Articles tagged with Metabolites
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study combining metabolomics and microbiome data identifies distinct patterns in patients with ME/CFS, allowing for 84% accurate prediction of the disorder. The findings provide a promising lead towards developing lab tests and potential therapies.
A WSU study using metabolomics found that shift work schedules alter 24-hour rhythms in digestive organs, disrupting metabolism and increasing the risk of obesity and diabetes. The study suggests that separate biological clocks in the liver, gut, and pancreas play a key role in this disruption.
Researchers found that green tea and red wine compounds can prevent the accumulation of toxic metabolites, which cause severe developmental disorders. This discovery could pave the way for new therapies to treat inborn congenital metabolic diseases.
A new study from the University of Eastern Finland found that adolescent drinking is associated with changes in metabolite profiles, which can lead to reduced brain grey matter volume. Heavy-drinking adolescents showed increased concentrations of 1-methylhistamine, linked to decreased brain grey matter volume.
Researchers found a clear association between the metabolite profile, sugar in diet, and NEC risk. Feeding lactose-containing formula protected piglets from NEC, while corn syrup solids increased risk.
Researchers developed a low-cost sensor made from semiconducting plastic that can measure critical metabolites in sweat, tears, saliva, or blood. The sensor offers higher sensitivity compared to traditional metal electrodes and can be easily modified to detect various metabolites.
A new study found that measuring ethyl sulphate in hair can assess alcohol consumption and detect a wider time frame of drinking behavior. Researchers successfully applied this method to patients with alcohol use disorders, highlighting the potential of hair as a non-invasive testing matrix.
A new blood test for autism has been validated for its exceptional success, predicting autism spectrum disorder with 88% accuracy in a second trial. The test uses an algorithm to analyze metabolites in a blood sample, offering a potential solution to lower the age of diagnosis and improve treatment outcomes.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a method to determine diet adherence from a blood sample. By analyzing small molecules called 'metabolites' in the blood, they found that levels differed significantly between participants following a prescribed diet and those not adhering to it.
Researchers at Nara Institute of Science and Technology have developed a novel method to detect specific metabolites in microalgae cells. By combining fluorogenic aptamers with femtosecond laser photoporation, scientists can identify efficient cells for metabolic engineering applications.
Researchers identified two tryptophan metabolites produced by gut bacteria that modulate inflammation, potentially reducing the severity of non-alcoholic fatty liver disease. The study found that these metabolites reduce cytokine levels and macrophage activity, which are key contributors to inflammation.
Researchers at Nagoya University have developed a new analytical system for real-time monitoring of metabolites in the brain, overcoming previous limitations in sensitivity and invasiveness. The system, combining probe electrospray ionization (PESI) and tandem mass spectrometry (MS/MS), successfully monitored cerebrum metabolites with ...
Researchers found that the microbes surrounding plant roots prefer a diet rich in organic acids, with sugars being preferred early in the growth cycle. This discovery could help scientists identify ways to enhance soil microbiome for improved carbon storage and plant productivity.
A Northwestern University study found that coffee consumption decreased endocannabinoid system metabolites, which regulate stress response, cognition, and appetite. The study also suggests coffee may facilitate the excretion of steroids, potentially affecting diseases such as cancers.
Researchers at Lund University found that certain amino acids in blood are connected to obesity and gut microbiome composition. The study analyzed 674 participants and identified metabolites linked to BMI, including glutamate and BCAA, which interact with intestinal bacteria.
Researchers have developed the first three-dimensional computer model to represent human metabolic processes. This new tool, Recon3D, integrates structural data on over 4,000 metabolites and nearly 13,000 proteins, allowing for more accurate simulations of metabolic reactions and better understanding of diseases such as Parkinson's.
A team of researchers has mapped the biochemical networks of Aedes aegypti mosquitoes, identifying key pathways that facilitate virus replication. The study's findings have significant implications for controlling mosquito-borne diseases like dengue, Zika, and chikungunya.
Metabolomics offers a unique opportunity to examine genotype-phenotype and genotype-environment relationships in cancer patients. By analyzing metabolic profiles, researchers can identify specific signatures that predict pharmacological responses to treatments.
Researchers have developed a new method to quantify protein-metabolite interactions, discovering hundreds of new interactions and binding sites. The approach has the potential to identify new regulatory mechanisms, enzymes, and metabolic reactions in cells.
A comprehensive dataset of cancer cell metabolites has been compiled, showing consistent increases or decreases in certain metabolites across multiple tumor types. The study's findings offer insights into the metabolic programming between normal and cancer cells, with potential applications for novel therapies.
