Articles tagged with Cell Cycle
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Houston have discovered a potential therapeutic strategy for counteracting muscle wasting in pancreatic cancer by blocking a specific cell pathway. Muscle wasting, also known as cachexia, is a debilitating syndrome affecting 60-85% of patients with pancreatic cancer.
Researchers discover that CDT1 overexpression suppresses DNA replication and induces DNA damage, potentially leading to genetic mutations and cancer. The study provides molecular insights into the role of CDT1 in cancer development.
Researchers at Hebrew University of Jerusalem unlock natural pathway to immortalize cow cells, overcoming major barrier to affordable cultivated beef. The study reveals bovine cells can spontaneously renew themselves indefinitely without genetic modification.
Researchers found that cells exiting the cell cycle show stronger signs of senescence and are more sensitive to senolytic drugs. DNA content plays a crucial role in how aging cells function and respond to treatment.
Researchers mapped human cell cycle gene activity and found recently evolved transcription factors play a crucial role in regulating the process. Disabling these genes caused cells to struggle with DNA copying and division timing.
Researchers developed a systems approach to measuring organelle changes in living cells as they grow. The study found that certain organelles grow faster than others and that the vacuole plays a key role in buffering the cell against randomness.
Researchers from Queen Mary University of London and the University of Dundee have discovered how microtubules decide whether to grow or shorten, a fundamental mechanism governing cellular processes. This breakthrough sheds new light on cell division and opens potential avenues for cancer treatment.
Researchers found that mutated cells dividing rapidly and having shorter cell cycles are more likely to develop cancer. In contrast, those with longer cycles exhibit resistance. The study suggests that interventions targeting cell cycle length could prevent cancer initiation in high-risk individuals.
A glitch in protein synthesis, known as stop codon readthrough, may affect tumour growth and cancer cell proliferation. The study found that preventing this process can lead to increased degradation of target proteins and a delayed cell cycle, resulting in slower tumour growth.
The study identified RNF144B as a tumour suppressor that prevents genomic instability, but low expression leads to poor prognosis and treatment resistance in lung adenocarcinoma. The research suggests that even non-mutated genes like RNF144B can have a significant impact on cancer development.
Scientists discover that multiciliated cells use cell division to control hair-like projections called cilia. This adaptation breaks the cancer-preventing rule of making only four centrioles per cell, producing hundreds instead.
Researchers at Johns Hopkins Medicine have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells. The findings reveal what goes wrong when a group of molecules and enzymes trigger the cell cycle, leading to cancer development.
A recent study published in PLOS Biology found that post-mitotic brain neurons re-entering the cell cycle rapidly succumb to senescence. This process is more common in Alzheimer's disease and may provide valuable information about neurodegeneration, while the technique used can be applied to other inquiries.
Researchers at U of T have mapped the movement of proteins encoded by the yeast genome throughout its cell cycle, identifying patterns of emergence and disappearance or movement to specific areas. The study provides a unique dataset that offers a genome-scale view of molecular changes during cell division.
A recent study published in Nature Aging suggests that mechanical damage to the cell membrane can induce cellular senescence, a state characterized by cell cycle arrest and tissue dysfunction. This mechanism involves calcium ion influx and the tumor suppressor gene p53, offering new insights into the aging process.
The study found that solely the omicron variant influences cell cycle genes, leading to increased p21 expression and a senescence-associated secretory phenotype. This results in premature cellular senescence, potentially contributing to the reported cytokine storm and development of long-COVID.
Cancer cells' uncontrolled growth leads to a loss of ability to divide due to genetic damage accumulation. Simultaneous treatment with growth and division inhibitors can restore cellular function.
Researchers at the University of Alabama at Birmingham have developed a modified messenger RNA that can temporarily induce cardiomyocyte cell division, leading to reduced infarct size and improved heart function. The treatment has shown promise in mouse and pig models without increasing the risk of deadly arrhythmias.
A research team sheds light on Dmc1 filament assembly mechanisms using single-molecule experiments. Swi5-Sfr1 and Hop2-Mnd1 proteins regulate Dmc1 assembly through distinct mechanisms, promoting efficient strand exchange during homologous recombination.
A team at Osaka University identified a crucial protein facilitating proper chromosome movement when cells divide. The research revealed that the Cupin domain of CENP-C is essential for its function, supporting centromere/kinetochore assembly and maintaining genomic integrity.
