Articles tagged with Pharmacology
Scientists identify Roseburia genus bacteria in human intestine associated with increased muscle mass and strength. The study suggests that the bacteria could be used as a probiotic to help preserve muscle strength during aging.
Jeonbuk National University researchers have developed DDINet, a lightweight and scalable model that can accurately predict drug-drug interactions for new, unseen drugs. This approach avoids overfitting to training data and is designed to handle binary and multi-classification tasks.
Researchers discovered yaku'amide B induces CD9 degradation, a cancer stem cell-related protein, in addition to inhibiting ATP synthase, leading to cellular energy depletion and cancer cell suppression. This natural compound has potential as a new therapeutic approach for cancer treatment.
The latest issue of Current Pharmaceutical Analysis features advanced analytical characterization and emerging trends in pharmaceutical science. Open access articles can be freely viewed and downloaded on ScienceDirect.
Researchers at Hokkaido University developed a new platform to evaluate male reproductive function in living mice, enabling non-invasive, real-time monitoring of fertility. This approach reduces animal use and costs, while providing continuous and long-term data, and has potential applications in oncofertility research.
Researchers at ETH Zurich have developed a new boron-based coupling method that enables the rapid production of key proteins for cancer therapies, overcoming the concentration barrier in chemical protein synthesis. This breakthrough allows for the creation of new peptide and protein medications, as well as unnatural amino acids with sp...
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
A low-cost digital intervention increased expectation to adopt health behaviors among adults using GLP-1RAs, with effects persisting for 2 weeks. The written microsteps intervention plus short video boosters may play a role in promoting sustained behavior change.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Researchers at Goethe University are developing non-hormonal contraceptives to address declining pill use and side effects. The PREVENT project aims to create safe and effective alternatives, focusing on small molecules that block proteins in sperm or egg cells.
A large cohort study found that people using anticholinergic medications, commonly prescribed for urinary incontinence and anxiety, have a higher risk of developing cardiovascular disease. The cumulative use of these drugs was associated with an increased risk of heart failure and arrhythmias.
A University of Sydney-led study found that honey made from mixed floral sources has superior performance against bacteria, with high levels of bioactive compounds. The findings could help develop new treatments for drug-resistant infections while supporting bushfire recovery and sustainable beekeeping practices.
A recent study by Mizzou researchers found that some young adults with autism exhibit abnormalities in dopamine transporters on brain scans, which could be early biomarkers for potential Parkinson's disease development. This discovery may help identify individuals at greater risk and inform preventative measures.
Researchers at Arizona State University uncovered a scientific principle governing how nanoparticles interact with water in the body, leading to improved drug delivery. The study measured hydration energetics on biomolecule-coated magnetite nanoparticles, revealing altered interactions, immune recognition, and circulation potential.
Researchers found Xijiaqi Formula reduces neuroinflammation and promotes neuroplasticity in CHF rats, improving cognitive function. The formula also enhances molecular signatures of neuroplasticity by regulating PDE4-cAMP/PKA/CREB signaling.
Researchers have found that remote ischemic conditioning can protect the heart without reducing antitumor efficacy in cancer patients undergoing anthracycline treatment. This non-pharmacological technique may reduce long-term cardiovascular complications and improve quality of life.
The Alliance for Clinical Trials in Oncology will host a webinar highlighting recent clinical advances in breast cancer, multiple myeloma, and leukemia. Researchers will present key findings from ASH and SABCS meetings, impacting treatment outcomes.
A novel delivery method using microscopic lipid bubbles has successfully delivered a neuroprotective molecule to the brain, improving motor function in mice with ALS. The breakthrough could pave the way for human clinical trials to slow down or halt disease progression.
The study found that opioids provide only small, time-limited pain relief for certain pain conditions, such as stomach pain and dental surgery. Regular use of opioids comes with a risk of harm, including dependence and overdose.
Researchers have identified new microbial species in corals that produce unique natural products, offering a vast arsenal of potential benefits to humanity. The study highlights the importance of protecting coral reefs' microbiomes to tap into this untapped resource before it's lost forever.
