Articles tagged with Metabolites
Researchers at Rensselaer Polytechnic Institute developed an algorithm that accurately predicts whether a child is on the Autism spectrum of disorder based on levels of metabolites found in a blood sample. The algorithm, which uses big data techniques, correctly identified 96.1% of neurotypical participants and 97.6% of children with ASD.
A new tool using nuclear magnetic resonance (NMR) measures hydrogen atoms to study metabolism and determine metabolic fluxes. This technique has been validated on human cancer cells and holds potential for understanding the mechanisms behind diseases like diabetes.
Exposure to newer organophosphate flame retardants has significantly increased over the past decade, with a metabolite of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) found at levels 15 times higher in 2014-2015 samples than in 2002-2003.
A study published in JAMA Cardiology found that habitual e-cigarette users have increased cardiac sympathetic activity and oxidative stress, which are mechanisms associated with tobacco cigarette smoking. These findings suggest a potential increased cardiovascular risk profile for habitual e-cigarette users.
An international team of researchers has spatially mapped molecules produced by an intact, complex microbial community for the first time. They used imaging mass spectrometry to track and plot metabolites made by both bacterial and fungal lichen members.
A new study suggests that a metabolite of ketamine can produce antidepressant-like effects in mice, potentially leading to further research on the efficacy and safety of ketamine in humans. Ketamine has been shown to have rapid and potent antidepressant effects in humans, even in those resistant to traditional treatments.
A new method of plant analysis has identified more than twenty metabolites in tomatoes that had never been reported before, including certain antioxidants in the skin. The Weizmann team's tools, WeizMass and MatchWeiz, can help study plant metabolism and identify useful biological activity
Bekzod Khakimov, a promising young researcher from the University of Copenhagen, has received the first Nils Foss Talent Prize. His work focuses on metabolomics, using Gas Chromatography-Mass spectrometry to improve data analysis and reproducibility.
Researchers used a new approach to measure metabolic diversity in various plant tissues, revealing distinct profiles for each tissue. The study identified specific genes regulating the biosynthesis of ecologically-important secondary metabolites, shedding light on how plants modulate their metabolite accumulation at the organ level.
Researchers have developed a game-changing blood test that can identify concussions with greater than 90% certainty, using metabolomics to analyze small molecules in the blood. The test is unique and has been proven to be effective in distinguishing concussed patients from non-concussed adolescents.
Researchers used NMR spectroscopy to identify a panel of 10 urinary metabolites associated with fetal growth and increased birth weight. Changes in these metabolites could explain 12% of the variation seen in birth weight, independent of other known predictors.
Researchers found that choline deficiency during pregnancy alters choline metabolite profiles, fatty acid compositions, and amino acid levels in sow milk. This study provides new insights into the importance of choline for human development and highlights the need for mandatory fortification programs to address this nutrient deficiency.
A new investigation finds that vitamin supplements can slow muscle wasting by boosting NAD+ levels in mice. The study supports the potential benefits of NAD+ precursors for patients with muscular dystrophy and other muscle disorders.
The first controlled clinical trial of nicotinamide riboside (NR) demonstrated that the compound is safe for humans and increases levels of a critical cell metabolite. NR supplementation has been shown to produce multiple health benefits, including improved control of blood sugar and cholesterol.
Researchers have identified a rare neurological disorder caused by GPT2 gene mutations, replicating the disease in lab cultures and mouse models. The study reveals insights into brain development, neurotransmitter function, and metabolic pathways, providing new opportunities for diagnosis and treatment.
Scientists at Whitehead Institute developed a novel method to isolate and measure mitochondrial metabolite concentrations, providing greater resolution than traditional methods. The new approach offers improved speed and specificity, allowing for more accurate analysis of mitochondrial function in various disorders.
Research at Tohoku University reveals genetic variants affecting enzymatic activities in healthy individuals, suggesting that moderate and rare variants contribute to metabolic differences and disease susceptibility. The study identifies five associations between metabolites and gene variants, including four related to metabolic diseases.
A study published in PNAS identifies a unique chemical signature for chronic fatigue syndrome, revealing an unexpected connection to hypometabolic syndromes like dauer. The findings show that CFS has a characteristic metabolic response, with 80% of diagnostic metabolites decreased, and provide a basis for personalized therapies.
Scientists have created gels that can instruct stem cells to differentiate into specific types, such as bone and cartilage. By monitoring stem cell behavior on these gels, researchers identified key metabolites that guide the differentiation process.
Research found that retained metabolites in the blood are associated with impaired cognitive function in patients with kidney failure. The study suggests that interventions may be necessary to safeguard the mental health of these patients.