A new study from the Stowers Institute for Medical Research reveals the placenta's polyploid cells play a vital role in supporting healthy embryonic development. The modified cell cycle controlling polyploidy is governed by the regulatory gene Myc, which supports DNA replication and prevents premature cellular aging.
Researchers investigated the cardiovascular effects of glucocorticoids on chicken embryos, finding that Betamethasone (Beta) caused more severe growth restriction, cellular stress, and cardiac dysfunction compared to Dexamethasone (Dex). Dex triggered oxidative stress, while Beta sustained glucocorticoid receptor activation
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
Researchers at the University of Groningen discovered that cells separate essential biochemical reactions into different time periods. This separation explains metabolic oscillations leading up to cell division and has implications for our understanding of cellular physiology, cancer, and aging.
Researchers at Weill Cornell Medicine have identified a crucial mechanism that prevents cells from replicating extra DNA, reducing the risk of cancer and genome instability. The study reveals that a licensing protein called CDT1 acts as a brake on DNA replication, preventing it from progressing once licensed sites are established.
Researchers from Washington University in St. Louis and Purdue University used single-cell data to develop a new framework for understanding the relationship between cell growth, DNA replication, and division in bacteria. They found that individual cells can exquisitely coordinate these processes, despite the 'noisiness' of each process.
Researchers identified USP7 as a novel cyclin F-interacting protein that stabilizes cyclin F protein. The study also found that USP7 regulates cyclin F mRNA, with pharmacological inhibition resulting in downregulation of cyclin F mRNA.
Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
Researchers at NC State University have developed a reproducible method for studying cellular communication in plant cells using 3D bioprinting. The study found that more than half of the bioprinted cells were viable and divided over time, with soybean embryonic cells remaining viable for two weeks after bioprinting.
A new experimental device has been developed to generate temperature gradients on a microtiter plate, allowing for the simultaneous testing of different temperatures. This innovation solves a common challenge in biological studies of living cells, unlocking new possibilities for studying cellular growth and development.
Researchers led by Jianyi Zhang aim to find key pathways for reprogramming adult heart muscle cells to proliferate in response to a heart attack, potentially leading to improved heart attack recovery through growth of new heart muscle cells. The grant will fund three projects at UAB and two other universities.
A new study from the University of Alabama at Birmingham reveals how impaired metabolism due to mutations in succinate dehydrogenase B disables a normal bioenergetic sensing mechanism, leading to uncontrolled cell proliferation. This discovery sheds light on how cancer cells divide despite having a less efficient energy production.
A mutated zebrafish eye provides a glimpse into the role of banp in preventing cell death and regulating the cell cycle. The study found that banp promotes the expression of 31 genes involved in DNA repair, tumor suppression, and cell duplication.
The Gerlich Group at IMBA found that histone acetylation establishes a sharp surface boundary on chromosomes, resisting microtubule perforation. Chromatin phase separation and DNA looping by condensin cooperates to build mitotic chromosomes with unique physical properties.
A new study led by Tokyo University of Science researchers identifies altered gene expression and cell function changes that drive DNA damage and neoplasia in cholangiocytes exposed to 1,2-dichloropropane. The findings highlight the importance of macrophage involvement in carcinogenesis.
Researchers at Tokyo Institute of Technology have successfully synthesized a synthetic mechanosensitive potassium channel, exhibiting stimuli responsiveness and selective ion transport. The new ion channel could lead to breakthroughs in therapeutic treatments for ion-channel related diseases.
Researchers at MIT have created a new liver tissue model that identifies one molecule playing a key role in human liver regeneration. The study also reveals several other candidates that will be explored further to discover new human-specific pathways.
Researchers discovered increased cell cycle activity and proliferation in cardiomyocytes after heart surgery, allowing for remuscularization of the left ventricle. The study identified key genes involved in pathways regulating heart development and cell proliferation.
Researchers at IRB Barcelona describe a cellular mechanism that coordinates inflammation resolution, with CPEB4 protein playing a crucial role. This regulation involves the balance between pro-inflammatory TTP and anti-inflammatory CPEB4 proteins.
A team of researchers has found a way to block the replication of one strain of the influenza virus in human cells by inhibiting a specific protein modification process called SUMOylation. This breakthrough could lead to highly effective treatments for the flu and other respiratory viruses.