A team of researchers sequenced and annotated the genomes of six Aspergillus species, identifying biosynthetic gene clusters for secondary metabolites of interest. The study highlights a new analysis method that pinpointed candidate genes for diverse compounds, providing potential tools for improving biofuel production.
A new study from The Scripps Research Institute found that dietary xenoestrogens like zearalenone and genistein can reverse the effects of palbociclib/letrozole combination therapy for breast cancer. Exposure to these compounds may significantly reduce the effectiveness of anti-estrogen treatments.
Researchers studied native biocrusts, discovering that specific compounds are transformed by and strongly associated with specific bacteria. The study links microbial community structure to soil chemistry, shedding light on the roles of soil microbes in the global carbon cycle.
Researchers found that CD4+ T effector cells upregulate Mdr1 in response to bile acids, maintaining intestinal homeostasis and limiting oxidative stress. This study provides valuable insights into the interaction between Teff cells and metabolites, potentially leading to new therapeutic agents for inflammatory bowel diseases.
Researchers at Tohoku University have created a visual database of metabolites from over 5,000 Japanese volunteers, offering valuable insights into how specific compounds relate to each other. The jMorp database contains information on 306 metabolites and 256 common proteins, with graphical correlation tools to facilitate further study.
A new methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures has been developed, providing direct identification of compounds with inhibitory properties. This approach allows for rapid assessment of pharmacokinetic properties of drugs and their metabolites, improving drug development.
A team led by OSU professor Kerry McPhail will study stromatolites in South Africa's barrage pools, seeking insights into chemical signaling and metabolite production among ancient microbial communities. The research aims to advance our understanding of the origins of life and develop new medicines.
Xanthones, antimicrobial compounds found in St. John's wort roots, are produced and stored in specific cell layers. The study's findings may aid in understanding xanthone biosynthesis and manipulating them for medicinal purposes.
Scientists at Scripps Research Institute found that taurine helps spark a process called remyelination, crucial for repairing nerve cells damaged in multiple sclerosis. Combining taurine with existing MS drugs and future remyelination-inducing treatments may improve overall efficacy.
A new study reveals that chronic kidney disease patients have abnormal metabolites in their cells' energy centers, supporting the view of CKD as a state of mitochondrial dysfunction. Researchers hope to identify novel therapeutic targets for CKD using metabolomics.
A study on rabbits found that exposure to BPA during pregnancy causes chronic inflammation in the intestines and liver, leading to changes in gut bacteria. This could have long-lasting health effects for the offspring, increasing the risk of obesity and inflammation-promoted diseases like colon cancer and type 2 diabetes.
Researchers found significant increases in glyphosate and its metabolite in the urine of older adults from Southern California between 1993 and 2016. Average glyphosate levels increased by 13 years, with detectable levels present in more than 70% of samples.
Research suggests that perinatal BPA exposure can lead to reduced gut bacterial diversity and elevated gut permeability, resulting in chronic colon and liver inflammation. Early correction of gut dysbiosis induced by environmental toxins may reduce the risk for chronic diseases later in life.
Scientists found that metabolic changes occur soon after quitting smoking and can lead to improved lung function and reduced heart attack risk. The study identified 52 metabolites altered by smoking, with several showing reversible changes towards a nonsmoker's profile.
Researchers at Aarhus University discovered a detoxification process in the body's fat-metabolism that captures and inhibits toxic methylglyoxal, a key player in age-related diseases. This finding may explain why low-carbohydrate diets with plenty of fat promote healthy aging and prevent diseases.
Researchers at Michigan State University studied the unique molecule acylsugars found in tomato trichomes, revealing their diverse structures and potential as natural pesticides. This discovery opens an evolutionary window into plant defense metabolism and could lead to innovative solutions for pest resistance and human medicine.
Researchers at NYU College of Dentistry have identified succinate as a promising target to prevent bone fractures in people with type 2 diabetes. The study found that hyperglycemic mice had significantly higher levels of succinate, leading to more fragile bones and increased risk of fractures.
Researchers at Washington University in St. Louis have caught primary metabolism in the act of evolving, revealing a novel form of an enzyme that produces tyrosine. This breakthrough could lead to increased production of essential compounds, such as vitamin E and opioids.
A metabolomics approach has identified a unique metabolic 'signature' that can accurately distinguish typhoid from other tropical diseases, providing a new approach for typhoid diagnostics. The study found excellent predictive power in distinguishing culture-positive typhoid patients from those with other diseases.
Researchers found that wine-derived human gut metabolites are protective against neuronal death in human cells under stress conditions. The exact composition of these metabolites depends on the individual's gut microbiota, highlighting the importance of personalized nutrition in preventing neurodegenerative diseases.