A team of scientists at Helmholtz Munich developed a protocol to analyze metabolite composition in fixed tissues using mass spectrometry imaging. This method allows for the study of spatial distribution of molecules with high precision, enabling the identification of new predictive, diagnostic and prognostic markers.
Researchers found that fruit flies adjust their gene expression and metabolism to cope with cold temperatures, with nearly a third of genes altered and half of metabolites changing expression. This adaptation is crucial for insect survival during winter months.
Scientists at The Institute of Cancer Research have developed a new method to assess cancer treatment efficacy by measuring blood metabolite levels. This approach has the potential to speed up the development of targeted drugs and tailor treatment for patients, offering a quick and simple way to monitor cancer therapy.
A new study found that vitamin nicotinamide riboside (NR) can protect mice from diabetes complications by lowering blood sugar levels, reducing fatty liver, and preventing peripheral nerve damage. NR is a precursor to NAD+, an important cellular metabolite required for energy conversion.
A study found that gut bacterial metabolites can accumulate in patients with chronic kidney disease, leading to an increased risk of cardiovascular disease and premature death. The accumulation of phenylacetylglutamine was particularly associated with poor health outcomes.
People with major depressive disorder may have altered purine metabolism, with higher levels of xanthine and lower inosine and guanosine. This dysregulation may be the body's compensatory mechanism to combat increased oxidative stress caused by depression.
Researchers found that a chemical byproduct of ketamine metabolism is responsible for its rapid antidepressant action, unlike the anesthetic and dissociative effects. This discovery holds promise for developing more robust and safer treatments for depression.
Scientists at Okinawa Institute of Science and Technology Graduate University identified 14 age-related compounds that decrease with age, including those related to muscle strength and antioxidants. These findings suggest the importance of consuming antioxidant-rich foods and exercising regularly after 65 to improve body conditions.
Researchers at USC and JPL are launching fungi into space to explore their potential as novel therapeutics for use both in space and on Earth. The study aims to discover new compounds that could be used to develop medicines for astronauts and potentially address life-threatening diseases like cancer and Alzheimer's.
Researchers found that butyrate production is reduced in the intestinal tract of experimental mice after bone marrow transplantation, leading to an increased risk of graft vs. host disease. Increasing butyrate levels can mitigate this condition by bolstering the gut lining's resistance to the donor immune system.
Researchers found that asparagus rhizome traits, specifically water content and metabolite levels, are key indicators of freezing tolerance. The study tested three cultivars, with Guelph Millennium proving to be the most tolerant, suggesting that adapting to colder climates may depend on optimizing rhizome characteristics.
Researchers from Colorado State University have discovered a potential diagnostic tool for dengue fever by analyzing metabolomic profiles in patient serum. The study found that distinct metabolic clusters were associated with different disease outcomes, including the progression to hemorrhagic fever/dengue shock syndrome.
Research from the University of Leicester found high levels of trimethylamine N-oxide in acute heart failure patients, a metabolite produced by gut bacteria breaking down L-carnitine from red meat. The study suggests a possible link between red meat consumption and increased risk of heart disease.
A human pilot trial investigated the absorption, metabolism, and excretion of mango galloyl derivatives. Seven metabolites were identified in healthy volunteers, with two microbial metabolites significantly more excreted after 10 days of mango consumption.
A new molecular pathway involved in heart attacks and death from heart disease has been identified by a Duke University research team. They found that stress on the endoplasmic reticulum organelle is associated with risk of future heart events and can be detected in bits of molecular detritus circulating in the blood.
Researchers found that polyamines, which decline with age, regulate the functioning of circadian clocks. Administering polyamine supplements restored clock function in older mice, suggesting potential clinical applications.
A study discovered six metabolites in the blood that strongly correlate with kidney function. Two of these metabolites, pseudouridine and C-mannosyltryptophan, are equally effective measures of kidney function as creatinine, offering potential improvements in diagnosing chronic kidney disease.
A new study reveals that gas chromatography mass spectrometry (GC-MS) fundamentally alters the samples it analyzes due to heat, affecting thousands of laboratories worldwide. The researchers used a data analysis platform to observe small molecules transforming and disappearing during an experiment meant to mimic the GC-MS process.
Scientists at ETH Zurich have developed a method to analyze hundreds of metabolites simultaneously in real-time, allowing for rapid analysis of cellular responses to external stimuli. This breakthrough enables the study of complex biological processes and has potential applications in developing new pharmaceutical agents.
