Articles tagged with Gene Expression
Researchers have developed a toolkit of genes and hardware using colored lights and engineered bacteria to test and debug genetic circuits. By varying the timing and intensity of lights, they can control exactly when and how much different genes are expressed.
Researchers at Lund University found epigenetic changes in approximately 800 genes of people with type 2 diabetes, which could contribute to reduced insulin production. Epigenetic changes are reversible and can be influenced by factors like age, BMI, and lifestyle.
Researchers from Karolinska Institutet found that the MYC gene promotes neural cell differentiation rather than proliferation in intact neural tissue. This discovery may lead to new approaches for treating spinal cord injuries and promoting nerve cell growth.
A study published in Nature Neuroscience suggests that abnormal gene expression resulting from DNA relaxation can be detected in the brain and blood of Alzheimer's patients. The researchers propose that drugs modifying DNA structure may be beneficial for treating Alzheimer's disease, paving the way for epigenetic-based therapies.
A recent study published in Human Gene Therapy evaluated the immune response to viral vector delivery systems and their impact on gene therapy's safety and efficacy. The researchers found that the systemic and local immune reactions induced by AAV-based gene therapy did not affect the safety of gene therapy or expression of the replace...
Research published in Cell Metabolism reveals that hotspots of fuel consumption in the adult brain are associated with ongoing development and remodeling. The study identifies 16 brain regions with elevated levels of aerobic glycolysis, which is linked to gene expression related to growth, synaptic transmission, and neurogenesis.
Researchers at Oregon State University have developed genetically modified poplar trees that grow faster, resistant to insect pests and retain genes for up to 14 years. These traits could be particularly valuable in the paper and pulp industries and emerging biofuel sector.
The Gene Expression Barcode 3.0 tool helps cancer researchers process and analyze massive amounts of genetic data from patients and mice, enabling the development of tailored treatments. The improved algorithm makes it faster and more accessible for researchers to use.
Researchers found that males secrete signaling molecules that shorten the lifespan of hermaphroditic females by more than 20%. The effect persists even when genders are separated or females are sterile, indicating it's not due to physical stress or energy demands. Pheromone production is also linked to male-induced demise.
Researchers developed a molecular test based on a 96 gene expression profile to improve diagnosis and treatment of EoE. The test identified patients with approximately 96% sensitivity and 98% specificity, providing a reliable next-generation diagnosis.
Researchers at the University of Texas at Arlington are developing a new method to deliver genes that allow expression of light-sensitive proteins, enabling optogenetic stimulation. This technique holds promise for treating neurological disorders and understanding brain function.
A study found profound changes in mouse eyes after a 13-day spaceflight, including oxidative stress, DNA damage repair genes, and apoptotic pathways. These changes were partially reversible upon return to Earth.
Researchers at Aarhus University are using pigs, zebrafish and jellyfish to investigate hereditary forms of nervous disorders. They have successfully transferred the SYN1 gene from humans to pigs, which is involved in communication between nerve cells, to create a model for neurodegenerative diseases like Parkinson's disease.
Researchers from CNIC and CSIC discover that inhibiting protein Rcan1 reduces burden of atherosclerosis in mice. Genetic inactivation of the protein represses disease development by favoring anti-inflammatory characteristics in macrophages.
A study found nearly 170 significant gene expression changes in patients with pouchitis, increasing to over 1,000 in those progressing to Crohn's-like changes. These alterations involved genes in inflammatory processes and metabolic pathways.
A Yale-led study has identified 52 genes that significantly correlate with outcome in patients with IPF, predicting shorter survival time and guiding treatment decisions. The discovery of these biomarkers may lead to better prediction of disease presence and severity.
Researchers discovered that aspirin improves survival in patients with colon cancer whose tumour cells express Human Leukocyte Antigen class I (HLA class I), a cell-surface protein involved in the immune system. The study found that HLA class I could be used to predict which patients benefit from aspirin therapy.
Researchers extended mouse lifespan by 20% through gene manipulation, with some organs aging better than others. This increase is equivalent to a 16-year boost in human lifespan, offering insights into aging and potential therapies for age-related diseases.
A study found that dominant male turkeys express genes more like males and less like females, leading to increased attractiveness. Researchers suggest a similar pattern may exist in females, with more attractive women exhibiting higher female gene expression.
Researchers found increased expression of interleukin-33 (IL-33) in human airways, linked to mucus production and other genes implicated in COPD. A mouse model also showed IL-33-producing epithelial progenitor cells induced by viral infection, suggesting potential therapeutic strategies.
