Articles tagged with Pharmacology
A special issue of Journal of Intensive Medicine provides key insights into selecting optimal non-invasive respiratory support strategies for AHRF, featuring review articles and original research. The collection offers guidance on the efficacy of HFNC, CPAP, NIV, and awake prone positioning to improve patient outcomes.
Researchers at Ruhr-University Bochum have discovered that hepatitis E viruses can infect kidney cells, leading to a potentially insurmountable challenge in treating the infection. The study found that infected kidney cells responded poorly to antiviral medication, suggesting the virus has evolved to evade treatment.
Dr. Danielle Beckman's research uses animal models to understand how viruses like COVID-19 trigger neurological damage and accelerate Alzheimer's disease. Her work has established critical connections between viral infections and neurodegenerative processes.
Researchers used computational simulations to investigate changes in synaptic connections during sleep-wake states. They found that synaptic connections are strengthened when specific levels of neural activity accompanied typical synaptic learning rules, enabling theoretical predictions of sleep learning conditions.
This study confirms Lycium barbarum contains multiple components that interact with various targets and pathways to treat liver cancer. The active ingredients have good binding ability, indicating a potential therapeutic effect.
A new study from Karolinska Institutet found that biological drugs used to treat severe asthma do not completely eradicate inflammatory cells. Researchers discovered an increase in blood levels of these cells during treatment, which could explain why inflammation often returns when treatment is tapered or discontinued. The study aims t...
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.
The SEB Conference 2025 will feature over 500 talks on latest advances in experimental research across animal, plant and cell biology. The event highlights groundbreaking research in biomechanics, wildlife conservation, human disease and bio-inspired robotics.
A new gene therapy delivery device called NANOSPRESSO could revolutionize how hospitals treat rare diseases by allowing them to create personalized nanomedicines in-house. This democratized approach to precision medicine could boost access to low-cost bespoke gene and RNA therapies, especially in low-resource settings.
Scientists have developed a method to produce macrocyclic peptides using brewer's yeast, which can be rapidly analyzed for therapeutic applications. The approach harnesses the natural machinery of yeast to create biocompatible and biodegradable peptide molecules with precision targeting and stability.
A new Center for Protein Design at the University of Copenhagen aims to create artificially designed proteins with tailored properties to tackle diseases, environmental issues, and industrial applications. The centre will drive fundamental research and translate basic findings into concrete solutions.
Research synthesizes evidence from dozens of studies on polygenic scores and their clinical implications, revealing consistent patterns that could contribute to personalized psychiatric care. Higher genetic risk for depression correlates with poorer treatment outcomes, including nonresponse to antidepressants and mood stabilizers.
A new study reveals that US Muslims show moderate openness to psychedelics in mental health therapy, with higher education correlating with favorable attitudes. Providing education about psychedelic therapies may help lower barriers to considering this treatment.
Researchers used nanomedicine and artificial intelligence to analyze plasma samples, identifying potential biomarkers for metastatic prostate cancer and atherosclerosis. This breakthrough discovery has the potential to advance early detection and develop targeted therapies for these conditions.
A new national guideline provides unified strategies for managing RSV infections in children under five, emphasizing rapid antigen detection, oxygen therapy, and pharmacological treatments. The guideline also supports the use of monoclonal antibodies and recommends non-pharmaceutical interventions to prevent pediatric RSV infections.
Scientists at Xi'an Jiaotong-Liverpool University developed a new nanoparticle capable of carrying high doses of chemotherapy drugs while staying stable for extended periods. This innovation could make treatments more effective and reduce side effects.
Researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine aim to reduce falls and adverse drug events among older adults by using personalized approach tailored to individual genetic profiles.
Dr. Stephen Ross's groundbreaking studies using psilocybin therapy have demonstrated rapid, substantial, and sustained improvements in psychological symptoms for patients with advanced cancer, substance use disorders, and major depressive disorder. His research has the potential to challenge conventional psychiatric medication approaches.
Researchers discover iguratimod, a rheumatoid arthritis drug, effectively treats excessive COVID-19 inflammation in mice by maintaining antiviral immune responses. The study provides hope for patients with severe COVID-19-related cytokine storms.
Researchers review nanozymes derived from Chinese herbs, including their catalytic properties, biomedical applications, and potential challenges in developing herbzymes for practical use. The review highlights three main types of herbzymes: herb carbon dot enzymes, polyphenol-metal nanozymes, and herb extract nanozymes.