A recent study by Weill Cornell Medicine and Dana Farber Cancer Institute reveals that CDC7 is replaceable by CDK1 in cell division, opening up new avenues for cancer therapies. The finding highlights the complex molecular orchestration of the cell cycle and suggests a powerful new strategy against cancer.
Researchers have successfully rejuvenated mouse organs through cellular reprogramming, improving their health and potential applications for cell therapy. The study identified key changes in metabolism, gene expression, and DNA status during aging, which are partially reversed by reprogramming.
Researchers create detailed 'atlas' of fallopian tube cells to better understand fertility and disease. The study identifies 10 epithelial cell subtypes and reveals new insights into ovarian cancer origins.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
Researchers develop alternative diagnostic technology to evaluate Li-ion battery degradation mechanism quickly and efficiently. The approach allows for rapid detection of LLI degradation, facilitating real-time monitoring of individual cells' state of health.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
Researchers discovered that yeast cells can actively regulate temperature-dependent phase separation in their membranes. This process is crucial for membrane function and cell division. By adjusting the temperature, yeast cells can maintain a consistent state of phase separation, which may be essential for optimal cellular performance.
Researchers found that glioma cells with mutated ATRX have reduced Chk1 activity, leading to dysregulated cell cycle and heightened sensitivity to ATM inhibitors. The study suggests that combining radiation therapy with these inhibitors may improve treatment outcomes for patients with this gene mutation.
Researchers found that slow release of TT-10 from nanoparticles improved heart function after a heart attack, accompanied by increased cardiomyocyte proliferation and smaller infarct size. The study suggests that PLGA nanoparticles could be used to improve treatment administration efficiency for cardiovascular drugs.
Researchers discovered that living cell interiors become softer and more fluid during mitosis, a process crucial for life. The findings could help ensure precise separation of cellular structures into daughter cells.
Researchers have found that heart cells regulate their circadian rhythms through changes in sodium and potassium ion levels, which can impact heart rate. This new understanding may lead to better treatments and preventative measures for combating heart conditions.
Researchers have discovered how PARP inhibitors selectively kill cancer cells carrying BRCA1 and BRCA2 mutations. The findings provide a mechanistic explanation for the selectivity of PARP inhibitors toward BRCA-mutant cells.
A new study finds that autodegredation, a process where mature cells break down specialized structures, enables regeneration in adult tissues. Genes Atf3 and Rab7b are upregulated during this process, allowing cells to return to the cell cycle and potentially contributing to cancer development.
Researchers at TU Graz developed the world's first digital model of a cancer cell, simulating rhythmic oscillation of membrane potential during cell cycle phases. The model enables prediction of changes in membrane potential caused by drug-induced switching on and off of ion channels.
ASU engineering researchers have discovered a new neural stem cell state that could be key to unlocking new methods of brain cancer treatment. The team found that the quiescent Neural G0 state is independent of a tumor's proliferation rate and can potentially be targeted for new drug treatments.
Researchers found that piperlongumine inhibits cell growth, impacts cell cycle, and triggers caspase-3 independent cell death in retinoblastoma cell lines. PL's toxicity was inhibited by a ROS scavenger treatment, suggesting its potential as an anticancer molecule for retinoblastoma treatment.
Researchers from the University of Groningen and Nagoya University developed a compound that can elongate the 24-hour cycle and be activated or deactivated using light. The study shows that it is possible to change the 24-hour cycle in cells or tissues to a 28-hour cycle, providing a new approach to analyzing the circadian clock system.
Researchers discover USP7 inhibitors cause premature activation of CDK1 protein, leading to uncontrolled cell division and cell death. This finding opens the door for potential therapeutic combinations that could increase the efficacy of these drugs in cancer patients.
Researchers have mapped 300 proteins that regulate cell division, a crucial step in cancer development, offering hope for tailored cancer treatments. The study provides new insights into cell-to-cell variation and the human cell cycle, with the data now available in the Human Protein Atlas.
Researchers at Technion-Israel Institute of Technology have discovered a new pathway that targets cancer cells specifically, minimizing damage to healthy cells. The folate cycle is essential for DNA and RNA production, and the team found that tumor cells relying on the cytosolic pathway are more susceptible to targeted treatments.