Researchers at the University of California, San Diego, have decoded the genetic basis of chronic mountain sickness, a disease affecting Andean highlanders. They found two genes, ANP32D and SENP1, that are overexpressed in CMS individuals and may hold key to treating the condition.
Researchers at Karolinska Institutet found that CHD5 is essential for stem cells to mature into neurons. In the absence of CHD5, stem cells are unable to silence certain genes and switch on those necessary for neuronal maturation. The study suggests restoring CHD5 in aggressive tumor cells could make them more treatable.
Researchers found that intracerebroventricular injection of neuropeptide Y gene suppressed mossy fiber sprouting, inhibited abnormal synaptophysin expression, and reduced epileptic seizures. This study suggests a recombinant adeno-associated virus expression vector carrying the neuropeptide Y gene as a potential therapeutic approach.
Researchers at Kansas State University have successfully restored hearing and balance in mice with a genetic mutation that causes hereditary deafness. The study, published in PLOS Genetics, uses a targeted approach to rescue hearing and balance by restoring pendrin expression in the endolymphatic sac. This finding has significant impli...
Scientists developed a histology expression predictor for common types of lung cancer using paraffin samples, achieving accuracy comparable to pathologists. The technology has potential applications in predicting responses to therapies and prognostication.
A study on rats found that stress even before conception causes changes in the expression of a gene linked to the stress mechanism, affecting offspring's brains. The research suggests a potential link between transgenerational influences and human experiences.
Research found epigenetic changes in fat cells after exercise, influencing genes linked to type 2 diabetes and obesity. The study provides new insights into the mechanisms of how physical activity affects disease risk.
Research finds that voluntary wheel running reduces pro-inflammatory gene expression in the colon, while forced treadmill running increases it. Forced exercise also disrupts the gut's microbial environment.
Researchers found that men with haplogroup I have lower numbers of copies of two important genes in macrophages, which may contribute to increased risk of coronary artery disease. The study used a sample of around 2,000 men from four European populations and aimed to decipher the genetic background behind the association.
The TEDDY study has identified a unique perspective on which molecular and environmental factors contribute to type 1 diabetes. By parsing genetic mutations, scientists can better predict disease progression and identify potential protective factors.
Researchers have discovered a push-pull system in the suprachiasmatic nucleus (SCN) that allows the biological clock to adjust to changes in day/night cycles. The system uses neurotransmitters GABA and VIP to synchronize neurons and maintain accuracy within minutes of the day.
Scientists have genetically engineered mice to mimic high levels of neuregulin-1 associated with schizophrenia, and found that reversing this gene expression eliminated classic symptoms. The study suggests that targeting excessive neuregulin-1 levels could be a new approach to treating the disorder.
Scientists have reversed behavioral and brain abnormalities in adult mice by restoring normal expression to the Neuregulin1 gene, which is over-expressed in humans with schizophrenia. The findings suggest that damage caused by abnormal prenatal expression may be reversible in adulthood, offering hope for treatment of some patients.
Researchers found that transgenic expression of normal CFTR in the intestine of CF pigs eased meconium ileus, a common symptom of CF. Despite this improvement, other CF symptoms persisted, highlighting tissue-specific gene replacement as a potential treatment strategy.
A recent study has revealed the magnitude of variation in gene expression measurements within breast cancers. Combining samples from multiple biopsies from a single tumour can effectively overcome this variation for selected genes, allowing for more precise treatment tailoring and reliable predictions related to disease progression.
A recent study published at the 5th IMPAKT Breast Cancer Conference finds that gene expression tests can effectively tailor cancer treatments to individual patients, despite variability in tumor cell types and gene expression. The researchers analyzed 78 biopsies from 26 tumors and found that some genomic tests were more reliable than ...
A new study found that certain compounds in honey, including p-coumaric acid and propolis, can stimulate the expression of detoxification genes and immunity genes in honey bees. This suggests that a diet rich in these substances may help protect against pesticide exposure and other threats.
A study by Dr. Susan K. Wood found that social stress can lead to inflammatory changes in the brain, increasing vulnerability to depression and heart disease. The research identified specific genes and proteins involved in this process, shedding light on potential targets for treatment.
The study reveals that turtles activate existing genes in new ways to adapt to oxygen deprivation, which may lead to improved treatments for human heart conditions. The research also highlights the importance of preserving turtle diversity due to their slow evolution rate and declining global populations.
