Articles tagged with Gene Expression
The study sequenced the human methylome from peripheral blood mononuclear cells, identifying allele-specific methylation differences associated with gene expression. The findings suggest that parental gene imprinting may be more common than previously thought, with implications for understanding human health and disease.
Christopher Gregg's groundbreaking research reveals how parental genetic cues influence brain development and disease, providing a roadmap for future research. His findings have major relevance for understanding brain evolution, function, and disease.
Scientists at the University of Illinois Chicago have found a gene expression mechanism that contributes to drug resistance in aggressive ER-positive breast tumors. The study reveals how estrogen and inflammatory proteins work together to drive cancer progression.
Researchers have discovered that RD114 envelope proteins can effectively pseudotype lentiviral vectors, offering an attractive alternative to VSV-G. This technology has the potential to enhance gene therapy approaches by increasing transduction efficiency and stability.
Researchers are calling for a new focus on hypertrophic cardiomyopathy (HCM), a genetic disorder causing sudden death in young people. A task force of cardiologists and cardiac biologists recommends studying the natural history of HCM, defining all genetic causes, supporting clinical trials, and preventing mutant gene expression.
A new software, Myrna, uses cloud computing to analyze RNA sequencing data at an unprecedented speed and cost-effectiveness. The software calculated differential expression from 1.1 billion reads in under 2 hours for a cost of around $66.
A $3 million NIH grant will help scientists at Jefferson Medical College study variations in platelet function, specifically the genetics of platelet gene expression. The goal is to identify biomarkers for predicting cardiovascular disease risk and developing novel therapeutic strategies.
Exposure to low doses of BPA affects the earliest stages of egg production in the ovaries of developing mouse fetuses. The study reveals a striking down-regulation of mitotic/cell cycle genes, raising concerns about the reproductive lifespan of female mice.
Researchers discovered a set of seven genes in whole blood that can diagnose major depressive disorder (MDD) with high accuracy. This breakthrough could lead to unbiased diagnosis and reduce stigma associated with mental health problems, ultimately helping patients receive better treatment.
Research finds key gene expression pathways involved in Candidiasis-associated denture stomatitis, with significant up-regulation of TLR2 and CD28 signaling. Saliva analysis reveals six extracellular protein genes linked to stomatitis.
A new study in the FASEB Journal suggests that polyphenols in virgin olive oil can down-regulate atherosclerosis-related genes, leading to improved lipid profiles and reduced inflammation. This research provides insight into how specific foods can modify gene expression, offering potential therapeutic benefits for cardiovascular disease.
Scientists have discovered how corals respond to ocean warming, shedding light on potential methods for preserving or restoring coral reefs. The research found that some corals cope better with heat stress than others due to genetic variability, offering new insights into coral reef restoration.
Scientists present evidence that imprinted genes from the father may promote excessive resource allocation to the fetus, while those from the mother are more conservative. This could lead to sex-dependent differences in disease risk and outcomes.
Cold Spring Harbor Laboratory has published new methods for plant gene expression and Xenopus imaging, enabling faster and more efficient investigation of gene function. These protocols utilize Agrobacterium-mediated transformation and confocal microscopy to study cellular behavior and subcellular processes in plants and frog embryos.
Researchers found that a Mediterranean diet high in phenols represses pro-inflammatory genes, which could contribute to reduced cardiovascular disease risk. The study also suggests that this diet can alter the activity of immune system cells, leading to a less deleterious inflammatory profile.
Research finds enhanced MMP-9 expression in gastric cancer, while normal tissue shows no difference. Profiling matrix metalloproteinases family to understand cancer development is next step.
A new mathematical approach, csSAM, allows for accurate and quick characterization of immune cells in human blood, enabling the distinction between health and disease states. This breakthrough method identifies changes in gene expression patterns, overcoming previous obstacles such as cell separation and variation in cell proportions.
Researchers discover that mother's milk induces liver production of FGF21, a molecule that activates brown fat to increase body temperature. This phenomenon may have far-reaching consequences for metabolic health in adulthood.
Children conceived through assisted reproductive technology are at greater risk of birth defects and low birth weight, associated with obesity and diabetes. Geneticist Carmen Sapienza found altered DNA methylation and gene expression in 5-10% of these children.
Researchers found reduced p16INK4a RNA expression and demethylation of the gene in 55% of patients, suggesting a novel susceptibility marker. Low to moderate 16INK4A protein expression was also detected in 45% of retinoblastoma tumor specimens.
