The addition of antioxidants to cell cultures can improve the production of monoclonal antibodies by reducing oxidative stress and increasing cell viability. This has potential benefits for therapies targeting cancer and autoimmune diseases.
SourceSociety of Chemical Industry·JournalJournal of Chemical Technology and Biotechnology·TypeExperimental study·DateFeb 15, 2023
A new class of SARS-CoV-2 antibodies has been shown to neutralise multiple variants of the virus, providing hope for a better antiviral medication. The antibodies work by attaching to a partially hidden part of the virus' spike protein that would be difficult for it to mutate.
SourceGarvan Institute of Medical Research·JournalNature Communications·TypeExperimental study·DateFeb 14, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
SourceUniversity of Colorado Anschutz Medical Campus·JournalThe Lancet·DateFeb 10, 2023
Researchers at the University of Maryland School of Medicine found that monoclonal antibody CIS43LS provided high levels of protection against controlled human malaria infection. The study's findings suggest that this treatment could be a potential game changer for deploying monoclonal antibody therapies in African countries.
SourceUniversity of Maryland School of Medicine·JournalThe Lancet Infectious Diseases·TypeRandomized controlled/clinical trial·DateJan 25, 2023
Researchers at Michigan Medicine have developed a new biomarker-based strategy to screen for immune checkpoint inhibitor-induced myocarditis, which can cause muscle damage and liver injury. Early detection of these biomarkers can lead to earlier treatment and improved survival rates.
SourceMichigan Medicine - University of Michigan·JournalJACC CardioOncology·TypeObservational study·DateDec 20, 2022
Researchers found that using tixagevimab-cilgavimab in blood cancer patients prevented moderate and severe COVID cases. The antibody provided protection but did not entirely prevent infection, highlighting the importance of additional safety measures.
SourceMedical University of South Carolina·JournalBlood·DateDec 15, 2022
Researchers at Lund University discovered an antibody with potential to protect against Strep A infection and a rare form of binding that leads to effective immune response. The finding could explain why many Group A strep vaccines have failed.
SourceLund University·JournalEMBO Molecular Medicine·DateDec 12, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Research finds that individuals who received monoclonal antibodies before COVID vaccination exhibit a diverse antibody response, increasing the coverage provided by vaccines. This phenomenon, known as antibody feedback inhibition, is beneficial for diversifying immune responses to viruses.
SourceRockefeller University·JournalNature·DateDec 6, 2022
A research team at the University of California, Riverside has discovered the structure of a human monoclonal antibody that protects against Crimean Congo Hemorrhagic Fever virus. The study provides insights into fighting a broad range of viral strains and could lead to targeted therapeutics for infected patients.
SourceUniversity of California - Riverside·JournalNature Communications·TypeExperimental study·DateNov 28, 2022
Scientists at Albert Einstein College of Medicine describe findings that could bolster the effectiveness of immune-checkpoint therapy by using natural killer (NK) cells. The research team developed a monoclonal antibody targeting KIR2DL5, which allowed NK cells to vigorously attack and shrink human tumors.
SourceAlbert Einstein College of Medicine·JournalJournal of Clinical Investigation·TypeExperimental study·DateNov 15, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateNov 14, 2022
Researchers report positive results from the first placebo-controlled trial of anifrolumab, a human monoclonal antibody targeting type I interferon receptor in patients with lupus. Treatment with anifrolumab was well-tolerated and sustained reduction in lupus disease activity.
SourceWiley·JournalArthritis & Rheumatology·DateNov 12, 2022
Researchers identified Spns2, an S1P transporter, as a novel drug target for Multiple Sclerosis treatment. Targeting this protein may improve safety profiles and reduce side effects associated with current therapies.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalCellular and Molecular Life Sciences·TypeExperimental study·DateNov 10, 2022
Researchers used monoclonal antibodies to suppress the immune system in mice, tracking human neural stem cell survival using luciferase. The study reveals that monoclonal antibody-mediated immunosuppression enabled long-term survival of transplanted human neural stem cells in mouse brains for at least six to eight months.
SourceMichigan Medicine - University of Michigan·JournalClinical and Translational Medicine·TypeExperimental study·DateNov 9, 2022
Idiopathic plasmacytic lymphadenopathy (IPL) has been confirmed as a distinct clinicopathologically uniform disease, which can be reclassified into an independent subtype of idiopathic multicentric Castleman disease (iMCD). IPL showed greater plasmacytosis and hyperplastic germinal centers compared to non-IPL groups.
