Articles tagged with Pharmacology
Researchers at Martin Luther University Halle-Wittenberg develop PROTAC molecule MA203, specifically binding to tumor protein CHK1, leading to its breakdown in cancer cells. This triggers a chain reaction destroying other tumor proteins, ultimately killing the cancer cells.
A new technique has been developed to study interactions between drugs and ion channels, allowing for faster and more economical design of targeted therapies. The method has been tested on P2X7 receptors, which are therapeutic targets for depression, autism spectrum disorders, and certain types of cancer.
Researchers discovered a cellular protein, FGD3, that enhances the effectiveness of breast cancer chemotherapy and immunotherapies. FGD3 weakens cancer cells when attacked by drugs like ErSO or doxorubicin, causing them to rupture and alert the immune system.
A new study by Yale Ancient Pharmacology Program reveals evidence of opium use in ancient Egyptian society, suggesting it was part of daily life. The discovery also raises the possibility that alabaster jars found in King Tut's tomb contained opium as part of an ancient tradition.
Researchers developed a 'humanized' model of aortic valve calcification, enabling testing of potential treatments. The breakthrough could lead to new therapies to stop or reverse calcium buildup, improving outcomes for people with heart disease.
Researchers have developed a chemical compound that degrades beta-amyloid plaques, reducing symptoms of Alzheimer's disease. The compound was tested on rats and showed promising results, including reduced memory loss and improved spatial awareness.
A recent landmark study identifies adenosine as the critical mediator of rapid antidepressant action, connecting ketamine, ECT, and hypoxia. The discovery raises questions about the potential interference of caffeine with these treatments, highlighting the need for further research on adenosinergic modulation in depression.
A study by Aston University academics found that while access to antiseizure medication is expanding globally, it's not always prescribed safely. Valproate, widely used, poses significant risks during pregnancy, including birth defects and neurodevelopmental problems.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
Researchers at Karlsruhe Institute of Technology discovered that enclosed water can influence its surroundings and favor binding between molecules. This finding could lead to the design of more effective drugs and new materials by leveraging the binding force of highly energetic water molecules.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
A major analysis by CNIC and international institutions found beta-blockers offer no clinical benefit for patients with preserved cardiac function after myocardial infarction. The study analyzed data from five global clinical trials, confirming that beta-blocker therapy does not reduce the risk of death or cardiovascular events.
Researchers aim to identify new neurobiological factors for potential intervention in AUD, including a connection between endogenous retroviruses (ERVs) and neuroinflammation. The study seeks to investigate ERV expression and genotypes in AUD pathophysiology using innovative bioinformatics tools.
Researchers found that early clindamycin administration significantly improved recovery rates in patients with invasive Group A Streptococcus (iGAS) infections. The study also showed that M1uk strain does not worsen prognosis in critically ill adults, but prompt treatment remains crucial.
A new study presents positive results for finerenone, a drug that blocks aldosterone receptors, in patients with type 1 diabetes and chronic kidney disease. The drug reduces protein excretion in urine by about a quarter, indicating reduced kidney damage and improved function.
A new national quality framework has been developed to evaluate medication management and clinical services provided by pharmacists in residential aged care. The PHARMA-Care National Quality Framework promotes a transparent, person-centred approach to medication management, aiming to reduce risks linked to polypharmacy.
Stuart S. Martin, PhD, has been appointed Chair of the Department of Pharmacology & Physiology at UMSOM, bringing over 20 years of success in advancing basic science research efforts and developing new drug therapies. His groundbreaking discovery of microtentacles on cancer cells promises to lead to new life-extending therapies.
A study published in the Chinese Medical Journal identified GSTP1 as a key regulator that blocks JNK-driven ferroptosis, providing protection against DOX-induced cardiomyopathy. Overexpression of GSTP1 inhibited ferroptosis and improved DOX-induced heart injury.
A USC Dornsife team of scientists visualized how opioids like loperamide and naloxone engage a key brain receptor, revealing new avenues for developing painkillers. The study also showed that Narcan blocks the receptor by interrupting the signaling process, providing insight into designing longer-lasting or faster-acting antidotes.
A new study predicts that aging populations in Europe will lead to a substantial increase in drug-resistant bloodstream infections. The study analyzed data from over 12 million routine blood tests and found that rates are expected to rise more in men than women and older age groups, particularly those over 65.
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
The POINT platform integrates multiple biological networks, advanced algorithms, and a comprehensive biomedical knowledge graph to analyze drug-disease interactions. It combines node degree with deep learning methods to improve target prediction accuracy.
The bioactive components of Scleromitrion diffusum exhibit potent anticancer activity by inhibiting proliferation, inducing apoptosis, and suppressing metastasis. Its multi-compound, multi-pathway approach targets several critical pathways in gastric cancer pathogenesis.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
A new broad-spectrum antivenom developed by DTU researchers covers 17 African snake species and provides better protection against tissue damage, with a lower risk of immune reactions. The antivenom has shown impressive results in laboratory studies and could revolutionize the treatment of venomous snakebites in Africa.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
A UH crystals expert has shown how to bend and twist crystals without physical force, using a molecule called a tautomer. This discovery has potential applications in drug delivery and material properties, such as optoelectronics and soft robotics.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
Researchers explore ZBP1-mediated programmed cell death, its mechanisms, and therapeutic strategies for systemic diseases. The review also discusses ZBP1's involvement in various types of cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis.
A preclinical study by University of Barcelona reveals a critical metabolic mechanism explaining palbociclib resistance in colorectal cancer cells. Combining palbociclib with telaglenastat inhibits cancer cell proliferation and avoids resistance, offering a promising clinical treatment proposal.