The University of Konstanz's biological chemistry working group has decoded a molecular mechanism that inhibits bacterial populations' swarming motility. This mechanism enables bacteria to produce various natural substances using minimal resources, which may aid in combating infectious diseases and antibiotic resistance.
Researchers have developed a highly sensitive method to detect even earlier stages of colorectal cancer by analyzing metabolites in blood plasma. The new screening method exceeds 96% sensitivity and specificity, confirming its effectiveness even for early-stage patients.
Researchers discovered a link between indolepropionic acid and reduced risk of type 2 diabetes. A diet rich in whole grain products and dietary fibre boosts indolepropionic acid production, promoting insulin secretion by pancreatic beta cells.
A new database of plant metabolites and computer tool have been developed to identify healthful antioxidants in tomato skins. The researchers found that valuable substances produced by exotic plants may be derived from more common species, and these findings suggest a broader range of potential uses for plant metabolism.
Researchers have discovered a unique metabolic signature in the urine of diabetic, obese black teenagers that may become a way to predict the development of type 2 diabetes. Levels of serotonin metabolites were found to be lower in those with diabetes, while other metabolites were higher.
Researchers have confirmed that resveratrol metabolites can be detected in ocular tissues, including the conjunctiva and aqueous fluid. This finding opens up new avenues for exploring the therapeutic potential of resveratrol in human eye health.
Researchers at Rensselaer Polytechnic Institute developed an algorithm that accurately predicts whether a child is on the Autism spectrum of disorder based on levels of metabolites found in a blood sample. The algorithm, which uses big data techniques, correctly identified 96.1% of neurotypical participants and 97.6% of children with ASD.
A new tool using nuclear magnetic resonance (NMR) measures hydrogen atoms to study metabolism and determine metabolic fluxes. This technique has been validated on human cancer cells and holds potential for understanding the mechanisms behind diseases like diabetes.
Exposure to newer organophosphate flame retardants has significantly increased over the past decade, with a metabolite of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) found at levels 15 times higher in 2014-2015 samples than in 2002-2003.
A study published in JAMA Cardiology found that habitual e-cigarette users have increased cardiac sympathetic activity and oxidative stress, which are mechanisms associated with tobacco cigarette smoking. These findings suggest a potential increased cardiovascular risk profile for habitual e-cigarette users.
An international team of researchers has spatially mapped molecules produced by an intact, complex microbial community for the first time. They used imaging mass spectrometry to track and plot metabolites made by both bacterial and fungal lichen members.
A new study suggests that a metabolite of ketamine can produce antidepressant-like effects in mice, potentially leading to further research on the efficacy and safety of ketamine in humans. Ketamine has been shown to have rapid and potent antidepressant effects in humans, even in those resistant to traditional treatments.
A new method of plant analysis has identified more than twenty metabolites in tomatoes that had never been reported before, including certain antioxidants in the skin. The Weizmann team's tools, WeizMass and MatchWeiz, can help study plant metabolism and identify useful biological activity
Bekzod Khakimov, a promising young researcher from the University of Copenhagen, has received the first Nils Foss Talent Prize. His work focuses on metabolomics, using Gas Chromatography-Mass spectrometry to improve data analysis and reproducibility.
Researchers used a new approach to measure metabolic diversity in various plant tissues, revealing distinct profiles for each tissue. The study identified specific genes regulating the biosynthesis of ecologically-important secondary metabolites, shedding light on how plants modulate their metabolite accumulation at the organ level.
Researchers have developed a game-changing blood test that can identify concussions with greater than 90% certainty, using metabolomics to analyze small molecules in the blood. The test is unique and has been proven to be effective in distinguishing concussed patients from non-concussed adolescents.
Researchers used NMR spectroscopy to identify a panel of 10 urinary metabolites associated with fetal growth and increased birth weight. Changes in these metabolites could explain 12% of the variation seen in birth weight, independent of other known predictors.
Researchers found that choline deficiency during pregnancy alters choline metabolite profiles, fatty acid compositions, and amino acid levels in sow milk. This study provides new insights into the importance of choline for human development and highlights the need for mandatory fortification programs to address this nutrient deficiency.
A new investigation finds that vitamin supplements can slow muscle wasting by boosting NAD+ levels in mice. The study supports the potential benefits of NAD+ precursors for patients with muscular dystrophy and other muscle disorders.
The first controlled clinical trial of nicotinamide riboside (NR) demonstrated that the compound is safe for humans and increases levels of a critical cell metabolite. NR supplementation has been shown to produce multiple health benefits, including improved control of blood sugar and cholesterol.