Researchers have created a numeric model of the chromosome that supports experimental data and provides a hypothesis on the bundle's function. The model identifies regions with specific genes, contradicting the chaotic view of the chromosome as a randomly entangled thread.
Researchers have identified the LY86 gene as a key contributor to obesity, finding high methylation levels associated with increased inflammation and insulin resistance. This association held up across various populations, suggesting a potential link between environmental factors and genetic expression.
Researchers unveil public domain DNA sequences and statistical models to engineer microbes with precision, increasing reliability and accuracy. This technological foundation enables more precise genetic engineering in the future.
Researchers have developed a novel therapeutic approach to treat deafness and balance impairment by injecting mice with an antisense oligonucleotide that targets a specific gene mutation. The treatment, which was tested on mice engineered to model human Usher syndrome, successfully rescues hearing and cures balance problems.
A new therapy called an antisense oligonucleotide (ASO) has been developed by researchers at LSU Health Sciences Center, which partially corrects gene and protein expression and rescues hearing and balance in a mouse model of Usher syndrome. This breakthrough suggests the potential for treating deafness and balance disorders.
Researchers developed a new gene therapy approach called exon skipping, which bypasses disease-causing mutations in genes to restore normal expression and protein production. This strategy has shown promising results in treating muscular dystrophy, with improved muscle force and increased body weight and muscle mass.
A study on heat-resistant corals reveals how they withstand extreme temperatures, potentially holding key to species survival for organisms worldwide. The research identified a genetic process allowing some corals to resist climate change, with 'frontloaded' genes already turned on before stress begins.
A University of Missouri study failed to replicate previous research on the toxic effects of BPA and genistein, two chemicals that have been linked to obesity and type 2 diabetes in humans. The findings suggest that the chemicals may not have the same adverse effects as previously reported, highlighting the need for more reliable data ...
Researchers found that microRNA-26a suppresses melanoma cell growth while leaving healthy cells unharmed. Reintroducing microRNA-26a to melanoma cell lines led to a marked decrease in cancer cell survival, suggesting it as a potential therapeutic target for melanoma treatment.
A recent study by Vall d'Hebron Institute of Oncology has led to the redefinition of hormone-sensitive breast tumours, improving diagnosis and treatment outcomes. Gene expression analysis revealed discrepancies between histopathological data and molecular profiles, prompting a new definition that incorporates progesterone receptor levels.
A Mayo Clinic study found that high levels of BubR1 preserve genomic integrity and reduce age-related disease in mice. The research suggests controlling levels of this regulator could extend healthy life span.
A new study on mice suggests that common anesthetic agents like Nitrous Oxide and isoflurane can cause neuronal cell death and changes in gene expression in developing brains. The findings have implications for the use of anesthesia during pregnancy and childbirth.
Researchers found that microRNA-218 is low in medulloblastoma patients and its addition stops disease occurrence. The microRNA also affects genes involved in tumor growth and migration, offering potential targets for therapy.
Researchers found that the development of hands and feet occurred through the gain of new DNA elements activating specific genes. This discovery helps understand the power of gene expression in shaping bodies and may shed light on genetic diseases associated with limb formation.
Two papers connect long non-coding RNAs to inherited conditions in humans, revealing a chromosomal translocation disrupting expression of PTHLH and SOX9 genes. A lncRNA on chromosome 12 is also linked to the development of the placenta.
Advaita Corporation, a startup based on Wayne State University tech, received $125,000 from the Michigan Emerging Technologies Fund program. Its Pathway-Guide software solution provides cutting-edge gene pathway analysis technology for researchers.
Researchers have shown how living organisms evolve new functions from limited genes by duplicating and mutating existing genes. The 'innovation, amplification and divergence' model explains how a newly duplicated gene sticks around long enough to pick up a useful new function.
Researchers have discovered a genetic structure that makes soybeans resistant to a devastating disease, and it's not just one gene but three neighboring genes working together. The unique structure of these genes, which are duplicated multiple times, is the key to their effectiveness.
A Simon Fraser University physicist has discovered a link between variable methylation in DNA and various attributes such as age, gender, stress, and socioeconomic status. The study found that childhood poverty left a detectable molecular mark on an individual's DNA, which correlated with gene expression.
A study by Emmanouil Dermitzakis and colleagues found that genetic variants impact gene expression differently in men and women. The researchers discovered that even with the same DNA mutation, the effect on gene expression varies between sexes.
The study reveals that human brains are more similar than different, with the same basic molecular blueprint across individuals. Key findings include regional similarity in biochemistry, homogeneous cortex structure, and widespread gene expression across brain areas.