A pioneering research brings psychedelic medicine into gastroenterology, exploring psilocybin's effects on treatment-resistant irritable bowel syndrome (IBS). Dr. Erin E. Mauney's study modulates interoception and uses integrated therapy sessions with neuroimaging to track brain changes.
Dr. Nikolaos Koundouros has been awarded the 2025 Tri-Institutional Breakout Award for his research on how cells detect and respond to dietary nutrients, specifically omega-6 and omega-3 fatty acids, in relation to breast cancer development.
A new study has identified a way to target the viral enzyme uracil-DNA glycosylase (vUNG) that helps HSV-1 evade the immune system, allowing reactivation of APOBEC1 and improving survival in infected mice. This approach offers a promising therapeutic strategy for treating HSV-1 encephalitis by strengthening brain immunity.
The Phase 1 study of EBC-129 has shown encouraging signs of efficacy in heavily pre-treated pancreatic ductal adenocarcinoma patients, with an overall response rate of 25% and disease control rate of 87.5%. The drug also demonstrated a manageable safety profile, with no major treatment-related adverse events.
Dr. Deanna Kaplan's innovative voice-capture app, Fabla, captures unstructured voice narratives to study how clinical interventions influence daily life. The platform has found applications across diverse health domains, including veteran experiences and healthcare provider burnout.
Researchers used breath analysis to monitor general anesthesia in children, achieving results comparable to blood tests. The method also detected oxidative stress and potential complications, enabling early detection and prevention.
A WVU microbiology student has discovered a new species of fungus, Periglandula clandestina, that produces effects similar to the semisynthetic drug LSD. The fungus is highly efficient at making ergot alkaloids, which can be used therapeutically to treat conditions like depression and addiction.
The Ochsner Health system implements pharmacogenomics to fine-tune treatments based on individual genetic profiles, transforming patient care through personalized medicine. Pharmacists play a pivotal role in spearheading these innovations, overcoming barriers and maximizing impact.
Researchers from Florida Atlantic University have discovered a potentially safer treatment for multiple disorders linked to altered dopamine signaling by blocking the kappa opioid receptor. The study found that this approach can correct behavioral deficits and normalize dopamine availability.
The Experimental Drug Development Centre's EBC-129, an antibody-drug conjugate targeting pancreatic cancer, has received FDA fast track designation. The treatment is undergoing Phase 1 clinical trials and aims to provide new treatment options for patients with solid tumours.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
Seven Clusters of Excellence at LMU Munich have been approved for funding, covering a broad range of fields from systems neurology to quantum science. The successful clusters reflect the university's exceptional commitment and cooperation with partners.
A new protocol has been developed to establish a safer standard for medication use during breastfeeding. The study focuses on the concentration of prednisolone and metformin in breast milk and infant plasma, addressing a significant knowledge gap in human lactation studies.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
A group of doctors has filed a complaint with the National Institutes of Health's Office of Laboratory Animal Welfare, alleging that Arizona State University used mice in a study on dietary supplements and adults with Down syndrome. The experiment involved invasive procedures and was deemed scientifically unjustifiable by experts.
The Center for Research Innovation in Biotechnology (CRIB) has developed a comprehensive database of active pharmaceutical ingredients with evidence of clinical testing. The database provides valuable information on drug discovery and development, including pricing, sponsors, and intended clinical applications.
Researchers developed a treatment strategy to address fentanyl-xylazine overdoses, combining naloxone with atipamezole to improve recovery outcomes in animal models. The co-administration of naloxone and atipamezole restored consciousness and physiological parameters in rats exposed to fentanyl and xylazine.
Researchers discovered that platelet-activating factor (PAF) triggers strong contractions in the esophagus and upper stomach, potentially linked to food allergies and acid reflux. PAF also causes rhythmic muscle movements in the colon, which may be connected to chronic digestive diseases.
A decade-long project has provided the first comprehensive functional blueprint of chemical transport pathways in human cells. The RESOLUTE consortium's groundbreaking studies have more than doubled existing knowledge on solute carriers, offering powerful new resources for biomedical discovery.
Researchers at Indiana University discovered a new way acetaminophen targets pain by inhibiting an enzyme that produces endocannabinoids. Reduced levels of these compounds may lead to decreased pain relief, providing a potential target for designing safer pain medications.
