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New peer-reviewed paper by more than 20 protein experts calls for rethinking dietary protein guidance beyond "eat more protein": National Pork Board reports

A new paper by over 20 protein experts examines widely held propositions about dietary protein, concluding that some science is insufficient or not robust enough to support certain claims. Key findings include the importance of protein quality, individual essential amino acids, and nuance in high-protein intake during weight loss.

SourceNational Pork Board·JournalCritical Reviews in Food Science and Nutrition·TypeCommentary/editorial·DateJun 8, 2026

Chinese Medical Journal review illuminates the multifaceted role of LRRK2 in health and disease

The review highlights LRRK2's diverse cellular functions and pathogenic mechanisms in various diseases, including Parkinson's disease and inflammatory disorders. Therapeutic strategies targeting LRRK2, such as kinase inhibitors and emerging approaches like PROTACs and gene therapy, show promise for correcting cellular imbalances and re...

SourceChinese Medical Journals Publishing House Co., Ltd.·JournalChinese Medical Journal·TypeLiterature review·DateApr 1, 2026
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UT Health San Antonio study finds amino acid supplement may boost exercise benefits for older adults

A new study suggests that supplementing with BCAAs alongside an exercise program may help reduce fatigue, improve strength, and ease symptoms of depression for older adults. The research found notable improvements in participants who combined a BCAA supplement with an eight-week exercise program.

SourceThe University of Texas at San Antonio Health Science Center·JournalDietetics·DateOct 30, 2025

Consensus paper: Carcinogenicity of gene therapies

Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·TypeCommentary/editorial·DateAug 29, 2024
Creality K1 Max 3D Printer

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Eating too much protein is bad for your arteries, and this amino acid is to blame

Researchers discovered that consuming over 22% of daily calories from protein can lead to increased activation of immune cells contributing to atherosclerotic plaque formation. Leucine, an amino acid found in animal-derived foods, plays a disproportionate role in driving pathological pathways linked to atherosclerosis.

SourceUniversity of Pittsburgh·JournalNature Metabolism·DateFeb 19, 2024

Sorghum bran packs bigger punch than whole grain

Researchers have found that sorghum bran packs a bigger nutritional punch than whole grain due to its high levels of calcium, magnesium, leucine, and valine. The climate-resilient grain holds its own against other top grains in terms of macro- and micronutrients.

SourceUniversity of Johannesburg·JournalHeliyon·TypeExperimental study·DateSep 11, 2023

Steric zipper interactions in artificial crystalline peptide β-sheets

Scientists develop a method to construct crystalline artificial steric zippers in peptide β-sheets, paving the way for novel therapeutic strategies and materials. The research utilizes metal ions to prevent aggregation and form needle-shaped crystals with specific structural characteristics.

SourceTokyo Institute of Technology·JournalJournal of the American Chemical Society·TypeExperimental study·DateAug 2, 2023
Apple iPhone 17 Pro

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Metformin & leucine prevent cellular senescence & proteostasis disruption

Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.

SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateMar 31, 2023

Chinese scientists discovered roles of hypothalamic amino acid sensing in antidepressant effects

Researchers in China find that a leucine deficient diet has antidepressant effects on chronic restraint stress-induced depression-related behaviors, mediated by hypothalamic AgRP neurons and GCN2 signal. This study provides a new perspective for exploring the relation of nutrition, hypothalamus, and depression.

SourceHigher Education Press·JournalLife Metabolism·TypeExperimental study·DateMar 3, 2023

The right diet can safeguard against acute kidney injury

Researchers at University of Cologne discovered that specific diets can safeguard against acute kidney injury in mouse models. The six tested diets showed overlapping changes in cysteine catabolism as a potential mechanism for organ protection.

