Articles tagged with Metabolites
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have identified a rare neurological disorder caused by GPT2 gene mutations, replicating the disease in lab cultures and mouse models. The study reveals insights into brain development, neurotransmitter function, and metabolic pathways, providing new opportunities for diagnosis and treatment.
Scientists at Whitehead Institute developed a novel method to isolate and measure mitochondrial metabolite concentrations, providing greater resolution than traditional methods. The new approach offers improved speed and specificity, allowing for more accurate analysis of mitochondrial function in various disorders.
Research at Tohoku University reveals genetic variants affecting enzymatic activities in healthy individuals, suggesting that moderate and rare variants contribute to metabolic differences and disease susceptibility. The study identifies five associations between metabolites and gene variants, including four related to metabolic diseases.
A study published in PNAS identifies a unique chemical signature for chronic fatigue syndrome, revealing an unexpected connection to hypometabolic syndromes like dauer. The findings show that CFS has a characteristic metabolic response, with 80% of diagnostic metabolites decreased, and provide a basis for personalized therapies.
Scientists have created gels that can instruct stem cells to differentiate into specific types, such as bone and cartilage. By monitoring stem cell behavior on these gels, researchers identified key metabolites that guide the differentiation process.
Research found that retained metabolites in the blood are associated with impaired cognitive function in patients with kidney failure. The study suggests that interventions may be necessary to safeguard the mental health of these patients.
A team of scientists at Helmholtz Munich developed a protocol to analyze metabolite composition in fixed tissues using mass spectrometry imaging. This method allows for the study of spatial distribution of molecules with high precision, enabling the identification of new predictive, diagnostic and prognostic markers.
Researchers found that fruit flies adjust their gene expression and metabolism to cope with cold temperatures, with nearly a third of genes altered and half of metabolites changing expression. This adaptation is crucial for insect survival during winter months.
Scientists at The Institute of Cancer Research have developed a new method to assess cancer treatment efficacy by measuring blood metabolite levels. This approach has the potential to speed up the development of targeted drugs and tailor treatment for patients, offering a quick and simple way to monitor cancer therapy.
A new study found that vitamin nicotinamide riboside (NR) can protect mice from diabetes complications by lowering blood sugar levels, reducing fatty liver, and preventing peripheral nerve damage. NR is a precursor to NAD+, an important cellular metabolite required for energy conversion.
A study found that gut bacterial metabolites can accumulate in patients with chronic kidney disease, leading to an increased risk of cardiovascular disease and premature death. The accumulation of phenylacetylglutamine was particularly associated with poor health outcomes.
People with major depressive disorder may have altered purine metabolism, with higher levels of xanthine and lower inosine and guanosine. This dysregulation may be the body's compensatory mechanism to combat increased oxidative stress caused by depression.
Researchers found that a chemical byproduct of ketamine metabolism is responsible for its rapid antidepressant action, unlike the anesthetic and dissociative effects. This discovery holds promise for developing more robust and safer treatments for depression.
Scientists at Okinawa Institute of Science and Technology Graduate University identified 14 age-related compounds that decrease with age, including those related to muscle strength and antioxidants. These findings suggest the importance of consuming antioxidant-rich foods and exercising regularly after 65 to improve body conditions.
Researchers at USC and JPL are launching fungi into space to explore their potential as novel therapeutics for use both in space and on Earth. The study aims to discover new compounds that could be used to develop medicines for astronauts and potentially address life-threatening diseases like cancer and Alzheimer's.
Researchers found that butyrate production is reduced in the intestinal tract of experimental mice after bone marrow transplantation, leading to an increased risk of graft vs. host disease. Increasing butyrate levels can mitigate this condition by bolstering the gut lining's resistance to the donor immune system.
Researchers found that asparagus rhizome traits, specifically water content and metabolite levels, are key indicators of freezing tolerance. The study tested three cultivars, with Guelph Millennium proving to be the most tolerant, suggesting that adapting to colder climates may depend on optimizing rhizome characteristics.
Researchers from Colorado State University have discovered a potential diagnostic tool for dengue fever by analyzing metabolomic profiles in patient serum. The study found that distinct metabolic clusters were associated with different disease outcomes, including the progression to hemorrhagic fever/dengue shock syndrome.
Research from the University of Leicester found high levels of trimethylamine N-oxide in acute heart failure patients, a metabolite produced by gut bacteria breaking down L-carnitine from red meat. The study suggests a possible link between red meat consumption and increased risk of heart disease.
A human pilot trial investigated the absorption, metabolism, and excretion of mango galloyl derivatives. Seven metabolites were identified in healthy volunteers, with two microbial metabolites significantly more excreted after 10 days of mango consumption.