Alpha-gal syndrome is a growing concern in Missouri and beyond, causing delayed symptoms such as hives, stomach pain, and severe throat swelling. Mizzou researchers and MU Extension are working together to educate the public about alpha-gal syndrome and provide resources for those affected.
Researchers at the University of Gothenburg have found that tirzepatide, the active ingredient in Mounjaro, reduces voluntary alcohol consumption by more than half in animals. The study also shows that the drug prevents relapse-like drinking and decreases drinking levels after a period without alcohol.
Researchers are developing a new compound that can break down MDM2, a cancer-driving protein often found in triple-negative breast cancer, showing promise in shrinking tumors. The goal is to create an entirely new class of therapies for this aggressive and difficult-to-treat form of the disease.
Researchers developed a free-to-use software tool, PSBench, to verify the accuracy of artificial intelligence-based protein structure predictions. The database includes 1.4 million annotated protein models, verified by experts, and provides reliable information for building more accurate AI systems.
The study identifies SRJ09 as a top candidate for treating beta thalassemia due to its favorable binding affinity to the active site of histone deacetylase 2 (HDAC2). The compound exhibited acceptable drug-likeness properties and stable complex behavior with HDAC2.
Researchers developed antibody–drug conjugates that combine CD4 mimic and neutralizing antibodies to target HIV entry, showing seven times better efficacy than existing approaches. The strategy aims to block HIV before it enters the host cell, offering a more targeted therapeutic profile and potentially reducing adverse effects.
MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, reducing production costs. The new model predicted which codons would work best for manufacturing six different proteins, including human growth hormone and a monoclonal antibody, with successful results.
The study investigated the bioactive polyphenolic compounds and their anti-degenerative properties in foliar tissues of Amaranthus hypochondriacus L. The results showed germplasm-specific variations in pharmacological potential, with some accessions exhibiting promising anti-degenerative properties.
Research shows that psychedelics suppress visual processing by activating the 2A receptor, leading to hallucinations as the brain fills the gap with fragmented memories. Short-term oscillations also play a crucial role in communication between brain areas.
Researchers investigated the binding thermodynamics of doxepin geometric isomers to the histamine H1 receptor, revealing differences in enthalpy and entropy contributions. The study highlights the importance of considering conformational constraints in designing ligands with optimized thermodynamic properties.
Matthew J. Robson, PhD, a University of Cincinnati associate professor, received the 2026 Neuropharmacology Early Career Award for his research on serotonin neurotransmission and its impact on traumatic brain injury. The award honors young independent investigators in neuropharmacology.
Researchers at NTU Singapore develop a new orally taken, gut-based compound that reduces dietary fat absorption in the intestines. The technology supports weight loss while minimizing effects on other organs and reducing stress on the liver when dietary fat intake is high.
A new Cochrane review found that nurse-led hospital care matches doctor-led care for safety and effectiveness, but may achieve better outcomes in some areas. Nurse substitution is not a one-size-fits-all approach, requiring the right training and support to work well.
A new national survey found that nearly three-quarters of clinicians encounter obstacles when starting buprenorphine treatment for patients using fentanyl. Researchers emphasize the need for evidence-based guidelines to initiate buprenorphine in light of more potent drugs.
Scientists have successfully grown human norovirus in the lab for up to 15 consecutive passages, enabling comprehensive studies of viral structure, antiviral drug screening, and vaccine development. The breakthrough uses a drug called TAK 779 to overcome host restrictions, allowing researchers to produce stable virus stocks.
Researchers have designed antibodies that recognize a unique sugar found on bacterial cells, providing a potential new treatment for multidrug-resistant hospital-acquired infections. The target of the antibody is pseudaminic acid, a sugar molecule produced exclusively by bacteria and used to evade immune responses.
Researchers discovered that ATG triggers rapid clotting and inflammation in the liver by activating a complement activation system and TGF-β pathway, leading to severe side effects. The study used human organoid models and imaging analysis to reveal the biphasic mechanism of ATG-induced liver injury.
A team of researchers has discovered an oral compound that selectively induces the mammalian clock gene Per1, promoting a dual E-box DNA element's activation. This results in the advancement of both central and peripheral clocks, advancing jet lag and shift work-related sleep disorders.
