical schools with stricter industry interaction policies had students report fewer gifts and interactions with marketing reps, suggesting these policies can reduce biases. The results suggest that limiting receipt of gifts should be a central feature of medical school regulations.
Scientists at the University of Southampton have identified key characteristics that enhance a nanoparticle's ability to penetrate skin. Researchers found that positively charged nanorod-shaped nanoparticles are up to ten times more effective in penetrating skin than others, with cell penetrating peptides further enhancing penetration.
A team of researchers uncovered how Protein Kinase A II-beta changes shape in response to cAMP, revealing its internal architecture and ability to regulate energy consumption and hormone interactions.
A recent study by the University of the Basque Country highlights the risks of drug-food interactions in mountaineering, particularly at high altitudes. The researchers emphasize the importance of controlling medications and nutritional ergogenic aids to prevent adverse reactions and ensure safe ascent.
Researchers at Texas Biomedical Institute have discovered new cellular factors essential for CCHFV infection, revealing the site where a drug therapy would need to act. The findings suggest that multivesicular bodies are critical for CCHFV replication and hold promise for broad-spectrum antiviral treatments.
A commentary calls for physicians to carefully review older patients' medication lists and consider their anticipated life expectancy, goals of care, and treatment targets. This approach can help reduce the number of unnecessary prescriptions and minimize harm from medications in older adults.
Researchers identified a unique interaction between cyclic-di-GMP and protein BldD, which controls the developmental switch in Streptomyces, turning it into an antibiotic factory. The small molecule assembles into a molecular glue, connecting two copies of BldD to regulate development.
Researchers used laser optical tweezers to study interactions between malaria parasites and red blood cells, revealing new insights into the disease process. The study found that attachment is mediated by multiple weak interactions, which could potentially be blocked by a combination of drugs or antibodies.
Researchers at Saint Louis University have trapped the part of a virus responsible for inserting its DNA into human cells, a crucial step in understanding how HIV infects people. By capturing integrase with x-ray crystallography, scientists aim to develop new treatments and better understand how existing drugs work.
A large-scale search of a national medical database found that St. John's wort is often prescribed with medications that may result in adverse reactions, such as serotonin syndrome or heart disease. The study highlights the importance of caution when combining St. John's wort with other medications.
A study by Wake Forest Baptist Medical Center found that St. John's wort use was associated with 28% of potentially harmful combinations in analyzed data. The herbal supplement can reduce the effectiveness of various medications, leading to impaired treatment outcomes and increased risk of conditions like serotonin syndrome.
The Kaiser Permanente Southern California Outpatient Safety Net Program uses electronic health records to identify and address potential gaps in patient care, targeting issues such as medication interactions and follow-up tests. The program has shown promise in improving patient safety across various clinical conditions.
A study by Xavier Salvatella and Modesto Orozco reveals the existence of information highways in proteins, enabling new sites for drug interaction. This discovery has the potential to improve drug efficiency and discovery.
Scientists have found new targets for potential intervention in breast cancer, which could increase effectiveness and reduce undesirable side effects. The study used hydrogen-deuterium exchange mass spectrometry to map the intricate interactions between the progesterone receptor's AF1 and AF2 domains.
Researchers at MIPT have developed an algorithm to predict the impact of various substances on signaling pathways, which can help speed up the search for longevity drugs and decrease their cost. The new algorithm is based on comparing gene expression in young and elderly patients' cells.
The review provides guidance on managing surgical patients taking new oral anticoagulants, including discontinuation before procedures and resuming after procedures, as well as dose reductions based on kidney function and liver dysfunction considerations.
Researchers at the Lunenfeld-Tanenbaum Research Institute used baker's yeast to study drug interactions, finding that one-fifth of combinations suppress each other's effectiveness and increasing the risk of adverse reactions. The study's findings have implications for personalized medicine and optimization of combination therapies.
A new study by the University of Michigan reveals that there is no single healthy microbiome, but rather a unique and varied collection of bacteria for each person. The research found that various factors such as diet, environment, medication use, and life history influence the types of bacteria present.
A York University study found that abnormal lipid molecules in prenatal brain development can affect neural pathways, triggering autism. Environmental factors such as chemical exposure and medication use can also impact these lipids.
Researchers have developed a new drug delivery method that targets cancer cells using nanoballoons encapsulating anti-cancer drugs. The nanoballoons release the drugs when struck by a red laser, limiting interactions with healthy bodily systems and reducing side effects.
A new simulation module developed at ETH Zurich uses an ant algorithm to predict the interaction of molecules with human proteins, identifying potential side effects and optimizing molecular design. The module can now design new active agents in minutes, suggesting necessary chemical synthesis steps.
Researchers at Mount Sinai Hospital have discovered how the Marburg virus interacts with host protein Keap1, allowing it to live longer and replicate better. This knowledge may lead to the development of targeted therapies to arrest the lethal virus.
A new biochemical technique allows researchers to study how specific proteins called kinases interact to trigger cellular behavior, such as cell movement. The method, developed by Klaus Hahn's team, enables the activation of just one kinase and its interaction with another molecule in real time.