A new molecular pathway involved in heart attacks and death from heart disease has been identified by a Duke University research team. They found that stress on the endoplasmic reticulum organelle is associated with risk of future heart events and can be detected in bits of molecular detritus circulating in the blood.
Researchers found that polyamines, which decline with age, regulate the functioning of circadian clocks. Administering polyamine supplements restored clock function in older mice, suggesting potential clinical applications.
A study discovered six metabolites in the blood that strongly correlate with kidney function. Two of these metabolites, pseudouridine and C-mannosyltryptophan, are equally effective measures of kidney function as creatinine, offering potential improvements in diagnosing chronic kidney disease.
A new study reveals that gas chromatography mass spectrometry (GC-MS) fundamentally alters the samples it analyzes due to heat, affecting thousands of laboratories worldwide. The researchers used a data analysis platform to observe small molecules transforming and disappearing during an experiment meant to mimic the GC-MS process.
Scientists at ETH Zurich have developed a method to analyze hundreds of metabolites simultaneously in real-time, allowing for rapid analysis of cellular responses to external stimuli. This breakthrough enables the study of complex biological processes and has potential applications in developing new pharmaceutical agents.
A Lund University study found that men with higher exposure to the chemical DEHP have lower sperm motility. This could lead to difficulties conceiving children. The study analyzed metabolite levels of DEHP in urine and semen quality among 300 young men.
A team of bioinformaticians at the University of Jena has developed a new search engine, 'CSI:FingerID', that significantly simplifies the identification of molecular structures of metabolites. The tool reduces the number of possible compounds from thousands to ten, making it feasible for precise lab tests to identify specific compounds.
Researchers used exometabolomics to study the interactions between soil microbes and their adaptations in desert biocrusts. The team found that diverse microbes target specific metabolites, supporting diverse microbial communities. This discovery suggests a possible mechanism for promoting soil biodiversity by specialization.
Researchers at RIKEN and Hiroshima University create technique to analyze metabolites, hormones, nutrients, and lipids in individual cells using nanospray tip and mass spectrometer. This breakthrough could speed up understanding of molecular distribution in time and space, transforming agricultural science.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
A study found that vaginal douching is associated with higher levels of phthalate metabolites in urine, increasing the risk of health problems. Black women are at higher risk due to frequent douching usage.
A team of Vanderbilt chemists used a novel approach called 'fight clubs' to identify promising new anti-cancer compounds from natural sources. By analyzing the interactions between bacteria and other microorganisms, they discovered a class of biomolecules with broad-spectrum activity.
A study by Montreal researchers found that the plasticizer DINCH's metabolite MINCH can act as a metabolic disrupter, affecting adipose tissue differentiation. The study suggests that DINCH exposure may pose a risk to human health and warrants further research.
Research from Inserm found a significant association between increased urinary levels of pyrethroid metabolites and decreased verbal comprehension and working memory in six-year-old children. The study suggests potential neurotoxic effects of pyrethroids on child development.
LCSB researchers analyzed metabolite signatures from hundreds of biomolecules in different brain regions, revealing a specific functional state of nerve cells. The study used an interdisciplinary approach and machine learning to derive metabolic profiles, which may offer new therapeutic opportunities for neurodegenerative diseases.
A new study has found an association between vitamin E concentrations and exposure to fine particulate pollution in the general population. Higher levels of alpha-tocopherol, a form of Vitamin E, were linked to lower lung function and reduced exposure to PM2.5.
Research finds that growth-promoting hormones like TBA used in beef production can persist in the environment at higher concentrations and for longer durations than previously thought. This persistence has significant impacts on aquatic ecosystems, including disrupting reproductive cycles and altering entire food webs.
A new study led by UMass Amherst epidemiologist Katherine Reeves is assessing the relationship between phthalate exposure and breast cancer risk. The three-year study will analyze urine samples from 500 women with invasive breast cancer and 1,000 healthy controls to measure levels of 11 phthalate metabolites.
Researchers have found a correlation between metabolic imbalance and increased risk of respiratory diseases in early childhood. Elevated concentrations of specific sugars, such as hexoses, were associated with elevated inflammatory immune parameters.
Research shows that muscle metabolites released during exercise activate neural pathways in people with chronic fatigue syndrome, leading to excessive feelings of fatigue. The study suggests that peripheral tissues like muscles contribute to fatigue, providing new insights into the disease's mechanisms and potential treatment targets.