SourceUniversity of Cologne·JournalTranslational Research·TypeExperimental study·DateMar 21, 2022
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Diet high in leucine may fuel breast cancer's drug resistance

Researchers at Beth Israel Deaconess Medical Center discover relationship between leucine and tamoxifen resistance in ER+ breast cancer. A diet high in leucine may fuel the growth of breast cancer cells, while reducing leucine levels could be beneficial for patients with ER+ breast cancer.

SourceBeth Israel Deaconess Medical Center·JournalNature·DateApr 17, 2019

Turns out protein quality matters when it comes to building muscle

Dr. Phillips' review suggests that protein sources high in leucine, such as whey protein, can maximize muscle protein synthesis and growth. Whey protein's high-quality amino acid profile and digestibility make it an ideal supplement for strength trainers and those looking to preserve muscle mass with age.

SourcePollock Communications·JournalNutrition and Metabolism·DateOct 25, 2016
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Dietary leucine may fight prediabetes, metabolic syndrome

Researchers found that mice on high-fat diets who received extra leucine showed improved glucose tolerance and insulin sensitivity. Adding leucine to the diet improved metabolic health in animals with prediabetes or metabolic syndrome.

SourceJoslin Diabetes Center·JournalPLOS ONE·DateJun 22, 2011
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Leucine deprivation proves deadly to malignant melanoma cells

Researchers at Whitehead Institute found that depriving human melanoma cells of the essential amino acid leucine can lead to their death. Leucine deprivation triggers apoptosis in melanoma cells, providing a potential framework for targeted therapy. The study suggests that inhibiting autophagy with chloroquine may enhance this effect.

SourceWhitehead Institute for Biomedical Research·JournalCancer Cell·DateMay 16, 2011

Production of mustard oils: On the origin of an enzyme

Researchers isolated an enzyme from Arabidopsis thaliana that catalyzes glucosinolate formation and found it resembles an enzyme involved in leucine synthesis. This structural similarity enabled the plant to produce toxic compounds as a defense mechanism, highlighting the importance of small genetic changes in evolutionary adaptations.

SourceMax Planck Institute for Chemical Ecology·JournalThe Plant Cell·DateMar 17, 2011

Alzheimer's patients can't effectively clear sticky plaque component

Researchers found that Alzheimer's disease is associated with disrupted brain clearance of a sticky plaque component called amyloid-beta. The study's findings have important implications for diagnosis and treatment, as scientists seek to understand how this process can be improved.

SourceWashU Medicine·JournalScience·DateDec 9, 2010
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Burning extra calories with a 'futile protein cycle'

Researchers found that mice with a disrupted enzyme involved in protein metabolism became slimmer despite eating more food, showing improved glucose and insulin tolerance. The study suggests a new potential weight-loss therapy by manipulating protein turnover through pharmacological means.

SourceCell Press·JournalCell Metabolism·DateSep 4, 2007

Feeling old?

Research found that adding leucine to the diet restored a balanced metabolism in old rats, which had excessive protein breakdown. The study suggests that age-related muscle loss results from defective inhibition of proteasome machinery, and leucine supplementation can fully restore correct function.

SourceBlackwell Publishing Ltd.·JournalThe Journal of Physiology·DateDec 2, 2005

Protein-rich diet boosts benefit of exercise

A protein-rich diet combined with exercise leads to greater weight loss and fat reduction compared to a high-carbohydrate, lower-protein diet. This study found that dieters on the protein-rich diet lost almost 100% of their weight in fat, while those on the low-protein diet lost 25-30% of their weight as muscle.

SourceEdelman Public Relations, New York·JournalJournal of Nutrition·DateAug 25, 2005
SAMSUNG T9 Portable SSD 2TB

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Eating proper foods at right time after exercise can speed recovery

Researchers at the University of Illinois found that consuming foods containing leucine immediately after intense workouts can stimulate muscle protein synthesis and improve recovery. The optimal dosage is unclear, but athletes are advised to consume a balanced diet with protein-rich food and carbohydrate-rich fluids.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalJournal of Nutrition·DateJul 7, 1999