SourceOkayama University·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateNov 4, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A monoclonal antibody was found to be up to 88.2% effective at preventing malaria infection in healthy, non-pregnant adults during a six-month malaria season in Mali, Africa. The study suggests that this antibody could complement other measures to protect vulnerable groups from seasonal malaria.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateOct 31, 2022
Researchers developed investigational monoclonal antibodies targeting EBV's gH and gL proteins, blocking infection in human cells and providing nearly complete protection against EBV infection in mice. The findings highlight viable vaccine targets and potential treatment options for immunocompromised patients.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalImmunity·DateOct 27, 2022
Researchers have isolated an effective monoclonal antibody that targets heroin, blocking its painkilling effect and overdose deaths in mice. The findings suggest that targeting heroin itself is more effective than its metabolites, paving the way for a new therapy.
SourceScripps Research Institute·JournalACS Central Science·DateOct 25, 2022
A study reveals that BA.2.75.2, a new Omicron sublineage, largely evades neutralizing antibodies and is resistant to several monoclonal antibody treatments, posing an increased risk of SARS-CoV-2 infections this winter.
SourceKarolinska Institutet·JournalThe Lancet Infectious Diseases·TypeExperimental study·DateOct 14, 2022
A new approach to allergy treatment has shown promise in reducing symptoms of allergic rhinitis by 36% after just one year of treatment. The combination of a monoclonal antibody with cat allergy shots was found to be more effective than allergy shots alone in providing long-lasting symptom relief.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalJournal of Allergy and Clinical Immunology·DateOct 11, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have designed a smart cell-based delivery system to treat Alzheimer's disease by targeting multiple pathologies, reducing the risk of side effects. The system uses bio-synthesizable drugs and immune cells to deliver combination therapy that addresses all pathologies in a targeted manner.
SourceBuck Institute for Research on Aging·DateOct 4, 2022
A new study found that fewer Asian, Black, and Hispanic patients qualify for anti-amyloid monoclonal antibody treatments, which may slow Alzheimer's progression. The treatment's effectiveness depends on the presence of amyloid plaques, with lower incidence in minorities.
SourceUniversity of California - San Francisco·JournalJAMA Neurology·DateOct 3, 2022
Researchers at UC Davis aim to develop monoclonal antibodies that can bind to specific ion channels in nerve cells, inhibiting pain signal transmission. The goal is to create a monthly, non-addictive pain medication to replace opioids, which can lead to addiction.
SourceUniversity of California - Davis Health·DateSep 20, 2022
A new biologic drug has been found to be highly effective in reducing the signs and symptoms of moderate-to-severe eczema in infants and young children. The study showed that more than half of treated children experienced a 75% reduction in eczema symptoms, leading to improved sleep and increased ability to lead normal lives.
SourceNorthwestern University·JournalThe Lancet·TypeRandomized controlled/clinical trial·DateSep 15, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A large number of patients received anti–SARS-CoV-2 monoclonal antibodies despite FDA deauthorization due to their limited effectiveness against the Omicron variant. This widespread use resulted in significant Medicare spending, estimated at over $71 million.
SourceJAMA Network·JournalJAMA Network Open·DateAug 29, 2022
Physician-scientists at Beth Israel Deaconess Medical Center found that despite FDA deauthorization, a large number of doses of ineffective COVID-19 treatments were administered to patients in 2022, with wide variability by state. The study highlights the need for improved transparency and regulation of COVID-19 therapies.
SourceBeth Israel Deaconess Medical Center·JournalJAMA Network Open·DateAug 29, 2022
Researchers at Tufts University have developed a novel mRNA-based approach to generate complex antibodies in muscle cells, which can be used to treat various diseases including botulism and cancer. The technique has shown promising results in neutralizing lethal doses of botulinum neurotoxins in mice.
SourceTufts University·JournalScientific Reports·TypeExperimental study·DateAug 25, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
The AABB has released clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma, recommending its use for nonhospitalized patients at high risk for disease progression. The guidelines suggest that CCP is most effective when transfused with high neutralizing titers early after symptom onset.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeSystematic review·DateAug 15, 2022
A Phase 1 clinical trial found a monoclonal antibody to be highly protective against malaria in US adults. L9LS was administered subcutaneously and fully protected 88% of participants from infection.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateAug 4, 2022
Researchers developed a monoclonal antibody that binds E-cadherin, strengthening cell adhesion and preventing cancer metastasis. The antibody, 19A11, has two binding modes that increase adhesive strength through salt bridge formation.
SourceUniversity of California - Davis·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 4, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A study by Goethe University Frankfurt found that antibodies against Omicron variants BA.1 and BA.2 decline rapidly, even after a second vaccination or booster shot, offering limited protection against infection.
