Articles tagged with Metabolites
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a computer-based method called CoMet to analyze cellular activity and predict anti-tumor activity of metabolites. The tool identified nine metabolites that exhibit anticancer properties when added to leukemia cells.
Diporeia, a small crustacean, has declined dramatically in Lake Michigan and other Great Lakes, threatening the ecosystem and $4 billion sport fishing industry. Researchers are exploring possible causes, including invasive mussels and pollutants like pesticides and PCBs.
Researchers at the University of Illinois Chicago have discovered a chemical compound, 2-aminoethyl phosphonate, in male blue crabs that is not present in females. The presence of this metabolite has significant implications for understanding animal development and biochemistry.
A new sewage screening test has been developed to track community-wide drug abuse trends, providing a fast, reliable, and inexpensive way to estimate illicit drug use. The method analyzes drug residues and metabolites in urine flushed into municipal sewage treatment plants.
Researchers at Purdue University have developed a new technique that improves the ability to detect genetic disorders in infants and young children, allowing for earlier diagnosis and treatment. The method uses metabolomics and nuclear magnetic resonance spectroscopy to analyze biomarkers in blood and urine.
Researchers at WashU Medicine discovered that women consuming most of their daily calcium from food have healthier bones than those relying on supplements. The study showed a significant association between dietary calcium intake and increased production of active estrogen metabolites, favoring bone density and osteoporosis prevention.
Researchers have discovered a way to create engineered minichromosomes in maize and attach genes to those minichromosomes. This breakthrough opens up new avenues for developing crops with multiple resistance traits, as well as producing medically useful proteins and metabolites.
Researchers found that polyphenols increase fatty acid breakdown and alter glucose usage in fat cells. Quercetin metabolites primarily accumulate in rat lungs, leading to increased fatty acid catabolism.
New research reveals that active estrogen metabolites are a strong predictor of bone mineral density in men. Higher levels of these hormones tend to result in higher bone density, while lower levels increase the risk of osteoporosis.
Researchers discovered that plant nectar contains secondary compounds, including nicotine, which repel pollinators and attract 'nectar thieves'. This finding suggests that plants may produce nectar to increase genetic diversity by attracting more visitors despite the potential risk of poisoning insects.
Researchers found that smoking cessation led to normalized brain metabolite concentrations, with decreased NAA levels in the anterior cingulate cortex correlating with smoking history. Choline and creatine levels were also affected, suggesting a link between smoking and neuronal dysfunction.
Researchers at Duke University Medical Center developed a new test that analyzes blood metabolites to identify genetic predispositions to coronary artery disease. The study found strong heritabilities in certain metabolites, suggesting the potential to detect people at risk of developing the disease at an early age.
A study found that lower estrogen levels, particularly estradiol and its metabolites, are associated with an increased risk of developing knee osteoarthritis. Women with lower estradiol concentrations had a higher odds of developing knee OA.
Researchers develop a new method to predict how individuals respond to drugs by analyzing their metabolite profiles, which can help diagnose diseases and tailor treatments for maximum efficacy and safety. The approach accounts for genetic and environmental factors influencing drug absorption and metabolism.
Researchers at VBI will utilize the database to identify key genes involved in tomato metabolism and apply RNA interference technology. The project aims to enhance tomato cultivation and expand its application in biotechnology research programs.
The team, led by Joerg Lahann, aims to create a non-invasive and inexpensive over-the-counter breast cancer screening test using metabolites present in breath. The device will utilize switchable surfaces that can attract and detect cancer-indicating metabolites.
A study by Emory University researchers found that organic diets significantly reduce children's exposure to two common pesticides, malathion and chlorpyrifos. The study, which involved 23 elementary students aged 3-11, showed a dramatic and immediate protective effect against the pesticides until conventional diets were reintroduced.
A new method has been developed to identify secondary metabolites in fungi, which are compounds that can have medicinal properties. The technique, known as genomic mining, allows researchers to pinpoint the genes responsible for producing these compounds, offering a promising tool for finding new medicines.
Researchers have identified differences in immune system cells and proteins in children with autism, raising hopes for an early diagnostic blood test. The study's findings could lead to a routine blood test that detects autism in newborns and allows for early treatment or prevention.
Researchers found that allicin, a compound in garlic, protects against severe chronic pulmonary hypertension in rats by inducing vasorelaxation. Daily consumption of garlic may provide similar benefits for humans, particularly those with respiratory issues.
Recent findings by Illinois researchers identified two new serotonin metabolites in the nervous system of marine mollusks, suggesting different chemical pathways exist to convert serotonin. This discovery could provide novel means to target tissue-specific diseases related to serotonin signaling.
A study found that community-based heavy drinkers have clear brain metabolite changes associated with lower brain function and are likely of behavioral significance. Brain damage is detectable even in those who function relatively well in the community.
Researchers found that paroxetine reduces levels of endoxifen, an active metabolite of tamoxifen, in breast cancer patients. This decrease was more pronounced in women with a normal CYP2D6 genotype, suggesting potential implications for tamoxifen treatment outcomes.
A nicotine metabolite, cotinine, may improve memory and protect brain cells from diseases like Alzheimer's and Parkinson's. Cotinine also displays antipsychotic properties, potentially offering a safer alternative to existing therapies.
Two newly identified metabolites of the gasoline additive MTBE have been found in human urine samples. These findings suggest that humans are exposed to MTBE and its byproducts through inhalation, and that further research is needed to understand their impact on human health.
Researchers have synthesized the major human metabolite of Taxol, 6-alpha-hydroxypaclitaxel, for the first time in a laboratory setting. This breakthrough will enable easier identification and quantification of the metabolite in complex mixtures, crucial for maximizing the clinical effectiveness of paclitaxel.
Researchers at Johns Hopkins Children's Center have found that certain metabolites of an antipsychotic drug inhibit HIV replication in human cell cultures, but at high concentrations. The findings suggest possible anti-viral activity against other viruses.