The MIT research team has designed a new type of tissue model that accurately replicates the physiology of the liver, including blood vessels and immune cells. The model was used to study metabolic dysfunction-associated steatotic liver disease (MASLD) and showed promising results in identifying potential treatments.
The UH College of Pharmacy is expanding its graduate program to offer a Doctor of Philosophy and Master of Science in Population Health & Pharmacoepidemiology, addressing a growing demand for training in evaluating medication safety and effectiveness.
A national clinical trial found that oxybutynin significantly reduced hot flash frequency and quality of life for men undergoing hormone therapy for prostate cancer. The study showed substantial improvements in hot flash symptoms, often within the first week of treatment.
Researchers found that carrying one mutant copy of ATP13A2 and GBA1 drives a slow, progressive neurodegeneration in flies, leading to movement problems, neuron loss, and disruption in neural communication. Accumulation of glucosylceramide in glial cells is linked to the disease process.
A pharmacokinetic recall study involving 114 Estonian Biobank participants reveals functional impact of rare CYP2C19 and CYP2D6 variants. These variants significantly affect how drugs are processed in the human body, emphasizing the need to look beyond common pharmacogenetic markers.
A BSC study analyzed 8,906 patient samples to explore disease connections between women and men. It identified different biological pathways for co-occurring diseases depending on sex, highlighting the need for sex-specific risk-reduction strategies.
The UK's response to NPS deaths highlights the importance of international cooperation and domestic legislation in reducing harm. Effective controls implemented in producing countries, such as China, were associated with larger reductions in NPS detections than controls introduced solely within consuming countries.
Researchers decode the molecular mechanisms of toad venom's medicinal properties, revealing a link to serotonin receptor interactions. The study identifies key components and their selective agonist activities on depression-related receptors, shedding light on traditional Chinese medicine's modern interpretation.
Researchers used the African turquoise killifish as a rapid-aging model to study kidney decline. The study revealed that sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction, protecting against aging-related damage.
Computational analysis reveals two strategies: stealthy plasmids pick up new genes first, while manipulative plasmids help them spread rapidly. This 'stealth-first' process can aid in predicting future resistance threats and tracking their emergence.
A multidisciplinary team at USC has developed selective compounds that inhibit an enzyme tied to brain inflammation in people at genetic risk for Alzheimer’s. The inhibitors preserve normal brain function and cross the blood-brain barrier, suggesting a promising therapeutic approach for neurodegenerative diseases.
Researchers at the University of Oulu have developed a pine-bark-based water-treatment medium that efficiently removes antibiotics and other pharmaceuticals from wastewater treatment plant effluent. The method uses modified pine bark and combination materials, achieving removal efficiencies in the tens of percent to over 90%.
Researchers at the University of Missouri are developing AI models to accurately detect melanoma by analyzing images of skin abnormalities. The technology can help dermatologists identify cases that may require closer attention, leading to earlier treatment and improved health outcomes.
Scientists develop ultra-selective crystalline membranes to recycle polluted textile wastewater and improve pharmaceutical medicine purity. The technology could significantly reduce energy consumption, enabling large-scale water reuse in industries.
A national clinical trial found that abemaciclib, an oral cancer drug, may slow tumor growth in patients with aggressive meningiomas with specific genetic mutations. The trial showed promising results, with a median progression-free survival of 10 months and a median overall survival of 29 months.
Researchers deciphered the function of ion channel TMEM175, showing it conducts potassium ions and protons in lysosomal membranes. This discovery establishes its decisive role in maintaining optimal pH levels, facilitating degradation processes, and may lead to new treatments for Parkinson's disease.
Research reveals that high blood pressure significantly increases risk of heart damage caused by anthracycline cancer treatments. The study identifies a 'perfect storm' effect when high blood pressure and anthracyclines coincide, leading to heart failure.
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
A major U.S. clinical trial has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Researchers found that men who carry a specific version of the gene SULT2A1 clear abiraterone from their bodies more slowly, which could affect how well it w...
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
Researchers uncover a key ion channel, TRPM4, that regulates intestinal fluid balance and identify a new druggable site. This discovery provides a blueprint for designing targeted treatments for gastrointestinal disorders.