Articles tagged with Pharmacology
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
The bioactive components of Scleromitrion diffusum exhibit potent anticancer activity by inhibiting proliferation, inducing apoptosis, and suppressing metastasis. Its multi-compound, multi-pathway approach targets several critical pathways in gastric cancer pathogenesis.
A new broad-spectrum antivenom developed by DTU researchers covers 17 African snake species and provides better protection against tissue damage, with a lower risk of immune reactions. The antivenom has shown impressive results in laboratory studies and could revolutionize the treatment of venomous snakebites in Africa.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
A UH crystals expert has shown how to bend and twist crystals without physical force, using a molecule called a tautomer. This discovery has potential applications in drug delivery and material properties, such as optoelectronics and soft robotics.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
A preclinical study by University of Barcelona reveals a critical metabolic mechanism explaining palbociclib resistance in colorectal cancer cells. Combining palbociclib with telaglenastat inhibits cancer cell proliferation and avoids resistance, offering a promising clinical treatment proposal.
Researchers explore ZBP1-mediated programmed cell death, its mechanisms, and therapeutic strategies for systemic diseases. The review also discusses ZBP1's involvement in various types of cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis.
The CPA journal was honored with the 'Great Progress Award' for its significant advancements in journal development and academic dissemination. Its impact factor has doubled to 1.5, reflecting substantial increases in academic influence and recognition.
Psychedelic substances profoundly alter our perception of time, inducing temporal distortions that offer unprecedented insights into consciousness. By suppressing the default mode network and modulating multiple brain regions, psychedelics provide unique windows into brain function and mental health treatment.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
Researchers found a targeted immunotherapy regimen yielded promising survival outcomes for patients with B-cell ALL, outperforming historical results. The treatment was well-tolerated, with more than half completing the full course of therapy, and responded similarly in patients with complex medical histories.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
The Critical Path Disease Modeling Coalition (CP-DMC) aims to develop regulatory-grade, quantitative disease progression models for pediatric Crohn's disease and ulcerative colitis. These models will transform clinical trial data into actionable descriptions of disease trajectories and treatment response.
Researchers developed DNA-based signaling cascades to report and quantify molecule concentrations in blood, enabling point-of-care devices for optimizing treatment. The breakthrough aids efforts to build affordable and portable devices for monitoring medication levels at home.
The Africa Centre for Therapeutic Innovation (ACTI) brings together diverse disciplines to address unique healthcare challenges in Africa. ACTI will focus on delivering mechanistic understanding of drug action and developing new laboratory methods to combat diseases like tuberculosis and malaria.
A TTUHSC researcher has been awarded a $198,822 CPRIT grant to investigate Integrin Subunit Alpha-V as a therapeutic target in ALT-dependent osteosarcomas. The goal is to develop a new drug to treat this difficult-to-treat cancer type.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
The review synthesizes clinical evidence on MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD), autism spectrum disorder, eating disorders, and existential distress. It identifies consistent patterns across diverse clinical applications and highlights the therapeutic potential of MDMA, including its oxytocin-mediated ...
The Critical Path Institute has been recognized for its innovative approaches to regulatory science, which have measurably improved public health. The organization's work in creating practical tools and cross-sector collaborations has shortened drug development timelines and improved regulatory decisions.
Research synthesizes current evidence on psychedelic therapy's potential to fundamentally alter treatment paradigms for depression, anxiety, and PTSD. Chronic stress contributes significantly to psychiatric illness worldwide, leaving traditional treatments with residual symptoms or side effects.
Researchers show low-molecular-weight kraft lignin restores insulin sensitivity and slashes blood glucose levels in diabetic rats. The fractionation process is simple, scalable, and cost-effective, positioning lignin as a renewable and non-toxic active ingredient for functional foods or therapies.
Researchers found that a high-fat, low-carb ketogenic diet can improve brain health and stop or slow cognitive decline in individuals with the APOE4 gene. This study suggests that precision nutrition tailored to an individual's genotype, gut microbiome, gender, and age may be more effective than a one-size-fits-all approach.
A University of Houston professor has received funding to develop effective treatments for Cryptosporidium infections, which cause severe diarrhea and have no existing cure. The team aims to design drugs that target the parasite's enzyme CDPK1 to minimize systemic exposure and maximize efficacy.
A new MOF, APF-80, enables the crystalline sponge method to capture and analyze nucleophilic compounds like alkaloids. This development opens possibilities for structural analysis in drug development and biochemistry.
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
Researchers at Korea University College of Medicine found that the c-Kit protein helps protect sweet-sensing taste cells from nerve damage, allowing them to survive and regenerate. This discovery may lead to new approaches for improving nutrition, supporting patients with taste disorders, and advancing flavor science.
Researchers found that combination of drugs effectively reduce fat accumulation in laboratory animal models of metabolic liver disease. The study suggests that this combination may also help reduce both liver involvement and associated cardiovascular complications.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
Scientists at the University of Liverpool have developed a low-cost, AI-powered blood test that measures key biomarkers of Alzheimer's disease in the blood with accuracy similar to expensive hospital-based tests. The device is powered by artificial intelligence and can be used instantly without specialist training.
Researchers developed COOKIE-Pro, a data analysis method for covalent inhibitors, to measure binding strength and reaction speed against thousands of proteins simultaneously. The technique promises to accelerate therapeutics design by precisely measuring affinity and reactivity.
