Articles tagged with Pharmacology
Researchers found that plant phenolic acids can dramatically boost the activity of existing antibiotics against multidrug resistant E. coli, reducing the chance of new resistance emerging. The compounds also make it easier for antibiotics to enter and stay inside bacterial cells.
MIT chemists successfully synthesized verticillin A, a fungal compound that has shown potential as an anticancer agent. The researchers then generated derivatives of the compound and tested them against pediatric brain tumors, finding that some were effective against cancer cells with high levels of EZHIP protein.
The UK has published a new clinical guideline recommending pharmacogenetic testing for all patients prescribed clopidogrel to determine their individual genetic response to the medication. This is due to variations in the CYP2C19 enzyme, which affects how clopidogrel works in different people.
Scientists at the University of Bonn have discovered a mechanism to inhibit the P2X4 receptor, which plays a role in chronic pain, inflammation, and some types of cancer. The findings open up a new pathway for developing effective drugs.
Researchers have developed a new microscopy technique that reveals influenza viruses actively recruit clathrin proteins to facilitate their entry into living cells. The study provides key insights into the development of antiviral drugs and the behavior of other viruses.
Researchers at LMU uncovered two crucial proteins controlling the assembly of Toxoplasma gondii's invasion machinery. The discovery provides a promising avenue for developing targeted therapies against toxoplasmosis.
Scientists predict that a simple AI-assisted blood test could diagnose cancer earlier and with greater precision by analyzing tiny particles known as exosomes. Exosomes carry molecular signatures of cancerous cells, offering a real-time view of what's happening inside tumors.
Researchers analyzed 1,240 wastewater samples from 351 cities worldwide and discovered latent antimicrobial resistance genes. The study highlights the need for broader surveillance of resistance in wastewater to curb future pandemics.
A monthly injection has helped 90% of severe asthma patients reduce their reliance on daily steroid tablets. Treatment with tezepelumab improved asthma symptoms, lung function, and overall quality of life, with two-thirds of patients experiencing no asthma attacks.
Researchers have identified a key mechanism behind statin-induced muscle damage, paving the way for new statins with reduced side effects. By understanding how statins interact with muscle proteins, scientists can design safer alternatives that preserve cholesterol-lowering benefits.
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
The Virtual Cell Pharmacology Initiative (VCPI) aims to build the first standardized framework for virtual cell modeling in drug discovery. Ginkgo Datapoints is offering free high-throughput RNA profiling via its platform, generating over 12 billion data points and aiming to test at least 100,000 compounds.
A systematic review and meta-analysis found that lithium supplementation did not significantly improve cognitive function in individuals with mild cognitive impairment or Alzheimer's disease. Alternative formulations like LIT-O may be a potential alternative to harness lithium's neuroprotective properties more efficiently.
Researchers at Martin Luther University Halle-Wittenberg develop PROTAC molecule MA203, specifically binding to tumor protein CHK1, leading to its breakdown in cancer cells. This triggers a chain reaction destroying other tumor proteins, ultimately killing the cancer cells.
A new technique has been developed to study interactions between drugs and ion channels, allowing for faster and more economical design of targeted therapies. The method has been tested on P2X7 receptors, which are therapeutic targets for depression, autism spectrum disorders, and certain types of cancer.
Researchers have developed a chemical compound that degrades beta-amyloid plaques, reducing symptoms of Alzheimer's disease. The compound was tested on rats and showed promising results, including reduced memory loss and improved spatial awareness.
Researchers discovered a cellular protein, FGD3, that enhances the effectiveness of breast cancer chemotherapy and immunotherapies. FGD3 weakens cancer cells when attacked by drugs like ErSO or doxorubicin, causing them to rupture and alert the immune system.
A new study by Yale Ancient Pharmacology Program reveals evidence of opium use in ancient Egyptian society, suggesting it was part of daily life. The discovery also raises the possibility that alabaster jars found in King Tut's tomb contained opium as part of an ancient tradition.
Researchers developed a 'humanized' model of aortic valve calcification, enabling testing of potential treatments. The breakthrough could lead to new therapies to stop or reverse calcium buildup, improving outcomes for people with heart disease.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
A recent landmark study identifies adenosine as the critical mediator of rapid antidepressant action, connecting ketamine, ECT, and hypoxia. The discovery raises questions about the potential interference of caffeine with these treatments, highlighting the need for further research on adenosinergic modulation in depression.
A study by Aston University academics found that while access to antiseizure medication is expanding globally, it's not always prescribed safely. Valproate, widely used, poses significant risks during pregnancy, including birth defects and neurodevelopmental problems.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
Researchers at Karlsruhe Institute of Technology discovered that enclosed water can influence its surroundings and favor binding between molecules. This finding could lead to the design of more effective drugs and new materials by leveraging the binding force of highly energetic water molecules.
A major analysis by CNIC and international institutions found beta-blockers offer no clinical benefit for patients with preserved cardiac function after myocardial infarction. The study analyzed data from five global clinical trials, confirming that beta-blocker therapy does not reduce the risk of death or cardiovascular events.
Researchers aim to identify new neurobiological factors for potential intervention in AUD, including a connection between endogenous retroviruses (ERVs) and neuroinflammation. The study seeks to investigate ERV expression and genotypes in AUD pathophysiology using innovative bioinformatics tools.
A new study presents positive results for finerenone, a drug that blocks aldosterone receptors, in patients with type 1 diabetes and chronic kidney disease. The drug reduces protein excretion in urine by about a quarter, indicating reduced kidney damage and improved function.