Research published in PLoS Biology discovered the adaptation of African cichlid fish visual sensitivity to ecological factors such as diet and water clarity. The study showed that both changes in gene expression and sequence contribute to organismal diversity, with complementary effects.
A team of researchers has identified the Chd1 gene as a crucial regulator of open chromatin in embryonic stem cells, enabling their ability to differentiate into any cell type. The study provides important insights into the mechanisms of stem cell pluripotency and opens up new avenues for the development of stem cell therapies.
A new study by Uppsala University researchers Elena Jazin and Björn Reinius found that genetic expression in cerebral cortices exhibits sex-based differences, which are thought to be associated with later divergences in brain development. The study suggests that genes on the Y chromosome play a crucial role in these differences.
A study of 124 patients with advanced biliary tract cancer found EGFR overexpression in 39.3% of tumors, while HER2 overexpression and gene amplification were present in only 5% of cases. This suggests that targeting EGFR may be a promising therapeutic approach for BTC, while routine testing and targeting of HER2 is not recommended.
The study found that S100A2 protein expression was reduced while p63 protein expression was increased, indicating their involvement in EC carcinogenesis. Combined expression of S100A2 and p63 may aid in early diagnosis and prognostication of ESCC.
A team of researchers at Washington University in St. Louis has discovered that individual cells isolated from the biological clock can keep a 24-hour rhythm, but they are unreliable on their own. The cells must communicate with each other to establish a coherent daily cycle.
Researchers discovered that PPAR-alpha's sumoylation process regulates gender-specific gene expression and protects female mice from estrogen-induced liver disease. This finding suggests potential new approaches to prevent this condition by targeting PPAR-alpha agonists.
Researchers have identified a new mechanism underlying sex-specific gene expression in mice, with PPAR-alpha repressing genes involved in immunity and steroid production. The study also found that this repression is mediated by sumoylation, a process only occurring in female mice, and suggests potential new approaches to prevent estrog...
Researchers found 44 genes up-regulated in CKD patients, including 11 involved in oxidative phosphorylation. Elevated reactive oxygen species (ROS) levels were also detected, suggesting a vicious circle of respiration dysregulation that contributes to CKD.
A new study by University of Illinois researchers reveals that environmental factors can alter aggression levels in honey bees. By analyzing gene expression patterns in response to alarm pheromone, the team found similarities between short-term and long-term changes, suggesting a connection between nurture and nature.
Researchers identified 66 genes involved in relapse, including those related to neuroplasticity and learning. The study used a heroin behavioral incubation model to mimic real-life situations that trigger relapse.
Research found that maternal exposure to titanium dioxide nanoparticles affects gene expression related to the central nervous system in developing mice. This may have implications for diseases such as autistic disorder, epilepsy, and learning disorders, as well as Alzheimer's disease, schizophrenia, and Parkinson's disease.
Researchers at OMT successfully created heritable, specific and permanent genetic modifications in rats using Zinc Finger Nuclease (ZFN) technology. This achievement paves the way for unrestricted development of a novel human monoclonal antibody platform.
The University of Leeds team is developing a digital model to predict the timing of plant flowering, which could help farmers improve crop yields. The model uses computer simulations to account for changes in genetic structure and environmental factors like climate.
The study found that DKK-3 and WIF-1 proteins are associated with liver cancer development, suggesting potential as biomarkers for early detection. The research suggests blocking this pathway may improve treatment options for liver cancer through further study.
A team of neuroscientists at Cold Spring Harbor Laboratory has discovered the mechanism by which a signaling protein controls the maturation and strength of excitatory synapses. The study, led by Professor Linda Van Aelst, found that oligophrenin-1 stabilizes postsynaptic AMPA receptors, which is essential for proper synaptic function.
A review of phase I clinical trial designs and the association between lymphovascular invasion and breast cancer recurrence, highlighting the need for new methods to expedite drug development and improve patient outcomes.
A recent study found that women have a more powerful innate immune system than men due to the presence of estrogen. Estrogen blocks an enzyme called Caspase-12, which prevents the inflammatory process, making women more resistant to infection.
Researchers propose trial designs to investigate the impact of physical activity and weight control on breast cancer risk, with potential causal relationships. Clusterin is identified as a tumor suppressor gene in mouse models of neuroblastoma, where its expression affects tumor growth and metastasis.
A study by University of Illinois scientists reveals the FRG1 gene is crucial for angiogenesis, contributing to blood vessel growth and organization in the retina. The findings support the idea that FRG1 expression is a main cause of visual deficits associated with facioscapulohumeral muscular dystrophy.
