Articles tagged with Metabolites
Mayo Clinic researchers found that endoxifen, a tamoxifen metabolite, degrades estrogen receptors and inhibits the growth of breast cancer cells. The study suggests that an agent mimicking endoxifen might be a more effective treatment than tamoxifen.
A new blood analysis technique identified markers that could improve treatment and save lives for patients having a heart attack. By analyzing hundreds of molecular markers, doctors can confirm the presence of a heart attack within minutes, allowing for rapid treatment.
Researchers developed a new method for early detection of heart attacks using metabolite profiling, detecting changes in blood samples 10 minutes after the event. The approach has potential to improve early treatment and survival rates.
Researchers used metabolomics to identify groups of relevant biomarkers of disease in healthy and diabetic mice. The study found that the ratios between certain metabolite concentrations were more informative than their absolute concentrations.
Researchers have made significant progress in understanding the complex metabolic networks involved in tomato fruit development. By analyzing over 1200 quantitative metabolic loci (QMLs), scientists identified associations between metabolites and genes that regulate fruit metabolism. This knowledge can be used to alter metabolic pathwa...
Researchers developed a computer-based method called CoMet to analyze cellular activity and predict anti-tumor activity of metabolites. The tool identified nine metabolites that exhibit anticancer properties when added to leukemia cells.
Diporeia, a small crustacean, has declined dramatically in Lake Michigan and other Great Lakes, threatening the ecosystem and $4 billion sport fishing industry. Researchers are exploring possible causes, including invasive mussels and pollutants like pesticides and PCBs.
A new sewage screening test has been developed to track community-wide drug abuse trends, providing a fast, reliable, and inexpensive way to estimate illicit drug use. The method analyzes drug residues and metabolites in urine flushed into municipal sewage treatment plants.
Researchers at the University of Illinois Chicago have discovered a chemical compound, 2-aminoethyl phosphonate, in male blue crabs that is not present in females. The presence of this metabolite has significant implications for understanding animal development and biochemistry.
Researchers at Purdue University have developed a new technique that improves the ability to detect genetic disorders in infants and young children, allowing for earlier diagnosis and treatment. The method uses metabolomics and nuclear magnetic resonance spectroscopy to analyze biomarkers in blood and urine.
Researchers at WashU Medicine discovered that women consuming most of their daily calcium from food have healthier bones than those relying on supplements. The study showed a significant association between dietary calcium intake and increased production of active estrogen metabolites, favoring bone density and osteoporosis prevention.
Researchers have discovered a way to create engineered minichromosomes in maize and attach genes to those minichromosomes. This breakthrough opens up new avenues for developing crops with multiple resistance traits, as well as producing medically useful proteins and metabolites.
Researchers found that polyphenols increase fatty acid breakdown and alter glucose usage in fat cells. Quercetin metabolites primarily accumulate in rat lungs, leading to increased fatty acid catabolism.
New research reveals that active estrogen metabolites are a strong predictor of bone mineral density in men. Higher levels of these hormones tend to result in higher bone density, while lower levels increase the risk of osteoporosis.
Researchers discovered that plant nectar contains secondary compounds, including nicotine, which repel pollinators and attract 'nectar thieves'. This finding suggests that plants may produce nectar to increase genetic diversity by attracting more visitors despite the potential risk of poisoning insects.
Researchers found that smoking cessation led to normalized brain metabolite concentrations, with decreased NAA levels in the anterior cingulate cortex correlating with smoking history. Choline and creatine levels were also affected, suggesting a link between smoking and neuronal dysfunction.
Researchers at Duke University Medical Center developed a new test that analyzes blood metabolites to identify genetic predispositions to coronary artery disease. The study found strong heritabilities in certain metabolites, suggesting the potential to detect people at risk of developing the disease at an early age.
A study found that lower estrogen levels, particularly estradiol and its metabolites, are associated with an increased risk of developing knee osteoarthritis. Women with lower estradiol concentrations had a higher odds of developing knee OA.
Researchers develop a new method to predict how individuals respond to drugs by analyzing their metabolite profiles, which can help diagnose diseases and tailor treatments for maximum efficacy and safety. The approach accounts for genetic and environmental factors influencing drug absorption and metabolism.
Researchers at VBI will utilize the database to identify key genes involved in tomato metabolism and apply RNA interference technology. The project aims to enhance tomato cultivation and expand its application in biotechnology research programs.
The team, led by Joerg Lahann, aims to create a non-invasive and inexpensive over-the-counter breast cancer screening test using metabolites present in breath. The device will utilize switchable surfaces that can attract and detect cancer-indicating metabolites.
A study by Emory University researchers found that organic diets significantly reduce children's exposure to two common pesticides, malathion and chlorpyrifos. The study, which involved 23 elementary students aged 3-11, showed a dramatic and immediate protective effect against the pesticides until conventional diets were reintroduced.
A new method has been developed to identify secondary metabolites in fungi, which are compounds that can have medicinal properties. The technique, known as genomic mining, allows researchers to pinpoint the genes responsible for producing these compounds, offering a promising tool for finding new medicines.
Researchers have identified differences in immune system cells and proteins in children with autism, raising hopes for an early diagnostic blood test. The study's findings could lead to a routine blood test that detects autism in newborns and allows for early treatment or prevention.
Researchers found that allicin, a compound in garlic, protects against severe chronic pulmonary hypertension in rats by inducing vasorelaxation. Daily consumption of garlic may provide similar benefits for humans, particularly those with respiratory issues.
Recent findings by Illinois researchers identified two new serotonin metabolites in the nervous system of marine mollusks, suggesting different chemical pathways exist to convert serotonin. This discovery could provide novel means to target tissue-specific diseases related to serotonin signaling.
A study found that community-based heavy drinkers have clear brain metabolite changes associated with lower brain function and are likely of behavioral significance. Brain damage is detectable even in those who function relatively well in the community.
Researchers found that paroxetine reduces levels of endoxifen, an active metabolite of tamoxifen, in breast cancer patients. This decrease was more pronounced in women with a normal CYP2D6 genotype, suggesting potential implications for tamoxifen treatment outcomes.
A nicotine metabolite, cotinine, may improve memory and protect brain cells from diseases like Alzheimer's and Parkinson's. Cotinine also displays antipsychotic properties, potentially offering a safer alternative to existing therapies.
Two newly identified metabolites of the gasoline additive MTBE have been found in human urine samples. These findings suggest that humans are exposed to MTBE and its byproducts through inhalation, and that further research is needed to understand their impact on human health.
Researchers have synthesized the major human metabolite of Taxol, 6-alpha-hydroxypaclitaxel, for the first time in a laboratory setting. This breakthrough will enable easier identification and quantification of the metabolite in complex mixtures, crucial for maximizing the clinical effectiveness of paclitaxel.
Researchers at Johns Hopkins Children's Center have found that certain metabolites of an antipsychotic drug inhibit HIV replication in human cell cultures, but at high concentrations. The findings suggest possible anti-viral activity against other viruses.