SourceGoethe University Frankfurt·JournalEBioMedicine·DateJul 22, 2022
Researchers discovered a potent universal coronavirus therapy that targets the S2 stalk region of the viral spike protein, highly conserved among beta-coronaviruses. The monoclonal antibody protected against infections when given as an intraperitoneal injection or nasal dose in animal experiments.
SourceUniversity of Alabama at Birmingham·JournalPLOS Pathogens·TypeExperimental study·DateJul 21, 2022
Researchers aim to develop a gene therapy that could suppress HIV replication and eliminate the need for life-long antiretroviral therapy. The study uses an AAV vector to produce leronlimab, a monoclonal antibody blocking HIV entry into immune cells.
SourceOregon Health & Science University·DateJul 8, 2022
Researchers at USAMRIID have demonstrated the use of messenger RNA (mRNA) to develop treatments for infectious diseases. The study found that administering mRNAs encoding monoclonal antibodies targeting poxviruses resulted in significant systemic levels of functional antibodies, offering potential for rapid response to disease outbreaks.
SourceUS Army Medical Research Institute of Infectious Diseases·JournalMolecular Therapy — Nucleic Acids·TypeExperimental study·DateJul 6, 2022
A Mayo Clinic study of 10,775 high-risk adult patients during the COVID-19 delta surge found that treatment with anti-spike neutralizing monoclonal antibodies led to low rates of severe disease, hospitalization, and mortality. The rates were lowest for patients treated with sotrovimab, with only 1.2% developing severe disease.
SourceMayo Clinic·JournalMayo Clinic Proceedings·DateJun 27, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers analyzed antibodies to internal and surface proteins of SARS-CoV-2, finding that profiles of internal proteins predicted survival outcomes as well as those for surface proteins. The study suggests targeting other parts of the virus could enhance COVID-19 vaccines and therapies.
SourceUniversity of Pittsburgh·JournalCell Reports·TypeObservational study·DateJun 24, 2022
Scientists at Institut Pasteur developed potent neutralizing antibodies from convalescent COVID-19 individuals effective against various SARS-CoV-2 variants. These human antibodies are promising candidates for immunotherapies to prevent severe forms and/or treat COVID-19 in immunocompromised patients.
SourceInstitut Pasteur·JournalJournal of Experimental Medicine·TypeExperimental study·DateJun 17, 2022
Researchers have identified two broadly neutralizing antibodies that can effectively neutralize all SARS-CoV-2 variants, including Omicron BA.1 and BA.2 subtypes. The antibodies, Cv2.1169 and Cv2.3194, were found to be fully active against Alpha, Beta, Gamma, and Delta variants.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·TypeExperimental study·DateJun 15, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers have developed a molecule that uses nanotechnology, chemotherapy and a monoclonal antibody to target glioblastoma multiforme, the most aggressive type of brain cancer. The treatment showed promise in isolated cells and animal models, with significant reductions in tumor volume and no increased toxicity.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Pharmaceutics·DateJun 14, 2022
Researchers developed an antibody cocktail effective against a Hendra virus variant, neutralizing its ability to mutate and evade recognition. The combination of four antibodies leaves the virus with minimal ability to further evolve, providing significant protection against this global biosecurity threat.
SourceOhio State University·JournalProceedings of the National Academy of Sciences·DateJun 13, 2022
Researchers at UC San Diego describe the underlying signaling pathway that causes PAH and a novel monoclonal antibody therapy that blocks abnormal blood vessel formation. The study reveals two opposing roles of NOTCH ligands and opens a door to a potentially new treatment for PAH.
SourceUniversity of California - San Diego·JournalScience Translational Medicine·DateMay 6, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A UCLA-led team found that an abnormally suppressed immune system, not a persistently hyperactive one, may be to blame for some cases of long COVID-19. The study suggests boosting immunity in those individuals could be a treatment option.
SourceUniversity of California - Los Angeles Health Sciences·JournalClinical Infectious Diseases·TypeRandomized controlled/clinical trial·DateApr 22, 2022
Researchers at Charité, MDC, and FU Berlin have studied the mechanisms of action of antibody and dexamethasone treatments for COVID-19. They found that combination therapy is more effective in reducing viral activity and inflammation in lung tissue, suggesting a potential game-changer in treating severe cases.
SourceCharité - Universitätsmedizin Berlin·JournalMolecular Therapy·TypeExperimental study·DateApr 13, 2022
Researchers evaluated monoclonal antibody administration methods and their impact on COVID-19 hospitalization and death rates. The study found no significant difference in effectiveness between injection and intravenous administration, suggesting that injection could expand outpatient treatment capacity.