A new national quality framework has been developed to evaluate medication management and clinical services provided by pharmacists in residential aged care. The PHARMA-Care National Quality Framework promotes a transparent, person-centred approach to medication management, aiming to reduce risks linked to polypharmacy.
Stuart S. Martin, PhD, has been appointed Chair of the Department of Pharmacology & Physiology at UMSOM, bringing over 20 years of success in advancing basic science research efforts and developing new drug therapies. His groundbreaking discovery of microtentacles on cancer cells promises to lead to new life-extending therapies.
Researchers found that early clindamycin administration significantly improved recovery rates in patients with invasive Group A Streptococcus (iGAS) infections. The study also showed that M1uk strain does not worsen prognosis in critically ill adults, but prompt treatment remains crucial.
A USC Dornsife team of scientists visualized how opioids like loperamide and naloxone engage a key brain receptor, revealing new avenues for developing painkillers. The study also showed that Narcan blocks the receptor by interrupting the signaling process, providing insight into designing longer-lasting or faster-acting antidotes.
A study published in the Chinese Medical Journal identified GSTP1 as a key regulator that blocks JNK-driven ferroptosis, providing protection against DOX-induced cardiomyopathy. Overexpression of GSTP1 inhibited ferroptosis and improved DOX-induced heart injury.
A new study predicts that aging populations in Europe will lead to a substantial increase in drug-resistant bloodstream infections. The study analyzed data from over 12 million routine blood tests and found that rates are expected to rise more in men than women and older age groups, particularly those over 65.
The POINT platform integrates multiple biological networks, advanced algorithms, and a comprehensive biomedical knowledge graph to analyze drug-disease interactions. It combines node degree with deep learning methods to improve target prediction accuracy.
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
The bioactive components of Scleromitrion diffusum exhibit potent anticancer activity by inhibiting proliferation, inducing apoptosis, and suppressing metastasis. Its multi-compound, multi-pathway approach targets several critical pathways in gastric cancer pathogenesis.
A new broad-spectrum antivenom developed by DTU researchers covers 17 African snake species and provides better protection against tissue damage, with a lower risk of immune reactions. The antivenom has shown impressive results in laboratory studies and could revolutionize the treatment of venomous snakebites in Africa.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
A UH crystals expert has shown how to bend and twist crystals without physical force, using a molecule called a tautomer. This discovery has potential applications in drug delivery and material properties, such as optoelectronics and soft robotics.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
A preclinical study by University of Barcelona reveals a critical metabolic mechanism explaining palbociclib resistance in colorectal cancer cells. Combining palbociclib with telaglenastat inhibits cancer cell proliferation and avoids resistance, offering a promising clinical treatment proposal.
Researchers explore ZBP1-mediated programmed cell death, its mechanisms, and therapeutic strategies for systemic diseases. The review also discusses ZBP1's involvement in various types of cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis.
The CPA journal was honored with the 'Great Progress Award' for its significant advancements in journal development and academic dissemination. Its impact factor has doubled to 1.5, reflecting substantial increases in academic influence and recognition.
Psychedelic substances profoundly alter our perception of time, inducing temporal distortions that offer unprecedented insights into consciousness. By suppressing the default mode network and modulating multiple brain regions, psychedelics provide unique windows into brain function and mental health treatment.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
Researchers found a targeted immunotherapy regimen yielded promising survival outcomes for patients with B-cell ALL, outperforming historical results. The treatment was well-tolerated, with more than half completing the full course of therapy, and responded similarly in patients with complex medical histories.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
The Critical Path Disease Modeling Coalition (CP-DMC) aims to develop regulatory-grade, quantitative disease progression models for pediatric Crohn's disease and ulcerative colitis. These models will transform clinical trial data into actionable descriptions of disease trajectories and treatment response.
Researchers developed DNA-based signaling cascades to report and quantify molecule concentrations in blood, enabling point-of-care devices for optimizing treatment. The breakthrough aids efforts to build affordable and portable devices for monitoring medication levels at home.
The Africa Centre for Therapeutic Innovation (ACTI) brings together diverse disciplines to address unique healthcare challenges in Africa. ACTI will focus on delivering mechanistic understanding of drug action and developing new laboratory methods to combat diseases like tuberculosis and malaria.
A TTUHSC researcher has been awarded a $198,822 CPRIT grant to investigate Integrin Subunit Alpha-V as a therapeutic target in ALT-dependent osteosarcomas. The goal is to develop a new drug to treat this difficult-to-treat cancer type.
The Critical Path Institute has been recognized for its innovative approaches to regulatory science, which have measurably improved public health. The organization's work in creating practical tools and cross-sector collaborations has shortened drug development timelines and improved regulatory decisions.
Research synthesizes current evidence on psychedelic therapy's potential to fundamentally alter treatment paradigms for depression, anxiety, and PTSD. Chronic stress contributes significantly to psychiatric illness worldwide, leaving traditional treatments with residual symptoms or side effects.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
The review synthesizes clinical evidence on MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD), autism spectrum disorder, eating disorders, and existential distress. It identifies consistent patterns across diverse clinical applications and highlights the therapeutic potential of MDMA, including its oxytocin-mediated ...
Researchers show low-molecular-weight kraft lignin restores insulin sensitivity and slashes blood glucose levels in diabetic rats. The fractionation process is simple, scalable, and cost-effective, positioning lignin as a renewable and non-toxic active ingredient for functional foods or therapies.
Researchers found that a high-fat, low-carb ketogenic diet can improve brain health and stop or slow cognitive decline in individuals with the APOE4 gene. This study suggests that precision nutrition tailored to an individual's genotype, gut microbiome, gender, and age may be more effective than a one-size-fits-all approach.