Psychedelic substances profoundly alter our perception of time, inducing temporal distortions that offer unprecedented insights into consciousness. By suppressing the default mode network and modulating multiple brain regions, psychedelics provide unique windows into brain function and mental health treatment.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
The CPA journal was honored with the 'Great Progress Award' for its significant advancements in journal development and academic dissemination. Its impact factor has doubled to 1.5, reflecting substantial increases in academic influence and recognition.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Researchers found a targeted immunotherapy regimen yielded promising survival outcomes for patients with B-cell ALL, outperforming historical results. The treatment was well-tolerated, with more than half completing the full course of therapy, and responded similarly in patients with complex medical histories.
The Critical Path Disease Modeling Coalition (CP-DMC) aims to develop regulatory-grade, quantitative disease progression models for pediatric Crohn's disease and ulcerative colitis. These models will transform clinical trial data into actionable descriptions of disease trajectories and treatment response.
Researchers developed DNA-based signaling cascades to report and quantify molecule concentrations in blood, enabling point-of-care devices for optimizing treatment. The breakthrough aids efforts to build affordable and portable devices for monitoring medication levels at home.
A TTUHSC researcher has been awarded a $198,822 CPRIT grant to investigate Integrin Subunit Alpha-V as a therapeutic target in ALT-dependent osteosarcomas. The goal is to develop a new drug to treat this difficult-to-treat cancer type.
The Africa Centre for Therapeutic Innovation (ACTI) brings together diverse disciplines to address unique healthcare challenges in Africa. ACTI will focus on delivering mechanistic understanding of drug action and developing new laboratory methods to combat diseases like tuberculosis and malaria.
Research synthesizes current evidence on psychedelic therapy's potential to fundamentally alter treatment paradigms for depression, anxiety, and PTSD. Chronic stress contributes significantly to psychiatric illness worldwide, leaving traditional treatments with residual symptoms or side effects.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
The review synthesizes clinical evidence on MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD), autism spectrum disorder, eating disorders, and existential distress. It identifies consistent patterns across diverse clinical applications and highlights the therapeutic potential of MDMA, including its oxytocin-mediated ...
The Critical Path Institute has been recognized for its innovative approaches to regulatory science, which have measurably improved public health. The organization's work in creating practical tools and cross-sector collaborations has shortened drug development timelines and improved regulatory decisions.
Researchers found that a high-fat, low-carb ketogenic diet can improve brain health and stop or slow cognitive decline in individuals with the APOE4 gene. This study suggests that precision nutrition tailored to an individual's genotype, gut microbiome, gender, and age may be more effective than a one-size-fits-all approach.
Researchers show low-molecular-weight kraft lignin restores insulin sensitivity and slashes blood glucose levels in diabetic rats. The fractionation process is simple, scalable, and cost-effective, positioning lignin as a renewable and non-toxic active ingredient for functional foods or therapies.
A University of Houston professor has received funding to develop effective treatments for Cryptosporidium infections, which cause severe diarrhea and have no existing cure. The team aims to design drugs that target the parasite's enzyme CDPK1 to minimize systemic exposure and maximize efficacy.
Researchers at Korea University College of Medicine found that the c-Kit protein helps protect sweet-sensing taste cells from nerve damage, allowing them to survive and regenerate. This discovery may lead to new approaches for improving nutrition, supporting patients with taste disorders, and advancing flavor science.
A new MOF, APF-80, enables the crystalline sponge method to capture and analyze nucleophilic compounds like alkaloids. This development opens possibilities for structural analysis in drug development and biochemistry.
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
Researchers found that combination of drugs effectively reduce fat accumulation in laboratory animal models of metabolic liver disease. The study suggests that this combination may also help reduce both liver involvement and associated cardiovascular complications.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
Scientists at the University of Liverpool have developed a low-cost, AI-powered blood test that measures key biomarkers of Alzheimer's disease in the blood with accuracy similar to expensive hospital-based tests. The device is powered by artificial intelligence and can be used instantly without specialist training.
Researchers developed COOKIE-Pro, a data analysis method for covalent inhibitors, to measure binding strength and reaction speed against thousands of proteins simultaneously. The technique promises to accelerate therapeutics design by precisely measuring affinity and reactivity.
A study published by TTUHSC researchers found that the blood-brain barrier remains intact in a commonly used mouse model of Alzheimer's disease, suggesting that drug delivery strategies may need to be redesigned. The discovery challenges long-standing assumptions about the impact of Alzheimer's on the brain's protective shield.
Published by Far Publishing Company, Current Pharmaceutical Analysis (CPA) provides a platform for researchers to share their latest findings. The journal focuses on drug discovery to clinical application, aiming to advance every aspect of pharmaceutical science.
Researchers have made significant strides in understanding osteoarthritis by identifying five hub genes that show high diagnostic performance. These genes, including IGKC, MCL1, and NFKBIA, are predicted to be targeted by several drugs, including rapamycin and Sodium_salicylate.
Current Molecular Pharmacology is a prominent journal covering mechanisms of new drugs, innovative technologies, and omics applications. It has an impact factor of 2.9 and CiteScore of 5.5, ranking Q2 in pharmacology.
A new study decodes the mechanism of glioblastoma's resistance to chemotherapy by identifying a HIF-independent circuit built around the epigenetic enzyme PRMT2. Researchers found that combining an existing orphan drug with standard chemotherapy can overcome this resistance, doubling survival without added toxicity.