SourceJAMA Network·JournalJAMA Network Open·DateApr 12, 2022
Researchers found that combining durvalumab with novel agents like oleclumab and monalizumab increased major pathological response rates compared to solo durvalumab. The study also identified key immune cell signatures associated with treatment outcomes.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateApr 11, 2022
Researchers studied the sensitivity of Omicron BA.1 and BA.2 to nine monoclonal antibodies, finding reduced neutralization activity against newer variants. The study suggests that treatments may be less clinically effective against Omicron infection than against Delta variant.
SourceInstitut Pasteur·JournalNature Medicine·DateApr 11, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at Yale have identified a remdesivir-resistant variant of the SARS-CoV-2 virus in an immunocompromised patient. The discovery raises concerns about drug resistance in COVID-19 patients, particularly those with weakened immune systems.
SourceYale School of Public Health·JournalNature Communications·TypeCase study·DateMar 23, 2022
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalNature Communications·DateMar 23, 2022
A study found that double vaccinated individuals generate a potent and broad neutralizing antibody response after a delta breakthrough infection. This response provides protection against current variants of concern, including omicron.
SourceAmerican Society for Microbiology·JournalmBio·DateMar 17, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have developed a monoclonal antibody called PRN100, which showed safe and encouraging results in treating Creutzfeldt-Jakob disease (CJD) in six patients. While the findings are preliminary and require further studies, they offer new prospects for this rare and fatal disease.
SourceUniversity College London·JournalThe Lancet Neurology·TypeExperimental study·DateMar 16, 2022
Researchers found that mRNA vaccines lose effectiveness against all three Omicron subvariants, BA.1, BA.1.1, and BA.2, while only bebtelovimab remains effective as a treatment. The study highlights the need for booster shots to sustain immunity.
SourceColumbia University Irving Medical Center·JournalNature·DateMar 3, 2022
A computational study finds that Omicron's spike protein has evolved to evade multiple classes of antibodies targeting SARS-CoV-2, even those from vaccinated individuals and monoclonal antibody treatments. The study suggests vaccines still offer protection due to the development of T cell immunity.
SourceMassachusetts Institute of Technology·TypeComputational simulation/modeling·DateFeb 1, 2022
The Omicron variant is more transmissible than the Delta variant, spreading to individuals with two vaccine doses and previously infected individuals. A booster dose of Pfizer or AstraZeneca vaccine significantly increases antibody levels that can neutralize Omicron.
SourceInstitut Pasteur·JournalNature·TypeExperimental study·DateJan 7, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new study finds that the Omicron variant can evade immunity from previous infections and vaccines, with antibodies from double-vaccinated individuals showing reduced neutralizing activity. The study suggests the need for new vaccines and treatments to combat evolving variants.
SourceColumbia University Irving Medical Center·JournalNature·TypeExperimental study·DateDec 23, 2021
Researchers found that mRNA vaccines were highly effective (86%) in preventing SARS-CoV-2-related deaths among vaccinated individuals, especially in the elderly population. However, vaccine effectiveness against infection was lower (69%) and decreased with increasing age and comorbidity burden.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateDec 20, 2021
The Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations by nearly 60% and improved lung function and asthma control in children ages 6 to 11. Dupilumab was also shown to be safe, with minimal adverse reactions.
SourceVanderbilt University Medical Center·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateDec 8, 2021
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
SourceDuke University·JournalScience Advances·TypeExperimental study·DateDec 3, 2021
Researchers at the Ragon Institute of MGH, MIT and Harvard have developed a new anti-malarial antibody that provides significant protection against malaria, outperforming existing best-in-class antibodies. The breakthrough could lead to improved distribution of monoclonal antibodies in endemic countries.
SourceMassachusetts General Hospital·JournalImmunity·TypeExperimental study·DateNov 16, 2021
A new study found that monoclonal antibodies protected aged, diabetic rhesus macaque monkeys from SARS-CoV-2 disease by reducing signs of inflammation. The treatment prevented viral RNA in the cerebrospinal fluid and infiltration of activated immune cells, suggesting a potential preventative measure for elderly residents during outbreaks.
SourceUniversity of California - Davis·JournalCell Reports·TypeExperimental study·DateNov 1, 2021
Researchers developed a viral panel that enables simultaneous testing for SARS-CoV-2 and common respiratory viruses, providing insight into coinfections and viral spread. The tool helps predict and mitigate future outbreaks by tracking novel viral variants and their patterns of spread.
SourceMedical College of Georgia at Augusta University·JournalViruses·DateNov 1, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.