Scientists have identified a new, infectious prion in yeast that can affect the expression of hundreds of genes. The discovery raises questions about the role of these proteins in degenerative brain diseases and their potential impact on human cells.
Researchers found that a significant amount of inbreeding depression is due to key genes affecting other genes, particularly those involved in metabolism and stress. The study also identified distinct gene expression changes across different chromosome regions, suggesting a complex interplay between genetic mechanisms.
Aspirin inhibits H. pylori growth and enhances susceptibility to metronidazole, clarithromycin and amoxicillin by affecting outer membrane protein expression and increasing endocellular antimicrobial concentrations.
Researchers found that gene expression profiles differed between tumor samples from patients who had taken vitamin E, selenium, or both supplements compared to those on placebo. The study provides insight into the effects of preoperative supplement use on prostate cancer gene expression, a potential area for future investigation.
Research suggests that blocking RHAMM expression can selectively induce fat cell generation, replacing lost cells in the aging process and reducing deposits of unhealthy visceral fat. This technique could provide a non-surgical approach for wrinkle reduction and skin normalization.
Researchers discovered that aging causes a dramatic drop in COX-2 enzyme levels, leading to reduced stem cell differentiation into cartilage and decreased bone formation. The study found that manipulating the COX-2 pathway with experimental drugs can rescue healing ability lost with age.
Researchers from USC and Cambridge have developed a method to track the activity of specific genes in real-time using a specially modified camera and computer vision techniques. This breakthrough has potential applications in various fields, including military, retail, and entertainment.
A new technique allows for the simultaneous tracking of gene expression and movement in Drosophila flies, enabling researchers to study correlations between behavior, gene expression, and aging. The method uses green fluorescent protein (GFP) and specially modified video cameras to track movement and quantify GFP expression in real-time.
Researchers found that among women under 40, black women have a higher breast cancer incidence rate than white women. However, this trend reverses among women over 40, with white women having a higher incidence rate. The study confirms the age-related crossover effect in breast cancer incidence rates between black and white ethnic groups.
Researchers have identified MEDNIK syndrome as a debilitating genetic disorder characterized by mental retardation, enteropathy, deafness, and other symptoms. The AP1S1 gene mutation is found to cause impairment of neural networks, including the spinal cord, inner ear, and brain.
Researchers have developed a new method to prioritize disease-associated SNPs by analyzing genes with high differential expression rates. This approach, called fitSNPs, successfully distinguished true disease genes from false positives in genome-wide association studies, and can serve as a powerful tool for prioritizing disease genes.
A team of researchers has discovered MEDNIK Syndrome, a debilitating genetic syndrome characterized by mental retardation, enteropathy, deafness, and peripheral neuropathy. The AP1S1 gene mutation causes this disorder, affecting development in the skin and spinal cord.
Scientists have developed a new approach to harness the power of microRNAs (miRNAs) as natural gene repressors for therapeutic purposes. By engineering mouse bone marrow cells to express genes only when miR-181a is downregulated, they were able to create immune cells that could target and destroy cancer cells.
Scientists at St. Jude Children's Research Hospital discovered that a specific differentiated cell type requires constant expression of the Prox1 gene to maintain its identity. In its absence, lymphatic endothelial cells reprogram into blood endothelial cells, gaining new characteristics.
Researchers have developed a new approach to modulate gene expression using miRNA natural gene repressors for therapeutic purposes, effectively treating cancer in mice. Additionally, the study has provided insight into the molecular mechanisms controlling epithelial fluid and HCO3– secretion, which may help understand cystic fibrosis.
New UGA research sheds light on the important role of the Foxn1 gene in maintaining T cell production in the thymus. The study suggests that understanding how this gene works could lead to new therapies for various illnesses, including age-related immunodeficiency disorders.
A new study from the University of Iowa found that lung airway cells can activate vitamin D, leading to the expression of genes involved in immune defense. The active form of vitamin D helps fight bacterial infections and reduces inflammation.
Researchers discovered that injecting human recombinant interleukin-6 improved insulin sensitivity and glucose absorption, increasing fat metabolism genes. A preliminary study suggests this molecule could help prevent diabetes and obesity in humans in the medium term.
Research reveals endocan protein expression is higher in normal tissues than in colorectal cancer, with positive correlation to tissue differentiation. Elevated serum levels of endocan found in late-stage lung cancer, suggesting its potential as a biomarker.
A new study finds that birds have a 'thumb' due to gene expression similar to alligators, not mice. The research rekindles the hypothesis of a developmental frameshift in the evolution of bird wings.