This study found that ceftazidime-avibactam is ineffective against most carbapenem-resistant gram-negative bacterial strains, with only a small proportion showing susceptibility. The results suggest that alternative strategies are needed to control antimicrobial resistance in Pakistan.
A recent study found that the average duration of ADHD medication for children and adolescents is more than three years. Long-term effects in children have not been sufficiently studied due to limited data on the safety of marketed ADHD medicines.
Researchers have discovered a new glycopeptide antibiotic, saarvienin A, with strong activity against highly resistant bacterial strains. The compound outperforms existing antibiotics, even against strains resistant to multiple others.
Researchers explore emerging technologies like Kerecis and NovoSorb BTM, which integrate antimicrobial properties into dermal substitutes. The review highlights the need for integrated antimicrobial agents to reduce antibiotic reliance and promote scarless healing.
A study reveals pharmacy care is perceived differently by diverse populations, with notable gaps in communication for patients with disabilities. The research highlights the importance of effective communication and accessible spaces for pharmacists to provide high-quality care.
Dr. Yehezkel Ben-Ari's Neuroarcheology framework links developmental mechanisms to disorders, offering new hope for previously untreatable conditions. His groundbreaking work has transformed our understanding of brain development and malfunctions.
This study investigates the anti-inflammatory and neuroprotective properties of rosiglitazone in preventing pentylenetetrazole-induced kindling in mice. Rosiglitazone delays seizure progression, reduces pro-inflammatory cytokine levels, and increases IL-10, indicating its potential as a therapeutic strategy for epilepsy management.
Researchers at Umeå University and Michigan State University have found a type of molecule that can kill chlamydia bacteria without harming human cells or beneficial bacteria. This breakthrough discovery opens the door for developing new antibiotics against chlamydia, the world's most common bacterial sexually transmitted disease.
A new breakthrough in photopharmacology has been achieved with the design of a wireless capable of remotely activating a photoactivable drug. The device demonstrates efficacy in treating pain and opens up new perspectives for designing safer and more effective analgesic treatments.
Researchers have found that psychedelic compounds can reverse a cascade involving brain-resident cells and immune cells, increasing fear behavior when chronic stress disrupts signaling. This finding represents a paradigm shift in understanding psychedelics' therapeutic potential.
The Psychedelics journal has expanded its focus to include all psychoactive drugs, challenging traditional classifications and embracing a broader understanding of consciousness-altering substances. This move aims to reveal novel therapeutic applications and deepen human knowledge of the mind.
Rasika Dias, a renowned chemist at UTA, has been named a 2025 fellow of the Royal Society of Chemistry for his groundbreaking contributions to chemical sciences. He is the second chemistry faculty member to receive this honor.
A recent study found that fine-tuned GPT-4 chatbot can provide trustworthy information to pregnant women with opioid use disorder. The chatbot uses motivational interviewing and evidence-based guidelines to help individuals overcome resistance to change and access local treatment centers.
Researchers from Kyushu University found that lipid peroxidation of lysosomes plays a key role in ferroptosis-mediated cell death, leading to iron leakage and membrane permeabilization. Administration of chloroquine promotes ferroptosis even in cancer cells less susceptible to the process.
The review highlights the limitations of existing dengue vaccines, such as CYD-TDV and TAK-003, and the urgent need for more effective vaccines to protect millions of people. The Butantan-DV vaccine has shown promise with its single-dose regimen, but its efficacy against DENV-3 and DENV-4 is still unclear.
A study by Emory University researchers has found that spiritual health practitioners' personal experiences with psychedelics drive their careers in the emerging field of psychedelic-assisted therapy. The study introduced a novel training approach, emphasizing self-literacy and reflective learning to balance personal experience with cl...
A mathematical modeling study suggests that sustained HIV remission or eradication could consistently reduce new HIV infections among men who have sex with men (MSM) in the Netherlands. However, transient remission with a risk of rebound may increase new infections if not closely monitored.
A single dose of a psychedelic compound can enhance cognitive flexibility for weeks after administration, according to a groundbreaking study. Mice treated with the compound showed improved performance in reversal learning tasks compared to control groups when tested weeks later.
The University of Missouri is partnering with a consortium to design and license a new research reactor, NextGen MURR, which will produce critical medical isotopes for cancer treatment. The project aims to enhance Missouri's role as a leader in nuclear science and medical research.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.