A Lund University study found that men with higher exposure to the chemical DEHP have lower sperm motility. This could lead to difficulties conceiving children. The study analyzed metabolite levels of DEHP in urine and semen quality among 300 young men.
A team of bioinformaticians at the University of Jena has developed a new search engine, 'CSI:FingerID', that significantly simplifies the identification of molecular structures of metabolites. The tool reduces the number of possible compounds from thousands to ten, making it feasible for precise lab tests to identify specific compounds.
Researchers used exometabolomics to study the interactions between soil microbes and their adaptations in desert biocrusts. The team found that diverse microbes target specific metabolites, supporting diverse microbial communities. This discovery suggests a possible mechanism for promoting soil biodiversity by specialization.
Researchers at RIKEN and Hiroshima University create technique to analyze metabolites, hormones, nutrients, and lipids in individual cells using nanospray tip and mass spectrometer. This breakthrough could speed up understanding of molecular distribution in time and space, transforming agricultural science.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
A study found that vaginal douching is associated with higher levels of phthalate metabolites in urine, increasing the risk of health problems. Black women are at higher risk due to frequent douching usage.
A team of Vanderbilt chemists used a novel approach called 'fight clubs' to identify promising new anti-cancer compounds from natural sources. By analyzing the interactions between bacteria and other microorganisms, they discovered a class of biomolecules with broad-spectrum activity.
A study by Montreal researchers found that the plasticizer DINCH's metabolite MINCH can act as a metabolic disrupter, affecting adipose tissue differentiation. The study suggests that DINCH exposure may pose a risk to human health and warrants further research.
Research from Inserm found a significant association between increased urinary levels of pyrethroid metabolites and decreased verbal comprehension and working memory in six-year-old children. The study suggests potential neurotoxic effects of pyrethroids on child development.
LCSB researchers analyzed metabolite signatures from hundreds of biomolecules in different brain regions, revealing a specific functional state of nerve cells. The study used an interdisciplinary approach and machine learning to derive metabolic profiles, which may offer new therapeutic opportunities for neurodegenerative diseases.
A new study has found an association between vitamin E concentrations and exposure to fine particulate pollution in the general population. Higher levels of alpha-tocopherol, a form of Vitamin E, were linked to lower lung function and reduced exposure to PM2.5.
Research finds that growth-promoting hormones like TBA used in beef production can persist in the environment at higher concentrations and for longer durations than previously thought. This persistence has significant impacts on aquatic ecosystems, including disrupting reproductive cycles and altering entire food webs.
A new study led by UMass Amherst epidemiologist Katherine Reeves is assessing the relationship between phthalate exposure and breast cancer risk. The three-year study will analyze urine samples from 500 women with invasive breast cancer and 1,000 healthy controls to measure levels of 11 phthalate metabolites.
Researchers have found a correlation between metabolic imbalance and increased risk of respiratory diseases in early childhood. Elevated concentrations of specific sugars, such as hexoses, were associated with elevated inflammatory immune parameters.
Research shows that muscle metabolites released during exercise activate neural pathways in people with chronic fatigue syndrome, leading to excessive feelings of fatigue. The study suggests that peripheral tissues like muscles contribute to fatigue, providing new insights into the disease's mechanisms and potential treatment targets.
A research team at KAIST used metabolite structural similarity to elucidate the mechanisms of action of traditional oriental medicine. The study found that TOM compounds interact with diverse metabolic pathways, showing strong efficacy for treating complex diseases.
A recent study found that quitting smoking has favorable metabolic effects, with reduced central fat distribution and improved hepatic glucose output. The study also showed a correlation between weight loss and increased glucose uptake and utilization of carbohydrate substrates.
Researchers discovered that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has anti-inflammatory effects. HYA alleviates intestinal inflammation in mice with colitis and improves epithelial barrier function.
A new study suggests that nicotine's metabolite cotinine amplifies the effect of acetylcholine, a primary chemical messenger involved in learning and memory, potentially providing therapeutic benefits for Alzheimer's and other memory disorders. Cotinine may also have synergistic effects with existing Alzheimer's therapies.
Researchers at Yale University found a compound produced by the body during dieting or fasting can block an immune system part involved in several inflammatory disorders. The compound BHB directly inhibits NLRP3, driving inflammation in diseases like autoimmune disorders, type 2 diabetes, and Alzheimer
Researchers found common biomarkers of sleep debt in humans and rats, indicating a link to metabolic disorders such as weight gain, diabetes, and cardiovascular disease. The study also identified potential biomarkers, oxalic acid and diacylglycerol 36:3, which could serve as indicators of sleep quality and quantity.