A study published by TTUHSC researchers found that the blood-brain barrier remains intact in a commonly used mouse model of Alzheimer's disease, suggesting that drug delivery strategies may need to be redesigned. The discovery challenges long-standing assumptions about the impact of Alzheimer's on the brain's protective shield.
Researchers have made significant strides in understanding osteoarthritis by identifying five hub genes that show high diagnostic performance. These genes, including IGKC, MCL1, and NFKBIA, are predicted to be targeted by several drugs, including rapamycin and Sodium_salicylate.
Published by Far Publishing Company, Current Pharmaceutical Analysis (CPA) provides a platform for researchers to share their latest findings. The journal focuses on drug discovery to clinical application, aiming to advance every aspect of pharmaceutical science.
A new study decodes the mechanism of glioblastoma's resistance to chemotherapy by identifying a HIF-independent circuit built around the epigenetic enzyme PRMT2. Researchers found that combining an existing orphan drug with standard chemotherapy can overcome this resistance, doubling survival without added toxicity.
Current Molecular Pharmacology is a prominent journal covering mechanisms of new drugs, innovative technologies, and omics applications. It has an impact factor of 2.9 and CiteScore of 5.5, ranking Q2 in pharmacology.
Researchers identified a promising treatment for PTSD, chronic pain, and alcohol misuse in rats. The study found that PPL-138 selectively reduced anxiety-like behavior, pain responses, and alcohol consumption in those with trauma-related anxiety.
A study found that lactate IV infusion increases brain-rejuvenating hormone BDNF levels in the bloodstream, similar to those after high-intensity exercise. The hormone promotes nerve cell growth and survival. Researchers suggest moderate exercise may be necessary for optimal benefits.
Pharmacy technicians alleviate clinicians' and nurses' workload by handling medication tasks, reducing pain points in medication access work. The study found that technicians improved perceptions of quality of care and patient access, with significant reductions in burden and task time.
A large international clinical trial found that elinzanetant significantly reduces hot flashes and night sweats in postmenopausal women by over 73%. The drug also shows secondary benefits such as improved quality of life and reduced sleep disturbances, with no harmful effects on the liver or bone density.
Researchers at the University of Liverpool have discovered a groundbreaking new class of antibiotics called Novltex, which targets lipid II in bacterial cell walls. This innovative approach offers potent and durable protection against multidrug-resistant bacteria, addressing one of the biggest challenges in modern medicine.
A smartphone app, Med Safety, improved the reporting of suspected adverse drug reactions (ADRs) by 73% among healthcare workers in Uganda. This landmark trial provides robust evidence for digital pharmacovigilance systems in low- and middle-income countries.
Researchers at DTU have discovered a way to combat antibiotic-resistant bacteria by nourishing special bifidobacteria that is naturally occurring in the gut. Special lactic acids produced by bifidobacteria play a key role in keeping antibiotic-resistant bacteria at bay.
A randomized clinical trial shows that low-dose aspirin reduces the risk of recurrence by 55% in patients with colon and rectal cancer harboring a specific genetic mutation. Aspirin's anti-inflammatory and anti-tumor effects may be responsible for its therapeutic benefits.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
A collaborative team from Texas Tech University Health Sciences Center has received a five-year, $2.9 million R01 grant and a competitive renewal of $3 million to explore therapies for ischemic stroke. The team aims to develop medications that mimic the brain's self-protective mechanisms.
The conference focused on accelerating drug development for rare diseases, neurology, type-1 diabetes, and pediatrics, with a focus on patient-centered evidence generation. Key commitments included early interception, trial modernization, and patient-first approaches.
Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
Scientists developed hollow microspheres with adjustable pore size, adhesion, and lubricity properties using mucus and polydopamine. These spheres can be used as drug delivery agents and may prevent tissue damage or provide a protective coating.
Ibezapolstat, a new antibiotic, has been shown to be effective in treating Clostridioides difficile (C. diff) infections with high rates of sustained clinical cures. The study found that ibezapolstat killed harmful bacteria without harming the good bacteria in the gut, which helps prevent recurrent C. diff infections.
Researchers Jeremy McCormack and Andrei Kuzhelev at Goethe University are investigating the reasons behind prehistoric shark extinctions using new isotopic analysis methods. They also develop a novel nuclear magnetic resonance spectroscopy technique to study large biomolecules.
Researchers analyzed 5 years of Yellow Card data on 13 drugs containing fluorine and found no significant correlation between fluorine content and adverse drug reactions. The study suggests that the way a drug acts is more likely to result in an adverse reaction, rather than the presence of fluorine.
Professor Gregor Hasler's pioneering research reveals how psychedelics like LSD, psilocybin, and MDMA enhance neuroplasticity, allowing the brain to rewire itself and break free from depression, PTSD, and addiction. His discoveries have the potential to fundamentally alter international approaches to mental health treatment.
A synthetic molecule called Pep19 has been shown to reduce visceral fat and improve sleep quality in overweight adults, with no side effects observed. The study involved 24 volunteers who took either a placebo or Pep19 in capsules, and found a 17% reduction in visceral fat and improved sleep quality in those who received the molecule.
A new approach to the Chan-Evans-Lam reaction enables the synthesis of multiple natural products, including novel vinylic ethers. This breakthrough expands the potential for complex, biologically active compounds in drug research.
Dr. Harriet de Wit's groundbreaking research bridges animal and human drug studies, demonstrating that MDMA enhances feelings of social connectedness and challenging addiction treatment strategies. Her discoveries have profound implications for treating trauma-related disorders globally.