A research team at KAIST used metabolite structural similarity to elucidate the mechanisms of action of traditional oriental medicine. The study found that TOM compounds interact with diverse metabolic pathways, showing strong efficacy for treating complex diseases.
A recent study found that quitting smoking has favorable metabolic effects, with reduced central fat distribution and improved hepatic glucose output. The study also showed a correlation between weight loss and increased glucose uptake and utilization of carbohydrate substrates.
Researchers discovered that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has anti-inflammatory effects. HYA alleviates intestinal inflammation in mice with colitis and improves epithelial barrier function.
A new study suggests that nicotine's metabolite cotinine amplifies the effect of acetylcholine, a primary chemical messenger involved in learning and memory, potentially providing therapeutic benefits for Alzheimer's and other memory disorders. Cotinine may also have synergistic effects with existing Alzheimer's therapies.
Researchers at Yale University found a compound produced by the body during dieting or fasting can block an immune system part involved in several inflammatory disorders. The compound BHB directly inhibits NLRP3, driving inflammation in diseases like autoimmune disorders, type 2 diabetes, and Alzheimer
Researchers found common biomarkers of sleep debt in humans and rats, indicating a link to metabolic disorders such as weight gain, diabetes, and cardiovascular disease. The study also identified potential biomarkers, oxalic acid and diacylglycerol 36:3, which could serve as indicators of sleep quality and quantity.
Researchers identified two lipid metabolites, lysophosphatidylcholine and sphingomyelin, associated with reduced risk of coronary heart disease, while monoglyceride was linked to increased risk. The study's findings suggest that these blood lipid metabolites could serve as predictors for cardiovascular disease.
Researchers have developed a new computational model that can predict and identify gut metabolites produced by microorganisms, which could lead to improved diagnosis and treatment of GI diseases. The model focused on aromatic amino acids and predicted over 49 different metabolites exclusive to the microbiota.
A new study found that people are contaminated with several toxic flame retardants, including TCEP, a carcinogen linked to cancer and reproductive harm. The study identifies biomarkers for detection in urine samples, opening up research into the group of chemicals.
New research reveals that gut bacteria convert red meat's L-carnitine into trimethylamine-N-oxide, a compound promoting atherosclerosis. Gamma-butyrobetaine, another metabolite produced by gut bacteria, also contributes to cardiovascular risk.
A study examining prenatal phthalate exposure found a significant association between DiNP metabolites and shorter anogenital distance in Swedish boys at age 21 months. This link raises concern about the safety of recent phthalate substitutions, particularly for male reproductive health.
Researchers identified 149 metabolites with altered concentrations in patients with non-small cell lung cancer compared to those at risk but without the disease. The study suggests a potential diagnostic biomarker for early lung cancer detection.
Scientists have developed a breath analyzer for dolphins, allowing for non-invasive diagnosis of health issues. The instrument captures metabolites in dolphin breath to identify changes associated with disease or environmental factors.
A study in JAMA Network found a strong association between tobacco use and the prevalence of oral human papillomavirus type 16 (HPV-16) infection. Tobacco users were more likely to be male, younger, and have higher lifetime oral sexual partners, and had greater levels of biomarkers for tobacco exposure.
A study published by The Endocrine Society found that diverse gut bacteria are associated with a favorable ratio of estrogen metabolites, which may reduce the risk of breast cancer. Researchers analyzed fecal and urine samples from 60 postmenopausal women and discovered a relationship between bacterial diversity and estrogen levels.
Researchers at Albert Einstein College of Medicine found that certain bacteria produce metabolites that strengthen the intestinal epithelium's barrier function. These metabolites activate a protein called PXR, which suppresses inflammatory responses and increases junction strength between epithelial cells.
Researchers discovered that a particular EPA metabolite, 18-hydroxyeicosapentaenoic acid (18-HEPE), plays a crucial role in protecting against cardiovascular diseases. This metabolite was produced by immune cells and confirmed its heart-protective effects.
Children with autism spectrum disorders have altered gut bacteria and distinct metabolite profiles, potentially affecting brain function and neurotransmitter balance. The study found lower levels of homovanillate and N,N-dimethylglycine, as well as a higher glutamine/glutamate ratio, in children with ASD.
Researchers have created an atlas of genetic associations with human metabolism, identifying 90 new genetic variants linked to metabolites. The study provides a powerful tool for understanding the molecular pathways underlying complex diseases and improving drug discovery for metabolic disorders.
Scientists at Brookhaven National Laboratory have found that certain desaturating fatty acid enzymes can link up to efficiently pass intermediate products from one enzyme to another. This process, known as metabolic channeling, enables the efficient production of useful plant products, such as healthful polyunsaturated fatty acids.